Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
2 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
3 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
4 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
5 | African trypanosomiasis 💬 9 genes, 22 drugs (DrugBank) and 59 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
6 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
7 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
8 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
9 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
10 | Allograft rejection 💬 11 genes, 23 drugs (DrugBank) and 56 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
11 | Allograft rejection 💬 11 genes, 23 drugs (DrugBank) and 56 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
12 | Allograft rejection 💬 11 genes, 23 drugs (DrugBank) and 56 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
13 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
14 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
15 | Amoebiasis 💬 19 genes, 29 drugs (DrugBank) and 63 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
16 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
17 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
18 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
19 | Antifolate resistance 💬 8 genes, 21 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
20 | Antigen processing and presentation 💬 4 genes, 15 drugs (DrugBank) and 52 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
21 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
22 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
23 | Apoptosis 💬 16 genes, 28 drugs (DrugBank) and 59 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
24 | Asthma 💬 8 genes, 22 drugs (DrugBank) and 55 diseases |
FCER1A [1] FCER1A 💬 |
Omalizumab Omalizumab 💬 |
Omalizumab | 046 [7] 46, 53, 65, 98, 162, 226, 299 💬 💬 |
25 | Asthma 💬 8 genes, 22 drugs (DrugBank) and 55 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
26 | Asthma 💬 8 genes, 22 drugs (DrugBank) and 55 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
27 | Asthma 💬 8 genes, 22 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
28 | Autoimmune thyroid disease 💬 22 genes, 15 drugs (DrugBank) and 35 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
29 | Autoimmune thyroid disease 💬 22 genes, 15 drugs (DrugBank) and 35 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
30 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
31 | Autophagy - other 💬 1 gene, 3 drugs (DrugBank) and 41 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
32 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
33 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
34 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
35 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CYSLTR1 [1] CYSLTR1 💬 |
Montelukast Montelukast 💬 |
Montelukast | 006 [8] 6 , 13, 46, 61, 63, 85, 98, 228 💬 💬 |
36 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
HRH1 [1] HRH1 💬 |
Loratadine Loratadine 💬 |
Loratadine | 013 [4] 13, 46, 89, 98 💬 💬 |
37 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
HRH2 [1] HRH2 💬 |
Famotidine Famotidine 💬 |
Famotidine | 006 [6] 6 , 46, 61, 86, 98, 107 💬 💬 |
38 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
39 | Central carbon metabolism in cancer 💬 18 genes, 29 drugs (DrugBank) and 56 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
40 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
41 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
42 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
43 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
VDR [1] VDR 💬 |
Cholecalciferol Cholecalciferol 💬 |
Cholecalciferol | 006 [24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬 💬 |
44 | Choline metabolism in cancer 💬 11 genes, 25 drugs (DrugBank) and 53 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
45 | Collecting duct acid secretion 💬 3 genes, 11 drugs (DrugBank) and 35 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Dexlansoprazole Dexlansoprazole 💬 |
Dexlansoprazole | 098 [1] 98 💬 💬 |
46 | Collecting duct acid secretion 💬 3 genes, 11 drugs (DrugBank) and 35 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
47 | Collecting duct acid secretion 💬 3 genes, 11 drugs (DrugBank) and 35 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Lansoprazole Lansoprazole 💬 |
Lansoprazole | 063 [7] 63, 71, 85, 98, 166, 222, 299 💬 💬 |
48 | Collecting duct acid secretion 💬 3 genes, 11 drugs (DrugBank) and 35 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Vonoprazan Vonoprazan 💬 |
Vonoprazan | 063 [2] 63, 98 💬 💬 |
49 | Colorectal cancer 💬 14 genes, 23 drugs (DrugBank) and 49 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
50 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
51 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
52 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
53 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
54 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
55 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
56 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
57 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL5RA [1] IL5RA 💬 |
Benralizumab Benralizumab 💬 |
Benralizumab | 044 [5] 44, 45, 98, 162, 299 💬 💬 |
58 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
59 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
TSLP [1] TSLP 💬 |
Tezepelumab Tezepelumab 💬 |
Tezepelumab | 098 [1] 98 💬 💬 |
60 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
61 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
62 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
63 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
64 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
VDR [1] VDR 💬 |
Cholecalciferol Cholecalciferol 💬 |
Cholecalciferol | 006 [24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬 💬 |
65 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
66 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
67 | ErbB signaling pathway 💬 14 genes, 26 drugs (DrugBank) and 53 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
68 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
FCER1A [1] FCER1A 💬 |
Omalizumab Omalizumab 💬 |
Omalizumab | 046 [7] 46, 53, 65, 98, 162, 226, 299 💬 💬 |
69 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
70 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
71 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
72 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
73 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
S1PR1 [2] S1PR1, S1PR4 💬 |
Etrasimod Etrasimod 💬 |
Etrasimod | 096 [3] 96, 97, 98 💬 💬 |
74 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
75 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Dexlansoprazole Dexlansoprazole 💬 |
Dexlansoprazole | 098 [1] 98 💬 💬 |
76 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
77 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Lansoprazole Lansoprazole 💬 |
Lansoprazole | 063 [7] 63, 71, 85, 98, 166, 222, 299 💬 💬 |
78 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Vonoprazan Vonoprazan 💬 |
Vonoprazan | 063 [2] 63, 98 💬 💬 |
79 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
HRH2 [1] HRH2 💬 |
Famotidine Famotidine 💬 |
Famotidine | 006 [6] 6 , 46, 61, 86, 98, 107 💬 💬 |
80 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
81 | Glioma 💬 15 genes, 30 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
82 | Graft-versus-host disease 💬 7 genes, 22 drugs (DrugBank) and 60 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
83 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
84 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
85 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
86 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
87 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL5RA [1] IL5RA 💬 |
Benralizumab Benralizumab 💬 |
Benralizumab | 044 [5] 44, 45, 98, 162, 299 💬 💬 |
88 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
89 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
90 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
91 | Hepatocellular carcinoma 💬 21 genes, 31 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
92 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
93 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
94 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
95 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
96 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
97 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
98 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
99 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
100 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
101 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
102 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
103 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
104 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
105 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
106 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
107 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
108 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
109 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
110 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
111 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
HRH1 [1] HRH1 💬 |
Loratadine Loratadine 💬 |
Loratadine | 013 [4] 13, 46, 89, 98 💬 💬 |
112 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
113 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
114 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
115 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
116 | Intestinal immune network for IgA production 💬 16 genes, 27 drugs (DrugBank) and 47 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
117 | Intestinal immune network for IgA production 💬 16 genes, 27 drugs (DrugBank) and 47 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
118 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
119 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
120 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
121 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL5RA [1] IL5RA 💬 |
Benralizumab Benralizumab 💬 |
Benralizumab | 044 [5] 44, 45, 98, 162, 299 💬 💬 |
122 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
123 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
TSLP [1] TSLP 💬 |
Tezepelumab Tezepelumab 💬 |
Tezepelumab | 098 [1] 98 💬 💬 |
124 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
125 | Legionellosis 💬 9 genes, 22 drugs (DrugBank) and 61 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
126 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
127 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
128 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
129 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
130 | Malaria 💬 15 genes, 28 drugs (DrugBank) and 61 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
131 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
132 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Dexlansoprazole Dexlansoprazole 💬 |
Dexlansoprazole | 098 [1] 98 💬 💬 |
133 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
134 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Lansoprazole Lansoprazole 💬 |
Lansoprazole | 063 [7] 63, 71, 85, 98, 166, 222, 299 💬 💬 |
135 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Vonoprazan Vonoprazan 💬 |
Vonoprazan | 063 [2] 63, 98 💬 💬 |
136 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
137 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 41 diseases |
VDR [1] VDR 💬 |
Cholecalciferol Cholecalciferol 💬 |
Cholecalciferol | 006 [24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬 💬 |
138 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
139 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
140 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
141 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
142 | Necroptosis 💬 28 genes, 39 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
143 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
144 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CYSLTR1 [1] CYSLTR1 💬 |
Montelukast Montelukast 💬 |
Montelukast | 006 [8] 6 , 13, 46, 61, 63, 85, 98, 228 💬 💬 |
145 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
146 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
HRH1 [1] HRH1 💬 |
Loratadine Loratadine 💬 |
Loratadine | 013 [4] 13, 46, 89, 98 💬 💬 |
147 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
HRH2 [1] HRH2 💬 |
Famotidine Famotidine 💬 |
Famotidine | 006 [6] 6 , 46, 61, 86, 98, 107 💬 💬 |
148 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Beclomethasone dipropionate Beclomethasone dipropionate 💬 |
Beclomethasone dipropionate | 085 [3] 85, 97, 98 💬 💬 |
149 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Budesonide Budesonide 💬 |
Budesonide | 066 [9] 66, 93, 94, 95, 96, 97, 98, 228, 299 💬 💬 |
150 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Fluticasone Fluticasone 💬 |
Fluticasone | 098 [3] 98, 228, 299 💬 💬 |
151 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Fluticasone propionate Fluticasone propionate 💬 |
Fluticasone propionate | 098 [2] 98, 228 💬 💬 |
152 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Mometasone Mometasone 💬 |
Mometasone | 098 [2] 98, 162 💬 💬 |
153 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Mometasone furoate Mometasone furoate 💬 |
Mometasone furoate | 098 [2] 98, 162 💬 💬 |
154 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
S1PR1 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 |
Etrasimod Etrasimod 💬 |
Etrasimod | 096 [3] 96, 97, 98 💬 💬 |
155 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
156 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
157 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
158 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
159 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
160 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
161 | Oxidative phosphorylation 💬 2 genes, 7 drugs (DrugBank) and 25 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Dexlansoprazole Dexlansoprazole 💬 |
Dexlansoprazole | 098 [1] 98 💬 💬 |
162 | Oxidative phosphorylation 💬 2 genes, 7 drugs (DrugBank) and 25 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
163 | Oxidative phosphorylation 💬 2 genes, 7 drugs (DrugBank) and 25 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Lansoprazole Lansoprazole 💬 |
Lansoprazole | 063 [7] 63, 71, 85, 98, 166, 222, 299 💬 💬 |
164 | Oxidative phosphorylation 💬 2 genes, 7 drugs (DrugBank) and 25 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Vonoprazan Vonoprazan 💬 |
Vonoprazan | 063 [2] 63, 98 💬 💬 |
165 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
166 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
VDR [1] VDR 💬 |
Cholecalciferol Cholecalciferol 💬 |
Cholecalciferol | 006 [24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬 💬 |
167 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
168 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
169 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
170 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
171 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
172 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL5RA [1] IL5RA 💬 |
Benralizumab Benralizumab 💬 |
Benralizumab | 044 [5] 44, 45, 98, 162, 299 💬 💬 |
173 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
174 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
175 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
176 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
177 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
178 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
179 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
FCER1A [1] FCER1A 💬 |
Omalizumab Omalizumab 💬 |
Omalizumab | 046 [7] 46, 53, 65, 98, 162, 226, 299 💬 💬 |
180 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
181 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
182 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
183 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
184 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
185 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
186 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
187 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
188 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
189 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
190 | Rheumatoid arthritis 💬 22 genes, 49 drugs (DrugBank) and 74 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
191 | RIG-I-like receptor signaling pathway 💬 22 genes, 18 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
192 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
193 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
GABRB1 [3] GABRB1, GABRB2, GABRB3 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
194 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
SLC6A4 [1] SLC6A4 💬 |
Citalopram Citalopram 💬 |
Citalopram | 006 [7] 6 , 8 , 13, 18, 46, 98, 127 💬 💬 |
195 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
196 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
197 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
FCER1A [1] FCER1A 💬 |
Omalizumab Omalizumab 💬 |
Omalizumab | 046 [7] 46, 53, 65, 98, 162, 226, 299 💬 💬 |
198 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
S1PR1 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 |
Etrasimod Etrasimod 💬 |
Etrasimod | 096 [3] 96, 97, 98 💬 💬 |
199 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
200 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
201 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SLC6A4 [1] SLC6A4 💬 |
Citalopram Citalopram 💬 |
Citalopram | 006 [7] 6 , 8 , 13, 18, 46, 98, 127 💬 💬 |
202 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
203 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
204 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
205 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
206 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
207 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
208 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
209 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
210 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
211 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
212 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
213 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
214 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
215 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
216 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
217 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
218 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
219 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Cholecalciferol Cholecalciferol 💬 |
Cholecalciferol | 006 [24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬 💬 |
220 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
221 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
222 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
223 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
224 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 29 drugs (DrugBank) and 60 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
225 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |