Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

ECM-receptor interaction 💬

[1] ITGA4 💬

Firategrast 💬

[1] 13 💬

2

ECM-receptor interaction 💬

[1] ITGA4 💬

Natalizumab 💬

[6] 13, 15, 25, 46, 63, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
96	Crohn disease;Terminal ileitis;

3

ECM-receptor interaction 💬

[2] ITGA4, ITGB7 💬

[2] 96, 97 💬

4

ECM-receptor interaction 💬

[2] ITGA4, ITGB7 💬

Vedolizumab 💬

[3] 94, 96, 97 💬

5

ECM-receptor interaction 💬

[1] ITGB7 💬

Etrolizumab 💬

[2] 96, 97 💬

6

ECM-receptor interaction 💬

[1] SV2A 💬

Brivaracetam 💬

[2] 149, 309 💬

7

ECM-receptor interaction 💬

[1] SV2A 💬

Levetiracetam 💬

[5] 2 , 4 , 6 , 13, 307 💬

8

ECM-receptor interaction 💬

[3] SV2A, SV2B, SV2C 💬

Padsevonil 💬

[1] 149 💬

9

ECM-receptor interaction 💬

[1] VWF 💬

Caplacizumab 💬

[1] 64 💬

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