Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
CPT1A [3] CPT1A, CPT1B, CPT1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
2 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
3 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
4 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
5 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
6 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
7 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
8 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
9 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
10 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
11 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
12 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
13 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
14 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
15 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
SCN5A [1] SCN5A 💬 |
Cifenline Cifenline 💬 |
Cibenzoline | 058 [1] 58 💬 💬 |
16 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
SCN5A [1] SCN5A 💬 |
Eleclazine Eleclazine 💬 |
Eleclazine | 058 [1] 58 💬 💬 |
17 | African trypanosomiasis 💬 9 genes, 22 drugs (DrugBank) and 59 diseases |
IL10 [4] IL10, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
18 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
19 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
20 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
21 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
CCL2 [5] CCL2, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
22 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
CPT1A [3] CPT1A, CPT1B, CPT1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
23 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
24 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
25 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
26 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
ADORA2A [2] ADORA2A, ADORA2B 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
27 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
28 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
29 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
30 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
31 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
32 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
33 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
34 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
35 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
36 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 [1] NR3C2 💬 |
Spironolactone Spironolactone 💬 |
Spironolactone | 046 [8] 46, 58, 67, 86, 113, 210, 218, 225 💬 💬 |
37 | Allograft rejection 💬 11 genes, 23 drugs (DrugBank) and 56 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
38 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
39 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
40 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
41 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
IL1A [4] IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
42 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
MME [1] MME 💬 |
Sacubitril Sacubitril 💬 |
Sacubitril | 058 [2] 58, 222 💬 💬 |
43 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
44 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
45 | Amoebiasis 💬 19 genes, 29 drugs (DrugBank) and 63 diseases |
IL10 [4] IL10, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
46 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
47 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
48 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
49 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
50 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
51 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
52 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
ADRA1A [1] ADRA1A 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
53 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
CPT1A [3] CPT1A, CPT1B, CPT1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
54 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
HMGCR [1] HMGCR 💬 |
Atorvastatin Atorvastatin 💬 |
Atorvastatin | 013 [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬 |
55 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
56 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
57 | Antifolate resistance 💬 8 genes, 21 drugs (DrugBank) and 66 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
58 | Antigen processing and presentation 💬 4 genes, 15 drugs (DrugBank) and 52 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
59 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
60 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
61 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
62 | Apoptosis 💬 16 genes, 28 drugs (DrugBank) and 59 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
63 | Arachidonic acid metabolism 💬 4 genes, 26 drugs (DrugBank) and 43 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
64 | Arginine and proline metabolism 💬 3 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
65 | Arginine and proline metabolism 💬 3 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
66 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
67 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
68 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
69 | Asthma 💬 8 genes, 22 drugs (DrugBank) and 55 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
70 | Autoimmune thyroid disease 💬 22 genes, 15 drugs (DrugBank) and 35 diseases |
IL10 [1] IL10 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
71 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
72 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
73 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Atorvastatin Atorvastatin 💬 |
Atorvastatin | 013 [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬 |
74 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
IL10 [4] IL10, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
75 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
76 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
77 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
78 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
79 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADORA2A [2] ADORA2A, ADORA2B 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
80 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
81 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
82 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
83 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
84 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
85 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
86 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
87 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
88 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
89 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
90 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
91 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
92 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADORA1 [2] ADORA1, ADORA2A 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
93 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
94 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
95 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
96 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
97 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
98 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
99 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
100 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
101 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
102 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
103 | Carbohydrate digestion and absorption 💬 14 genes, 19 drugs (DrugBank) and 30 diseases |
CACNA1D [1] CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
104 | Carbohydrate digestion and absorption 💬 14 genes, 19 drugs (DrugBank) and 30 diseases |
CACNA1D [1] CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
105 | Carbohydrate digestion and absorption 💬 14 genes, 19 drugs (DrugBank) and 30 diseases |
CACNA1D [1] CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
106 | Cardiac muscle contraction 💬 13 genes, 17 drugs (DrugBank) and 26 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
107 | Cardiac muscle contraction 💬 13 genes, 17 drugs (DrugBank) and 26 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
108 | Cardiac muscle contraction 💬 13 genes, 17 drugs (DrugBank) and 26 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
109 | Cardiac muscle contraction 💬 13 genes, 17 drugs (DrugBank) and 26 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
110 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
CACNA1D [1] CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
111 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
CACNA1D [1] CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
112 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
CACNA1D [1] CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
113 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
IL1A [2] IL1A, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
114 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
115 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADORA1 [2] ADORA1, ADORA3 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
116 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
117 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
118 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
119 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
120 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
121 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
122 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
123 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
124 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
125 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
126 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
127 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
128 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
129 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
130 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
131 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
132 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
CCL2 [5] CCL2, IL10, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
133 | Chemical carcinogenesis - DNA adducts 💬 1 gene, 24 drugs (DrugBank) and 40 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
134 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
135 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
136 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
137 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
138 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
139 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
140 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
141 | Chemokine signaling pathway 💬 22 genes, 29 drugs (DrugBank) and 51 diseases |
CCL2 [1] CCL2 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
142 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
143 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
144 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
145 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
146 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
147 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
148 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
149 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
150 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
151 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
152 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
153 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
154 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
155 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
156 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
157 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
158 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
159 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
160 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
161 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
162 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
163 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
164 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
165 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
166 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
167 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
168 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
CCL2 [6] CCL2, IL10, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
169 | Cytosolic DNA-sensing pathway 💬 17 genes, 12 drugs (DrugBank) and 28 diseases |
IL1B [2] IL1B, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
170 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
171 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
172 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
173 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
174 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
CPT1B [2] CPT1B, CPT2 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
175 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
176 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
177 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
178 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
179 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
180 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
181 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
182 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
183 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
184 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
185 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
186 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
187 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
188 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
189 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
190 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SCN1A [1] SCN1A 💬 |
Cifenline Cifenline 💬 |
Cibenzoline | 058 [1] 58 💬 💬 |
191 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SCN1A [1] SCN1A 💬 |
Eleclazine Eleclazine 💬 |
Eleclazine | 058 [1] 58 💬 💬 |
192 | Drug metabolism - cytochrome P450 💬 5 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
193 | Drug metabolism - cytochrome P450 💬 5 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
194 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
195 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
IL6 [2] IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
196 | Fatty acid degradation 💬 7 genes, 2 drugs (DrugBank) and 3 diseases |
CPT1A [4] CPT1A, CPT1B, CPT1C, CPT2 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
197 | Fatty acid metabolism 💬 4 genes, 1 drug (DrugBank) and 2 diseases |
CPT1A [4] CPT1A, CPT1B, CPT1C, CPT2 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
198 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
199 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
CCL2 [4] CCL2, IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
200 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
IL10 [2] IL10, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
201 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
202 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
203 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
204 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
205 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
206 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
207 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
208 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
209 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
CPT1A [3] CPT1A, CPT1B, CPT1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
210 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
211 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
212 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
213 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
214 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
215 | Glycine, serine and threonine metabolism 💬 5 genes, 10 drugs (DrugBank) and 9 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
216 | Glycine, serine and threonine metabolism 💬 5 genes, 10 drugs (DrugBank) and 9 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
217 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
218 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
219 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
220 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
221 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
222 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
223 | Graft-versus-host disease 💬 7 genes, 22 drugs (DrugBank) and 60 diseases |
IL1A [4] IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
224 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
225 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
226 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
227 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL1A [4] IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
228 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
MME [1] MME 💬 |
Sacubitril Sacubitril 💬 |
Sacubitril | 058 [2] 58, 222 💬 💬 |
229 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
IL6 [2] IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
230 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
231 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
232 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
233 | Histidine metabolism 💬 2 genes, 7 drugs (DrugBank) and 7 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
234 | Histidine metabolism 💬 2 genes, 7 drugs (DrugBank) and 7 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
235 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
236 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
237 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
238 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
239 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
240 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
241 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
242 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
IL6 [2] IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
243 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
244 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Benazepril Benazepril 💬 |
Benazepril | 049 [4] 49, 57, 218, 224 💬 💬 |
245 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Captopril Captopril 💬 |
Captopril | 006 [8] 6 , 17, 46, 86, 96, 97, 107, 271 💬 💬 |
246 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Cilazapril Cilazapril 💬 |
Cilazapril | 066 [1] 66 💬 💬 |
247 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Cilazapril Cilazapril 💬 |
Cilazapril | 066 [1] 66 💬 💬 |
248 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
249 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Imidapril Imidapril 💬 |
Imidapril | 067 [1] 67 💬 💬 |
250 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
251 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
252 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Moexipril Moexipril 💬 |
Moexipril | 093 [1] 93 💬 💬 |
253 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
254 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Quinapril Quinapril 💬 |
Quinapril | 019 [1] 19 💬 💬 |
255 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
256 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Amlodipine Amlodipine 💬 |
Amlodipine | 013 [4] 13, 51, 67, 298 💬 💬 |
257 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Cilnidipine Cilnidipine 💬 |
Cilnidipine | 067 [1] 67 💬 💬 |
258 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
259 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Isradipine Isradipine 💬 |
Isradipine | 006 [1] 6 💬 💬 |
260 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Nicardipine Nicardipine 💬 |
Nicardipine | 070 [2] 70, 86 💬 💬 |
261 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Nifedipine Nifedipine 💬 |
Nifedipine | 050 [2] 50, 81 💬 💬 |
262 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Nilvadipine Nilvadipine 💬 |
Nilvadipine | 090 [1] 90 💬 💬 |
263 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
264 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Propiverine Propiverine 💬 |
Propiverine | 226 [1] 226 💬 💬 |
265 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
266 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
267 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA2D1 [2] CACNA2D1, CACNA2D2 💬 |
Mirogabalin Mirogabalin 💬 |
Mirogabalin | 070 [1] 70 💬 💬 |
268 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
Gabapentin Gabapentin 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 💬 |
269 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
Pregabalin Pregabalin 💬 |
Pregabalin | 013 [5] 13, 36, 46, 70, 298 💬 💬 |
270 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Casimersen Casimersen 💬 |
Casimersen | 113 [1] 113 💬 💬 |
271 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Drisapersen Drisapersen 💬 |
Drisapersen | 113 [1] 113 💬 💬 |
272 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Eteplirsen Eteplirsen 💬 |
Eteplirsen | 113 [1] 113 💬 💬 |
273 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Golodirsen Golodirsen 💬 |
Golodirsen | 113 [1] 113 💬 💬 |
274 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Viltolarsen Viltolarsen 💬 |
Viltolarsen | 113 [1] 113 💬 💬 |
275 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
IL6 [1] IL6 💬 |
Olokizumab Olokizumab 💬 |
Olokizumab | 046 [2] 46, 96 💬 💬 |
276 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
IL6 [1] IL6 💬 |
Siltuximab Siltuximab 💬 |
Siltuximab | 028 [2] 28, 331 💬 💬 |
277 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
IL6 [1] IL6 💬 |
Sirukumab Sirukumab 💬 |
Sirukumab | 041 [2] 41, 46 💬 💬 |
278 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
IL6 [2] IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
279 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
IL6 [2] IL6, TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
280 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ITGA4 [1] ITGA4 💬 |
Firategrast Firategrast 💬 |
Firategrast | 013 [1] 13 💬 💬 |
281 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ITGA4 [1] ITGA4 💬 |
Natalizumab Natalizumab 💬 |
Natalizumab | 013 [6] 13, 15, 25, 46, 63, 96 💬 💬 |
282 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ITGA4 [2] ITGA4, ITGB7 💬 |
Abrilumab Abrilumab 💬 |
Abrilumab | 096 [2] 96, 97 💬 💬 |
283 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ITGA4 [2] ITGA4, ITGB7 💬 |
Vedolizumab Vedolizumab 💬 |
Vedolizumab | 094 [3] 94, 96, 97 💬 💬 |
284 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ITGB7 [1] ITGB7 💬 |
Etrolizumab Etrolizumab 💬 |
Etrolizumab | 096 [2] 96, 97 💬 💬 |
285 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
286 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
287 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TGFB1 [3] TGFB1, TGFB2, TGFB3 💬 |
Fresolimumab Fresolimumab 💬 |
Fresolimumab | 051 [3] 51, 85, 222 💬 💬 |
288 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
289 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
290 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
291 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
292 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
293 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
294 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
295 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
296 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
297 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
298 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
299 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IL10 [5] IL10, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
300 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
IL1B [1] IL1B 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
301 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
CCL2 [5] CCL2, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
302 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
CPT1A [2] CPT1A, CPT1B 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
303 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
IL6 [2] IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
304 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
305 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
306 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
307 | Intestinal immune network for IgA production 💬 16 genes, 27 drugs (DrugBank) and 47 diseases |
IL10 [2] IL10, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
308 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL10 [2] IL10, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
309 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
310 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
311 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
312 | Legionellosis 💬 9 genes, 22 drugs (DrugBank) and 61 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
313 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
IL10 [4] IL10, IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
314 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
315 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
316 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
317 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
318 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
CACNA1C [1] CACNA1C 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
319 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
CACNA1C [1] CACNA1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
320 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
CACNA1C [1] CACNA1C 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
321 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
322 | Malaria 💬 15 genes, 28 drugs (DrugBank) and 61 diseases |
CCL2 [5] CCL2, IL10, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
323 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
324 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
325 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
326 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
IL1A [3] IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
327 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
328 | Measles 💬 40 genes, 44 drugs (DrugBank) and 52 diseases |
IL1A [3] IL1A, IL1B, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
329 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
330 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
HMGCR [1] HMGCR 💬 |
Atorvastatin Atorvastatin 💬 |
Atorvastatin | 013 [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬 |
331 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
332 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
333 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
334 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
335 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
336 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
ADORA1 [1] ADORA1 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
337 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
338 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
339 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
340 | Necroptosis 💬 28 genes, 39 drugs (DrugBank) and 68 diseases |
IL1A [3] IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
341 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADORA1 [4] ADORA1, ADORA2A, ADORA2B, ADORA3 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
342 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
343 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
344 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
345 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
346 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
347 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
348 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
349 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
350 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
351 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
352 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
IL1B [2] IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
353 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
354 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
355 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
IL1A [4] IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
356 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
357 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
IL1A [3] IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
358 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
359 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
360 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
361 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
362 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
363 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
364 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
365 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
366 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
367 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
ADORA2A [1] ADORA2A 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
368 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
369 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
370 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
371 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
372 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
373 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
374 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
375 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
376 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
377 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
378 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
379 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
380 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
381 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
IL1A [4] IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
382 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
383 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
384 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
385 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
IL10 [5] IL10, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
386 | Phenylalanine metabolism 💬 6 genes, 12 drugs (DrugBank) and 15 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
387 | Phenylalanine metabolism 💬 6 genes, 12 drugs (DrugBank) and 15 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
388 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
389 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
390 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
391 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
392 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
393 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
PTGS1 [1] PTGS1 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
394 | PPAR signaling pathway 💬 10 genes, 14 drugs (DrugBank) and 32 diseases |
CPT1A [4] CPT1A, CPT1B, CPT1C, CPT2 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
395 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
396 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
397 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
398 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
IL1A [4] IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
399 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
400 | Protein digestion and absorption 💬 7 genes, 7 drugs (DrugBank) and 13 diseases |
MME [1] MME 💬 |
Sacubitril Sacubitril 💬 |
Sacubitril | 058 [2] 58, 222 💬 💬 |
401 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
402 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
403 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
404 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
405 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
406 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
ADORA2A [2] ADORA2A, ADORA2B 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
407 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADORA1 [1] ADORA1 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
408 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
409 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
410 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
411 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
412 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
413 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
414 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
415 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADORA1 [1] ADORA1 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
416 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
417 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
418 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
419 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
420 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
421 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
422 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
423 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
424 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
425 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
426 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
427 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
428 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
429 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
430 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
431 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
432 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
433 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
MME [1] MME 💬 |
Sacubitril Sacubitril 💬 |
Sacubitril | 058 [2] 58, 222 💬 💬 |
434 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
435 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
436 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
437 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
438 | Rheumatoid arthritis 💬 22 genes, 49 drugs (DrugBank) and 74 diseases |
CCL2 [5] CCL2, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
439 | RIG-I-like receptor signaling pathway 💬 22 genes, 18 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
440 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
441 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
442 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Dobutamine Dobutamine 💬 |
Dobutamine | 057 [4] 57, 58, 86, 215 💬 💬 |
443 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Esmolol Esmolol 💬 |
Esmolol | 058 [1] 58 💬 💬 |
444 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
445 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
446 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
447 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
448 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
449 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
450 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
451 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
452 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
453 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
IL1B [2] IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
454 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
455 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
ADORA1 [2] ADORA1, ADORA3 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
456 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
457 | Staphylococcus aureus infection 💬 12 genes, 19 drugs (DrugBank) and 34 diseases |
IL10 [1] IL10 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
458 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
459 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
460 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
461 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
462 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
463 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
464 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Cifenline Cifenline 💬 |
Cibenzoline | 058 [1] 58 💬 💬 |
465 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Eleclazine Eleclazine 💬 |
Eleclazine | 058 [1] 58 💬 💬 |
466 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Atorvastatin Atorvastatin 💬 |
Atorvastatin | 013 [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬 |
467 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
468 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
469 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1B [2] IL1B, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
470 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
471 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CPT1A [4] CPT1A, CPT1B, CPT1C, CPT2 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
472 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
473 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
474 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
475 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
476 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
477 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
478 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
479 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
480 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
481 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
482 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
483 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
484 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL10 [5] IL10, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
485 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
486 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1A [3] IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
487 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
488 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
489 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
490 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
491 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
492 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
493 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
494 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADORA2A [1] ADORA2A 💬 |
Regadenoson Regadenoson 💬 |
Regadenoson | 058 [1] 58 💬 💬 |
495 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADORA2A [2] ADORA2A, ADORA2B 💬 |
Adenosine Adenosine 💬 |
Adenosine | 013 [3] 13, 58, 65 💬 💬 |
496 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Midodrine Midodrine 💬 |
Midodrine | 006 [3] 6 , 17, 58 💬 💬 |
497 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
Candesartan Candesartan 💬 |
Candesartan | 058 [2] 58, 67 💬 💬 |
498 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
499 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
500 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
501 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
502 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
CACNA1C [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
503 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
GUCY1A1 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 |
Amyl nitrite Amyl nitrite 💬 |
Amyl Nitrite | 058 [1] 58 💬 💬 |
504 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
505 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
506 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
507 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
508 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 29 drugs (DrugBank) and 60 diseases |
CCL2 [4] CCL2, IL10, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
509 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
510 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
CCL2 [5] CCL2, IL10, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |