Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Natural killer cell mediated cytotoxicity 💬

[1] BRAF 💬

Dabrafenib 💬

[1] 34 💬

2

Natural killer cell mediated cytotoxicity 💬

[2] BRAF, RAF1 💬

[2] 34, 86 💬

3

Natural killer cell mediated cytotoxicity 💬

[1] CSF2 💬

[1] 46 💬

4

Natural killer cell mediated cytotoxicity 💬

[2] FYN, LCK 💬

[2] 51, 85 💬

5

Natural killer cell mediated cytotoxicity 💬

[2] FYN, LCK 💬

[2] 51, 85 💬

6

Natural killer cell mediated cytotoxicity 💬

[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 ...

Name	Full Name
IFNA1	interferon alpha 1
IFNA10	interferon alpha 10
IFNA13	interferon alpha 13
IFNA14	interferon alpha 14
IFNA16	interferon alpha 16
IFNA17	interferon alpha 17
IFNA2	interferon alpha 2
IFNA21	interferon alpha 21
IFNA4	interferon alpha 4
IFNA5	interferon alpha 5
IFNA6	interferon alpha 6
IFNA7	interferon alpha 7
IFNA8	interferon alpha 8

Rontalizumab 💬

[1] 49 💬

7

Natural killer cell mediated cytotoxicity 💬

[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 ...

Name	Full Name
IFNA1	interferon alpha 1
IFNA10	interferon alpha 10
IFNA13	interferon alpha 13
IFNA14	interferon alpha 14
IFNA16	interferon alpha 16
IFNA17	interferon alpha 17
IFNA2	interferon alpha 2
IFNA21	interferon alpha 21
IFNA4	interferon alpha 4
IFNA5	interferon alpha 5
IFNA6	interferon alpha 6
IFNA7	interferon alpha 7
IFNA8	interferon alpha 8

Sifalimumab 💬

[1] 49 💬

8

Natural killer cell mediated cytotoxicity 💬

[2] IFNAR1, IFNAR2 💬

Anifrolumab 💬

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

9

Natural killer cell mediated cytotoxicity 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa 💬

Interferon alfa

[6] 13, 25, 26, 28, 56, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
56	Behcet disease;Behçet disease;BD;
96	Crohn disease;Terminal ileitis;

10

Natural killer cell mediated cytotoxicity 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2a 💬

Interferon alfa-2a

[1] 56 💬

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