Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Pathways in cancer 💬

[1] ABL1 💬

[2] 2 , 67 💬

2

Pathways in cancer 💬

[1] ABL1 💬

Saracatinib 💬

[3] 6 , 89, 272 💬

3

Pathways in cancer 💬

[3] ABL1, KIT, PDGFRA 💬

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

4

Pathways in cancer 💬

[4] ABL1, KIT, PDGFRA, PDGFRB 💬

Name	Full Name
ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase
KIT	KIT proto-oncogene, receptor tyrosine kinase
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta

[5] 6 , 8 , 34, 51, 86 💬

5

Pathways in cancer 💬

[3] ABL1, KIT, PDGFRB 💬

[2] 51, 85 💬

6

Pathways in cancer 💬

[3] ABL1, KIT, PDGFRB 💬

[2] 51, 85 💬

7

Pathways in cancer 💬

[1] AGTR1 💬

Angiotensin II 💬

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

8

Pathways in cancer 💬

[1] AGTR1 💬

Angiotensin II 💬

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

9

Pathways in cancer 💬

[1] AGTR1 💬

Candesartan 💬

[2] 58, 67 💬

10

Pathways in cancer 💬

[1] AGTR1 💬

Candesartan cilexetil 💬

Candesartan cilexetil

[1] 67 💬

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