144. レノックス・ガストー症候群 Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 111 / 薬物数 : 72 - (DrugBank : 14) / 標的遺伝子数 : 49 - 標的パスウェイ数 : 61
薬物ごとの開発者（Primary Sponsor）、臨床試験情報（抜粋）です。
12-Lead ECG
Gillette Children's Specialty Healthcare
2017 Phase 1/Phase 2 NCT02815540 United States;
Any other approved Antiepileptic Drug
Eisai Inc.
2011 Phase 3 NCT01405053 Canada;France;Greece;India;Italy;Poland;South Africa;United States;
CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.
GW Research Ltd
2015 Phase 3 EUCTR2014-001834-27-PL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-NL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
Cannabidiol
GW Research Ltd
2021 Phase 4 NCT05044819 United States;
Gillette Children's Specialty Healthcare
2017 Phase 1/Phase 2 NCT02815540 United States;
Yonsei University
2020 Phase 3 NCT04611438 Korea, Republic of;
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
2018 Phase 1/Phase 2 NCT03467113 United States;
Cannabidiol (CBD)
GW Research Ltd
2015 Phase 3 EUCTR2014-002940-42-GB France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002940-42-ES France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-PL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-NL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-GB Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-FR France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-ES France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
GW Research Ltd.
2015 Phase 3 EUCTR2014-002941-23-PL Netherlands;Poland;United States;
2015 - EUCTR2014-002941-23-NL Netherlands;Poland;United States;
Cannabidiol Oral Solution
INSYS Therapeutics Inc
2017 Phase 3 NCT02318537 -
Carisbamate
SK Life Science, Inc.
2019 Phase 1 NCT04062981 United States;
2019 Phase 1 NCT03731715 United States;
Clobazam
Lundbeck LLC
2005 Phase 3 NCT01160770 -
Clobazam High Dose
Lundbeck LLC
2007 Phase 3 NCT00518713 Australia;Belarus;India;Lithuania;Serbia;United States;
2005 Phase 2 NCT00162981 United States;
Clobazam Low Dose
Lundbeck LLC
2007 Phase 3 NCT00518713 Australia;Belarus;India;Lithuania;Serbia;United States;
2005 Phase 2 NCT00162981 United States;
Clobazam Medium Dose
Lundbeck LLC
2007 Phase 3 NCT00518713 Australia;Belarus;India;Lithuania;Serbia;United States;
Clobazam PhEur
Lundbeck Inc
2008 - EUCTR2007-004322-24-LT Bulgaria;Lithuania;
Ovation Pharmaceuticals Inc.
2008 - EUCTR2007-004322-24-BG Bulgaria;Lithuania;
Clobazam Tablets
Lundbeck Inc
2008 - EUCTR2007-004350-82-LT Bulgaria;Lithuania;
2008 - EUCTR2007-004322-24-LT Bulgaria;Lithuania;
Ovation Pharmaceuticals
2008 - EUCTR2007-004350-82-BG Bulgaria;Lithuania;
Ovation Pharmaceuticals Inc.
2008 - EUCTR2007-004322-24-BG Bulgaria;Lithuania;
E2007
Eisai Co., Ltd.
2016 Phase 3 JPRN-JapicCTI-173536 Japan, Asia except Japan, North America, Europe, Oceania;
Eisai Limited
2018 Phase 3 EUCTR2014-002321-35-BE Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-LV Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-HU Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-CZ Australia;Belgium;Canada;Czech Republic;Czechia;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-PL Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-FR Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
E2080
Eisai Co, Ltd.
- Phase 3 EUCTR2016-004953-34-Outside-EU/EEA Japan;
- Phase 3 EUCTR2016-004952-30-Outside-EU/EEA Japan;
EZOGABINE (US ONLY)
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
EZOGABINE (US only)
GlaxoSmithKline R&D Limited
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
Ezogabine/retigabine
GlaxoSmithKline
2012 Phase 2 NCT01494584 United States;
FENFLURAMINE HYDROCHLORIDE
Zogenix International Inc.
2018 Phase 3 EUCTR2017-002628-26-IT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited
2019 Phase 3 EUCTR2019-001331-31-IT Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-ES Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited, a wholly owned subsidiary of Zogenix Inc.
2019 Phase 3 EUCTR2017-002628-26-SE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-NL Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-FR Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-BE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-PL Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-AT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Fenfluramina cloridrato
Zogenix International Limited
2019 Phase 3 EUCTR2019-001331-31-IT Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
Fenfluramine
KU Leuven
2016 Phase 2 NCT02655198 Belgium;
YAMAMOTO Hideichiro
2019 Phase 3 JPRN-jRCT2041200096 Australia;Belgium;Canda;Denmark;France;Germany;Italy;Japan;Mexico;Netherland;Poland;Spain;Sweeden;US;
Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine
Zogenix International Inc.
2018 Phase 3 EUCTR2017-002628-26-IT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited
2018 Phase 3 EUCTR2017-002628-26-ES Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited, a wholly owned subsidiary of Zogenix Inc.
2019 Phase 3 EUCTR2017-002628-26-SE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-NL Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-FR Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-BE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-PL Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-AT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Fenfluramine hydrochloride (colorless)
Zogenix International Limited
2020 Phase 3 EUCTR2019-001331-31-SE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-NL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DK Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-GB Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-FR Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-ES Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-PL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-BE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
Fycompa
EISAI LIMITED
2017 Phase 3 EUCTR2014-002321-35-IT Australia;Belgium;Canada;Czech Republic;Czechia;France;Hungary;Italy;Japan;Korea, Democratic People's Republic of;Korea, Republic of;Latvia;Lithuania;Poland;United States;
Eisai Limited
2018 Phase 3 EUCTR2014-002321-35-BE Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-LV Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-HU Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-CZ Australia;Belgium;Canada;Czech Republic;Czechia;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-PL Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-FR Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
GW582892
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
GWP42003-P
GW Research Ltd
2020 Phase 4 NCT04133480 United States;
2015 Phase 3 NCT02224573 -
2015 Phase 3 NCT02224560 France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002940-42-GB France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002940-42-ES France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-PL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-NL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-GB Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-FR France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-ES France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
GW Research Ltd.
2015 Phase 3 EUCTR2014-002941-23-PL Netherlands;Poland;United States;
2015 - EUCTR2014-002941-23-NL Netherlands;Poland;United States;
GWP42003-P 20 mg/kg/day Dose
GW Research Ltd
2015 Phase 3 NCT02224690 Netherlands;Poland;United States;
Inovelon
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Eisai Co, Ltd.
- Phase 3 EUCTR2016-004953-34-Outside-EU/EEA Japan;
- Phase 3 EUCTR2016-004952-30-Outside-EU/EEA Japan;
Eisai Co., Ltd.
2013 - JPRN-JapicCTI-132169 Japan;
Investigators Choice of Approved AED
Eisai Ltd
2012 - EUCTR2010-023505-36-GR Greece;Italy;South Africa;United States;
- Phase 3 EUCTR2010-023505-36-Outside-EU/EEA Canada;United States;
- Phase 3 EUCTR2010-023505-36-FR France;Greece;India;Italy;United States;
Investigators choice of approved AEDs
Eisai Ltd
2012 - EUCTR2010-023505-36-GR Greece;Italy;South Africa;United States;
- Phase 3 EUCTR2010-023505-36-Outside-EU/EEA Canada;United States;
- Phase 3 EUCTR2010-023505-36-FR France;Greece;India;Italy;United States;
Lamictal
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Lamotrigine
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Melatonin
Institution de Lavigny
2011 Phase 4 NCT01370486 Switzerland;
PEG
Nonomura Hidenori
2021 Phase 3 JPRN-jRCT2051210073 Australia;Belgium;Canada;China,;France;Greece;Hungary;Italy;Japan;Korea;Latvia;Netherlands;Poland,;Russia;Serbia;Spain;Ukraine;United Kingdom;United States;
Perampanel
Eisai Co., Ltd.
2016 Phase 3 JPRN-JapicCTI-173536 Japan, Asia except Japan, North America, Europe, Oceania;
Eisai Inc.
2016 Phase 3 NCT02834793 Australia;Austria;Belgium;Czechia;India;Japan;Korea, Republic of;United States;
2015 - NCT02307578 Belgium;Chile;Estonia;Hungary;Latvia;Lithuania;Poland;Spain;
Placebo
Eisai Co., Ltd.
2016 Phase 3 JPRN-JapicCTI-173536 Japan, Asia except Japan, North America, Europe, Oceania;
Potiga
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
RETIGABINE/EZOGABINE
GlaxoSmithKline R&D Limited
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
Retigabine/Ezogabine
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
Retigabine/ezogabine
GlaxoSmithKline
2012 Phase 3 NCT01668654 United States;
Rufinamide
Eisai Co., Ltd.
2013 - NCT02175173 Japan;
2013 - JPRN-JapicCTI-132169 Japan;
2010 Phase 3 NCT01151540 Japan;
Eisai Inc.
2019 - NCT03778424 Poland;
2011 Phase 3 NCT01405053 Canada;France;Greece;India;Italy;Poland;South Africa;United States;
Rufinamide (E2080)
Eisai Limited
2010 Phase 3 NCT01146951 Japan;
Rufinamide oral suspension
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Eisai Ltd
2012 - EUCTR2010-023505-36-GR Greece;Italy;South Africa;United States;
- Phase 3 EUCTR2010-023505-36-Outside-EU/EEA Canada;United States;
- Phase 3 EUCTR2010-023505-36-FR France;Greece;India;Italy;United States;
Sodio valproato
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Soticlestat
Ovid Therapeutics, Inc.
2019 Phase 2 EUCTR2018-002485-39-PL Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
TAKEDA DEVELOPMENT CENTER AMERICAS INC.
2021 Phase 3 EUCTR2021-002481-40-IT Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Takeda
2022 Phase 3 NCT05163314 Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
2021 Phase 3 NCT04938427 Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
2018 Phase 2 NCT03635073 Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
Takeda Development Center Americas, Inc.
2021 Phase 3 EUCTR2021-002481-40-PL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-NL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-HU Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-GR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-ES Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-BE Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-LV Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-FR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
TAK-935
Ovid Therapeutics, Inc.
2019 Phase 2 EUCTR2018-002485-39-PL Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
TAKEDA DEVELOPMENT CENTER AMERICAS INC.
2021 Phase 3 EUCTR2021-002481-40-IT Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Takeda
2018 Phase 2 NCT03650452 Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
Takeda Development Center Americas, Inc
2022 Phase 3 EUCTR2021-002482-17-GR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
- Phase 3 EUCTR2021-002482-17-BE Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
Takeda Development Center Americas, Inc.
2021 Phase 3 EUCTR2021-002481-40-PL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-NL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-HU Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-GR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-ES Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-BE Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-Outside-EU/EEA Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-LV Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-FR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Topimarate
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Topimarato
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Topiramate
Janssen Cilag Pharmaceutica S.A.C.I., Greece
2003 - NCT00297349 -
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
1993 Phase 3 NCT00236756 -
National Center for Research Resources (NCRR)
1993 Phase 3 NCT00004776 -
Turmeric
NYU Langone Health
2018 - NCT03254680 United States;
ZX008
Zogenix International Limited
2020 Phase 3 EUCTR2019-001331-31-SE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-NL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DK Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-IT Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-GB Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-FR Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-ES Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-PL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-BE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
ZX008 (Fenfluramine Hydrochloride)
Zogenix, Inc.
2019 Phase 3 NCT03936777 Australia;Belgium;Canada;Denmark;France;Germany;Italy;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
ZX008 0.2 or 0.8 mg/kg/day
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
2017 Phase 3 NCT03355209 Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United States;
ZX008 0.2 to 0.8 mg/kg/day
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
2018 Phase 1/Phase 2 NCT03467113 United States;
Gillette Children's Specialty Healthcare
2017 Phase 1/Phase 2 NCT02815540 United States;
Any other approved Antiepileptic Drug
Eisai Inc.
2011 Phase 3 NCT01405053 Canada;France;Greece;India;Italy;Poland;South Africa;United States;
CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.
GW Research Ltd
2015 Phase 3 EUCTR2014-001834-27-PL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-NL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
Cannabidiol
GW Research Ltd
2021 Phase 4 NCT05044819 United States;
Gillette Children's Specialty Healthcare
2017 Phase 1/Phase 2 NCT02815540 United States;
Yonsei University
2020 Phase 3 NCT04611438 Korea, Republic of;
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
2018 Phase 1/Phase 2 NCT03467113 United States;
Cannabidiol (CBD)
GW Research Ltd
2015 Phase 3 EUCTR2014-002940-42-GB France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002940-42-ES France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-PL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-NL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-GB Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-FR France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-ES France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
GW Research Ltd.
2015 Phase 3 EUCTR2014-002941-23-PL Netherlands;Poland;United States;
2015 - EUCTR2014-002941-23-NL Netherlands;Poland;United States;
Cannabidiol Oral Solution
INSYS Therapeutics Inc
2017 Phase 3 NCT02318537 -
Carisbamate
SK Life Science, Inc.
2019 Phase 1 NCT04062981 United States;
2019 Phase 1 NCT03731715 United States;
Clobazam
Lundbeck LLC
2005 Phase 3 NCT01160770 -
Clobazam High Dose
Lundbeck LLC
2007 Phase 3 NCT00518713 Australia;Belarus;India;Lithuania;Serbia;United States;
2005 Phase 2 NCT00162981 United States;
Clobazam Low Dose
Lundbeck LLC
2007 Phase 3 NCT00518713 Australia;Belarus;India;Lithuania;Serbia;United States;
2005 Phase 2 NCT00162981 United States;
Clobazam Medium Dose
Lundbeck LLC
2007 Phase 3 NCT00518713 Australia;Belarus;India;Lithuania;Serbia;United States;
Clobazam PhEur
Lundbeck Inc
2008 - EUCTR2007-004322-24-LT Bulgaria;Lithuania;
Ovation Pharmaceuticals Inc.
2008 - EUCTR2007-004322-24-BG Bulgaria;Lithuania;
Clobazam Tablets
Lundbeck Inc
2008 - EUCTR2007-004350-82-LT Bulgaria;Lithuania;
2008 - EUCTR2007-004322-24-LT Bulgaria;Lithuania;
Ovation Pharmaceuticals
2008 - EUCTR2007-004350-82-BG Bulgaria;Lithuania;
Ovation Pharmaceuticals Inc.
2008 - EUCTR2007-004322-24-BG Bulgaria;Lithuania;
E2007
Eisai Co., Ltd.
2016 Phase 3 JPRN-JapicCTI-173536 Japan, Asia except Japan, North America, Europe, Oceania;
Eisai Limited
2018 Phase 3 EUCTR2014-002321-35-BE Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-LV Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-HU Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-CZ Australia;Belgium;Canada;Czech Republic;Czechia;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-PL Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-FR Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
E2080
Eisai Co, Ltd.
- Phase 3 EUCTR2016-004953-34-Outside-EU/EEA Japan;
- Phase 3 EUCTR2016-004952-30-Outside-EU/EEA Japan;
EZOGABINE (US ONLY)
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
EZOGABINE (US only)
GlaxoSmithKline R&D Limited
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
Ezogabine/retigabine
GlaxoSmithKline
2012 Phase 2 NCT01494584 United States;
FENFLURAMINE HYDROCHLORIDE
Zogenix International Inc.
2018 Phase 3 EUCTR2017-002628-26-IT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited
2019 Phase 3 EUCTR2019-001331-31-IT Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-ES Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited, a wholly owned subsidiary of Zogenix Inc.
2019 Phase 3 EUCTR2017-002628-26-SE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-NL Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-FR Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-BE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-PL Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-AT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Fenfluramina cloridrato
Zogenix International Limited
2019 Phase 3 EUCTR2019-001331-31-IT Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
Fenfluramine
KU Leuven
2016 Phase 2 NCT02655198 Belgium;
YAMAMOTO Hideichiro
2019 Phase 3 JPRN-jRCT2041200096 Australia;Belgium;Canda;Denmark;France;Germany;Italy;Japan;Mexico;Netherland;Poland;Spain;Sweeden;US;
Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine
Zogenix International Inc.
2018 Phase 3 EUCTR2017-002628-26-IT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited
2018 Phase 3 EUCTR2017-002628-26-ES Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Zogenix International Limited, a wholly owned subsidiary of Zogenix Inc.
2019 Phase 3 EUCTR2017-002628-26-SE Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-NL Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-FR Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DK Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-DE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
2018 Phase 3 EUCTR2017-002628-26-BE Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-PL Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-GB Australia;Austria;Belgium;Canada;Denmark;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2017-002628-26-AT Australia;Austria;Belgium;Canada;Denmark;Finland;France;Germany;Ireland;Israel;Italy;Japan;Mexico;Netherlands;Norway;Poland;Spain;Sweden;Switzerland;United Kingdom;United States;
Fenfluramine hydrochloride (colorless)
Zogenix International Limited
2020 Phase 3 EUCTR2019-001331-31-SE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-NL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DK Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-GB Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-FR Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-ES Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-PL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-BE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
Fycompa
EISAI LIMITED
2017 Phase 3 EUCTR2014-002321-35-IT Australia;Belgium;Canada;Czech Republic;Czechia;France;Hungary;Italy;Japan;Korea, Democratic People's Republic of;Korea, Republic of;Latvia;Lithuania;Poland;United States;
Eisai Limited
2018 Phase 3 EUCTR2014-002321-35-BE Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-LV Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-HU Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
2017 Phase 3 EUCTR2014-002321-35-CZ Australia;Belgium;Canada;Czech Republic;Czechia;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-PL Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
- Phase 3 EUCTR2014-002321-35-FR Australia;Belgium;Canada;Czech Republic;France;Hungary;Italy;Japan;Korea, Republic of;Latvia;Poland;United States;
GW582892
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
GWP42003-P
GW Research Ltd
2020 Phase 4 NCT04133480 United States;
2015 Phase 3 NCT02224573 -
2015 Phase 3 NCT02224560 France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002940-42-GB France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-002940-42-ES France;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-PL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-NL Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-GB Australia;France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-FR France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
2015 Phase 3 EUCTR2014-001834-27-ES France;Israel;Netherlands;Poland;Spain;United Kingdom;United States;
GW Research Ltd.
2015 Phase 3 EUCTR2014-002941-23-PL Netherlands;Poland;United States;
2015 - EUCTR2014-002941-23-NL Netherlands;Poland;United States;
GWP42003-P 20 mg/kg/day Dose
GW Research Ltd
2015 Phase 3 NCT02224690 Netherlands;Poland;United States;
Inovelon
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Eisai Co, Ltd.
- Phase 3 EUCTR2016-004953-34-Outside-EU/EEA Japan;
- Phase 3 EUCTR2016-004952-30-Outside-EU/EEA Japan;
Eisai Co., Ltd.
2013 - JPRN-JapicCTI-132169 Japan;
Investigators Choice of Approved AED
Eisai Ltd
2012 - EUCTR2010-023505-36-GR Greece;Italy;South Africa;United States;
- Phase 3 EUCTR2010-023505-36-Outside-EU/EEA Canada;United States;
- Phase 3 EUCTR2010-023505-36-FR France;Greece;India;Italy;United States;
Investigators choice of approved AEDs
Eisai Ltd
2012 - EUCTR2010-023505-36-GR Greece;Italy;South Africa;United States;
- Phase 3 EUCTR2010-023505-36-Outside-EU/EEA Canada;United States;
- Phase 3 EUCTR2010-023505-36-FR France;Greece;India;Italy;United States;
Lamictal
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Lamotrigine
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Melatonin
Institution de Lavigny
2011 Phase 4 NCT01370486 Switzerland;
PEG
Nonomura Hidenori
2021 Phase 3 JPRN-jRCT2051210073 Australia;Belgium;Canada;China,;France;Greece;Hungary;Italy;Japan;Korea;Latvia;Netherlands;Poland,;Russia;Serbia;Spain;Ukraine;United Kingdom;United States;
Perampanel
Eisai Co., Ltd.
2016 Phase 3 JPRN-JapicCTI-173536 Japan, Asia except Japan, North America, Europe, Oceania;
Eisai Inc.
2016 Phase 3 NCT02834793 Australia;Austria;Belgium;Czechia;India;Japan;Korea, Republic of;United States;
2015 - NCT02307578 Belgium;Chile;Estonia;Hungary;Latvia;Lithuania;Poland;Spain;
Placebo
Eisai Co., Ltd.
2016 Phase 3 JPRN-JapicCTI-173536 Japan, Asia except Japan, North America, Europe, Oceania;
Potiga
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
RETIGABINE/EZOGABINE
GlaxoSmithKline R&D Limited
- - EUCTR2010-020154-33-Outside-EU/EEA United States;
Retigabine/Ezogabine
GlaxoSmithKline R&D Limited
- - EUCTR2012-001132-60-Outside-EU/EEA United States;
Retigabine/ezogabine
GlaxoSmithKline
2012 Phase 3 NCT01668654 United States;
Rufinamide
Eisai Co., Ltd.
2013 - NCT02175173 Japan;
2013 - JPRN-JapicCTI-132169 Japan;
2010 Phase 3 NCT01151540 Japan;
Eisai Inc.
2019 - NCT03778424 Poland;
2011 Phase 3 NCT01405053 Canada;France;Greece;India;Italy;Poland;South Africa;United States;
Rufinamide (E2080)
Eisai Limited
2010 Phase 3 NCT01146951 Japan;
Rufinamide oral suspension
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Eisai Ltd
2012 - EUCTR2010-023505-36-GR Greece;Italy;South Africa;United States;
- Phase 3 EUCTR2010-023505-36-Outside-EU/EEA Canada;United States;
- Phase 3 EUCTR2010-023505-36-FR France;Greece;India;Italy;United States;
Sodio valproato
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Soticlestat
Ovid Therapeutics, Inc.
2019 Phase 2 EUCTR2018-002485-39-PL Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
TAKEDA DEVELOPMENT CENTER AMERICAS INC.
2021 Phase 3 EUCTR2021-002481-40-IT Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Takeda
2022 Phase 3 NCT05163314 Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
2021 Phase 3 NCT04938427 Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
2018 Phase 2 NCT03635073 Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
Takeda Development Center Americas, Inc.
2021 Phase 3 EUCTR2021-002481-40-PL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-NL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-HU Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-GR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-ES Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-BE Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-LV Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-FR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
TAK-935
Ovid Therapeutics, Inc.
2019 Phase 2 EUCTR2018-002485-39-PL Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
TAKEDA DEVELOPMENT CENTER AMERICAS INC.
2021 Phase 3 EUCTR2021-002481-40-IT Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Takeda
2018 Phase 2 NCT03650452 Australia;Canada;China;Israel;Poland;Portugal;Spain;United States;
Takeda Development Center Americas, Inc
2022 Phase 3 EUCTR2021-002482-17-GR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
- Phase 3 EUCTR2021-002482-17-BE Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United States;
Takeda Development Center Americas, Inc.
2021 Phase 3 EUCTR2021-002481-40-PL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-NL Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-HU Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-GR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-ES Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
2021 Phase 3 EUCTR2021-002481-40-BE Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-Outside-EU/EEA Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-LV Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2021-002481-40-FR Australia;Belgium;Canada;China;France;Greece;Hungary;Italy;Japan;Latvia;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Topimarate
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Topimarato
EISAI LTD UK
2011 - EUCTR2010-023505-36-IT Greece;Italy;
Topiramate
Janssen Cilag Pharmaceutica S.A.C.I., Greece
2003 - NCT00297349 -
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
1993 Phase 3 NCT00236756 -
National Center for Research Resources (NCRR)
1993 Phase 3 NCT00004776 -
Turmeric
NYU Langone Health
2018 - NCT03254680 United States;
ZX008
Zogenix International Limited
2020 Phase 3 EUCTR2019-001331-31-SE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-NL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DK Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2020 Phase 3 EUCTR2019-001331-31-DE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-IT Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-GB Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-FR Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001331-31-ES Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-PL Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
- Phase 3 EUCTR2019-001331-31-BE Australia;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
ZX008 (Fenfluramine Hydrochloride)
Zogenix, Inc.
2019 Phase 3 NCT03936777 Australia;Belgium;Canada;Denmark;France;Germany;Italy;Mexico;Netherlands;Poland;Spain;Sweden;United Kingdom;United States;
ZX008 0.2 or 0.8 mg/kg/day
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
2017 Phase 3 NCT03355209 Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Spain;Sweden;United States;
ZX008 0.2 to 0.8 mg/kg/day
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
2018 Phase 1/Phase 2 NCT03467113 United States;