171. Wilson disease Disease details / Clinical trials / Drug dev / DR info


Clinical trials : 79 Drugs : 77 - (DrugBank : 17) / Drug target genes : 6 - Drug target pathways : 30

Drugs and their primary sponsors and trial info
64CuCl2   
   Aarhus University Hospital
      2021   Phase 2   EUCTR2021-000102-25-DK   Denmark;
   The Department of Hepatology and Gastroenterology, Aarhus University Hospital
      2019   Phase 4   EUCTR2019-000905-57-DK   Denmark;
64Cu]Cl2   
   Aarhus University Hospital
      2021   Phase 2   EUCTR2021-000102-25-DK   Denmark;
ALXN1840   
   Aarhus University Hospital
      2021   Phase 2   EUCTR2021-000102-25-DK   Denmark;
   Alexion Pharmaceuticals
      2021   Phase 3   NCT05047523   Australia;Japan;Korea, Republic of;Poland;Spain;
      2020   Phase 2   NCT04573309   New Zealand;United Kingdom;United States;
      2020   Phase 1   NCT04526210   United States;
      2020   Phase 1   NCT04526197   United States;
      2018   Phase 3   NCT03403205   Australia;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Taiwan;Turkey;United Kingdom;United States;
      2014   Phase 2   NCT02273596   Austria;Germany;Poland;United Kingdom;United States;
   Alexion Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-005832-31-DK   Denmark;
   Alexion Pharmaceuticals, Inc
      2021   Phase 2   EUCTR2019-003711-60-DE   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2017-004135-36-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2017-004135-36-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-GB   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-FR   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-DK   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-AT   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-SE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-DK   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
   Alexion Pharmaceuticals, Inc.
      2021   Phase 3   EUCTR2021-001015-82-ES   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001015-82-DE   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2020-001104-41-GB   United Kingdom;
      -   Phase 3   EUCTR2021-001015-82-PL   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
Adeno-associated viral vector serotype 3B encoding shortened human ATP7B   
   Vivet Therapeutics SAS
      2021   Phase 1;Phase 2   EUCTR2020-000963-22-DK   Denmark;Germany;United Kingdom;United States;
      2021   Phase 1;Phase 2   EUCTR2020-000963-22-DE   Denmark;Germany;United Kingdom;United States;
Adeno-associated viral vector serotype 9 encoding human ATP7B   
   Ultragenyx Pharmaceutical Inc.
      2022   Phase 1;Phase 2;Phase 3   EUCTR2020-005266-34-ES   Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
Artamin   
   Orphalan
      2019   Phase 3   EUCTR2016-003876-29-BE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
BIS-CHOLINE TETRATHIOMOLYBDATE   
   Aarhus University Hospital
      2021   Phase 2   EUCTR2021-000102-25-DK   Denmark;
   Alexion Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-005832-31-DK   Denmark;
   Alexion Pharmaceuticals, Inc
      2021   Phase 2   EUCTR2019-003711-60-DE   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2017-004135-36-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2017-004135-36-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-GB   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-FR   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-DK   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-003711-60-AT   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-SE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-DK   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
   Alexion Pharmaceuticals, Inc.
      2020   Phase 2   EUCTR2020-001104-41-GB   United Kingdom;
      -   Phase 3   EUCTR2017-004135-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
   Wilson Therapeutics AB
      2018   Phase 3   EUCTR2017-004135-36-HU   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-GB   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-ES   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
BIS-CHOLINE TETRATHIOMOLYBDATE, bis[(2-Hydroxyethyl)trimethylammonium] tetrathiomolybdate   
   Alexion Pharmaceuticals, Inc.
      2021   Phase 3   EUCTR2021-001015-82-ES   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001015-82-DE   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2021-001015-82-PL   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
Bis-Choline Tetrathiomolybdate   
   Alexion Pharmaceuticals
      2020   Phase 2   NCT04422431   Australia;Austria;Belgium;Canada;Denmark;Germany;Korea, Republic of;New Zealand;Poland;Russian Federation;Singapore;Spain;United Kingdom;United States;
Bis-choline TETRATHIOMOLYBDATE   
   Alexion Pharmaceuticals, INC.
      2014   Phase 2   EUCTR2014-001703-41-DE   Austria;Germany;Poland;United Kingdom;United States;
   Alexion Pharmaceuticals, Inc.
      2014   Phase 2   EUCTR2014-001703-41-AT   Austria;Germany;Poland;United Kingdom;United States;
   Wilson Therapeutics AB
      2015   Phase 2   EUCTR2014-001703-41-GB   Austria;Germany;Poland;United Kingdom;United States;
      2014   Phase 2   EUCTR2014-001703-41-PL   Austria;Germany;Poland;United Kingdom;United States;
Bupropion Hydrochloride   
   Alexion Pharmaceuticals
      2020   Phase 1   NCT04526210   United States;
COPPER (64CU) CHLORIDE   
   Aarhus University Hospital
      2021   Phase 2   EUCTR2021-000102-25-DK   Denmark;
   The Department of Hepatology and Gastroenterology, Aarhus University Hospital
      2019   Phase 4   EUCTR2019-000905-57-DK   Denmark;
Celecoxib   
   Alexion Pharmaceuticals
      2020   Phase 1   NCT04526197   United States;
Copper   
   Anhui Provincial Hospital
      2017   -   ChiCTR-DDD-17010552   China;
   Shanghai Tongren Hospital
      2019   Phase 0   ChiCTR1900023410   China;
Cufence (trientine dihydrochloride)   
   Univar Solutions, B.V.
      2021   Phase 4   EUCTR2020-004604-33-PL   Denmark;Germany;Poland;
      2021   Phase 4   EUCTR2020-004604-33-DK   Denmark;Germany;Poland;
      2021   Phase 4   EUCTR2020-004604-33-DE   Denmark;France;Germany;Poland;
      -   Phase 4   EUCTR2020-004604-33-FR   Denmark;France;Germany;Poland;
Cuprior   
   Alexion Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-005832-31-DK   Denmark;
Cuprior 150 mg film-coated tablets   
   Orphalan
      2019   Phase 3   EUCTR2016-003876-29-BE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DK   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Cuprior 150mg film-coated tablets   
   gmp-orphan SA
      2017   Phase 3   EUCTR2016-003876-29-GB   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
D-penicillamine   
   GMP ORPHAN SA
      2017   Phase 3   EUCTR2016-003876-29-IT   Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
   Orphalan
      2019   Phase 3   EUCTR2016-003876-29-BE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DK   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
   gmp-orphan SA
      2017   Phase 3   EUCTR2016-003876-29-GB   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
DMPS   
   Second Affiliated Hospital, School of Medicine, Zhejiang University
      2019   Early Phase 1   NCT03957720   China;
DMSA   
   Second Affiliated Hospital, School of Medicine, Zhejiang University
      2019   Early Phase 1   NCT03957720   China;
Fibroscan   
   University of Aarhus
      2016   -   NCT02702765   Denmark;
Functional hepatic nitrogen clearance   
   University of Aarhus
      2016   -   NCT02702765   Denmark;
Galactose   
   University of Aarhus
      2016   -   NCT02702765   Denmark;
Gold   
   Anhui Provincial Hospital
      2017   -   ChiCTR-DDD-17010552   China;
   Shanghai Tongren Hospital
      2019   Phase 0   ChiCTR1900023410   China;
Liver biopsy   
   University of Aarhus
      2016   -   NCT02702765   Denmark;
Low copper diet   
   Second Affiliated Hospital, School of Medicine, Zhejiang University
      2004   -   NCT04965545   China;
Metalcaptase   
   Alexion Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-005832-31-DK   Denmark;
Metalcaptase® 150 mg gastro-resistant tablet   
   Orphalan
      2017   Phase 3   EUCTR2016-003876-29-DE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
Metalcaptase® 300 mg gastro-resistant tablet   
   Orphalan
      2017   Phase 3   EUCTR2016-003876-29-DE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
NPC-02   
   Nobelpharma
      2005   Phase 3   NCT00212355   -
None   
   Alexion Pharmaceuticals, INC.
      2014   Phase 2   EUCTR2014-001703-41-DE   Austria;Germany;Poland;United Kingdom;United States;
   Alexion Pharmaceuticals, Inc.
      2014   Phase 2   EUCTR2014-001703-41-AT   Austria;Germany;Poland;United Kingdom;United States;
   Wilson Therapeutics AB
      2015   Phase 2   EUCTR2014-001703-41-GB   Austria;Germany;Poland;United Kingdom;United States;
      2014   Phase 2   EUCTR2014-001703-41-PL   Austria;Germany;Poland;United Kingdom;United States;
Once a day Trientine   
   Yale University
      2010   -   NCT01472874   United States;
Oral corticosteroids   
   Ultragenyx Pharmaceutical Inc
      2021   Phase 1/Phase 2   NCT04884815   United States;
PEMINE - 150 MG CAPSULE RIGIDE 50 CAPSULE   
   GMP ORPHAN SA
      2017   Phase 3   EUCTR2016-003876-29-IT   Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
Penicillamine   
   GMP-Orphan SAS
      2018   Phase 3   NCT03539952   Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
   Orphalan
      2017   Phase 3   EUCTR2016-003876-29-DE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
   Second Affiliated Hospital, School of Medicine, Zhejiang University
      2019   Early Phase 1   NCT03957720   China;
   gmp-orphan SA
      2017   Phase 3   EUCTR2016-003876-29-AT   Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
SoC Therapy   
   Alexion Pharmaceuticals
      2018   Phase 3   NCT03403205   Australia;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;New Zealand;Poland;Russian Federation;Serbia;Singapore;Spain;Taiwan;Turkey;United Kingdom;United States;
TETA 4HCL   
   GMP-Orphan SAS
      2018   Phase 3   NCT03539952   Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
TETA 4HCl   
   Orphalan
      2019   Phase 3   EUCTR2016-003876-29-BE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DK   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
   gmp-orphan SA
      2017   Phase 3   EUCTR2016-003876-29-GB   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-AT   Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
TETA.4HCI   
   GMP ORPHAN SA
      2017   Phase 3   EUCTR2016-003876-29-IT   Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
TETA.4HCl   
   gmp-orphan SA
      2017   Phase 3   EUCTR2016-003876-29-GB   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
TRIENTINE DIHYDROCHLORIDE   
   Alexion Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-005832-31-DK   Denmark;
   Alexion Pharmaceuticals, Inc
      2020   Phase 3   EUCTR2017-004135-36-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2017-004135-36-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-SE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-DK   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
   Wilson Therapeutics AB
      2018   Phase 3   EUCTR2017-004135-36-HU   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-GB   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-ES   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
Tetrathiomolybdate   
   National Center for Research Resources (NCRR)
      1994   Phase 3   NCT00004339   United States;
Tiomolibdic acid   
   Alexion Pharmaceuticals, Inc.
      2021   Phase 3   EUCTR2021-001015-82-ES   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001015-82-DE   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2021-001015-82-PL   Australia;Austria;Canada;Czechia;Denmark;France;Germany;Hungary;Japan;Korea, Republic of;Netherlands;Poland;Russian Federation;Serbia;Spain;Turkey;United Kingdom;United States;
Trientine   
   Excelsior
      2018   -   NCT03299829   Taiwan;
   National Center for Research Resources (NCRR)
      1994   Phase 3   NCT00004339   United States;
Trientine dihydrochloride   
   Univar BV
      2016   Phase 4   NCT02426905   Germany;Greece;Italy;United Kingdom;
      2013   Phase 1   NCT01874028   Germany;
Trientine dihydrochloride 300mg capsules   
   UNIVAR LTD
      2016   Phase 2   EUCTR2013-003564-31-IT   France;Germany;Greece;Italy;Spain;United Kingdom;
   Univar B.V.
      2014   Phase 4   EUCTR2013-003564-31-DE   Germany;Italy;
Trientine tetrahydrochloride   
   GMP ORPHAN SA
      2017   Phase 3   EUCTR2016-003876-29-IT   Austria;Brazil;Denmark;France;Germany;Italy;Micronesia, Federated States of;Poland;United Kingdom;United States;
   Orphalan
      2019   Phase 3   EUCTR2016-003876-29-BE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DK   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-DE   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
   gmp-orphan SA
      2017   Phase 3   EUCTR2016-003876-29-GB   Austria;Belgium;Brazil;Denmark;France;Germany;Italy;Poland;Sweden;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003876-29-AT   Austria;Brazil;Denmark;France;Germany;Italy;Poland;United Kingdom;
Triethylenetetramine dihydrochloride   
   Univar Solutions, B.V.
      2021   Phase 4   EUCTR2020-004604-33-PL   Denmark;Germany;Poland;
      2021   Phase 4   EUCTR2020-004604-33-DK   Denmark;Germany;Poland;
      2021   Phase 4   EUCTR2020-004604-33-DE   Denmark;France;Germany;Poland;
      -   Phase 4   EUCTR2020-004604-33-FR   Denmark;France;Germany;Poland;
UX701   
   Ultragenyx Pharmaceutical Inc
      2021   Phase 1/Phase 2   NCT04884815   United States;
UX701 (1.0 × 10^13 genome copies/kg)   
   Ultragenyx Pharmaceutical Inc.
      2022   Phase 1;Phase 2;Phase 3   EUCTR2020-005266-34-ES   Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
UX701 (2.0 × 10^13 genome copies/kg)   
   Ultragenyx Pharmaceutical Inc.
      2022   Phase 1;Phase 2;Phase 3   EUCTR2020-005266-34-ES   Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
UX701 (5.0 × 10^12 genome copies/kg)   
   Ultragenyx Pharmaceutical Inc.
      2022   Phase 1;Phase 2;Phase 3   EUCTR2020-005266-34-ES   Argentina;Austria;Brazil;Canada;France;Germany;Italy;Japan;Poland;Portugal;Spain;United Kingdom;United States;
Ultrasound   
   University of Aarhus
      2016   -   NCT02702765   Denmark;
VTX-801   
   Vivet Therapeutics SAS
      2021   Phase 1;Phase 2   EUCTR2020-000963-22-DK   Denmark;Germany;United Kingdom;United States;
      2021   Phase 1;Phase 2   EUCTR2020-000963-22-DE   Denmark;Germany;United Kingdom;United States;
WTX101   
   Alexion Pharmaceuticals, INC.
      2014   Phase 2   EUCTR2014-001703-41-DE   Austria;Germany;Poland;United Kingdom;United States;
   Alexion Pharmaceuticals, Inc.
      2014   Phase 2   EUCTR2014-001703-41-AT   Austria;Germany;Poland;United Kingdom;United States;
   Wilson Therapeutics AB
      2018   Phase 3   EUCTR2017-004135-36-HU   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-GB   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-ES   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-001703-41-GB   Austria;Germany;Poland;United Kingdom;United States;
      2014   Phase 2   EUCTR2014-001703-41-PL   Austria;Germany;Poland;United Kingdom;United States;
Wilzin   
   The Department of Hepatology and Gastroenterology, Aarhus University Hospital
      2019   Phase 4   EUCTR2019-000905-57-DK   Denmark;
ZINC ACETATE DIHYDRATE   
   Alexion Pharmaceuticals, Inc
      2020   Phase 3   EUCTR2017-004135-36-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2017-004135-36-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-SE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-004135-36-DK   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Democratic People's Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-004135-36-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Denmark;France;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
   Alexion Pharmaceuticals, Inc.
      -   Phase 3   EUCTR2017-004135-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Japan;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;United Kingdom;United States;
   Wilson Therapeutics AB
      2018   Phase 3   EUCTR2017-004135-36-HU   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-GB   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;Sweden;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-004135-36-ES   Austria;Czech Republic;France;Germany;Hungary;Israel;Italy;Poland;Spain;United Kingdom;United States;
Zinc   
   Prof. Elon Pras
      2018   -   NCT03659331   -
Zinc acetate   
   National Center for Research Resources (NCRR)
      1993   Phase 4   NCT00004338   United States;
   Nobelpharma
      2004   Phase 3   NCT00212368   -
   The Department of Hepatology and Gastroenterology, Aarhus University Hospital
      2019   Phase 4   EUCTR2019-000905-57-DK   Denmark;
Zinc gluconate   
   Second Affiliated Hospital, School of Medicine, Zhejiang University
      2019   Early Phase 1   NCT03957720   China;
Zink Natur-Drogeriet   
   The Department of Hepatology and Gastroenterology, Aarhus University Hospital
      2019   Phase 4   EUCTR2019-000905-57-DK   Denmark;