19. Lysosomal storage disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 899 / Drugs : 684 - (DrugBank : 99) / Drug target genes : 51 - Drug target pathways : 182
Lysosomal storage disease and other diseases between which drug repositioning might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Drug repositionability
ID | Diseases (Sorted by drug repositionability) |
---|---|
19 | Lysosomal storage disease |
96 | Crohn disease |
13 | Multiple sclerosis/Neuromyelitis optica |
46 | Malignant rheumatoid arthritis |
284 | Diamond-Blackfan anemia |
49 | Systemic lupus erythematosus |
65 | Primary immunodeficiency |
285 | Fanconi anemia |
60 | Aplastic anemia |
6 | Parkinson disease |
283 | Acquired pure red cell aplasia |
20 | Adrenoleukodystrophy |
53 | Sjogren syndrome |
41 | Giant cell arteritis |
66 | IgA nephropathy |
55 | Relapsing polychondritis |
45 | Eosinophilic granulomatosis with Polyangiitis |
326 | Osteopetrosis |
164 | Oculocutaneous albinism |
62 | Paroxysmal nocturnal hemoglobinuria |
36 | Epidermolysis bullosa |
222 | Primary nephrotic syndrome |
234 | Peroxisomal disease (except Adrenoleukodystrophy) |
224 | Purpura nephritis |
107 | Juvenile idiopathic arthritis |
95 | Autoimmune hepatitis |
93 | Primary biliary cholangitis |
286 | Hereditary sideroblastic anemia |
299 | Cystic fibrosis |
40 | Takayasu arteritis |
50 | Dermatomyositis |
42 | Polyarteritis nodosa |
51 | Scleroderma |
2 | Amyotrophic lateral sclerosis |
11 | Myasthenia gravis |
85 | Idiopathic interstitial pneumonia |
97 | Ulcerative colitis |
162 | Pemphigoid |
86 | Pulmonary arterial hypertension |
56 | Behcet disease |
75 | Cushing disease |
26 | HTLV-1-associated myelopathy |
226 | Interstitial cystitis with Hunners ulcer |
151 | Rasmussen encephalitis |
61 | Autoimmune hemolytic anemia |
28 | Systemic amyloidosis |
302 | Leber hereditary optic neuropathy |
274 | Osteogenesis Imperfecta |
228 | Bronchiolitis obliterans |
39 | Toxic epidermal necrolysis |
38 | Stevens-Johnson syndrome |
35 | Pemphigus |
84 | Sarcoidosis |
113 | Muscular dystrophy |
160 | Congenital ichthyosis |
43 | Microscopic polyangiitis |
300 | IgG4-related disease |
269 | Pyogenic arthritis |
44 | Wegener granulomatosis |
98 | Eosinophilic gastrointestinal disease |
271 | Ankylosing spondylitis |
64 | Thrombotic thrombocytopenic purpura |
270 | Chronic recurrent multifocal osteomyelitis |
94 | Primary sclerosing cholangitis |
296 | Biliary atresia |
63 | Idiopathic thrombocytopenic purpura |
256 | Muscle glycogenosis |
331 | Idiopathic multicentric castleman disease |
58 | Hypertrophic cardiomyopathy |
257 | Hepatic glycogenosis |
139 | Congenital cerebral hypomyelination |
298 | Hereditary pancreatitis |
158 | Tuberous sclerosis |
227 | Osler disease |
16 | Crow-Fukase syndrome |
15 | Inclusion body myositis |
254 | Porphyria |
218 | Alport syndrome |
17 | Multiple system atrophy |
172 | Hypophosphatasia |
80 | Resistance to thyroid hormone |
90 | Retinitis pigmentosa |
57 | Idiopathic dilated cardiomyopathy |
106 | Cryopyrin-associated periodic syndrome |
91 | Budd-Chiari syndrome |
238 | Vitamin D-resistant rickets |
235 | Hypoparathyroidism |
5 | Progressive supranuclear palsy |
70 | Spinal stenosis |
137 | Focal cortical dysplasia |
192 | Cockayne syndrome |
277 | Lymphangiomatosis |
281 | Klippel-Trenaunay-Weber syndrome |
191 | Werner syndrome |
52 | Mixed connective tissue disease |
220 | Rapidly progressive glomerulonephritis |
30 | Distal myopathy |