210. Single Ventricle Disease details / Clinical trials / Drug dev / DR info


Clinical trials : 51 Drugs : 53 - (DrugBank : 22) / Drug target genes : 32 - Drug target pathways : 67

Drugs and their primary sponsors and trial info
ACT-064992   
   Actelion Pharmaceuticals Ltd
      2020   Phase 3   EUCTR2018-002821-45-CZ   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-002821-45-FR   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-002821-45-DK   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003320-23-GB   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003320-23-DK   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003320-23-DE   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2018-002821-45-PL   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2018-002821-45-GB   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2018-002821-45-DE   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2016-003320-23-PL   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
Administration of an ACE-inhibitor or not   
   University Hospital, Ghent
      2002   Phase 2   NCT00263406   Belgium;
Aesculus Hippocastanum / Horse Chestnut   
   Casa Espirita Terra de Ismael
      2017   Phase 2   NCT04035317   Brazil;
Ambrisentan   
   Kevin Hill
      2015   Phase 2   NCT02080637   United States;
   Washington University School of Medicine
      2012   Phase 4   NCT01971580   United States;
Aspirin   
   Janssen-Cilag International N.V
      2017   Phase 3   EUCTR2015-002610-76-NL   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-ES   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-BE   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      -   Phase 3   EUCTR2015-002610-76-FR   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
Autologous Tissue-Engineered Vascular Graft   
   University of Zurich
      2011   -   EUCTR2011-001187-21-DE   Germany;
BAY 59-7939   
   Janssen-Cilag International N.V
      2017   Phase 3   EUCTR2015-002610-76-NL   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-ES   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-BE   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      -   Phase 3   EUCTR2015-002610-76-FR   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
Bosentan   
   Rigshospitalet, Denmark
      2011   Phase 2   NCT01292551   Denmark;Sweden;
   Shanghai Jiao Tong University School of Medicine
      2010   Phase 2   NCT01662037   China;
   University Hospital Birmingham
      2008   Phase 4   EUCTR2005-005898-29-GB   United Kingdom;
   University of California, Los Angeles
      2010   -   NCT00989911   United States;
Carvedilol   
   University of Texas Southwestern Medical Center
      2016   Phase 4   NCT02946892   United States;
Colchicine   
   University of Michigan
      2018   Phase 2/Phase 3   NCT03575572   United States;
Digoxin   
   Christoph P Hornik, MD MPH
      2019   -   NCT03877965   United States;
Enalapril   
   National Heart, Lung, and Blood Institute (NHLBI)
      2003   Phase 3   NCT00113087   Canada;United States;
Eplerenone   
   Washington University School of Medicine
      2013   Phase 4   NCT01971593   United States;
JNJ-39039039   
   Janssen-Cilag International N.V
      2017   Phase 3   EUCTR2015-002610-76-NL   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-ES   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-BE   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      -   Phase 3   EUCTR2015-002610-76-FR   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
Liothyronine I 131   
   FDA Office of Orphan Products Development
      1994   Phase 1   NCT00004828   -
MPC   
   Boston Children's Hospital
      2017   Phase 1/Phase 2   NCT03079401   United States;
MZ101   
   Mezzion Pharma Co. Ltd
      2018   -   NCT03430583   Canada;United States;
Milk   
   The University of Texas Health Science Center at San Antonio
      2016   -   NCT02860702   United States;
Mysildecard   
   University Hospital of Montpellier
      -   Phase 3   EUCTR2018-004828-11-FR   France;
Nitric Oxide   
   Jewish General Hospital
      2020   -   NCT04292483   Canada;
Normal Saline   
   Advocate Health Care
      2016   Phase 2/Phase 3   NCT02975999   United States;
ODSH at 0.125 mg/kg/h   
   Chimerix
      2010   Phase 1   NCT01161641   United States;
ODSH at 0.250 mg/kg/h   
   Chimerix
      2010   Phase 1   NCT01161641   United States;
ODSH at 0.375 mg/kg/h   
   Chimerix
      2010   Phase 1   NCT01161641   United States;
Opsumit®   
   Actelion Pharmaceuticals Ltd
      2020   Phase 3   EUCTR2018-002821-45-CZ   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-002821-45-FR   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-002821-45-DK   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003320-23-GB   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003320-23-DK   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-003320-23-DE   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2018-002821-45-PL   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2018-002821-45-GB   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2018-002821-45-DE   Australia;China;Czech Republic;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2016-003320-23-PL   Australia;China;Czech Republic;Czechia;Denmark;France;Germany;Ireland;New Zealand;Poland;Taiwan;United Kingdom;United States;
Rexlemestrocel-L   
   Boston Children's Hospital
      2017   Phase 1/Phase 2   NCT03079401   United States;
SCRM001_TEVG   
   University of Zurich
      2011   -   EUCTR2011-001187-21-DE   Germany;
Sildenafil   
   Tokyo Women'
   University Hospital, Montpellier
      2022   Phase 3   NCT03997097   -
   s Medical University
Sildenafil by injection   
   Duke University
      2011   Phase 1   NCT01169519   United States;
Spironolactone   
   Children's Hospital of Philadelphia
      2021   Phase 1/Phase 2   NCT04901975   United States;
Spironolactone (drug)   
   Emory University
      2004   -   NCT00211081   United States;
Sugar pill   
   University of Utah
      2011   Phase 1   NCT01291069   United States;
Tadalafil Citrate   
   University of Utah
      2011   Phase 1   NCT01291069   United States;
Tracleer   
   Lars Søndergaard
      2010   -   EUCTR2010-022389-28-DK   Denmark;
   University Hospital Birmingham
      2008   Phase 4   EUCTR2005-005898-29-GB   United Kingdom;
Treprostinil   
   Stanford University
      2015   -   NCT02498444   United States;
Udenafil   
   Mezzion Pharma Co. Ltd
      2017   Phase 3   NCT03013751   Canada;Korea, Republic of;United States;
      2016   Phase 3   NCT02741115   Canada;Korea, Republic of;United States;
      2014   Phase 1/Phase 2   NCT02201342   Canada;United States;
Vasopressin   
   Advocate Health Care
      2016   Phase 2/Phase 3   NCT02975999   United States;
Vasopressin, Arginine   
   Medical College of Wisconsin
      2017   Phase 2/Phase 3   NCT03088345   United States;
Vitamin C   
   University of Michigan
      2009   -   NCT00974025   United States;
Xarelto   
   Janssen-Cilag International N.V
      2017   Phase 3   EUCTR2015-002610-76-NL   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-ES   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-002610-76-BE   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;
      -   Phase 3   EUCTR2015-002610-76-FR   Argentina;Australia;Belgium;Brazil;Canada;China;France;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Spain;Thailand;United Kingdom;United States;