DR info

Clinical trials : 500 / Drugs : 614 - (DrugBank : 119) / Drug target genes : 92 - Drug target pathways : 217

Primary immunodeficiency and other diseases between which drug repositioning might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Drug repositionability

ID	Diseases (Sorted by drug repositionability)
65	Primary immunodeficiency
46	Malignant rheumatoid arthritis
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
2	Amyotrophic lateral sclerosis
96	Crohn disease
85	Idiopathic interstitial pneumonia
51	Scleroderma
93	Primary biliary cholangitis
60	Aplastic anemia
285	Fanconi anemia
331	Idiopathic multicentric castleman disease
56	Behcet disease
107	Juvenile idiopathic arthritis
26	HTLV-1-associated myelopathy
97	Ulcerative colitis
53	Sjogren syndrome
42	Polyarteritis nodosa
284	Diamond-Blackfan anemia
11	Myasthenia gravis
222	Primary nephrotic syndrome
41	Giant cell arteritis
34	Neurofibromatosis
299	Cystic fibrosis
50	Dermatomyositis
6	Parkinson disease
28	Systemic amyloidosis
19	Lysosomal storage disease
40	Takayasu arteritis
283	Acquired pure red cell aplasia
162	Pemphigoid
326	Osteopetrosis
35	Pemphigus
164	Oculocutaneous albinism
271	Ankylosing spondylitis
256	Muscle glycogenosis
113	Muscular dystrophy
228	Bronchiolitis obliterans
55	Relapsing polychondritis
269	Pyogenic arthritis
45	Eosinophilic granulomatosis with Polyangiitis
266	Familial mediterranean fever
62	Paroxysmal nocturnal hemoglobinuria
20	Adrenoleukodystrophy
86	Pulmonary arterial hypertension
84	Sarcoidosis
95	Autoimmune hepatitis
286	Hereditary sideroblastic anemia
64	Thrombotic thrombocytopenic purpura
61	Autoimmune hemolytic anemia
44	Wegener granulomatosis
233	Wolfram syndrome
63	Idiopathic thrombocytopenic purpura
160	Congenital ichthyosis
90	Retinitis pigmentosa
300	IgG4-related disease
102	Rubinstein-Taybi syndrome
66	IgA nephropathy
226	Interstitial cystitis with Hunners ulcer
58	Hypertrophic cardiomyopathy
274	Osteogenesis Imperfecta
39	Toxic epidermal necrolysis
151	Rasmussen encephalitis
38	Stevens-Johnson syndrome
234	Peroxisomal disease (except Adrenoleukodystrophy)
158	Tuberous sclerosis
302	Leber hereditary optic neuropathy
36	Epidermolysis bullosa
127	Frontotemporal lobar degeneration
210	Single Ventricle
3	Spinal muscular atrophy
224	Purpura nephritis
37	Generalised pustular psoriasis
265	Lipodystrophy
78	Hypopituitarism
89	Lymphangioleiomyomatosis
83	Addison disease
76	Pituitary gonadotropin secretion hyperthyroidism
5	Progressive supranuclear palsy
227	Osler disease
235	Hypoparathyroidism
71	Idiopathic osteonecrosis of the femoral head
43	Microscopic polyangiitis
323	Aromatic L-amino acid decarboxylase deficiency
94	Primary sclerosing cholangitis
270	Chronic recurrent multifocal osteomyelitis
21	Mitochondrial disease
15	Inclusion body myositis
251	Urea cycle disorder
215	Tetralogy of Fallot
206	Fragile X syndrome
81	Congenital adrenal hyperplasia
98	Eosinophilic gastrointestinal disease
77	Growth hormone secreting pituitary adenoma
268	Nakajo-Nishimura syndrome
325	Hereditary autoinflammatory syndrome
337	Homocystinuria
282	Congenital dyserythropoietic anemia
280	Huge arteriovenous malformation with cervicofacial or limb lesion
301	Macular dystrophy
16	Crow-Fukase syndrome
298	Hereditary pancreatitis
149	Hemiconvulsion hemiplegia epilepsy syndrome
70	Spinal stenosis
288	Autoimmune acquired coagulation factor deficiency
18	Spinocerebellar degeneration
225	Congenital nephrogenic diabetes insipidus
14	Chronic inflammatory demyelinating polyneuropathy
8	Huntington disease
229	Autoimmune pulmonary alveolar proteinosis
172	Hypophosphatasia
75	Cushing disease
118	Myelomeningocele
212	Tricuspid atresia
74	Prolactin secreting pituitary adenoma
22	Moyamoya disease
169	Menkes disease
170	Occipital horn syndrome
106	Cryopyrin-associated periodic syndrome
238	Vitamin D-resistant rickets
137	Focal cortical dysplasia
192	Cockayne syndrome
277	Lymphangiomatosis
281	Klippel-Trenaunay-Weber syndrome
232	Carney complex
191	Werner syndrome
68	Ossification of the ligamentum flavum
52	Mixed connective tissue disease
220	Rapidly progressive glomerulonephritis
30	Distal myopathy