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 215. ファロー四徴症 [臨床試験数:14,薬物数:16(DrugBank:13),標的遺伝子数:13,標的パスウェイ数:39] 

Searched query = "Tetralogy of Fallot", "Fallot tetralogy"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/21/2019, 11/20/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.

Search in Page    e.g. "Phase 3", "Not recruiting", "Japan"    Synonyms (DrugBank) were also searched for.
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1ChiCTR19000255132019-09-012 September 2019The safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperative cardiac function in children with tetralogy of fallot (pulmonary atresia): a preliminary studyThe safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperative cardiac function in children with tetralogy of fallot (pulmonary atresia): a preliminary studytetralogy of fallot (pulmonary atresia)01:N/A ;02:Oral coenzyme Q10, 2.5mg, t.i.d.;03:Oral coenzyme Q10, 5mg, t.i.d.;04:Oral coenzyme Q10, 10mg, t.i.d.;05:Oral coenzyme Q10, 20mg, t.i.d.;Fuwai Central China Cardiovascualr HospitalNot Recruiting02Both01:8;02:8;03:8;04:8;05:8;Phase 0China
2NCT04017975August 201922 July 2019Optical Tissue Identification for Myocardial ArchitectureOptical Tissue Identification for Myocardial Architecture (OPTIMA Study)Ventricular Septal Defect;Complete Atrioventricular Canal;Tetralogy of Fallot With Pulmonary StenosisDrug: Fluorescite;Device: Cellvizio 100 Series System with Confocal MiniprobesAditya KazaNational Heart, Lung, and Blood Institute (NHLBI)Not recruitingN/A18 YearsAll70Phase 2United States
3ChiCTR18000195782018-12-0119 November 2018Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgeryEffects of different tranexamic acid regimen in cyanotic pediatric cardiac surgeryTetralogy of FallotConventional treatment group:Childen did not receive an antifibrinolytic agent during surgery;Low dose of tranexamic acid group:Loading dose: 10mg/kg (infant), 5mg/kg (children); Infusion: 2mg/kg.h; CPB prime dose: 20ug/mL of prime volume;High dose of tranexamic acid group:Loading dose: 30mg/kg (infant), 15mg/kg (children); Infusion: 6mg/kg.h; CPB prime dose: 60ug/mL of prime volume;National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeNot RecruitingBothConventional treatment group:225;Low dose of tranexamic acid group:225;High dose of tranexamic acid group:225;OtherChina
4ChiCTR-IOR-160085712016-06-0618 April 2017Premedication for children with Tetralogy of FallotA comparative evalution of varies premedication regimes on children with Tetralogy of FallotTetralogy of Fallotoral dexmedetomidine:oral dexmedetomidine;oral ketamine:oral ketamine;oral dexmedetomidine mixed with ketamine:oral dexmedetomidine mixed with ketamine;Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong UniversityRecruitingBothoral dexmedetomidine:20;oral ketamine:20;oral dexmedetomidine mixed with ketamine:20;OtherChina
5EUCTR2013-002091-41-NL09/10/201427 October 2014Research into the effect of the drug losartan in adult patients with a reduced function of the right cardiac chamber and a cardiac birth defectRight vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system - Redefine trialTo study the effect of losartan in adult patients with Tetralogy of Fallot and right ventricular dysfunction, defined as right ventricular ejection fraction <50%. Without severe valvular lesions.;Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]Trade Name: Losartan
Product Name: Losartan
Pharmaceutical Form: Capsule, hard
INN or Proposed INN: Losartan Potassium
CAS Number: 124750-99-8
Current Sponsor code: losartan
Other descriptive name: LOSARTAN POTASSIUM
Concentration unit: mg milligram(s)
Concentration type: equal
Concentration number: 150-
Pharmaceutical form of the placebo: Capsule, hard
Route of administration of the placebo: Oral use
Academisch medisch centrumAuthorisedFemale: yes
Male: yes
Netherlands
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
6NCT01915277April 2, 201411 June 2018A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsA Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsTransposition of the Great Arteries;Tetralogy of Fallot;Ventricular Septal DefectDrug: DexmedetomidineNew England Research InstitutesNational Heart, Lung, and Blood Institute (NHLBI)Not recruitingN/A180 DaysAll119Phase 1United States
7NCT02010905December 20134 January 2016Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone SystemRight Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone SystemTetralogy of Fallot;Heart Defects, Congenital;Ventricular Dysfunction, RightDrug: Losartan;Drug: PlaceboAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)The Interuniversity Cardiology Institute of the NetherlandsRecruiting18 Years80 YearsBoth120Phase 2Netherlands
8NCT01941576September 20132 May 2016Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of FallotEffects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of FallotCongenital Heart Defects;Tetralogy Of FallotDrug: recombinant human brain natriuretic peptide (rhBNP);Drug: Placebo (0.9% sodium chloride)Shanghai Jiao Tong University School of MedicineRecruiting1 Month18 YearsBoth100Phase 2/Phase 3China
9NCT01971593August 201311 June 2018The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseEplerenone to Prevent Myocardial Fibrosis in Congenital Heart DiseaseTetralogy of Fallot;Transposition of the Great Vessels With an Arterial Switch;Single Ventricle With a Fontan PalliationDrug: EplerenoneWashington University School of MedicinePfizerNot recruiting18 Years80 YearsAll26Phase 4United States
10NCT00848393November 20083 August 2015Measures to Lower the Stress Response in Pediatric Cardiac SurgeryStress Response in Children Undergoing Cardiac Surgery: a Prospective Randomized Comparison Between Low Dose Fentanyl, Low Dose Fentanyl Plus Dexmedetomidine and High Dose Fentanyl.Tetralogy of Fallot;Ventricular Septal Defects;Atrioventricular Septal DefectsDrug: Fentanyl;Drug: Dexmedetomidine and FentanylNationwide Children's HospitalNot recruiting1 Month3 YearsBoth52N/AUnited States
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
11EUCTR2007-003461-41-DE13/11/200728 August 2012Cardiac imaging under dobutamine stress for early assessment of right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation - Fallot-stressCardiac imaging under dobutamine stress for early assessment of right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation - Fallot-stressFallot tetralogy late after repair with marked pulmonary valve incompetencePharmaceutical Form: Intravenous infusion
INN or Proposed INN: Dobutamine
Concentration unit: µg/kg microgram(s)/kilogram
Concentration type: range
Concentration number: 10-20
Deutsche Herzzentrum Berlin, Kompetenznetz Angeborene HerzfehlerNot RecruitingFemale: yes
Male: yes
80Germany
12NCT00557934October 200719 February 2015Right Ventricular Contractility Reserve Following Repair of Tetralogy of FallotEvaluation of Right Ventricular Contractility Reserve Function During Dobutamine Stress in Patients Following Surgical Repair of Tetralogy of FallotRight Ventricular DysfunctionOther: dobutamineUniversity Hospital TuebingenFördergemeinschaft Deutsche Kinderherzzentren, Bonn, GermanyNot recruiting4 YearsN/ABoth16N/AGermany
13NCT00573066May 200419 October 2017Understanding Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryThe Pharmacokinetics, Pharmacogenetics, and Pharmacodynamics of Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryHypoplastic Left Heart;Tetralogy of Fallot;Tricuspid AtresiaDrug: DexmedetomidineAthena ZuppaNot recruiting1 Month24 MonthsAll56Phase 1
14NCT00004361July 199519 February 2015Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac DefectsHypoparathyroidism;Tetralogy of Fallot;Pulmonary Valve Stenosis;Conotruncal Cardiac Defects;Heart Defects, Congenital;Pulmonary AtresiaDrug: calcium gluconate;Drug: sodium citrateNational Center for Research Resources (NCRR)Ann & Robert H Lurie Children's Hospital of ChicagoNot recruiting18 YearsN/ABoth150N/A

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