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 26. HTLV-1関連脊髄症 [臨床試験数:23,薬物数:39(DrugBank:26),標的遺伝子数:37,標的パスウェイ数:116] 

Searched query = "HTLV-1-associated myelopathy", "Tropical spastic paraparesis", "HTLV-1", "HTLV-I-associated myelopathy"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/21/2019, 11/20/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.

Search in Page    e.g. "Phase 3", "Not recruiting", "Japan"    Synonyms (DrugBank) were also searched for.
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
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Target_
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PhaseCountries
1NCT02655471July 1, 20173 June 2019Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 InfectionEffect of Raltegravir in Patients With Myelopathy/Tropical Spastic Paraparesis Associated With Infection by Human T-Lymphotropic Virus 1 (HTLV-1). Pilot StudyHTLV-I Infections;Tropical Spastic ParaparesisDrug: Raltegravir and ZidovudineUniversidad Peruana Cayetano HerediaMerck Sharp & Dohme Corp.Not recruiting18 YearsN/AAll10Early Phase 1Peru
2JPRN-JapicCTI-17360801/6/201716 July 2019A Phase 3 Study of KW-0761 in Subjects with HTLV-1 Associated Myelopathy (HAM)A Phase 3 Multicenter, Randomized, Double-Blind and Placebo-Controlled Study, and Open Study of KW-0761 in Subjects with HTLV-1 Associated Myelopathy (HAM)HTLV-1 associated Myelopathy (HAM)Intervention name : KW-0761
INN of the intervention : Mogamulizumab
Dosage And administration of the intervention : 0.3 mg/kg, IV
Kyowa Hakko Kirin Co., Ltd.Not Recruiting20BOTH52Phase 3
3NCT03075553May 17, 201730 September 2019Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell LymphomaPhase 2 Single-Arm, Open-Label Study of Nivolumab in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma (PTCL)Blastic Plasmacytoid Dendritic Cell Neoplasm;Hepatosplenic T-Cell Lymphoma;HTLV-1 Infection;NK-Cell Lymphoma, Unclassifiable;Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Negative;Recurrent Adult T-Cell Leukemia/Lymphoma;Recurrent Anaplastic Large Cell Lymphoma;Recurrent Angioimmunoblastic T-cell Lymphoma;Recurrent Enteropathy-Associated T-Cell Lymphoma;Recurrent Mycosis Fungoides;Refractory Adult T-Cell Leukemia/Lymphoma;Refractory Anaplastic Large Cell Lymphoma;Refractory Angioimmunoblastic T-cell Lymphoma;Refractory Enteropathy-Associated T-Cell Lymphoma;Refractory Mycosis Fungoides;Refractory Nasal Type Extranodal NK/T-Cell Lymphoma;Refractory Peripheral T-Cell Lymphoma, Not Otherwise SpecifiedOther: Laboratory Biomarker Analysis;Biological: NivolumabMayo ClinicNational Cancer Institute (NCI)Not recruiting18 YearsN/AAll12Phase 2United States
4JPRN-UMIN0000240852016/09/162 April 2019Phase IIb clinical trial of steroid therapy in patients with HAM(Slow progressor)HTLV-1-Associated-Myelopathy Tropical Spastic Paraparesis (HAM/TSP)Prednisolone is orally administered at a maximum dose of 0.5mg/kg/day and then tapered to a maintenance dose of 5mg/day.
Indistinguishable placebo is orally administered for 24 weeks, and then 5mg/day of prednisolone for the next 24 weeks.
St. Marianna University School of Medicine HospitalRecruiting18years-oldNot applicableMale and Female40Phase 2,3Japan
5JPRN-UMIN0000240862016/09/162 April 2019Phase IIb clinical trial of steroid therapy in patients with HAM(Non progressor)HTLV-1-Associated-Myelopathy Tropical Spastic Paraparesis (HAM/TSP)Drugs which possibly affect assessment in the study (e.g. methylprednisolone, prednisolone and other agents targeted to HAM) will be forbidden or limited until Week 48 and periodic evaluation and tests will be performed.St. Marianna University School of Medicine HospitalRecruiting18years-oldNot applicableMale and Female5Not applicableJapan
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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sponsor
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Status
Inclusion_
agemin
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PhaseCountries
6JPRN-UMIN0000237982016/08/312 April 2019Phase IIb clinical trial of steroid therapy in patients with HAMHTLV-1-Associated-Myelopathy Tropical Spastic Paraparesis (HAM/TSP)Following to administrate Methylprednisolone 1000mg/day intravenously slowly for consecutive three days, Prednisolone is administered orally for a maximum dose in 0.5mg/kg/day, then decreased gradually and terminated. There is a case to maintain the dose of Prednisolone by the degree of a progress of underlying disease.
Prednisolone is administered orally for a maximum dose in 0.5mg/kg/day, then decreased gradually and terminated. There is a case to maintain the dose of Prednisolone by the degree of a progress of underlying disease.
St. Marianna University School of Medicine HospitalRecruiting18years-oldNot applicableMale and Female8Phase 2,3Japan
7NCT02961712July 201616 December 2017Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM)Immunotherapy of Natural Killer in HTLV-1 Associated MyelopathyHAMBiological: NK cells;Biological: amniotic epithelial cellsThe Second Affiliated Hospital of Fujian Medical UniversityShanghai iCELL Biotechnology Co., Ltd, Shanghai, ChinaRecruiting18 Years75 YearsAll15Phase 1China
8NCT02631746June 3, 201630 September 2019Nivolumab in Treating Patients With HTLV-Associated T-Cell Leukemia/LymphomaPhase II Trial of Nivolumab for HTLV-Associated Adult T Cell Leukemia/LymphomaAcute Adult T-Cell Leukemia/Lymphoma;Adult T-Cell Leukemia/Lymphoma;CD4-Positive Neoplastic Cells Present;Chronic Adult T-Cell Leukemia/Lymphoma;HTLV-1 Infection;Lymphomatous Adult T-Cell Leukemia/Lymphoma;Recurrent Adult T-Cell Leukemia/Lymphoma;Smoldering Adult T-Cell Leukemia/LymphomaOther: Laboratory Biomarker Analysis;Biological: Nivolumab;Other: Pharmacogenomic StudyNational Cancer Institute (NCI)Not recruiting18 YearsN/AAll3Phase 2United States
9JPRN-UMIN0000166832015/03/132 April 2019Novel autologous dendritic cell vaccine therapy targeting HTLV-1 specific antigen Combined with anti-CCR4 antibody for previously treated patients with adult T-cell leukemia. A phase Ia/Ib study.Adult T-cell leukemia/lymphomaTax-targeting DC vaccine
KW-0761 (Mogamulizumab)
Japan Agency for Medical Research and DevelopmentNational Hospital Organization Kyushu Cancer CenterNot Recruiting20years-old75years-oldMale and Female9Phase 1Japan
10JPRN-UMIN0000155872014/11/042 April 2019Clinical trial with NaPPS for HTLV-1-associated myelopathy (HAM) patientsHTLV-1-associated myelopathy (HAM)period of intervention: 12 weeks
0-4 weeks: Normal saline solution by subcutaneous injection
4-12 weeks: NaPPS(Pentosan Polysulfate sodium) 50 mg by subcutaneous injection
period of intervention: 12 weeks
0-4 weeks: Normal saline solution by subcutaneous injection
4-12 weeks: NaPPS(Pentosan Polysulfate sodium) 100 mg by subcutaneous injection
period of intervention: 12 weeks
0-4 weeks: NaPPS 100mg/week by subcutaneous injection
4-12 weeks: NaPPS(Pentosan Polysulfate sodium) 50 mg by subcutaneous injection
period of intervention: 12 weeks
0-4 weeks: NaPPS 100mg/week by subcutaneous injection
4-12 weeks: NaPPS(Pentosan Polysulfate sodium) 100
100 mg by subcutaneous injection
ReqMed Company, LtdNot Recruiting20years-oldNot applicableMale and Female12Phase 2Japan
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
11NCT01867320May 21, 20131 October 2018Raltegravir for HAM/TSPPilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)HTLV-I InfectionDrug: RaltegravirNational Institute of Neurological Disorders and Stroke (NINDS)Not recruiting18 YearsN/AAll19Early Phase 1United States
12NCT01640002May 201219 February 2015A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive BladderA Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive BladderOveractive Bladder Associated With HTLV-1Drug: Propantheline Bromide;Drug: PlaceboHospital Universitário Professor Edgard SantosRecruiting18 YearsN/ABoth42Phase 1Brazil
13NCT01620736January 20125 February 2018Trial to Assess Effect of Raltegravir on HTLV-1 Proviral LoadPhase II Trial to Assess Effect of Raltegravir on HTLV-1 Proviral LoadHuman T-cell Leukemia Virus Type 1 InfectionDrug: RaltegravirWashington University School of MedicineMerck Sharp & Dohme Corp.Not recruiting18 YearsN/AAll0Phase 2United States
14NCT01343355January 201119 February 2015Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)Open-Label, Exploratory Study of the Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)HTLV-I-Associated MyelopathyDrug: TamibaroteneSt. Marianna University School of MedicineNot recruiting30 Years75 YearsBoth15Phase 2/Phase 3Japan
15NCT01274533December 201019 October 2017Lenalidomide in HTLV-1 Adult T-Cell LeukemiaA Phase II Study of Lenalidomide in Patients With Relapsed or Refractory HTLV-1 Associated Adult T Cell Leukemia/LymphomaAdult T Cell Leukemia/LymphomaDrug: LenalidomideColumbia UniversityCelgene CorporationNot recruiting18 YearsN/AAll4Phase 2United States
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
16NCT01000285September 201016 December 2017EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia LymphomaPhase I/II Trial of Dose-Adjusted EPOCH Chemotherapy With Bortezomib Combined With Integrase Inhibitor Therapy for HTLV-1 Associated T-Cell Leukemia LymphomaLeukemia-Lymphoma, Adult T-CellDrug: Bortezomib;Drug: Etoposide;Drug: Vincristine;Drug: Doxorubicin;Drug: Prednisone;Drug: Cyclophosphamide;Drug: RaltegravirWashington University School of MedicineNot recruiting18 YearsN/AAll18Phase 1/Phase 2United States
17NCT01472263September 200930 March 2015Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) DiseasesEffectiveness of Pentoxifylline in Attenuating Neurological Disease Associated With HTLV-1 and Negative Modulator of Pathological Immune Response.HTLV-1;Tropical Spastic Paraparesis;Immune System Diseases;Physical Disability;PentoxifyllineDrug: Pentoxifylline;Drug: PlaceboHospital Universitário Professor Edgard SantosNot recruiting18 Years80 YearsBoth48Phase 3Brazil
18NCT00681980February 200814 December 2015Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)Study Of Valproic Acid To Treat TSP/HAM Patients In Sao Paulo, BrazilParaparesis Spastic TropicalDrug: Valproic acid;Drug: costicosteroids;Drug: valproid acid plus corticosteroidsUniversity of Sao PauloNot recruiting18 Years70 YearsBoth60Phase 3Brazil
19NCT00773292August 200619 February 2015Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)The HAM Ciclosporin Study : an Observational Trial of Therapy in Early or Progressing HAM/TSPHTLV I Associated MyelopathyDrug: ciclosporinImperial College LondonMedical Research Council;Selly Oak Hospital, Birmingham, UK;St Mary Hospital, Imperial College Healthcare NHS Trust, London, UKNot recruiting16 Years75 YearsBoth7Phase 2/Phase 3United Kingdom
20NCT00076843February 3, 200415 July 2019Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisPhase I Study of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Using the Humanized MiK-Beta-1 Monoclonal Antibody Directed Toward the IL-2L-15R-Beta; Subunit (CD122) That Blocks IL-15 ActionHTLV-1Drug: Hu MiK-Beta-1National Institute of Neurological Disorders and Stroke (NINDS)Not recruiting18 YearsN/AAll9Phase 1United States
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
21NCT00041327October 200215 February 2016Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/LymphomaPhase II Trial Of Induction Therapy With EPOCH Chemotherapy And Maintenance Therapy With Combivir/Interferon ALPHA-2a For HTLV-1 Associated T-Cell Non-Hodgkin's LymphomaLymphomaBiological: filgrastim;Biological: recombinant interferon alfa;Drug: Etoposide;Drug: cyclophosphamide;Drug: doxorubicin hydrochloride;Drug: lamivudine;Drug: prednisone;Drug: vincristine sulfate;Drug: zidovudineAIDS Malignancy ConsortiumNational Cancer Institute (NCI)Not recruiting18 Years120 YearsBoth19Phase 2United States
22NCT00272480November 8, 199929 July 2019Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised TrialZidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised TrialHTLV-I-associated MyelopathyDrug: Zidovudine/lamivudine;Drug: PlacebosImperial College LondonNot recruiting16 Years75 YearsAll16Phase 2/Phase 3United Kingdom
23NCT00001785September 199819 February 2015Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)Combined Virological and Immunological Evaluation of Treatment of Patients With Early HTLV-1-Associated Myelopathy With Recombinant Human Interferon Beta-1aHTLV-I Infection;Spinal Cord Disease;Tropical Spastic ParaparesisDrug: Recombinant human interferon beta-1aNational Institute of Neurological Disorders and Stroke (NINDS)Not recruitingN/AN/ABoth12Phase 2United States

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