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 294. 先天性横隔膜ヘルニア [臨床試験数:7,薬物数:12(DrugBank:4),標的遺伝子数:5,標的パスウェイ数:14] 

Searched query = "Congenital diaphragmatic hernia"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/21/2019, 11/20/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.

Search in Page    e.g. "Phase 3", "Not recruiting", "Japan"    Synonyms (DrugBank) were also searched for.
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT03526588August 1, 201829 April 2019Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)Congenital Diaphragmatic HerniaBiological: Autologous umbilical cord bloodThe University of Texas Health Science Center, HoustonTexas Medical Center Regenerative Medicine ConsortiumRecruitingN/A7 DaysAll20Phase 1United States
2EUCTR2017-000421-13-AT13/07/201823 July 2018Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trialCongenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
Pharmaceutical Form: Solution for injection/infusion
INN or Proposed INN: Sildenafil
CAS Number: 171599-83-0
Concentration unit: mg/kg milligram(s)/kilogram
Concentration type: equal
Concentration number: 0.4-
Trade Name: INOmax 800ppm mol/mol inhalatiegas
Pharmaceutical Form: Medicinal gas, compressed
INN or Proposed INN: NITRIC OXIDE
CAS Number: 10102-43-9
Concentration unit: PPM part per million
Concentration type: equal
Concentration number: 20-
Erasmus MCAuthorisedFemale: yes
Male: yes
330Phase 4Austria;Netherlands
3NCT03787160March 22, 201826 August 2019Microbiome and Volatile Organic Compounds in Patients With CDHDetermining the Effect of Probiotics on Microbiome and Volatile Organic Compounds in Patients After Surgical Repair of Congenital Diaphragmatic HerniaCongenital Diaphragmatic HerniaDiagnostic Test: initial VOC;Diagnostic Test: initial fecal microbiome;Diagnostic Test: initial pulmonary microbiome;Diagnostic Test: Maximum oxygen uptake;Diagnostic Test: Functional residual capacity;Dietary Supplement: Probiotic treatment;Diagnostic Test: VOC probiotic;Diagnostic Test: Fecal microbiome probiotic;Diagnostic Test: Pulmonary microbiome probioticMedical University of GrazUniversity of RostockNot recruiting6 Years16 YearsAll20N/AAustria
4NCT02951130August 22, 201725 March 2019Milrinone in Congenital Diaphragmatic HerniaMilrinone in Congenital Diaphragmatic HerniaCongenital Diaphragmatic Hernia;Persistent Pulmonary Hypertension of the Newborn;Hypoxemic Respiratory Failure;Pulmonary HypoplasiaDrug: Milrinone;Drug: Placebo (5% Dextrose)NICHD Neonatal Research NetworkEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)RecruitingN/A168 HoursAll66Phase 2United States
5EUCTR2017-000421-13-NL27/07/201721 August 2017Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trialCongenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
Pharmaceutical Form: Solution for injection/infusion
Trade Name: INOmax 800ppm mol/mol inhalatiegas
Pharmaceutical Form: Medicinal gas, compressed
INN or Proposed INN: NITRIC OXIDE
CAS Number: 10102-43-9
Trade Name: Neophyr 1000ppm mol/mol
Pharmaceutical Form: Medicinal gas, compressed
Erasmus MCAuthorisedFemale: yes
Male: yes
330Phase 3Netherlands
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
6NCT02453750February 20121 June 2015Airway Inflammation in Congenital Diaphragmatic Hernia PatientsInvestigation of Airway Inflammation in Congenital Diaphragmatic Hernia PatientsCongenital Diaphragmatic HerniaDrug: Hypersaline;Drug: Bronchodilator ResponseThe Hospital for Sick ChildrenNot recruiting6 Years18 YearsBoth21N/ACanada
7NCT00226044September 200522 October 2019Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.Rectal and Oral Omeprazole Treatment of Gastroesophageal Reflux in Infants With Esophageal Atresia or Congenital Diaphragmatic Hernia; A Pharmacodynamic and Pharmacokinetic Study.Gastroesophageal Reflux;Esophageal Atresia;Hernia, DiaphragmaticDrug: Omeprazole rectally 1mg/kgRijnstate HospitalErasmus Medical CenterNot recruiting6 Weeks3 MonthsAll17Phase 3Netherlands

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