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 296. 胆道閉鎖症 [臨床試験数:23,薬物数:37(DrugBank:21),標的遺伝子数:35,標的パスウェイ数:35] 

Searched query = "Biliary atresia"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/21/2019, 11/20/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.

Search in Page    e.g. "Phase 3", "Not recruiting", "Japan"    Synonyms (DrugBank) were also searched for.
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
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size
PhaseCountries
1ChiCTR19000238432019-07-0117 June 2019Effects of intestinal flora distribution and mucosal structure on pediatric liver transplantation with biliary atresiaEffects of intestinal flora distribution and mucosal structure on pediatric liver transplantation with biliary atresiaBiliary Atresia1:No;2:probiotics;3:Rifaximin;Tianjin First Center HospitalNot Recruiting018Both1:20;2:10;3:10;Phase 0China
2NCT03563378July 28, 20182 July 2018Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver TransplantationEffects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation: A Double-blind Randomized TrialBiliary Atresia Intrahepatic Syndromic FormDrug: Lactated Ringer;Drug: Normal salineRenJi HospitalRecruiting3 Months6 YearsAll200N/AChina
3ChiCTR-IOR-170135852018-06-1416 July 2018Comparison of renal injury in children with liver transplantation under combined anesthesia with sevoflurane and propofolThe influence of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantionCongenital biliary atresiaP:Propofol compound anesthesia;Se:Sevoflurane compound anesthesia;Tianjin First Central HospitalRecruiting0.52BothP:60;Se:60;OtherChina
4NCT03499249May 18, 201820 May 2019N-Acetylcysteine in Biliary Atresia After Kasai PortoenterostomyA Phase 2 Trial of N-Acetylcysteine in Biliary Atresia After Kasai PortoenterostomyBiliary AtresiaDrug: N-Acetyl cysteineBaylor College of MedicineRecruitingN/A90 DaysAll16Phase 2United States
5ChiCTR18000157782018-04-2030 April 2018Myocardial protection in pediatric patients undergoing liver transplantationMyocardial protective strategies of pediatric liver transplantation with biliary atresiaCongenital biliary atresiaPropofol:Propofol compound anesthesia;Sev:Sev compound anesthesia;Tianjin First Center HospitalRecruiting02BothPropofol:60;Sev:60;OtherChina
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
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PhaseCountries
6NCT03395028January 15, 201826 August 2019GCSF Adjunct Therapy for Biliary AtresiaGranulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary AtresiaBiliary AtresiaDrug: Granulocyte Colony-Stimulating FactorHolterman, Ai-Xuan, M.D.T Rose Clinical, Inc.;Children's National Health SystemNot recruitingN/A180 DaysAll6Early Phase 1United States;Vietnam
7JPRN-jRCTs04118008801/12/201610 September 2019Influence of fatty acid metabolism for clinical course of biliary atresiaThe difference of the profile of fatty acids and eicosanoids in clinical course and the effect to the prognosis by collection of biliary atresiabiliary atresia, neonatal hepatitis, Alagille syndrome, PFIC, etc.oral administration of 30(+/- 10)mg/kg/day of eicosapentaenoic acidWataru SumidaHiroo UchidaRecruitingNot applicableNot applicableBoth30N/Anone
8ChiCTR-IPR-160086092016-07-0112 June 2017Therapeutic effect of prophylactic intravenous antibiotics after Kasai procedure in biliary atresiaA clinical randomized controlled study to investigate the preventive effect of prophylactic intravenous antibiotics against cholangitis after Kasai procedure in biliary atresiabiliary atresiaShort-term Group:Cefoperazone 5 days;Long-term Group:Cefoperazone 14 days;Children's Hospital of Fudan UniversityNot Recruiting01BothShort-term Group:86;Long-term Group:86;Post-marketChina
9ChiCTR-OOC-160087072016-06-0118 April 2017Study on pharmacodynamics of continuous infusion of rocuronium during transplantation of living donor liver transplantation for infantsStudy on pharmacodynamics of continuous infusion of rocuronium during transplantation of living donor liver transplantation for infantscongenital biliary atresiaobstructive jaundice group:continuous infusion of rocuronium;after Kasai portoenterostomy group :continuous infusion of rocuronium;Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityRecruitingBothobstructive jaundice group:15;after Kasai portoenterostomy group :15;OtherChina
10EUCTR2014-004693-42-GB29/06/201517 August 2015A study to look at how the study drug Obeticholic Acid (OCA), when given as a single dose and multiple doses, is tolerated in children who have biliary atresia and to look at the effects that the study drug has on the body.A Multicenter, Randomized, Open Label, Single- and Multiple-Dose, Dose Finding Study and Open-Label Extension to Assess the Effects of Obeticholic Acid in Pediatric Subjects with Biliary AtresiaBiliary atresia
MedDRA version: 18.0 Level: LLT Classification code 10004653 Term: Biliary atresia System Organ Class: 100000004850
MedDRA version: 18.0 Level: LLT Classification code 10004654 Term: Biliary atresia, congenital System Organ Class: 100000004850 ;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: OCA 1.5mg
Product Code: OCA
Pharmaceutical Form: Tablet
INN or Proposed INN: obeticholic acid
CAS Number: 459789-99-2
Current Sponsor code: OCA
Concentration unit: mg milligram(s)
Concentration type: equal
Concentration number: 1.5-
Product Name: OCA 5mg
Product Code: OCA
Pharmaceutical Form: Tablet
INN or Proposed INN: obeticholic acid
CAS Number: 459789-99-2
Current Sponsor code: OCA
Concentration unit: mg milligram(s)
Concentration type: equal
Concentration number: 5-
Intercept Pharmaceuticals, Inc.AuthorisedFemale: yes
Male: yes
60United States;Canada;United Kingdom
No.TrialIDDate_
enrollement
Last_Refreshed_
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Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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sponsor
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Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
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Target_
size
PhaseCountries
11NCT01854827October 20137 October 2019Safety Study of Intravenous Immunoglobulin (IVIG) Post-Portoenterostomy in Infants With Biliary AtresiaA Phase 1/2A Trial of Intravenous Immunoglobulin (IVIG) Therapy Following Portoenterostomy in Infants With Biliary AtresiaBiliary AtresiaDrug: Intravenous immunoglobulin (IVIG)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Not recruitingN/A120 DaysAll30Phase 1/Phase 2United States;Canada
12NCT01774487January 201316 December 2017Pentoxifylline Therapy in Biliary AtresiaA Phase II Trial of Pentoxifylline in Newly-Diagnosed Biliary AtresiaBiliary AtresiaDrug: PentoxifyllineBaylor College of MedicineTexas Children's HospitalRecruitingN/A180 DaysAll60Phase 2United States
13NCT02471209January 201229 June 2015Biliary Atresia, Hepatic Buffer Response and SevofluraneBiliary AtresiaDrug: SevofluraneChildren's Hospital of Fudan UniversityNot recruiting1 Month3 MonthsBoth25N/A
14NCT01443572September 201119 February 2015The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai OperationKasai Operation;Biliary AtresiaDrug: desflurane anesthetics;Drug: sevoflurane anestheticsYonsei UniversityNot recruitingN/A1 YearBoth40N/AKorea, Republic of
15NCT02137668July 201021 November 2016Treating Primary Sclerosing Cholangitis and Biliary Atresia With VancomycinThe Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With VancomycinPrimary Sclerosing Cholangitis;Biliary AtresiaDrug: Oral VancomycinSacramento Pediatric GastroenterologyRecruitingN/A40 YearsBoth200Phase 1United States
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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sponsor
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Status
Inclusion_
agemin
Inclusion_
agemax
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size
PhaseCountries
16EUCTR2009-014886-21-NL26/01/201019 March 2012Intraoperative bile duct visualisation in children with biliary atresia using a fluorescence camera system: a pilot study - Bile duct mapping with fluorescence in BAIntraoperative bile duct visualisation in children with biliary atresia using a fluorescence camera system: a pilot study - Bile duct mapping with fluorescence in BABiliary atresiaTrade Name: ICG-Pulsion 25mg
Product Name: ICG Pulsion
Product Code: VO4CX
Pharmaceutical Form: Emulsion for injection
University Medical Centre GroningenAuthorisedFemale: yes
Male: yes
4Netherlands
17NCT02298218September 200919 February 2015Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary AtresiaBiliary Atresia, Kasai Portoenterostomy StatusDrug: MeloxicamYonsei UniversityNot recruiting2 Years17 YearsBoth50Phase 4
18NCT01322386May 200719 October 2017Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With VancomycinThe Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin.Primary Sclerosing Cholangitis;Biliary AtresiaDrug: VancomycinStanford UniversityNot recruiting1 Month20 YearsAll32Phase 1
19ChiCTR-TNRC-090003312007-01-0118 April 2017Intervention and Efficacy Evaluation Study of Combined Modality Therapy in Patients with Biliary Atrisia after Kasai OperationruIntervention and Efficacy Evaluation Study of Combined Modality Therapy in Patients with Biliary Atrisia after Kasai OperationruBiliary Atresiagroup 1:Given Yinzhihuang with Ligustrazine from the day 3 after operation;group 2:Given Yinzhihuang with placebo from the day 3;group A:Divide two groups according different glucocorticoid, group A is given dexamethasone from the seventh day after operation;group B:Divide two groups according different glucocorticoid, group B is given methylprednisolone from the seventh day after operation;The First Affiliated Hospital of Sun Yat Sen UniversityNot RecruitingBothgroup 1:50;group 2:50;group A:50;group B:50;Post-marketChina
20NCT00294684November 200528 October 2019A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following PortoenterostomyA Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants With Biliary AtresiaBiliary AtresiaDrug: Corticosteroids;Drug: PlaceboNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Not recruitingN/A6 MonthsAll141N/AUnited States
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
21NCT00166868December 200319 February 2015Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai PortoenterostomyUse of Probiotics to Prevent Cholangitis in Children With Biliary AtresiaBiliary AtresiaDrug: Lactobacillus casei rhamnosus (Lcr35);Drug: NeomycinNational Taiwan University HospitalNot recruiting4 Months3 YearsBoth30N/ATaiwan
22NCT00007033October 200019 February 2015Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver DiseaseAlagille Syndrome;Cholestasis;Biliary AtresiaDrug: magnesium gluconate;Drug: magnesium sulfateNational Center for Research Resources (NCRR)Children's Hospital Medical Center, CincinnatiNot recruiting3 Years18 YearsBoth25N/AUnited States
23NCT00539565January 200019 February 2015RCT of Steroids Following Kasai Portoenterostomy for Biliary Atresia.Phase IIIb Study of Corticosteroids as Post-Operative Adjuvant Therapy in Biliary AtresiaBiliary AtresiaDrug: prednisolone;Drug: placeboKing's College Hospital NHS TrustRecruitingN/A100 DaysBoth100Phase 3United Kingdom

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