34. 神経線維腫症 Neurofibromatosis Clinical trials / Disease details


臨床試験数 : 137 薬物数 : 214 - (DrugBank : 76) / 標的遺伝子数 : 87 - 標的パスウェイ数 : 200

  
2 trials found
No.TrialIDDate_
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PhaseCountries
1EUCTR2011-001789-16-GB
(EUCTR)
26/08/201117/05/2011Investigation of the intra-tumoural concentration and activity of sorafenib in cutaneous schwannomas - Sorafenib in NF2Investigation of the intra-tumoural concentration and activity of sorafenib in cutaneous schwannomas - Sorafenib in NF2 Neurofibromatosis, type 2 (acoustic neurofibromatosis)
MedDRA version: 14.0;Level: LLT;Classification code 10029271;Term: Neurofibromatosis, type 2 (acoustic neurofibromatosis);System Organ Class: 10010331 - Congenital, familial and genetic disorders
Trade Name: Nexavar
INN or Proposed INN: sorafenib (as tosylate)
Other descriptive name: Nexavar
Plymouth Hospital NHS TrustNULLNot Recruiting Female: yes
Male: yes
14 Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): yesUnited Kingdom
2NCT00727233
(ClinicalTrials.gov)
July 8, 200831/7/2008Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform NeurofibromasPhase I Trial of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, Nexavar) in Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform NeurofibromasNeurofibromatosis Type I;Plexiform NeurofibromaDrug: Nexavar (BAY 43-9006) (Sorafenib);Drug: Toxicity, Pharmacokinetics;Drug: Pharmacodynamics;Drug: Radiographic Evaluation;Drug: QOL assessment, Neuropsychological;Drug: Bony ToxicityNational Cancer Institute (NCI)NULLCompleted3 Years18 YearsAll9Phase 1United States