36. 表皮水疱症 Epidermolysis bullosa Clinical trials / Disease details


臨床試験数 : 160 薬物数 : 196 - (DrugBank : 47) / 標的遺伝子数 : 49 - 標的パスウェイ数 : 123

  
3 trials found
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04177498
(ClinicalTrials.gov)
August 24, 20217/11/2019Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCCA Pilot, Open Study to Assess Efficacy and Safety of Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated Locally Advanced/Metastatic Squamous Cell CarcinomaRecessive Dystrophic Epidermolysis BullosaDrug: Rigosertib Sodium;Other: Quality-of-Life AssessmentThomas Jefferson UniversityOnconova Therapeutics, Inc.Recruiting18 Years79 YearsAll6Early Phase 1United States
2NCT03786237
(ClinicalTrials.gov)
April 12, 202114/11/2018Rigosertib for RDEB-SCCA Phase II, Open Study to Assess Efficacy and Safety of Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated Locally Advanced/Metastatic Squamous Cell CarcinomaEpidermolysis Bullosa Dystrophica;Squamous Cell CarcinomaDrug: Rigosertib Oral Capsules / Rigosertib IntravenousProf. Johann BauerNULLRecruiting18 Years79 YearsAll12Phase 1/Phase 2Austria
3EUCTR2016-003832-19-AT
(EUCTR)
11/12/201709/08/2017Clinical Trial to evaluate the efficacy of the drug Rigosertib against non- melanoma skin cancer in Butterfly Children.A Phase II, Open Study to Assess Efficacy and Safety of Rigosertib in Patients with Recessive Dystrophic Epidermolysis bullosa associated Locally Advanced/Metastatic Squamous Cell Carcinoma - Rigosertib for RDEB-SCC Recessive dystrophic epidermolysis bullosa (RDEB) is a severe genodermatose caused by mutations in COL7A1, characterized by generalized skin blistering and involvement of mucous membranes. Aggressive metastasizing squamous cell carcinomas (SCCs) are a common complication, which reduce patients’ average life expectancy to less than 40 years. The aim of this study is to evaluate anti-tumor activity of oral Rigosertib, a PLK1 inhibitor, in RDEB patients diagnosed with SCCs.;Therapeutic area: Diseases [C] - Cancer [C04]Product Name: Rigosertib
Product Code: ON 01910.Na
INN or Proposed INN: rigosertib
Other descriptive name: ON 01910.NA
Product Name: Rigosertib
Product Code: ON 01910.Na
INN or Proposed INN: rigosertib
Other descriptive name: ON 01910.NA
Gemeinn. Salzburger Landeskliniken BetriebsGesmbH, University Hospital for Dermatology, EB-House AustriaNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
12Phase 2Austria