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 70. 広範脊柱管狭窄症 [臨床試験数:69,薬物数:104(DrugBank:42),標的遺伝子数:56,標的パスウェイ数:80] 

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/21/2019, 11/20/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.

Search in Page    e.g. "Phase 3", "Not recruiting", "Japan"    Synonyms (DrugBank) were also searched for.
No.TrialIDDate_
enrollement
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1NCT04066296September 20192 September 2019Outcomes for Lumbar Decompressions With Use of Liposomal BupivicaineA Double Blinded Randomized Control Trial in Outcomes for Lumbar Decompressions With Use of Liposomal BupivicaineLumbar Spinal StenosisDrug: Liposomal bupivacaineUniversity of Colorado, DenverNot recruiting18 YearsN/AAll100Phase 2
2NCT03879447June 24, 201911 November 2019Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/SpondylolisthesisObservational Study on the Effectiveness and Safety of Integrative Korean Medicine Treatment for Patients With Low Back Pain or Sciatica Due to Lumbar Stenosis or SpondylolisthesisLumbar Spinal Stenosis;Lumbar Spondylolisthesis;Low Back Pain;Sciatica;Neurogenic ClaudicationDrug: Herbal medicine;Procedure: Chuna manual medicine;Procedure: Bee venom pharmacopuncture;Procedure: Pharmacopuncture;Procedure: Acupuncture;Procedure: Electroacupuncture;Procedure: Cupping;Procedure: Other intervention(s)Jaseng Medical FoundationRecruiting19 Years75 YearsAll240Phase 2Korea, Republic of
3NCT04007094February 12, 201915 July 2019Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar SurgeryA Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone MatrixDegenerative Disc Disease;Spinal Stenosis;Spondylosis;SpondylolisthesisDrug: ViviGen Cellular Bone MatrixOhio State UniversityDePuy SynthesRecruiting18 YearsN/AAll50Phase 4United States
4NCT03745040January 26, 201918 March 2019Liposomal Bupivacaine in One-level Instrumented Posterior Spinal FusionDoes Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With InstrumentationLumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Disc Disease;Lumbar SpondylolisthesisDrug: Liposomal bupivacaineAllina Health SystemTwin Cities Spine CenterRecruiting18 YearsN/AAll60Phase 4United States
5NCT03883022September 3, 20181 April 2019Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine SurgeryVancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine SurgerySpinal Fusion;Spinal Stenosis;SpondylolisthesisDrug: with U-VANCO (vancomycin hydrochloride);Drug: without U-VANCO (vancomycin hydrochloride)Taipei Veterans General Hospital, TaiwanRecruiting20 YearsN/AAll400N/ATaiwan
No.TrialIDDate_
enrollement
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agemin
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PhaseCountries
6NCT03647501August 22, 201830 September 2019Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody CagesLumbar Fusion With 3D-Printed Porous Titanium Interbody Cages - A Single-Blinded Randomized Controlled Trial Evaluating Nexxt Matrixx(TM) Versus PEEK CagesLumbar Degenerative Disc Disease;Lumbar Spinal Stenosis;Lumbar Spondylolisthesis;Lumbar Spinal Deformity;Lumbar SpondylosisDevice: Interbody cage (titanium);Device: Interbody cage (PEEK)Ohio State UniversityNexxt Spine, LLCRecruiting18 YearsN/AAll70N/AUnited States
7ChiCTR18000169682018-07-159 July 2018A prospective study on the effect of different antiosteoporosis drugs on patients after lumbar fusion surgeryA prospective study on the effect of different antiosteoporosis drugs on patients after lumbar fusion surgeryOsteoporosis with lumbar spinal stenosisC:Lumbar Fusion Surgery+Basic anti-osteoporosis drugs;A:Lumbar Fusion Surgery+MenatetrenoneSoft Capsules;B:Lumbar Fusion Surgery+Teriparatide acetate;Qilu Hospital of Shandong UniversityRecruiting2080BothC:40;A:40;B:40;OtherChina
8NCT03553186July 11, 201815 July 2019Tranexamic Acid in Adult Spinal Deformity SurgeryTopical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity SurgerySpinal Deformity;Degenerative Lumbar Spinal Stenosis;Blood Loss, SurgicalDrug: Tranexamic Acid 100 MG/ML;Drug: PlaceboHospital for Special Surgery, New YorkRecruiting18 Years80 YearsAll100Phase 3United States
9NCT03584074July 1, 201816 July 2018Clinical Trial of Pregabalin and COX2 in Spinal StenosisComparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled TrialSpinal Stenosis LumbarDrug: Celebrex 200Mg Capsule;Drug: Pregabalin 75mgSeoul National University Bundang HospitalNot recruiting40 YearsN/AAll60Phase 4
10JPRN-JapicCTI-18386602/2/201816 July 2019Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study)Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study)LSSIntervention name : NS-304
INN of the intervention : Selexipag
Dosage And administration of the intervention : Oral administration
Control intervention name : NS-304 Placebo
INN of the control intervention : -
Dosage And administration of the control intervention : Oral administration
Nippon Shinyaku Co., Ltd.Not Recruiting4079BOTH120Phase 2Japan
No.TrialIDDate_
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11JPRN-UMIN0000308812018/01/182 April 2019Dietary supplementation in patients following lumbar spine surgery: a randomized controlled triallumbar spinal stenosisIntervention group
Twice-daily ingestion of amino acids supplementation for 3 weeks after spinal surgery (100kcal, protein 10g)
Postoperative rehabilitation for 3 weeks
Control group
Twice-daily ingestion of placebo (non amino acids) supplementation for 3 weeks after spinal surgery (100kcal, protein 0g )
Postoperative rehabilitation for 3 weeks
Wakayama Medical UniversityRecruiting50years-old90years-oldMale and Female80Not selectedJapan
12NCT03245671December 201716 December 2017Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal StenosisParticulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized StudyLumbar Spinal StenosisDrug: Kenalog Injectable Product;Drug: Decadron Phosphate, Injectable;Procedure: Epidural Steroid InjectionHospital for Special Surgery, New YorkNot recruiting18 Years90 YearsAll0Phase 4United States
13ChiCTR-INR-170124032017-09-0121 August 2017Application of erythropoietin in enriched bone marrow stem cells technique to promote bone regenerationApplication of erythropoietin in enriched bone marrow stem cells technique to promote bone regenerationbone defect, bone non-union and lumber spinal stenosistreatment group:administer erythropoietin (150U/kg) three to five times via subcutaneous or intravenous injection before operation;controlled group:administer normal saline three times via subcutaneous or intravenous injection before operation;Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of MedicineNot Recruiting1865Bothtreatment group:44;controlled group:44;New Treatment Measure Clinical StudyChina
14NCT02975011March 4, 201719 November 2018Effectiveness and Safety of Korean Medicine for Lumbar Stenosis Patients With SciaticaObservational Study on the Effectiveness and Safety of Integrative Korean Medicine Treatment for Patients With Sciatica Due to Lumbar Stenosis: Multicenter, Prospective, Single Group Observational StudyLumbar Spinal StenosisDrug: Herbal medicine;Procedure: Chuna manipulation;Procedure: Bee venom pharmacopuncture;Procedure: Pharmacopuncture;Procedure: Acupuncture;Procedure: Electroacupuncture;Procedure: Cupping;Other: Other intervention(s)Jaseng Medical FoundationNot recruiting19 Years75 YearsAll38Phase 2Korea, Republic of
15NCT03011866February 201716 December 2017Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine SurgeriesIntravenous Versus Topical Use of Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS) : A Prospective, Randomized, Double Blind, Head-to-head Comparison StudySpinal Stenosis;Intervertebral Disc DisplacementDrug: Wound topically irrigated with 500mg TXA;Drug: 1mg/kg/hr TXA intravenous infusion till the last suturePeking Union Medical College HospitalNot recruiting50 YearsN/AAll176N/A
No.TrialIDDate_
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16EUCTR2016-002887-14-FI31/10/20167 November 2016Dose-response of ketamine in patient controlled analgesia in orthopaedic surgery patientsDose response study of Patient Controlled Analgesia (PCA) of S-ketamine in orthopaedic spine surgery patients - DoseRespKetaPatients who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation
MedDRA version: 19.0 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 100000004859 ;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11]
Trade Name: Ketanest-S
Pharmaceutical Form: Injection
INN or Proposed INN: KETAMINE
CAS Number: 6740-88-1
Concentration unit: mg/ml milligram(s)/millilitre
Concentration type: equal
Concentration number: 5-
Trade Name: Oxycodone Orion
Pharmaceutical Form: Injection
INN or Proposed INN: OXYCODONE
CAS Number: 76-42-6
Concentration unit: mg/ml milligram(s)/millilitre
Concentration type: equal
Concentration number: 10-
University of TurkuAuthorisedFemale: yes
Male: yes
Phase 1;Phase 4Finland
17NCT02939482October 1, 201615 July 2019A Study Comparison of Clinical Outcome After Different Rate of Infusion in Caudal Epidural Steroid InjectionA Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid InjectionSpinal Stenosis;Lumbosacral Spondylosis;RadiculopathyDrug: Triamcinolone Acetonide and normal saline solutionNavamindradhiraj UniversityNot recruiting20 YearsN/AAll112N/AThailand
18NCT02932020October 201611 June 2018AlloGen-LI Treatment of Spinal StenosisPilot Study Investigating the Utility of Epidural AlloGen-LI Injection for Treatment of Spinal Stenosis SymptomsLow Back PainDrug: AlloGen-LI;Drug: depomedrol;Device: MRI;Drug: 0.5% marcaineUniversity of Southern CaliforniaVivex Biomedical, Inc.Not recruiting18 YearsN/AAll0N/AUnited States
19NCT02902380September 27, 201612 March 2018The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal SurgerySpinal StenosisDrug: dexmedetomidine group;Drug: control groupYonsei UniversityNot recruiting20 Years70 YearsAll52N/AKorea, Republic of
20EUCTR2015-002694-37-FI01/09/201611 January 2016Dexmedetomidine is a drug that is used mainly for sedation in the intensive care unit. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee.Dexmedetomidine infusion in pain management during low back surgery Dexmedetomidine is an alpha-2-adrenergic agonist that is used mainly for sedation in the intensive care unit. Alpha-2-adrenoceptors agonists have several beneficial actions in a surgical patient. They decrease symphatetic tone, reduce anesthetic and opioid requirements and cause sedation and analgesia. Pain after low back surgery is intense and can become chronic. We need a new drug to manage pain during postoperative period and to prevent chronic pain. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. Study is single centered, randomized and placebo-controlled study. A total of 60 patients scheduled for low back surgery will be enrolled in this study. Patients eligibility will be assessed by pre-determined inclusion-exclusion-criteria. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. Patients in the dexmedetomidine group receive dexmedetomidine loading dose 1ug/kg for 10 minutes and continuous infusion 1.4 ug/kg/h during surgery and post-anesthesia care unit. Total infusion time will be four hours. Anesthesia is standardized and post-operative pain is treated with patient controlled analgesia made of oxycodone. Questionnaires will be used to assess pain control. Study is scheduled to start as soon as we obtain permission from Finnish Medicines Agency and receive sufficient funding.Low back pain, Discus prolapse, Spinal stenosis;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]Trade Name: Dexmedetomidine
Product Name: Dexdor
Pharmaceutical Form: Concentrate and solvent for solution for infusion
INN or Proposed INN: DEXMEDETOMIDINE
CAS Number: 113775-47-6
Pharmaceutical form of the placebo: Concentrate and solvent for solution for infusion
Route of administration of the placebo: Intravenous use
Kuopio University hospitalAuthorisedFemale: no
Male: yes
Finland
No.TrialIDDate_
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21NCT02838615July 201616 December 2017Comparison of Transforaminal vs. Parasagittal Interlaminar Epidural InjectionComparison of Lumbar Epidural Steroid Injection: Transforaminal vs. Parasagittal Interlaminar ApproachSpinal StenosisProcedure: epidural steroid (dexamethasone) injectionKeimyung University Dongsan Medical CenterNot recruitingN/AN/AAll56N/A
22NCT02826889May 24, 201616 December 2017Assessing the Diagnostic Accuracy of Corrected Flow Time (FTc) and Pleth Variability Index (PVI) as Predictors of Fluid Responsiveness in Patients in the Prone Position Using the Jackson TableElective Posterior Lumbar Spinal Fusion for Spinal Stenosis;Spondylolisthesis;Spinal Fractures;Scoliosis or TumorsDevice: Pleth Variability Index (PVI);Device: Philips Intelivue MP70 monitorYonsei UniversityNot recruiting19 Years75 YearsAll58N/AKorea, Republic of
23NCT02700451March 20164 November 2019Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion OutcomesA Randomized Controlled Trial of Post-operative Acetaminophen Versus Nonsteroidal Anti-Inflammatory Drug (NSAID) Use on Lumbar Spinal Fusion OutcomesLumbar Osteoarthritis;Spondylosis;Lumbar Disc Disease;Spinal StenosisDrug: Ketorolac;Drug: Acetaminophen;Drug: PlaceboHospital for Special Surgery, New YorkRecruiting18 Years75 YearsAll300N/AUnited States
24NCT02725723March 201611 April 2016Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural InjectionsThermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural InjectionsSpinal StenosisDevice: Therm-AppTM TH, thermographic camera;Drug: epidural injectionTel-Aviv Sourasky Medical CenterNot recruiting18 Years80 YearsBoth40Phase 2/Phase 3
25NCT02625194January 1, 201622 July 2019The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided IntubationThe Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided IntubationLumbar Spinal StenosisDrug: OxygenYonsei UniversityNot recruiting20 Years60 YearsAll36N/AKorea, Republic of
No.TrialIDDate_
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26NCT02444351June 26, 201521 January 2019Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal StenosisSpinal Stenosis With Nocturnal Calf CrampsDrug: botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle;Other: no interventionYonsei UniversityNot recruiting20 Years80 YearsAll50N/AKorea, Republic of
27EUCTR2014-003252-31-FI15/05/201510 July 2015Dose-response of dexmedetomidine in patient controlled analgesia in orthopaedic surgery patientsDose response study of Patient Controlled Analgesia (PCA) of Dexmedetomidine in orthopaedic spine surgery patients - DoserespDex_2.0Patients, who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation
MedDRA version: 17.1 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 100000004859 ;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11]
Trade Name: Dexdor
Pharmaceutical Form: Infusion
INN or Proposed INN: deksmedetomidiini
CAS Number: 145108-58-3
Other descriptive name: DEXMEDETOMIDINE HYDROCHLORIDE
Trade Name: Oxanest
Pharmaceutical Form: Injection
INN or Proposed INN: oksikodoni
CAS Number: 124-90-3
Other descriptive name: OXYCODONE HYDROCHLORIDE
University of TurkuAuthorisedFemale: yes
Male: yes
Finland
28NCT02459392May 201515 July 2019EuroPainClinics® Study II (Prospective Trial)EuroPainClinics® Study II (Prospective Randomized Double Blinded Trial)Lumbar Spinal StenosisOther: Epiduroscopy;Drug: Hyaluronic Acid;Drug: DepoMedrolEuropainclinics z.ú.Recruiting18 YearsN/AAll300N/ACzechia;Czech Republic
29NCT02416804January 201516 December 2017Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal SurgeryPostoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal SurgerySpinal Stenosis;Pain, PostoperativeDrug: Buprenorphine;Drug: TramadolSeoul National University HospitalNot recruiting20 YearsN/AAll69Phase 4Korea, Republic of
30NCT02093520May 201416 December 2017The MiDAS ENCORE StudyMILD® Percutaneous Image-Guided Lumbar Decompression Versus Epidural Steroid Injections in Patients With Lumbar Spinal Stenosis Exhibiting Neurogenic ClaudicationSpinal Stenosis, Lumbar Region, With Neurogenic ClaudicationProcedure: MILD Procedure;Drug: Epidural Steroid InjectionVertos Medical, Inc.Not recruiting65 YearsN/AAll302N/AUnited States
No.TrialIDDate_
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31JPRN-UMIN0000129182014/04/012 April 2019Long-term efficacy and safety of Limaprost for the treatment of Lumbar Spinal StenosisLumbar Spinal StenosisLimaprost alfadex(15 micro g/day), 1yrs.Kansai LSS ForumNot Recruiting50years-old80years-oldMale and Female300Not selectedJapan
32NCT02070484February 201416 December 2017Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc DiseaseEfficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc DiseaseLumbar Degenerative Disc Disease;Spinal Stenosis;Spondylolisthesis;Spondylosis;Intervertebral Disk Displacement;Intervertebral Disk Degeneration;Spinal Diseases;Bone Diseases;Musculoskeletal Diseases;SpondylolysisBiological: NuCel;Biological: Demineralized Bone MatrixOhioHealthNuTech Medical, IncNot recruiting18 Years75 YearsAll6N/AUnited States
33NCT02103543January 201416 December 2017Comparison of the Order of Treatment in Lumbar Spinal StenosisA Randomized Trial in Patients With Lumbar Spinal Stenosis, Comparing the Order of Treatment With Epidural Corticosteroid Injections and Physical TherapyLumbar Spinal StenosisOther: physical therapy;Procedure: lumbar interlaminar epidural steroid injection;Drug: epidural steroid injectionEmory UniversityNot recruiting18 Years65 YearsAll0N/AUnited States
34NCT02023372December 201327 May 2019Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar SpineNuTech NuCel®: A Prospective, Efficacy Study of NuCel® in Patients Undergoing Fusion for One, Two or Three Level Degenerative Disease of the Lumbar Spine.Intervertebral Disc Disease;Intervertebral Disc Degeneration;Spondylosis;Spondylolisthesis;Spinal StenosisBiological: NuCel with AutograftNuTech Medical, IncCarolina Neurosurgery & Spine Associates;Atrium Health;OrganogenesisRecruiting21 YearsN/AAll57N/AUnited States
35NCT01943435November 20, 201311 June 2018Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)A Comparison of Non-Surgical Treatment Methods for Patients With Lumbar Spinal StenosisLumbar Spinal StenosisDrug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;Procedure: Lumbar epidural injection;Other: Joint Mobilizations (spine, sacroiliac, hip);Other: Individualized exercises: clinical setting;Other: Group Exercise: community settingMichael Schneider, DC, PhDPatient-Centered Outcomes Research InstituteNot recruiting60 YearsN/AAll259N/AUnited States
No.TrialIDDate_
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36NCT01934868November 201312 March 2018Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the LegA Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the LegSciatica;Spinal Stenosis of Lumbar Region;Degeneration of Lumbar or Lumbosacral Intervertebral DiscDrug: prolotherapy solution of 20% dextrose;Drug: Epidural Steroid InjectionHadassah Medical OrganizationReuth Medical CenterRecruiting18 Years90 YearsAll160Early Phase 1Israel
37NCT01995461May 201319 October 2017Bilateral Transforaminal Epidural Steroid Injections for Degenerative Lumbar Spinal StenosisEffectiveness of Bilateral Transforaminal Epidural Steroid Injections in Degenerative Lumbar Spinal Stenosis Patients With Neurogenic Claudication: A Prospective Outcome StudySpinal Stenosis, Lumbar Region, With Neurogenic ClaudicationDrug: bilateral transforaminal epidural steroid injectionsMarshfield Clinic Research FoundationNot recruiting40 Years90 YearsAll26N/AUnited States
38NCT01888536February 201328 December 2015A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal StenosisA Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal StenosisNeurologic Claudication in Patients With Lumbar Spinal StenosisDrug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost)Yungjin Pharm. Co., Ltd.Not recruiting20 Years75 YearsBoth182Phase 4Korea, Republic of
39ChiCTR-TRC-130036392012-09-1318 April 2017The application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal SurgeryThe application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal SurgeryLumbar spinal stenosis and/or lumbar intervertebral disc herniationANI group:ANI guide the administration of remifentanil;control group:remifentanil was adapted by Anaesthesiologist corresponding to clinical experiences ;Peking University Third HospitalNot Recruiting1870BothANI group:30;control group:30;OtherChina
40NCT02063035August 201216 December 2017Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal SurgeryTopical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal SurgeryLumbar Spinal Stenosis;Thoracic Spinal StenosisDrug: Tranexamic Acid;Drug: PlaceboMassachusetts General HospitalNot recruiting18 Years85 YearsAll29Phase 4United States
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41NCT02090244August 201229 April 2019Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans?Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi?Spinal StenosisDrug: TeriparatideUniversity Hospital, LinkoepingMedical Research Council of Southeast SwedenNot recruitingN/AN/AAll34Phase 4Sweden
42EUCTR2011-006152-36-DK10/05/201223 July 2018Does postoperative treatment with parathyroidea hormone Forteo® improve the disability in elderly patients undergoing spinal stabilization fusion surgery compared with patients treated with placebo. If that is the case, is there a correlation between improvement of disability and solid osseous healing?Postoperative treatment with parathyroidea hormone Forteo® in patients undergoing posterolateral spinal fusion surgery. A prospektive and a randomized double-blinded, placebo-controlled study - PTH-U-DESE-STUDYSpinal stenosis
MedDRA version: 14.1 Level: LLT Classification code 10041597 Term: Spinal stenosis of lumbar region System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]
Trade Name: Forteo
Product Name: Forsteo
Product Code: 0002-8971
Pharmaceutical Form: Solution for injection in pre-filled pen
INN or Proposed INN: teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34)
CAS Number: 52232-67-4
Other descriptive name: rhPTH (1-34)
Concentration unit: mg milligram(s)
Concentration type: equal
Concentration number: 20-
Pharmaceutical form of the placebo: Injection
Route of administration of the placebo: Subcutaneous use
Middelfart RygsektorNot RecruitingFemale: yes
Male: yes
100Phase 2Denmark
43NCT02271191May 201219 February 2015Effect of Nicardipine on Renal Function in Deliberate HypotensionEffect of Nicardipine on Renal Function in Deliberate HypotensionSpinal StenosisDrug: NicardipineYonsei UniversityNot recruiting20 YearsN/ABoth64Phase 4
44EUCTR2012-000747-26-FI27/04/201228 February 2019Ketamine to reduce postoperative pain in back surgeryAdministration of S-Ketamine during spinal surgery to reduce postoperative painadult patients undergoing spinal surgery
MedDRA version: 14.1 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
Trade Name: Ketanest-S
Product Name: Ketanest-S
Pharmaceutical Form: Injection
CAS Number: 33643-46-8
Other descriptive name: ESKETAMINE HYDROCHLORIDE
Pharmaceutical form of the placebo: Injection
Route of administration of the placebo: Intravenous use
Helsinki Universiy Central HospitalNot Recruiting Female: yes
Male: yes
192Phase 4Finland
45JPRN-UMIN0000074192012/04/012 April 2019A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal StenosisLumbar Spinal StenosisCelecoxib

Pregabalin
Department of Orthopedic Surgery Kobe University Graduate School of MedicineNot Recruiting50years-old90years-oldMale and Female80Not selectedJapan
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46NCT01618435March 201219 September 2016The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative SpondylolisthesisThe Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis OperationSpinal StenosisBiological: i-FACTORSygehus LillebaeltCeraPedics, IncNot recruiting60 YearsN/ABoth108Phase 3Denmark
47NCT01522846January 201219 February 2015Heparin Solution and INTEM/HEPTEM AnalysisInfluence by Heparinized Flush Solution of the Radial Artery Catheter: INTEM and HEPTEM Analysis.Brain Tumor;Spinal Stenosis;Cerebral Artery AnuerysmDrug: HeparinSeoul National University Bundang HospitalNot recruiting20 YearsN/ABoth25N/AKorea, Republic of
48NCT02257723January 201219 November 2018The Effect of Integrated CAM Treatment in Hospitalized PatientsThe Effect of Integrated CAM Treatment in Patients Hospitalized at a Korean Medicine HospitalLow Back Pain;Neck Pain;Knee Pain;Shoulder Pain;Intervertebral Disc Herniation;Spinal StenosisDrug: Herbal medicine;Procedure: Acupuncture;Procedure: Pharmacopuncture;Procedure: Bee venom pharmacopuncture;Procedure: Chuna manipulationJaseng Hospital of Korean MedicineNot recruitingN/AN/AAll2946Phase 4Korea, Republic of
49JPRN-UMIN0000065882011/11/012 April 2019Effect of antiplatelet agent on muscle cramps after surgery of lumbar spinal stenosis in patients with lumbar spinal canal stenosis and peripheral artery diseaseLumbar spinal canal stenosisContinuous administration of cilostazolJuntendo University Department of Orthopaedic SurgeryRecruitingNot applicableNot applicableMale and Female30Not applicableJapan
50NCT01456377July 201119 February 2015The Effectiveness of Oral Corticosteroids in the Treatment of Lumbar StenosisA Prospective Controlled Study Randomized Double Blind Study, Evaluate the Effectiveness of Oral Corticosteroids in the Treatment of Stenosis of Lumbar Canal In Symptomatic PatientsSpinal Stenosis of Lumbar RegionDrug: predinose oral;Drug: placebo groupFederal University of São PauloRecruiting50 Years75 YearsBoth60N/ABrazil
No.TrialIDDate_
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51NCT01238536April 201116 December 2017Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and OlderSpinal Stenosis;Low Back PainProcedure: Epidural steroid with local anesthetic injection;Procedure: Epidural local anesthetic injection;Drug: Epidural steroid injection;Drug: Epidural local anesthetic injectionUniversity of WashingtonKaiser Permanente;University of California, San Francisco;Henry Ford Hospital;Harvard Pilgrim Health Care;Harvard Vanguard Medical Associates;University of Colorado, Denver;Mayo Clinic;Stanford University;Massachusetts General Hospital;Virginia Spine Research Institute;Oregon Health and Science University;Dallas VA Medical CenterNot recruiting50 YearsN/AAll400Phase 4United States
52NCT01315145March 201119 October 2017MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation StudyMiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation StudyLumbar Spinal StenosisProcedure: Percutaneous Lumbar Decompression;Drug: Epidural Steroid InjectionVertos Medical, Inc.Not recruiting50 YearsN/AAll138N/AUnited States
53JPRN-UMIN0000048252011/01/012 April 2019A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOLLumbar spinal stenosis15ug/day Limaprost arfadex for 8 weeks
200mg/day Celecoxib for 8 weeks
University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare FederationMito Kyodo HospitalNot Recruiting40years-old85years-oldMale and Female134Phase 3Japan
54NCT01275547January 201119 February 2015The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal MidazolamThe Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery PatientsAnalgesia, Patient-controlled;Spinal StenosisDrug: s-ketamine & midazolam;Drug: Morphine PCAUniversity Hospital, Basel, SwitzerlandNot recruiting18 YearsN/ABoth22Phase 2/Phase 3Switzerland
55JPRN-UMIN0000053822010/12/012 April 2019Intraoperative perineural infiltration of ropivacaine for acute postlaminectomy painlumbar spinal stenosisGeneral anesthesia and NSAIDs.
As a contorol,saline 10ml infiltrate per one interspinal segment.
Generalanesthesia and NSAIDs.
0.2%ropivacaine 10ml infiltrate per one interspinal segment.
General anesthesia and NSAIDs.
From catheter in injury part,administration of 0.2%ropivacaine 6ml/h.
Duration of administration:2 days after the operation.
Higashi Ohmiya general hospitalNot Recruiting20years-old75years-oldMale and Female60Not selectedJapan
No.TrialIDDate_
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PhaseCountries
56JPRN-UMIN0000059592010/11/012 April 2019Prospective clinical study of the therapeutic effects of prostaglandin in patients with combined lumbar spinal stenosis and arteriosclerosis obliterans showing intermittent claudicationPatients with combined lumbar spinal stenosis and arteriosclerosis obliteransProstaglandin for injection (alprostadil) group: 60 mcg of prostaglandin for injection is intravenously administered once a week or more. This therapy is repeated 10 times or more.
Ripple injection (alprostadil Injection) group: 10 mcg of ripple injection is administered intravenously once a week or more. This treatment is repeated 10 times or more.
Conventional treatment group
Tokai University Hospital Department of Orthopaedic SurgeryNot Recruiting20years-oldNot applicableMale and Female300Not selectedJapan
57NCT03532945October 28, 201011 June 2018A Follow-up Study to Evaluate the Efficacy and Safety of Novomax in Posterior Lumbar Interbody FusionA Long-term Follow-up Study to Evaluate the Efficacy and Safety for the Patients With Bioactive Glass-ceramic Intervertebral Spacer (Novomax) in Posterior Lumbar Interbody Fusion: Comparison With a Titanium CageDegenerative Lumbar Spinal StenosisDevice: Bioactive Glass-Ceramic Spacer;Device: Titanium cageBioAlpha Inc.Not recruiting30 Years80 YearsAll62N/A
58NCT01377623September 201016 December 2017Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal FusionPilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal FusionSpinal Stenosis;InflammationDrug: Dexmedetomidine group;Drug: Placebo groupNew York University School of MedicineHospira, now a wholly owned subsidiary of PfizerNot recruiting18 YearsN/AAll66N/AUnited States
59NCT01097486June 201026 August 2019Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical DiscectomyPhase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate FixationCervical Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal StenosisBiological: NeoFuse;Procedure: AllograftMesoblast, Ltd.Not recruiting18 Years70 YearsAll24Phase 2United States
60NCT01127100May 20108 August 2016Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic PainGabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority TrialNeuropathic Pain;Spinal StenosisDrug: transdermal fentanyl matrix, gabapentinSeoul National University HospitalSeoul National University Bundang Hospital;Asan Medical Center;Inje University;Chonnam National University Hospital;Chung-Ang University Hosptial, Chung-Ang University College of Medicine;Dankook UniversityNot recruiting20 Years80 YearsBoth108Phase 4Korea, Republic of
No.TrialIDDate_
enrollement
Last_Refreshed_
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PhaseCountries
61NCT01052324March 201019 February 2015The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic IntubationThe Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic IntubationCervical Disc Herniation;Cervical Spinal Stenosis;Cervical Spine DamageDrug: RemifentanilYonsei UniversityNot recruiting20 Years65 YearsBoth19Phase 4Korea, Republic of
62NCT00996073September 200926 August 2019Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody FusionA Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With InstrumentationDegenerative Disc Disease;Degenerative Spondylolisthesis;Spinal StenosisBiological: Lumbar Interbody Fusion with Autograft;Biological: Lumbar Interbody Fusion with NeoFuseMesoblast, Ltd.Not recruiting18 Years70 YearsAll24Phase 2United States
63NCT00995371August 200919 October 2017Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal StenosisComparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal StenosisLumbar Spinal StenosisDevice: MILD® (Minimally Invasive Lumbar Decompression);Drug: Epidural Steroid InjectionCoastal Orthopedics & Sports MedicineVertos Medical, Inc.Not recruiting18 YearsN/AAll38Phase 4United States
64NCT00808665June 200911 June 2018Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine FusionDoes Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled StudySpinal Fusion Acquired;Spinal Stenosis;Lesions of Lumbosacral Intervertebral Disc;Spinal DiseasesDrug: Dexmedetomidine;Drug: 0.9% SalineVanderbilt University Medical CenterNot recruiting18 Years85 YearsAll68Phase 4United States
65NCT00908375May 200919 October 2017Efficacy of Pregabalin in Patients With Radicular PainEfficacy of Pregabalin in Patients With Radicular PainNeuropathy; Radicular, Lumbar, Lumbosacral;Failed Back Surgery Syndrome;Spinal Stenosis;Herniated DiscDrug: Pregabalin;Drug: Sugar PillNorthwestern UniversityNot recruiting18 Years64 YearsAll39Phase 4United States
No.TrialIDDate_
enrollement
Last_Refreshed_
on
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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sponsor
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Status
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agemin
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PhaseCountries
66NCT00638443March 200819 October 2017Lumbar Stenosis Outcomes Research (LUSTOR)Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back PainLumbar Spinal StenosisDrug: Pregabalin;Drug: DiphenhydramineUniversity of RochesterPfizerNot recruiting50 YearsN/AAll29Phase 4United States
67NCT00652093March 200819 October 2017Lumbar Stenosis Outcomes Research IILumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over TrialLumbar Spinal StenosisDrug: opana then darvocet then placebo;Drug: opana then placebo then darvocet;Drug: placebo then opana then darvocet;Drug: Placebo then darvocet then opana;Drug: Darvocet then opana then placebo;Drug: Darvocet then placebo then opanaUniversity of RochesterEndo PharmaceuticalsNot recruiting50 YearsN/AAll24Phase 4United States
68NCT00370799January 200719 February 2015Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity PainA Randomized, Prospective, Double-Blind Controlled Evaluation of the Effectiveness of Caudal Epidural Injections in Lumbar Disc Herniations, Spinal Stenosis, Discogenic Pain, and Post-Lumbar Laminectomy SyndromeLow Back PainDrug: Caudal epidural injection;Drug: Caudal Epidural Injection with generic Celestone;Drug: Caudal Epidural Injection with Celestone;Drug: Caudal Epidural Injection with DepoMedrolPain Management Center of PaducahNot recruiting18 YearsN/ABoth240Phase 0United States
69NCT00320619September 20008 August 2016Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine SurgeryAminocaproic Acid and Bleeding in Spinal SurgeryScoliosis;Kyphosis;Lordosis;Spondylitis;Spinal StenosisDrug: Epsilon-Aminocaproic Acid (EACA);Drug: PlaceboNational Heart, Lung, and Blood Institute (NHLBI)Not recruiting18 YearsN/ABoth182N/AUnited States

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