Copper

( DrugBank: Copper / KEGG DRUG: - )

4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	1
169	メンケス病	5

告示番号	疾患名（ページ内リンク）	臨床試験数
170	オクシピタル・ホーン症候群	1
171	ウィルソン病	26

2. 筋萎縮性側索硬化症

臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01259050 (ClinicalTrials.gov)	October 2010	10/12/2010	Safety Study of High Doses of Zinc in ALS Patients	Phase 1 Open Label Study of Zinc Therapy in ALS Patients	Amyotrophic Lateral Sclerosis	Drug: Zinc and Copper	Phoenix Neurological Associates, LTD	NULL	Completed	18 Years	85 Years	Both	10	Phase 1/Phase 2	United States

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169. メンケス病

臨床試験数 : 6 / 薬物数 : 6 - (DrugBank : 4) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 14

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04074512 (ClinicalTrials.gov)	October 15, 2019	27/8/2019	Copper Histidinate Treatment for Menkes Disease	Copper Histidinate Treatment for Menkes Disease	Menkes Disease	Drug: Copper Histidinate	Cyprium Therapeutics, Inc.	NULL	Available	N/A	6 Years	All			NULL
2	JPRN-UMIN000030626	2014/11/28	28/12/2017	Investigation on the effectiveness of histidine copper treatment of Menkes disease patients	Investigation on the effectiveness of histidine coppertreatment of Menkes disease patients - Investi ...	Menkes disease	Weekly,subcutaneous injection of histidine copper(750microgram once) is performed three times per we ...	Hamamatsu University School of Medicine	NULL	Complete: follow-up complete	Not applicable	Not applicable	Male and Female	2	Not selected	Japan
3	JPRN-UMIN000005259	2011/03/03	18/03/2011	Clinical trial of histidine-copperand diethyldithiocarbamate combination therapy for patients with M ...	Clinical trial of histidine-copperand diethyldithiocarbamate combination therapy for patients with M ...	Menkes disease	give a dose of copper-histidine and diethyldithiocarbamate	Kobe Unniversitu Graduate School of Medicine	NULL	Complete: follow-up complete	Not applicable	Not applicable	Male and Female	2	Not selected	Japan
4	NCT00811785 (ClinicalTrials.gov)	February 27, 2009	18/12/2008	Molecular Bases of Response to CopperTreatment in Menkes Disease, Related Phenotypes, and Unexplaine ...	Molecular Bases of Response to CopperTreatment in Menkes Disease, Related Phenotypes, and Unexplaine ...	Menkes Disease;Occipital Horn Syndrome;Unexplained Copper Deficiency	Drug: Copper Histidine	Cyprium Therapeutics, Inc.	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);National Cen ...	Completed	N/A	80 Years	All	93	Phase 3	United States
5	NCT00001262 (ClinicalTrials.gov)	June 1990	3/11/1999	Copper Histidine Therapy for Menkes Diseases	Early Copper Histidine Therapy in Menkes Disease	Kinky Hair Syndrome	Drug: Copper Histidine	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	NULL	Completed	N/A	N/A	All	60	Phase 1/Phase 2	United States

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170. オクシピタル・ホーン症候群

臨床試験数 : 2 / 薬物数 : 4 - (DrugBank : 3) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 14

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00811785 (ClinicalTrials.gov)	February 27, 2009	18/12/2008	Molecular Bases of Response to CopperTreatment in Menkes Disease, Related Phenotypes, and Unexplaine ...	Molecular Bases of Response to CopperTreatment in Menkes Disease, Related Phenotypes, and Unexplaine ...	Menkes Disease;Occipital Horn Syndrome;Unexplained Copper Deficiency	Drug: Copper Histidine	Cyprium Therapeutics, Inc.	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);National Cen ...	Completed	N/A	80 Years	All	93	Phase 3	United States

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171. ウィルソン病

臨床試験数 : 79 / 薬物数 : 77 - (DrugBank : 17) / 標的遺伝子数 : 6 - 標的パスウェイ数 : 30

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200058434	2022-04-01	2022-04-09	Prediction of prognosis of Wilson's disease by anti-coppertreatment using transfer learning-quantita ...	The study of migration learning-quantitative MRI intelligent model for predicting the prognosis of n ...	Wilson's disease	Neuro-WD:Penicillamine, zinc;Hep-WD:Zinc;Control group:None;	The First Affiliated Hospital, Sun Yat-Sen University	NULL	Pending	10	64	Both	Neuro-WD:60;Hep-WD:60;Control group:60;	Phase 1	China
2	EUCTR2020-005266-34-ES (EUCTR)	11/02/2022	06/09/2021	A study to understand the safety and the effects of a virus that transfers a modified protein respon ...	A Randomized, Double-blind, Placebo-controlled, Multicenter, Seamless, Adaptive, Safety, Dose-findin ...	Wilson disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease;S ...	Product Name: UX701 (5.0 × 10^12 genome copies/kg) INN or Proposed INN: UX701 Other descriptive name: ...	Ultragenyx Pharmaceutical Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	94	Phase 1;Phase 2;Phase 3	United States;Portugal;Spain;Austria;Italy;United Kingdom;France;Canada;Argentina;Brazil;Poland;Germ ...
3	EUCTR2020-005832-31-DK (EUCTR)	13/04/2021	01/02/2021	The effect of ALXN1840 on uptake of copper in the liver as measured by copper PET/CT scan.	Efficacy of ALXN1840 on human hepatic copperuptake quantified with 64CuCl2 PET/CT-scan. - ALXN1840-H ...	Healthy Volunteers (Wilson's disease) MedDRA version: 22.0;Level: SOC;Classification code 10022891;T ...	Trade Name: Cuprior 150 mg INN or Proposed INN: TRIENTINE DIHYDROCHLORIDE Other descriptive name: Cupr ...	Alexion Pharmaceuticals Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	32	Phase 2	Denmark
4	EUCTR2021-000102-25-DK (EUCTR)	09/04/2021	01/02/2021	The effect of ALXN1840 on excretion of copper in gall as measured by copper PET/MR-scan.	Efficacy of ALXN1840 on human biliary copperexcretion quantified with 64CuCl2 PET/MR-scan - ALXN1840 ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 INN or Proposed INN: ALXN1840 Other descriptive name: BIS-CHOLINE TETRATHIOMOLY ...	Aarhus University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	5	Phase 2	Denmark
5	EUCTR2019-003711-60-DE (EUCTR)	15/01/2021	02/06/2020	A Phase 2 clinical study to assess copperlevels and liver changes in patients with Wilson disease wh ...	A Phase 2, single-arm, pathologist-blinded study using liver biopsy specimens to assess copperconcen ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: Not applied Other descriptive name: ...	Alexion Pharmaceuticals, Inc	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	28	Phase 2	United States;Serbia;Spain;Turkey;Austria;Russian Federation;United Kingdom;France;Canada;Belgium;Po ...
6	NCT04422431 (ClinicalTrials.gov)	December 2, 2020	22/5/2020	CopperConcentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Tr ...	A Phase 2, Single-arm Pathologist-blinded 48-week Study Using Liver Biopsy Specimens to Assess Coppe ...	Wilson Disease	Drug: Bis-Choline Tetrathiomolybdate	Alexion Pharmaceuticals	NULL	Active, not recruiting	18 Years	N/A	All	31	Phase 2	United States;Denmark;New Zealand;Russian Federation;Singapore;Spain;United Kingdom;Australia;Austri ...
7	EUCTR2019-003711-60-FR (EUCTR)	22/10/2020	20/08/2020	A Phase 2 clinical study to assess copperlevels and liver changes in patients with Wilson disease wh ...	A Phase 2, single-arm, pathologist-blinded study using liver biopsy specimens to assess copperconcen ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: Not applied Other descriptive name: ...	Alexion Pharmaceuticals, Inc	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	28	Phase 2	United States;Serbia;Spain;Turkey;Austria;Russian Federation;United Kingdom;France;Canada;Belgium;Po ...
8	EUCTR2019-003711-60-AT (EUCTR)	23/09/2020	01/10/2020	A Phase 2 clinical study to assess copperlevels and liver changes in patients with Wilson disease wh ...	A Phase 2, single-arm, pathologist-blinded study using liver biopsy specimens to assess copperconcen ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: Not applied Other descriptive name: ...	Alexion Pharmaceuticals, Inc	NULL	Not Recruiting			Female: yes Male: yes	28	Phase 2	United States;Serbia;Spain;Turkey;Austria;Russian Federation;United Kingdom;France;Canada;Belgium;Po ...
9	NCT04573309 (ClinicalTrials.gov)	September 7, 2020	28/9/2020	Copper and Molybdenum Balance in Participants With Wilson Disease Treated With ALXN1840	A Phase 2, Open-label Study to Assess Copperand Molybdenum Balance in Participants With Wilson Disea ...	Wilson Disease	Drug: ALXN1840	Alexion Pharmaceuticals	NULL	Completed	18 Years	N/A	All	8	Phase 2	United States;New Zealand;United Kingdom
10	EUCTR2019-003711-60-DK (EUCTR)	27/08/2020	19/06/2020	A Phase 2 clinical study to assess copperlevels and liver changes in patients with Wilson disease wh ...	A Phase 2, single-arm, pathologist-blinded study using liver biopsy specimens to assess copperconcen ...	Wilson's Disease MedDRA version: 20.0;Level: LLT;Classification code 10047988;Term: Wilson's disease ...	Product Name: ALXN1840 Product Code: ALXN1840 INN or Proposed INN: Not applied Other descriptive name: ...	Alexion Pharmaceuticals, Inc	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	28	Phase 2	United States;Serbia;Spain;Turkey;Austria;Russian Federation;United Kingdom;France;Canada;Belgium;Po ...

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