1 |
(4s,5r)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’- |
- |
- |
- |
- |
079 [1] 79 💬 |
2 |
1,2-dihexadecanoyl-sn-glycero-3-phospho-(1-raac-glycerol) |
Glycerin |
[1] D00028 D00028 💬 |
- |
- |
079 [1] 79 💬 |
3 |
Aav directed hldlr gene therapy |
- |
- |
- |
- |
079 [1] 79 💬 |
4 |
Aav8.tbg.hldlr |
- |
- |
- |
- |
079 [1] 79 💬 |
5 |
Acetate |
Acetate |
- |
- |
- |
001 [43] 1 , 2 , 6 , 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299 💬 |
6 |
Aegr-733 |
- |
- |
- |
- |
079 [1] 79 💬 |
7 |
Ak102 |
- |
- |
- |
- |
079 [1] 79 💬 |
8 |
Akcea-angptl3-lrx |
- |
- |
- |
- |
079 [2] 79, 265 💬 |
9 |
Alirocumab |
Alirocumab |
[1] D10335 D10335 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
10 |
Alirocumab sar236553 (regn727) |
Alirocumab |
[1] D10335 D10335 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
11 |
Aln-60212 |
- |
- |
- |
- |
079 [1] 79 💬 |
12 |
Aln-pcssc |
Inclisiran |
[1] D11931 D11931 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
13 |
Amg 145 |
- |
- |
- |
- |
079 [1] 79 💬 |
14 |
Amg145 |
- |
- |
- |
- |
079 [1] 79 💬 |
15 |
Anacetrapib |
Anacetrapib |
[1] D08855 D08855 💬 |
CETP [1] CETP 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
16 |
Atorvastatin |
Atorvastatin |
[3] D00258 D00258, D00887 D00887, D07474 D07474 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
013 [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬 |
17 |
Calcium |
Calcium |
- |
- |
- |
006 [27] 6 , 13, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 265, 274, 298, 299 💬 |
18 |
Calcium rosuvastatin |
Calcium |
[2] D01915 D01915, D08492 D08492 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
079 [1] 79 💬 |
19 |
Cer-001 |
- |
- |
- |
- |
079 [1] 79 💬 |
20 |
Cholestyramine |
Cholestyramine |
- |
- |
- |
013 [2] 13, 79 💬 |
21 |
Comparator: ezetimibe |
Ezetimibe |
[1] D01966 D01966 💬 |
NPC1L1 [1] NPC1L1 💬 |
Fat digestion and absorption [1] Fat digestion and absorption |
079 [2] 79, 260 💬 |
22 |
Crestor |
- |
- |
- |
- |
049 [3] 49, 79, 299 💬 |
23 |
Crestor film-coated tablet |
- |
- |
- |
- |
079 [1] 79 💬 |
24 |
Crestor tablets (calcium rosuvastatin) film-coated tablets |
Calcium |
[2] D01915 D01915, D08492 D08492 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
079 [1] 79 💬 |
25 |
Current lipid-lowering treatment |
- |
- |
- |
- |
079 [1] 79 💬 |
26 |
Device: dextran sulfate adsorption |
Dextran |
[1] D00060 D00060 💬 |
- |
- |
079 [1] 79 💬 |
27 |
Device: heparin-induced extracorporeal ldl precipitation |
Heparin |
[1] D07510 D07510 💬 |
SERPINC1 [1] SERPINC1 💬 |
Complement and coagulation cascades [1] Complement and coagulation cascades |
079 [1] 79 💬 |
28 |
Dextran |
Dextran |
[1] D00060 D00060 💬 |
- |
- |
002 [5] 2 , 62, 79, 96, 97 💬 |
29 |
Dppg |
- |
- |
- |
- |
079 [1] 79 💬 |
30 |
Evinacumab |
Evinacumab |
[1] D11753 D11753 💬 |
ANGPTL3 [1] ANGPTL3 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
31 |
Evinacumab (regn1500) |
Evinacumab |
[1] D11753 D11753 💬 |
ANGPTL3 [1] ANGPTL3 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
32 |
Evolocumab |
Evolocumab |
[1] D10557 D10557 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [2] 79, 222 💬 |
33 |
Evolocumab (amg 145) |
Evolocumab |
[1] D10557 D10557 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
34 |
Ezetimibe |
Ezetimibe |
[1] D01966 D01966 💬 |
NPC1L1 [1] NPC1L1 💬 |
Fat digestion and absorption [1] Fat digestion and absorption |
049 [4] 49, 79, 93, 260 💬 |
35 |
Fenofibrate |
Fenofibrate |
[1] D00565 D00565 💬 |
PPARA [1] PPARA 💬 |
Adipocytokine signaling pathway [8] Adipocytokine signaling pathway, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway |
008 [5] 8 , 79, 93, 94, 265 💬 |
36 |
Fluvastatin |
Fluvastatin |
[2] D00892 D00892, D07983 D07983 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
079 [3] 79, 218, 222 💬 |
37 |
Gemcabene |
Gemcabene |
- |
- |
- |
079 [2] 79, 265 💬 |
38 |
Glycerol |
Glycerin |
[1] D00028 D00028 💬 |
- |
- |
006 [5] 6 , 13, 79, 316, 317 💬 |
39 |
Heparin |
Heparin |
[1] D07510 D07510 💬 |
SERPINC1 [1] SERPINC1 💬 |
Complement and coagulation cascades [1] Complement and coagulation cascades |
060 [11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 💬 |
40 |
Ibi306 |
- |
- |
- |
- |
079 [1] 79 💬 |
41 |
Implitapide |
Implitapide |
- |
- |
- |
079 [1] 79 💬 |
42 |
Inclisiran |
Inclisiran |
[1] D11931 D11931 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
43 |
Inclisiran for injection |
Inclisiran |
[1] D11931 D11931 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
44 |
Inclisiran sodium |
Inclisiran |
[1] D11931 D11931 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
45 |
Isis 301012 |
- |
- |
- |
- |
079 [1] 79 💬 |
46 |
Isis 301012 phosphorothioate oligonucleotide |
- |
- |
- |
- |
079 [1] 79 💬 |
47 |
Isis 703802 |
- |
- |
- |
- |
079 [1] 79 💬 |
48 |
Js002 |
- |
- |
- |
- |
079 [1] 79 💬 |
49 |
Kjx839 |
- |
- |
- |
- |
079 [1] 79 💬 |
50 |
Lapaquistat |
Lapaquistat |
- |
- |
- |
079 [1] 79 💬 |
51 |
Lapaquistat acetate and current lipid-lowering treatment |
Acetate |
- |
- |
- |
079 [1] 79 💬 |
52 |
Lib003 |
- |
- |
- |
- |
079 [1] 79 💬 |
53 |
Lojuxta |
- |
- |
- |
- |
079 [1] 79 💬 |
54 |
Lojuxta 10 mg hard capsules |
- |
- |
- |
- |
079 [1] 79 💬 |
55 |
Lojuxta 20 mg hard capsules |
- |
- |
- |
- |
079 [1] 79 💬 |
56 |
Lojuxta 5 mg hard capsules |
- |
- |
- |
- |
079 [1] 79 💬 |
57 |
Lomitapide |
Lomitapide |
[1] D09637 D09637 💬 |
MTTP [1] MTTP 💬 |
Fat digestion and absorption [1] Fat digestion and absorption |
079 [1] 79 💬 |
58 |
Lomitapide 2mg hard capsules |
Lomitapide |
[1] D09637 D09637 💬 |
MTTP [1] MTTP 💬 |
Fat digestion and absorption [1] Fat digestion and absorption |
079 [1] 79 💬 |
59 |
Lovastatin |
Lovastatin |
[1] D00359 D00359 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
006 [11] 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 |
60 |
Mbx-8025 |
MBX-8025 |
- |
- |
- |
079 [3] 79, 93, 94 💬 |
61 |
Mbx-8025 50 mg (dose escalation period 1) |
MBX-8025 |
- |
- |
- |
079 [1] 79 💬 |
62 |
Mbx-8025 50 mg or 100 mg (dose escalation period 2) |
MBX-8025 |
- |
- |
- |
079 [1] 79 💬 |
63 |
Mbx-8025 50 mg, 100 mg or 200 mg (dose escalation period 3) |
MBX-8025 |
- |
- |
- |
079 [1] 79 💬 |
64 |
Mipomersen |
Mipomersen |
[1] D08946 D08946 💬 |
- |
- |
079 [1] 79 💬 |
65 |
Mk-0859 |
- |
- |
- |
- |
079 [1] 79 💬 |
66 |
Nicotinic acid |
Niacin |
[1] D00049 D00049 💬 |
- |
- |
079 [1] 79 💬 |
67 |
Omega-3 |
Omega-3 fatty acids |
- |
- |
- |
013 [7] 13, 46, 49, 66, 79, 96, 299 💬 |
68 |
Omega-3 fatty acids |
Omega-3 fatty acids |
- |
- |
- |
013 [2] 13, 79 💬 |
69 |
Phospholipids |
Omega-3 fatty acids |
- |
- |
- |
079 [1] 79 💬 |
70 |
Placebo |
- |
- |
- |
- |
003 [26] 3 , 5 , 6 , 13, 14, 37, 40, 46, 49, 50, 51, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬 |
71 |
Praluent |
- |
- |
- |
- |
079 [1] 79 💬 |
72 |
Pravastatin |
Pravastatin |
[2] D00893 D00893, D08410 D08410 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
013 [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬 |
73 |
Recombinant human apolipoprotein |
- |
- |
- |
- |
079 [1] 79 💬 |
74 |
Recombinant human apolipoprotein a-i |
- |
- |
- |
- |
079 [1] 79 💬 |
75 |
Recombinant human apolipoprotein a-i/phospholipids complex |
Omega-3 fatty acids |
- |
- |
- |
079 [1] 79 💬 |
76 |
Recombinant human apolipoprotein a1 |
- |
- |
- |
- |
079 [1] 79 💬 |
77 |
Regn1500 |
- |
- |
- |
- |
079 [1] 79 💬 |
78 |
Regn1500 250 mg sc/15 mg/kg iv/450 mg sc |
- |
- |
- |
- |
079 [1] 79 💬 |
79 |
Repatha |
- |
- |
- |
- |
079 [1] 79 💬 |
80 |
Repatha (evolocumab) |
Evolocumab |
[1] D10557 D10557 💬 |
PCSK9 [1] PCSK9 💬 |
Cholesterol metabolism [1] Cholesterol metabolism |
079 [1] 79 💬 |
81 |
Repatha 140 mg solution for injection in pre-filled pen |
- |
- |
- |
- |
079 [1] 79 💬 |
82 |
Repatha 420 mg solution for injection in cartridge |
- |
- |
- |
- |
079 [1] 79 💬 |
83 |
Rosuvastatin |
Rosuvastatin |
[2] D01915 D01915, D08492 D08492 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 |
84 |
Rosuvastatin 20mg |
Rosuvastatin |
[2] D01915 D01915, D08492 D08492 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
079 [1] 79 💬 |
85 |
Rosuvastatin calcium |
Calcium |
[2] D01915 D01915, D08492 D08492 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
049 [4] 49, 79, 97, 299 💬 |
86 |
Sar236553 |
- |
- |
- |
- |
079 [1] 79 💬 |
87 |
Sfingomielina |
- |
- |
- |
- |
079 [1] 79 💬 |
88 |
Shr-1209 |
- |
- |
- |
- |
079 [1] 79 💬 |
89 |
Simvastatin |
Simvastatin |
[1] D00434 D00434 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
006 [21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 |
90 |
Single intravenous (iv) dose of human low density lipoprotein receptor (ldlr) gene therapy |
- |
- |
- |
- |
079 [1] 79 💬 |
91 |
Sphingomyelin |
- |
- |
- |
- |
079 [1] 79 💬 |
92 |
Standard of care |
- |
- |
- |
- |
006 [12] 6 , 13, 14, 46, 49, 51, 63, 64, 79, 85, 158, 271 💬 |
93 |
Statins |
- |
- |
- |
- |
046 [2] 46, 79 💬 |
94 |
Sulfate |
Sulfate ion |
- |
- |
- |
002 [25] 2 , 6 , 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 222, 226, 265, 296, 297, 299 💬 |
95 |
Tak-475 |
TAK-475 |
- |
- |
- |
079 [1] 79 💬 |
96 |
Zd4522 |
- |
- |
- |
- |
079 [1] 79 💬 |