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e.g. Sirolimus, Adalimumab

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29 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  2,4-thiazolidinedione [2] 5-[4-[2-(5-(1-hydroxyethyl)-2-pyridinyl)ethoxy]benzyl]-2,4-thiazolidinedione hydrochloride; 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride;  -  -  -  [1] 20 💬
 2  Acetylcysteine [12] Acetylcysteine; Acetylcysteine effervescent tablets; Acetylcysteine sodium; Fluimucil (acetylcysteine); Glatiramer acetate, n-acetylcysteine; Jaktinib dihydrochloride monohydrate 50mg bid and mimic tablets of jakitinib hydrochloride 75mg bid and acetylcysteine effervescent tablets; Jaktinib dihydrochloride monohydrate 75mg bid and mimic tablets of jakitinib hydrochloride 50mg bid and acetylcysteine effervescent tablets; N acetylcysteine; N-acetylcysteine; N-acetylcysteine (nac); N-acetylcysteine capsule; N-acetylcysteine, (nac);  [1] D00221 💬  -  -  [17]  6 , 13, 19, 20, 34, 49, 51, 58, 85, 90, 94, 111, 164, 193, 233, 298, 299 💬
 3  Alemtuzumab [20] Alemtuzumab; Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994; Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994); Alemtuzumab (campath ); Alemtuzumab (campath); Alemtuzumab (gz402673); Alemtuzumab 0.2 mg; Alemtuzumab 0.3 mg; Alemtuzumab 12 mg; Alemtuzumab 24 mg; Alemtuzumab and rituximab; Alemtuzumab gz402673; Alemtuzumab immunotherapy; Alemtuzumab injection; Alemtuzumab injection [lemtrada]; Alemtuzumab, rituximab; Campath-1h (alemtuzumab); Filgrastim, alemtuzumab; Transplant conditioning with mobilization and alemtuzumab; Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan;  [1] D02802 💬  -  -  [21] 13, 15, 19, 20, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326 💬
 4  Bezafibrate [10] Bezafibrate; Bezafibrate (400mg) in addition to standard 15-20 mg/kg/jour udca therapy; Bezafibrate (drug); Bezafibrate (inn 3968); Bezafibrate 200 mg; Bezafibrate 400 mg; Bezafibrate ir; Bezafibrate sr; Bezafibrate, beza, bzf, bezalip; Bezafibrate, beza, bzf, bezalip mono;  [1] D01366 💬 [1] PPARA 💬 [8] Adipocytokine signaling pathway, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway  [6] 20, 93, 94, 160, 316, 324 💬
 5  Biotin [7] Biotin; Biotina; D-biotin; D-biotina; High doses of thiamine y biotin; Moderate doses of thiamine y biotin; Prebiotics (prebiotin prebiotic fiber stick pac);  [1] D00029 💬  -  -  [5]  2 ,  8 , 10, 13, 20 💬
 6  Busulfan [15] Busulfan; Busulfan iv; Busulfan test dose; Busulfan, cyclophosphamide, antithymocyte globulin; Busulfan, cyclophosphamide, atg; Busulfan, cyclophosphamide, atg, gcsf; Busulfan, cyclophosphamide, thymoglobulin, fludarabine (conditioning regimen); Busulfan, fludarabine and atg; Busulfan, fludarabine, & cyclophosphamide with immunosuppression with atg and cyclosporine.; Busulfan, fludarabine, atg, tli; Busulfan/fludarabine phosphate/tacrolimus/methotrexate/g-csf; Busulfano; Campath, busulfan, clofarabine; Fludarabine, busulfan, thymoglobulin; Fludarabine/busulfan;  [1] D00248 💬  -  -  [13] 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 💬
 7  Chenodeoxycholic acid [1] Chenodeoxycholic acid;  [1] D00163 💬 [1] NR1H4 💬 [1] Bile secretion  [4] 20, 96, 234, 263 💬
 8  Cholecalciferol [11] 5000 iu of cholecalciferol; Calcium and cholecalciferol; Cholecalciferol; Cholecalciferol (vitamin d3); Cholecalciferol (vitamind3); Cholecalciferol 10,000 iu; Cholecalciferol 400 iu; Cholecalciferol and c. xanthorrhiza; Cholecalciferol concentrate; Cholecalciferol concentrate (water-dispersible form); Cholecalciferol, vitamin d3;  [1] D00188 💬 [1] VDR 💬 [4] Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis  [23]  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬
 9  Cholic Acid [4] Chenodeoxycholic acid; Cholic acid; Cholic acids; Obeticholic acid;  [1] D10699 💬 [1] NR1H4 💬 [1] Bile secretion  [4] 20, 234, 265, 310 💬
 10  Clofarabine [3] Campath, busulfan, clofarabine; Clofarabine; Radiation: fluorine f 18 clofarabine;  [1] D03546 💬 [3] POLA1, POLA2, RRM1 💬 [6] DNA replication, Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism  [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬
 11  Cyclophosphamide [55] Busulfan, cyclophosphamide, antithymocyte globulin; Busulfan, cyclophosphamide, atg; Busulfan, cyclophosphamide, atg, gcsf; Busulfan, cyclophosphamide, thymoglobulin, fludarabine (conditioning regimen); Busulfan, fludarabine, & cyclophosphamide with immunosuppression with atg and cyclosporine.; Campath, fludarabine, cyclophosphamide; Cyclophosphamide; Cyclophosphamide (cy); Cyclophosphamide (cy) (plan 1); Cyclophosphamide (cy) (plan 2); Cyclophosphamide (cytoxan); Cyclophosphamide (drug); Cyclophosphamide + pred; Cyclophosphamide 100mg; Cyclophosphamide 150mg; Cyclophosphamide 30; Cyclophosphamide 40; Cyclophosphamide 50mg; Cyclophosphamide 50mg oral tablet; Cyclophosphamide and atg; Cyclophosphamide and fludarabine; Cyclophosphamide and steroids; Cyclophosphamide dose level 1; Cyclophosphamide dose level 2; Cyclophosphamide dose level 3; Cyclophosphamide dose level 4; Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids; Cyclophosphamide injection 1g; Cyclophosphamide monohydrate; Cyclophosphamide post transplant; Cyclophosphamide(ctx); Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Cyclophosphamide, bortezomib, and dexamethasone (cybord); Cyclophosphamide, bortezomib, dexamethasone; Cyclophosphamide, bortezomib, dexamethasone plus daratumumab; Cyclophosphamide, fludarabine; Cyclophosphamide, fludarabine , thymoglobulin; Cyclophosphamide, fludarabine, rabbit atg; Cyclophosphamide, fludarabine, thymoglobulin; Cyclophosphamide,campath ih and tbi; Cyclophosphamide,cyclosporine a; Cyclophosphamide-prednisone-azathioprine; Cyclophosphamide/glatiramer acetate; Fludarabine, cyclophosphamide; Haploidentical hsct using tbi free regimen, ''atg'' with ''post transplant cyclophosphamide''; High-dose cyclophosphamide; Iv cyclophosphamide; Lenalidomide, dexamethasone and cyclophosphamide; Prednisone and cyclophosphamide; Prednisone plus cyclophosphamide; Prednisone, cyclophosphamide; Prednisone, methylprednisolone,cyclophosphamides; Procedure: cyclophosphamide; Rituximab and cyclophosphamide iv; Thalidomide, cyclophosphamide and prednisone;  [2] D00287
D07760 💬		  -  -  [44] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 💬
 12  Cyclosporine [26] Atg+cyclosporine; Atg+rapamune+cyclosporine; Busulfan, fludarabine, & cyclophosphamide with immunosuppression with atg and cyclosporine.; Cyclophosphamide,cyclosporine a; Cyclosporine; Cyclosporine (gengraf ); Cyclosporine (usan); Cyclosporine 5 mg/kg bid days 0-14; Cyclosporine a; Cyclosporine a (csa); Cyclosporine a dry powder inhalation (drug); Cyclosporine combine with mycophenolate mofetil; Cyclosporine inhalation solution; Cyclosporine inhalation solution (cis); Cyclosporine oral product; Cyclosporine pill; Cyclosporine vs infliximab; Cyclosporine-a; Device: cyclosporine a; Liposomal aerosol cyclosporine; Liposomal cyclosporine a; Liposomal cyclosporine a 10 mg; Liposomal cyclosporine a 5 mg; Oral cyclosporine; Rabbit atg, cyclosporine, levamisole; Twice-daily dosage with 0.5% cyclosporine-a eyedrops;  [1] D00184 💬 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 [32] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway  [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 13  Glyceryl Trierucate [2] Glyceryl trierucate; Glyceryl trierucate/glyceryl trioleate;  -  -  -  [1] 20 💬
 14  Glyceryl Trioleate [2] Glyceryl trierucate/glyceryl trioleate; Glyceryl trioleate;  -  -  -  [1] 20 💬
 15  Human interferon beta [6] Human interferon beta; Human interferon beta 1a (rebif); Human interferon beta-1a and glatiramer acetate; New formulation of rebif - human interferon beta-1a; Recombinant human interferon beta; Recombinant human interferon beta-1a;  -  -  -  [5] 13, 20, 26, 96, 97 💬
 16  Hydroxyurea [1] Hydroxyurea;  [1] D00341 💬 [1] RRM2 💬 [6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway  [8]  3 , 13, 19, 20, 65, 85, 86, 284 💬
 17  Imidacloprid - -  -  -  [5] 19, 20, 125, 234, 326 💬
 18  Leriglitazone [1] Leriglitazone;  [1] D11603 💬 [1] PPARG 💬 [9] AMPK signaling pathway, Huntington disease, Longevity regulating pathway, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer  [1] 20 💬
 19  Lipoic acid [9] Alpha lipoic acid; Alpha-lipoic acid; Alpha-lipoic acid and l-acetyl carnitine; Lipoic acid; Lipoic acid (la) with fish oil and la without fish oil; Lipoic acid and omega-3 fatty acids; Lipoic acid group; Oral lipoic acid (la); R lipoic acid;  [2] D00048
D00086 💬		  -  -  [5]  2 ,  5 , 13, 14, 20 💬
 20  Melphalan [10] Carmustine, etoposide, cytarabine, and melphalan (beam); Fludarabine, melphalan, thiotepa; Fludarabine/ melphalan; Melphalan; Melphalan fulfenamide hydrochloride; Melphalan hydrochloride; Melphalan, thalidomide and dexamethasone; Melphalan-flufenamide (melflufen); Propylene glycol-free melphalan hydrochloride; Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan;  [1] D00369 💬  -  -  [15] 11, 13, 14, 19, 20, 28, 60, 62, 65, 96, 164, 234, 284, 285, 299 💬
 21  Mycophenolate mofetil [19] Azathioprine or mycophenolate mofetil; Cellcept (mycophenolate mofetil); Cyclosporine combine with mycophenolate mofetil; Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate); Mycophenolate mofetil; Mycophenolate mofetil (cellcept); Mycophenolate mofetil (mmf); Mycophenolate mofetil (mmf) 3 g/day; Mycophenolate mofetil 2 g/day; Mycophenolate mofetil [cellcept]; Mycophenolate mofetil orally 1000 mg twice a day (bid); Mycophenolate mofetil plus lower dose of prednisone; Mycophenolate mofetil(mmf); Mycophenolate mofetil, low dose steroid; Mycophenolate mofetil,methotrexate; Prednisolone and mycophenolate mofetil; Prednisone and mycophenolate mofetil; Prednisone, ciclosporin and mycophenolate mofetil; Symptomatic treatment, steroids, immunosuppressive agents( azathioprine, tacrolimus, mycophenolate mofetil);  [3] D00752
D05094
D05095 💬		 [2] IMPDH1, IMPDH2 💬 [3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism  [32]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
 22  Mycophenolic acid [2] Mycophenolic acid; Mycophenolic acid mofetil;  [1] D05096 💬 [2] IMPDH1, IMPDH2 💬 [3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism  [34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
 23  Pioglitazone [6] Actos (pioglitazone); Pioglitazone; Pioglitazone 15 mg; Pioglitazone and tretinoin; Pioglitazone or metformin; Tretinoin and pioglitazone hcl;  [2] D00945
D08378 💬		 [1] PPARG 💬 [9] AMPK signaling pathway, Huntington disease, Longevity regulating pathway, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer  [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
 24  Plerixafor [3] Plerixafor; Plerixafor for conditioning before hsct.; Plerixafor mobilization of autologous cd117 stem cells;  [1] D08971 💬 [1] CXCR4 💬 [12] Axon guidance, Calcium signaling pathway, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Intestinal immune network for IgA production, Leukocyte transendothelial migration, Pathways in cancer, Regulation of actin cytoskeleton, Viral protein interaction with cytokine and cytokine receptor  [6] 19, 20, 51, 65, 285, 299 💬
 25  Sobetirome [2] Sobetirome; Sobetirome (nv1205);  [1] D09381 💬 [1] THRB 💬 [2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway  [1] 20 💬
 26  Thalidomide [10] Fpf 300 (thalidomide); Melphalan, thalidomide and dexamethasone; Thalidomide; Thalidomide (drug); Thalidomide 100mg; Thalidomide 150mg; Thalidomide celgene - 50 mg capsula rigida - uso orale - blister (pvc/pe/aclar/alu) 28 capsule; Thalidomide celgene*28cps 50mg; Thalidomide pharmion; Thalidomide, cyclophosphamide and prednisone;  [1] D00754 💬 [1] TNF 💬 [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
 27  Thiotepa [5] Fludarabine, melphalan, thiotepa; Thiotepa; Thiotepa--escalated dose; Thiotepa--single daily dose; Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan;  [1] D00583 💬  -  -  [11] 13, 19, 20, 28, 51, 60, 65, 85, 96, 164, 284 💬
 28  Ursodeoxycholic acid [16] Norursodeoxycholic acid; Tauroursodeoxycholic acid; Tauroursodeoxycholic acid capsules; Tauroursoursodeoxycholic acid, brand name tudcabil; Udca (ursodeoxycholic acid); Ursodeoxycholic acid; Ursodeoxycholic acid (udca); Ursodeoxycholic acid (urso); Ursodeoxycholic acid 300mg capsule; Ursodeoxycholic acid 300mg tablet; Ursodeoxycholic acid capsules; Ursodeoxycholic acid combination of immunosuppressive agents; Ursodeoxycholic acid combined with total glucosides of paeony; Ursodeoxycholic acid only; Ursodeoxycholic acid+low dose glucocorticoid(prednisone); Ursodiol (ursodeoxycholic acid, udca);  [1] D00734 💬 [1] NR1H4 💬 [1] Bile secretion  [13]  6 ,  8 , 20, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
 29  Vitamin E [9] Ascorbic acid (vitamin c) and alpha-tocopherol (vitamin e); Coenzyme q10 with vitamin e; Omega-3 and vitamin e supplementation; Vitamin c 10mg/kg vitamin e 10 mg/kg; Vitamin e; Vitamin e - tgps; Vitamin e 800iu; Vitamin e supplement; Vitamin e/selenium;  [1] D02331 💬  -  -  [12]  2 ,  6 , 13, 20, 46, 49, 90, 96, 97, 206, 299, 317 💬