168. Ehlers-Danlos syndrome
7 clinical trials, 16 drugs (DrugBank: 8 drugs), 9 drug target genes, 54 drug target pathways
Searched query = "Ehlers-Danlos syndrome", "EDS", "cEDS", "hEDS", "clEDS", "vEDS", "kEDS", "aEDS", "dEDS", "DDEDS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04036305 (ClinicalTrials.gov) | July 26, 2019 | 25/7/2019 | Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers | Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers | Ehlers-Danlos Syndrome;Anesthesia, Local | Drug: 0.9% Sodium Chloride Injection;Drug: Lidocaine Injection 2%;Drug: Bupivacaine Injection 0.5% | Vanderbilt University Medical Center | University of Calgary | Enrolling by invitation | 18 Years | N/A | All | 230 | United States | |
| 2 | NCT02597361 (ClinicalTrials.gov) | January 2016 | 23/10/2015 | Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome (ARCADE) | Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome: a Double Blind, Randomized, Placebo Controlled, Multicenter Trial. | Ehlers-Danlos Syndrome, Vascular Type | Drug: Irbesartan;Drug: Placebo | Assistance Publique - Hôpitaux de Paris | Ministry of Health, France | Completed | 18 Years | 70 Years | All | 61 | Phase 3 | France |
| 3 | EUCTR2015-001065-76-FR (EUCTR) | 28/09/2015 | 08/09/2015 | N/A | N/A - ARCADE | MedDRA version: 18.0;Level: PT;Classification code 10014316;Term: Ehlers-Danlos syndrome;System Organ Class: 10010331 - Congenital, familial and genetic disorders | Trade Name: IRBESARTAN Product Name: IRBESARTAN INN or Proposed INN: irbesartan | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | NULL | Not Recruiting | Female: yes Male: yes | 169 | Phase 3 | France | ||
| 4 | NCT01446783 (ClinicalTrials.gov) | September 2011 | 27/9/2011 | IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients | IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients | Ehlers-Danlos Syndrome, Classic | Drug: mecasermin;Drug: Saline | Bispebjerg Hospital | NULL | Completed | 18 Years | N/A | Both | 15 | N/A | Denmark |
| 5 | NCT01307527 (ClinicalTrials.gov) | November 2008 | 1/3/2011 | Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI | Brittle Cornea Syndrome;Ehlers-Danlos Syndrome Type 6 | Drug: Riboflavin;Device: Kera-X | Hadassah Medical Organization | NULL | Enrolling by invitation | 18 Years | N/A | Both | 1 | N/A | Israel | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT00190411 (ClinicalTrials.gov) | October 2003 | 13/9/2005 | Celiprolol in Patients With Ehlers-Danlos Syndrome, Vascular Type | Prevention of Vascular Complications by BetaBlocker Treatment in Vascular Ehlers-Danlos Syndrome | EHLERS-DANLOS SYNDROME, TYPE IV, AUTOSOMAL DOMINANT;CHROMOSOME 2q31.2 DELETION SYNDROME | Drug: celiprolol;Drug: Control | Assistance Publique - Hôpitaux de Paris | Aventis Pharmaceuticals | Completed | 15 Years | 65 Years | Both | 54 | Phase 4 | France |
| 7 | NCT00001966 (ClinicalTrials.gov) | January 2000 | 18/1/2000 | Mind-Body Therapy for Pain in Ehlers-Danlos Syndrome | A Pilot Study of Mind-Body Therapy for Chronic Pain in Ehlers-Danlos Syndrome | Ehlers-Danlos Syndrome;Pain | Drug: Mind-body therapy | National Human Genome Research Institute (NHGRI) | NULL | Completed | N/A | N/A | Both | 40 | Phase 2 | United States |