Helium    (DrugBank: Helium)

3 diseases
IDDisease name (Link within this page)Number of trials
228Bronchiolitis obliterans1
299Cystic fibrosis4
330Congenital tracheal stenosis / Congenital subglottic stenosis [Congenital tracheal stenosis (~Mar 2018)]1

228. Bronchiolitis obliterans    [ 92 clinical trials,   125 drugs,   (DrugBank: 34 drugs),   33 drug target genes,   152 drug target pathways]
Searched query = "Bronchiolitis obliterans", "Obliterating bronchiolitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 92 trial found
No.TrialIDDate_
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PhaseCountries
1NCT02316392
(ClinicalTrials.gov)
December 201410/12/2014Imaging and Understanding BOS in Lung TransplantationImaging and Understanding BOS in Lung TransplantationBronchiolitis Obliterans SyndromeDrug: Hyperpolarized Helium-3 MRIChildren's Hospital Medical Center, CincinnatiNULLCompleted1 Year25 YearsAll6N/AUnited States

299. Cystic fibrosis    [ 1,592 clinical trials,   1,539 drugs,   (DrugBank: 255 drugs),   81 drug target genes,   162 drug target pathways]
Searched query = "Cystic fibrosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
4 / 1,592 trials found
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1NCT02163681
(ClinicalTrials.gov)
January 1, 201110/6/2014MRI as a Means to Measure Lung Function: Non-Invasive Imaging in Neonates and ChildrenHealthy;Cystic Fibrosis (CF);Asthma;Bronchopulmonary Dysplasia (BPD)Drug: Hyperpolarized Helium-3 MRI of the chestUniversity of VirginiaXemed LLCCompleted4 Months65 YearsAll77N/AUnited States
2NCT01161537
(ClinicalTrials.gov)
October 20109/7/2010Study of the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis and the G551D MutationA Phase 2, Single-Blind, Placebo-Controlled Study to Evaluate the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis, the G551D Mutation, and FEV1 =40% PredictedCystic FibrosisDrug: VX-770;Drug: PlaceboVertex Pharmaceuticals IncorporatedCystic Fibrosis Foundation TherapeuticsCompleted12 YearsN/AAll13Phase 2United States
3NCT00846573
(ClinicalTrials.gov)
November 200816/2/2009Hyperpolarized Noble Gas MR Imaging for Pulmonary DisordersHyperpolarized Noble Gas MR Imaging for Pulmonary DisordersCOPD;Cystic Fibrosis;Asthma;HealthyDrug: Hyperpolarized Helium-3University of Massachusetts, WorcesterNULLTerminated5 YearsN/AAll14N/AUnited States
4EUCTR2017-000672-28-Outside-EU/EEA
(EUCTR)
27/03/2017Study of the Effect of VX-770 on Hyperpolarized Helium-3 MagneticResonance Imaging in Subjects With Cystic Fibrosis and the G551DMutationA Phase 2, Single-Blind, Placebo-Controlled Study to Evaluate the Effectof VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging inSubjects With Cystic Fibrosis, the G551D Mutation, and FEV1 =40%Predicted cystic fibrosis
MedDRA version: 19.1;Level: SOC;Classification code 10010331;Term: Congenital, familial and genetic disorders;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trade Name: Kalydeco
Product Name: ivacaftor
Product Code: VX-770
INN or Proposed INN: IVACAFTOR
Vertex Pharmaceuticals IncorporatedNULLNAFemale: yes
Male: yes
17Phase 2United States

330. Congenital tracheal stenosis / Congenital subglottic stenosis [Congenital tracheal stenosis (~Mar 2018)]    [ 1 clinical trial,   3 drugs,   (DrugBank: 2 drugs),   0 drug target gene,   0 drug target pathway]
Searched query = "Congenital tracheal stenosis / Congenital subglottic stenosis [Congenital tracheal stenosis (~Mar 2018)]", "Congenital tracheal stenosis", "Congenital subglottic stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 1 trial found
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
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Status
Inclusion_
agemin
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agemax
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gender
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size
PhaseCountries
1JPRN-JMA-IIA00357
01/07/201819/06/2018Phase II trial of helium / oxygen mixed gas for respiratory failure secondary to airway obstructive lesion in childrenPhase II trial of helium / oxygen mixed gas for respiratory failure secondary to airway obstructive lesion in children Respiratory failure due to airway obstructive lesion such as acute bronchiolitis, congenital tracheal stenosis, bronchial asthma attackIntervention type:DRUG. Intervention1:Helium / oxygen mixed gas inhalation therapy, Dose form:INSUFFLATION, Route of administration:INHALATIONAL, intended dose regimen:Helium / oxygen mixed gas .Tokyo Metropolitan Children's Medical CenterNational Center for Child Health and DevelopmentRecruitingNo Limit<20 YEARSBOTH15Phase 2Japan