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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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105 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adherens junction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 2  Adrenergic signaling in cardiomyocytes 
 5 genes, 1 drug (DrugBank), 5 diseases shown 		  [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 3  Alcoholism 
 6 genes, 3 drugs (DrugBank), 15 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 4  Aldosterone synthesis and secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 5  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 6  Allograft rejection 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 7  Alzheimer disease 
 9 genes, 3 drugs (DrugBank), 15 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 8  Amphetamine addiction 
 11 genes, 3 drugs (DrugBank), 15 diseases shown 		  [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 9  AMPK signaling pathway 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] HMGCR   D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 10  Amyotrophic lateral sclerosis (ALS) 
 7 genes, 3 drugs (DrugBank), 15 diseases shown 		  [2] GRIA1, GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 11  Antigen processing and presentation 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 12  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 13  Asthma 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 14  Autoimmune thyroid disease 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 15  Bile secretion 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] HMGCR   D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 16  Calcium signaling pathway 
 9 genes, 4 drugs (DrugBank), 18 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 17  cAMP signaling pathway 
 14 genes, 4 drugs (DrugBank), 18 diseases shown 		  [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 18  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 19  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 20  Cell adhesion molecules (CAMs) 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 21  Cellular senescence 
 7 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 22  cGMP-PKG signaling pathway 
 5 genes, 2 drugs (DrugBank), 6 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 23  Cholinergic synapse 
 5 genes, 2 drugs (DrugBank), 12 diseases shown 		  [1] ACHE   D00670   Donepezil   [9] 5, 6, 13, 46, 78, 124, 127, 156, 206 
 D07869 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 24  Circadian entrainment 
 11 genes, 3 drugs (DrugBank), 15 diseases shown 		  [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 25  Cocaine addiction 
 7 genes, 4 drugs (DrugBank), 18 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 26  Collecting duct acid secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 27  Cortisol synthesis and secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 28  Cushing syndrome 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 29  Dilated cardiomyopathy (DCM) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 30  Dopaminergic synapse 
 10 genes, 4 drugs (DrugBank), 18 diseases shown 		  [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 31  Endocytosis 
 6 genes, 1 drug (DrugBank), 4 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 32  Epstein-Barr virus infection 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 33  FoxO signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 34  GABAergic synapse 
 20 genes, 1 drug (DrugBank), 5 diseases shown 		  [20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 35  Gap junction 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] DRD2, HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 36  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 37  Glutamatergic synapse 
 16 genes, 3 drugs (DrugBank), 15 diseases shown 		  [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 38  Glycerophospholipid metabolism 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ACHE   D00670   Donepezil   [9] 5, 6, 13, 46, 78, 124, 127, 156, 206 
 D07869 
 39  GnRH secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 40  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 41  Graft-versus-host disease 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 42  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 43  Hematopoietic cell lineage 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 44  Herpes simplex virus 1 infection 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 45  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 46  Human cytomegalovirus infection 
 6 genes, 1 drug (DrugBank), 4 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 47  Human immunodeficiency virus 1 infection 
 6 genes, 1 drug (DrugBank), 4 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 48  Human papillomavirus infection 
 6 genes, 1 drug (DrugBank), 4 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 49  Human T-cell leukemia virus 1 infection 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 50  Huntington disease 
 2 genes, 2 drugs (DrugBank), 12 diseases shown 		  [2] GRIN1, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 51  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 52  Inflammatory bowel disease (IBD) 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 53  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 54  Influenza A 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 55  Insulin resistance 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 56  Insulin secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 57  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 58  Intestinal immune network for IgA production 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 59  Kaposi sarcoma-associated herpesvirus infection 
 6 genes, 1 drug (DrugBank), 4 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 60  Leishmaniasis 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 61  Long-term depression 
 3 genes, 1 drug (DrugBank), 5 diseases shown 		  [3] GRIA1, GRIA2, GRIA3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 62  Long-term potentiation 
 8 genes, 3 drugs (DrugBank), 15 diseases shown 		  [3] CACNA1C, GRIA1, GRIA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 63  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 64  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 65  MAPK signaling pathway 
 5 genes, 2 drugs (DrugBank), 6 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 66  Metabolic pathways 
 3 genes, 2 drugs (DrugBank), 13 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] HMGCR   D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 67  Morphine addiction 
 16 genes, 1 drug (DrugBank), 5 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 68  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 69  Natural killer cell mediated cytotoxicity 
 5 genes, 1 drug (DrugBank), 4 diseases shown 		  [5] HLA-A, HLA-B, HLA-C, HLA-E, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 70  Neuroactive ligand-receptor interaction 
 33 genes, 5 drugs (DrugBank), 19 diseases shown 		  [2] DRD2, HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 71  Nicotine addiction 
 25 genes, 3 drugs (DrugBank), 15 diseases shown 		  [20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 72  Nitrogen metabolism 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 73  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 74  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 75  Oxytocin signaling pathway 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 76  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CA2   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 77  Parkinson disease 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 78  Phagosome 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 79  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 80  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 81  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] CA2, CA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 82  Rap1 signaling pathway 
 5 genes, 4 drugs (DrugBank), 15 diseases shown 		  [1] DRD2   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 83  Ras signaling pathway 
 4 genes, 3 drugs (DrugBank), 12 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 84  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 85  Renin secretion 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 86  Retrograde endocannabinoid signaling 
 24 genes, 1 drug (DrugBank), 5 diseases shown 		  [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 87  Rheumatoid arthritis 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 88  Serotonergic synapse 
 9 genes, 3 drugs (DrugBank), 10 diseases shown 		  [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] HTR2A   D00426   Risperidone   [5] 8, 156, 179, 187, 206 
 [1] SLC6A4   D00812   Desipramine   [2] 120, 156 
 D07791 
 89  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 90  Staphylococcus aureus infection 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 91  Synaptic vesicle cycle 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] SLC6A2, SLC6A4   D00812   Desipramine   [2] 120, 156 
 D07791 
 92  Systemic lupus erythematosus 
 16 genes, 3 drugs (DrugBank), 12 diseases shown 		  [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 93  Taste transduction 
 10 genes, 1 drug (DrugBank), 5 diseases shown 		  [10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 94  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] HMGCR   D00359   Lovastatin   [10] 6, 34, 46, 79, 156, 160, 195, 206, 263, 310 
 95  Th1 and Th2 cell differentiation 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 96  Th17 cell differentiation 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 97  Tight junction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 98  Toxoplasmosis 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 99  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] GRIA3   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 100  Tuberculosis 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 101  Type I diabetes mellitus 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 102  Type II diabetes mellitus 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] CACNA1C, CACNA1D   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 [1] INSR   D00085   Insulin Human   [2] 96, 156 
 D03230 
 103  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank), 5 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   [5] 6, 140, 144, 156, 193 
 104  Viral carcinogenesis 
 6 genes, 1 drug (DrugBank), 4 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 105  Viral myocarditis 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 

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