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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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174 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adipocytokine signaling pathway 
 2 genes, 3 drugs (DrugBank), 51 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 3  Adrenergic signaling in cardiomyocytes 
 6 genes, 5 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 4  African trypanosomiasis 
 4 genes, 2 drugs (DrugBank), 21 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 5  AGE-RAGE signaling pathway in diabetic complications 
 13 genes, 8 drugs (DrugBank), 38 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 6  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 7  Aldosterone synthesis and secretion 
 5 genes, 7 drugs (DrugBank), 44 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 8  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] NR3C2   D10528   Aldosterone   [1] 222 
 9  Allograft rejection 
 5 genes, 4 drugs (DrugBank), 34 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 10  Alzheimer disease 
 7 genes, 5 drugs (DrugBank), 60 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 11  Amoebiasis 
 7 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 12  Amphetamine addiction 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 13  AMPK signaling pathway 
 3 genes, 4 drugs (DrugBank), 49 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 14  Amyotrophic lateral sclerosis (ALS) 
 10 genes, 6 drugs (DrugBank), 60 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 15  Antifolate resistance 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 16  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 17  Apelin signaling pathway 
 2 genes, 5 drugs (DrugBank), 50 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 18  Apoptosis 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 19  Asthma 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 20  Autoimmune thyroid disease 
 4 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 21  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 22  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 23  Axon guidance 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 24  B cell receptor signaling pathway 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 25  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 26  Bile secretion 
 1 gene, 2 drugs (DrugBank), 18 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 27  Breast cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 28  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 29  C-type lectin receptor signaling pathway 
 13 genes, 6 drugs (DrugBank), 60 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 30  Calcium signaling pathway 
 10 genes, 9 drugs (DrugBank), 74 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 31  cAMP signaling pathway 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 32  Cell adhesion molecules (CAMs) 
 3 genes, 2 drugs (DrugBank), 24 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 33  Cell cycle 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 34  Cellular senescence 
 15 genes, 7 drugs (DrugBank), 73 diseases shown 		  [2] IL1A, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 35  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 36  cGMP-PKG signaling pathway 
 6 genes, 7 drugs (DrugBank), 65 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 37  Chagas disease (American trypanosomiasis) 
 13 genes, 6 drugs (DrugBank), 26 diseases shown 		  [1] ACE   D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   [2] 167, 222 
 D03753 
 [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 38  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] CCL2   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 39  Cholesterol metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] PCSK9   D10557   Evolocumab   [2] 79, 222 
 40  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 41  Chronic myeloid leukemia 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 42  Circadian entrainment 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 43  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] ATP4A, ATP4B   D00355   Lansoprazole   [6] 63, 71, 98, 166, 222, 299 
 44  Colorectal cancer 
 4 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 45  Complement and coagulation cascades 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [1] C5AR1   D11093   Avacopan   [4] 43, 44, 222, 223 
 46  Cortisol synthesis and secretion 
 5 genes, 7 drugs (DrugBank), 44 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 47  Cushing syndrome 
 5 genes, 7 drugs (DrugBank), 44 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 48  Cytokine-cytokine receptor interaction 
 12 genes, 6 drugs (DrugBank), 30 diseases shown 		  [6] CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CD40   D11357   Bleselumab   [1] 222 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 49  Cytosolic DNA-sensing pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 50  Dilated cardiomyopathy (DCM) 
 4 genes, 3 drugs (DrugBank), 22 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 51  Dopaminergic synapse 
 7 genes, 4 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 52  Drug metabolism - other enzymes 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 53  EGFR tyrosine kinase inhibitor resistance 
 3 genes, 3 drugs (DrugBank), 44 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 54  Endocrine resistance 
 5 genes, 2 drugs (DrugBank), 37 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 55  Endocytosis 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 56  Epithelial cell signaling in Helicobacter pylori infection 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 57  Epstein-Barr virus infection 
 8 genes, 5 drugs (DrugBank), 23 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 58  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 59  Fc epsilon RI signaling pathway 
 5 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 60  Fluid shear stress and atherosclerosis 
 8 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 61  FoxO signaling pathway 
 9 genes, 3 drugs (DrugBank), 12 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 62  GABAergic synapse 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 63  Gastric acid secretion 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] ATP4A, ATP4B   D00355   Lansoprazole   [6] 63, 71, 98, 166, 222, 299 
 64  Gastric cancer 
 4 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 65  Glioma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 66  Glucagon signaling pathway 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 67  Glutamatergic synapse 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 68  GnRH secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 69  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 70  Graft-versus-host disease 
 6 genes, 3 drugs (DrugBank), 34 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 71  Growth hormone synthesis, secretion and action 
 5 genes, 2 drugs (DrugBank), 37 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 72  Hematopoietic cell lineage 
 7 genes, 5 drugs (DrugBank), 55 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 73  Hepatitis B 
 10 genes, 5 drugs (DrugBank), 24 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 74  Hepatitis C 
 2 genes, 3 drugs (DrugBank), 22 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 75  Hepatocellular carcinoma 
 4 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 76  Herpes simplex virus 1 infection 
 7 genes, 5 drugs (DrugBank), 56 diseases shown 		  [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 77  HIF-1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 41 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 78  Hippo signaling pathway 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 79  Human cytomegalovirus infection 
 15 genes, 8 drugs (DrugBank), 76 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 80  Human immunodeficiency virus 1 infection 
 11 genes, 7 drugs (DrugBank), 76 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 81  Human papillomavirus infection 
 3 genes, 4 drugs (DrugBank), 52 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 82  Human T-cell leukemia virus 1 infection 
 13 genes, 9 drugs (DrugBank), 60 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 83  Huntington disease 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 84  Hypertrophic cardiomyopathy (HCM) 
 6 genes, 5 drugs (DrugBank), 26 diseases shown 		  [1] ACE   D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   [2] 167, 222 
 D03753 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 85  IL-17 signaling pathway 
 8 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 86  Inflammatory bowel disease (IBD) 
 8 genes, 3 drugs (DrugBank), 22 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 87  Inflammatory mediator regulation of TRP channels 
 5 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] IL1B   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 88  Influenza A 
 6 genes, 3 drugs (DrugBank), 22 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 89  Insulin resistance 
 3 genes, 3 drugs (DrugBank), 51 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 90  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 91  Intestinal immune network for IgA production 
 7 genes, 5 drugs (DrugBank), 30 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 92  JAK-STAT signaling pathway 
 5 genes, 4 drugs (DrugBank), 44 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 93  Kaposi sarcoma-associated herpesvirus infection 
 13 genes, 8 drugs (DrugBank), 78 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 94  Legionellosis 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 95  Leishmaniasis 
 12 genes, 5 drugs (DrugBank), 24 diseases shown 		  [4] IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 96  Leukocyte transendothelial migration 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 97  Long-term potentiation 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 98  Longevity regulating pathway 
 2 genes, 2 drugs (DrugBank), 39 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 99  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 100  Malaria 
 9 genes, 4 drugs (DrugBank), 22 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CD40   D11357   Bleselumab   [1] 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 101  MAPK signaling pathway 
 18 genes, 8 drugs (DrugBank), 68 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 102  Measles 
 5 genes, 3 drugs (DrugBank), 17 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 103  Metabolic pathways 
 10 genes, 8 drugs (DrugBank), 61 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] ATP4A, ATP4B   D00355   Lansoprazole   [6] 63, 71, 98, 166, 222, 299 
 [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 104  MicroRNAs in cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 105  mTOR signaling pathway 
 2 genes, 3 drugs (DrugBank), 51 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 106  Natural killer cell mediated cytotoxicity 
 6 genes, 5 drugs (DrugBank), 60 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 107  Necroptosis 
 4 genes, 3 drugs (DrugBank), 22 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 108  Neuroactive ligand-receptor interaction 
 6 genes, 12 drugs (DrugBank), 76 diseases shown 		  [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [1] C5AR1   D11093   Avacopan   [4] 43, 44, 222, 223 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   [5] 78, 83, 113, 145, 222 
 [1] NR3C1   D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 109  Neurotrophin signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 110  NF-kappa B signaling pathway 
 4 genes, 4 drugs (DrugBank), 26 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 111  Nicotinate and nicotinamide metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 112  NOD-like receptor signaling pathway 
 9 genes, 4 drugs (DrugBank), 23 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 113  Non-alcoholic fatty liver disease (NAFLD) 
 5 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 114  Oocyte meiosis 
 9 genes, 4 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 115  Osteoclast differentiation 
 16 genes, 9 drugs (DrugBank), 62 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 116  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] ATP4A, ATP4B   D00355   Lansoprazole   [6] 63, 71, 98, 166, 222, 299 
 117  Oxytocin signaling pathway 
 6 genes, 4 drugs (DrugBank), 55 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 118  Pancreatic cancer 
 5 genes, 3 drugs (DrugBank), 40 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 119  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 120  Pathogenic Escherichia coli infection 
 7 genes, 3 drugs (DrugBank), 22 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 121  Pathways in cancer 
 9 genes, 10 drugs (DrugBank), 57 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 122  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 11 genes, 6 drugs (DrugBank), 73 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 123  Pertussis 
 10 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 124  Phospholipase D signaling pathway 
 2 genes, 5 drugs (DrugBank), 50 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 125  PI3K-Akt signaling pathway 
 4 genes, 4 drugs (DrugBank), 44 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 126  Platelet activation 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 127  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 128  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 129  Prion diseases 
 4 genes, 2 drugs (DrugBank), 16 diseases shown 		  [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 130  Progesterone-mediated oocyte maturation 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 131  Prolactin signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 132  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 133  Prostate cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 134  Proteoglycans in cancer 
 8 genes, 5 drugs (DrugBank), 53 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 135  Purine metabolism 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 136  Rap1 signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 137  Relaxin signaling pathway 
 5 genes, 2 drugs (DrugBank), 5 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 138  Renal cell carcinoma 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 139  Renin secretion 
 8 genes, 10 drugs (DrugBank), 65 diseases shown 		  [1] ACE   D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   [2] 167, 222 
 D03753 
 [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] REN   D03208   Aliskiren   [3] 66, 167, 222 
 140  Renin-angiotensin system 
 4 genes, 7 drugs (DrugBank), 24 diseases shown 		  [1] ACE   D00362   Lisinopril   [5] 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   [2] 167, 222 
 D03753 
 [1] AGTR1   D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [2] AGTR1, AGTR2   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 [1] REN   D03208   Aliskiren   [3] 66, 167, 222 
 141  Retrograde endocannabinoid signaling 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 142  Rheumatoid arthritis 
 11 genes, 5 drugs (DrugBank), 36 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 143  RIG-I-like receptor signaling pathway 
 5 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 144  Salivary secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CD38   D10777   Daratumumab   [2] 28, 222 
 145  Salmonella infection 
 7 genes, 2 drugs (DrugBank), 11 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 146  Shigellosis 
 7 genes, 4 drugs (DrugBank), 52 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 147  Signaling pathways regulating pluripotency of stem cells 
 5 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 148  Sphingolipid signaling pathway 
 5 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 149  Staphylococcus aureus infection 
 3 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [1] C5AR1   D11093   Avacopan   [4] 43, 44, 222, 223 
 [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 150  Systemic lupus erythematosus 
 6 genes, 5 drugs (DrugBank), 38 diseases shown 		  [1] C5   D03940   Eculizumab   [7] 11, 13, 14, 62, 109, 222, 223 
 [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 151  T cell receptor signaling pathway 
 11 genes, 6 drugs (DrugBank), 60 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 152  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 153  Terpenoid backbone biosynthesis 
 1 gene, 2 drugs (DrugBank), 18 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   [3] 79, 218, 222 
 D07983 
 154  TGF-beta signaling pathway 
 4 genes, 3 drugs (DrugBank), 22 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 155  Th1 and Th2 cell differentiation 
 11 genes, 6 drugs (DrugBank), 56 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 156  Th17 cell differentiation 
 15 genes, 9 drugs (DrugBank), 74 diseases shown 		  [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 157  Thermogenesis 
 6 genes, 3 drugs (DrugBank), 40 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 158  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 159  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 160  TNF signaling pathway 
 8 genes, 3 drugs (DrugBank), 22 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 161  Toll-like receptor signaling pathway 
 10 genes, 5 drugs (DrugBank), 35 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 162  Toxoplasmosis 
 11 genes, 6 drugs (DrugBank), 24 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 163  Transcriptional misregulation in cancer 
 4 genes, 4 drugs (DrugBank), 30 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] PPARG   D00596   Rosiglitazone   [5] 46, 75, 97, 222, 265 
 D08491 
 164  Tuberculosis 
 18 genes, 8 drugs (DrugBank), 60 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 165  Type I diabetes mellitus 
 7 genes, 4 drugs (DrugBank), 45 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 166  Type II diabetes mellitus 
 3 genes, 4 drugs (DrugBank), 58 diseases shown 		  [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 167  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 168  Vascular smooth muscle contraction 
 1 gene, 4 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00150   Angiotensin II   [7] 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   [4] 66, 167, 168, 222 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 169  VEGF signaling pathway 
 9 genes, 4 drugs (DrugBank), 55 diseases shown 		  [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 170  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 171  Viral myocarditis 
 3 genes, 2 drugs (DrugBank), 24 diseases shown 		  [1] CD40   D11357   Bleselumab   [1] 222 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 172  Viral protein interaction with cytokine and cytokine receptor 
 5 genes, 3 drugs (DrugBank), 24 diseases shown 		  [4] CCL2, IL10, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 173  Wnt signaling pathway 
 5 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   [1] 222 
 174  Yersinia infection 
 9 genes, 3 drugs (DrugBank), 22 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [4] MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   [2] 113, 222 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 

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