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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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106 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 2  Adrenergic signaling in cardiomyocytes 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ADRB1, ADRB2   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 3  African trypanosomiasis 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  AGE-RAGE signaling pathway in diabetic complications 
 3 genes, 4 drugs (DrugBank), 25 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 5  Allograft rejection 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  Alzheimer disease 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 7  Amoebiasis 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 8  Amyotrophic lateral sclerosis (ALS) 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Antifolate resistance 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Apoptosis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 12  Asthma 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Bladder cancer 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 14  Breast cancer 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 15  C-type lectin receptor signaling pathway 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Calcium signaling pathway 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ADRB1, ADRB2   D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 17  cAMP signaling pathway 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] ADRB1, ADRB2   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 18  Cellular senescence 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 19  cGMP-PKG signaling pathway 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ADRB1, ADRB2   D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 20  Chagas disease (American trypanosomiasis) 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 21  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 22  Cytokine-cytokine receptor interaction 
 4 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 23  Cytosolic DNA-sensing pathway 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 24  Dilated cardiomyopathy (DCM) 
 2 genes, 4 drugs (DrugBank), 24 diseases shown 		  [1] ADRB1   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 25  EGFR tyrosine kinase inhibitor resistance 
 2 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 26  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 2 drugs (DrugBank), 5 diseases shown 		  [1] ESR1   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 27  Endocrine resistance 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 28  Epstein-Barr virus infection 
 4 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 29  Estrogen signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 30  Fc epsilon RI signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 31  Fluid shear stress and atherosclerosis 
 2 genes, 4 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 32  Focal adhesion 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 33  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 34  Gap junction 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] ADRB1   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 35  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 36  GnRH secretion 
 1 gene, 2 drugs (DrugBank), 5 diseases shown 		  [1] ESR2   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 37  Graft-versus-host disease 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 38  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 39  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 40  Hepatitis B 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] IFNAR1   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 41  Hepatitis C 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 42  Herpes simplex virus 1 infection 
 4 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 43  HIF-1 signaling pathway 
 2 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 44  Human cytomegalovirus infection 
 3 genes, 4 drugs (DrugBank), 25 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 45  Human immunodeficiency virus 1 infection 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 46  Human papillomavirus infection 
 4 genes, 5 drugs (DrugBank), 26 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 47  Human T-cell leukemia virus 1 infection 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 48  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 49  IL-17 signaling pathway 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  Inflammatory bowel disease (IBD) 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 51  Influenza A 
 5 genes, 4 drugs (DrugBank), 24 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 52  Insulin resistance 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 53  Intestinal immune network for IgA production 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 54  JAK-STAT signaling pathway 
 3 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 55  Kaposi sarcoma-associated herpesvirus infection 
 4 genes, 4 drugs (DrugBank), 14 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 56  Legionellosis 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 57  Leishmaniasis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 58  Malaria 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 59  MAPK signaling pathway 
 2 genes, 4 drugs (DrugBank), 25 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 60  Measles 
 3 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 61  MicroRNAs in cancer 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 62  mTOR signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  Natural killer cell mediated cytotoxicity 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  Necroptosis 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 65  Neuroactive ligand-receptor interaction 
 5 genes, 4 drugs (DrugBank), 17 diseases shown 		  [2] ADRB1, ADRB2   D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 66  NF-kappa B signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 67  NOD-like receptor signaling pathway 
 4 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  Osteoclast differentiation 
 3 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 70  Pancreatic cancer 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 71  Pathogenic Escherichia coli infection 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 72  Pathways in cancer 
 6 genes, 6 drugs (DrugBank), 16 diseases shown 		  [2] ESR1, ESR2   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 73  Pertussis 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 74  PI3K-Akt signaling pathway 
 4 genes, 4 drugs (DrugBank), 14 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 75  Prion diseases 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 76  Prolactin signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 77  Proteoglycans in cancer 
 3 genes, 6 drugs (DrugBank), 26 diseases shown 		  [1] ESR1   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 78  Rap1 signaling pathway 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 79  Ras signaling pathway 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 80  Regulation of lipolysis in adipocytes 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ADRB1, ADRB2   D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 81  Relaxin signaling pathway 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 82  Renal cell carcinoma 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 83  Renin secretion 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ADRB1, ADRB2   D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 84  Rheumatoid arthritis 
 3 genes, 4 drugs (DrugBank), 25 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 85  RIG-I-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Salivary secretion 
 3 genes, 2 drugs (DrugBank), 6 diseases shown 		  [2] ADRB1, ADRB2   D00378   Timolol   [2] 157, 227 
 D00603 
 D08600 
 [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 87  Salmonella infection 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 88  Shigellosis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  Sphingolipid signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 91  Systemic lupus erythematosus 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  T cell receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Th17 cell differentiation 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 95  Thermogenesis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 96  Thyroid hormone signaling pathway 
 1 gene, 2 drugs (DrugBank), 5 diseases shown 		  [1] ESR1   D00185   Estriol   [2] 13, 227 
 D01986 
 D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 97  TNF signaling pathway 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 98  Toll-like receptor signaling pathway 
 4 genes, 3 drugs (DrugBank), 20 diseases shown 		  [2] IFNAR1, IFNAR2   D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Toxoplasmosis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 100  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 101  Tuberculosis 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  Type I diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 103  Type II diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 104  VEGF signaling pathway 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 D05697   Ranibizumab   [4] 34, 166, 227, 301 
 105  Viral protein interaction with cytokine and cytokine receptor 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 106  Yersinia infection 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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