Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	ADRA2A	2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	D00514	Dexmedetomidine	14件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280
2	ADRA2B	2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	D00514	Dexmedetomidine	14件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280
3	ADRA2C	2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	D00514	Dexmedetomidine	14件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280
4	ACE	6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D00251	Captopril	8件: 6, 17, 46, 86, 96, 97, 107, 271
5	HTR3C	2件: Serotonergic synapse, Taste transduction	D00456	Ondansetron	3件: 6, 97, 107
6	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
7	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
8	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
9	HTR3D	2件: Serotonergic synapse, Taste transduction	D00456	Ondansetron	3件: 6, 97, 107
10	FDPS	4件: Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...	D08484	Risedronic acid	9件: 46, 50, 66, 93, 95, 96, 107, 113, 274

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