46. 悪性関節リウマチ Malignant rheumatoid arthritis Clinical trials / Disease details
臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT02936180 (ClinicalTrials.gov) | October 2016 | 7/10/2016 | Standard Versus High Dose Inactivated Influenza Vaccine in RA | Improving Influenza Immunization Responses in Rheumatoid Arthritis: A Strategy To Enhance Protection Against A Preventable Cause Of Death In An At Risk Population? | Rheumatoid Arthritis | Biological: HD-TIV;Biological: SD-QIV | McGill University Health Centre/Research Institute of the McGill University Health Centre | The Arthritis Society, Canada | Unknown status | 18 Years | N/A | All | 280 | Phase 4 | Canada |
| 2 | NCT02748785 (ClinicalTrials.gov) | September 2015 | 8/9/2015 | MTX Discontinuation and Vaccine Response | Effect of Methotrexate Discontinuation on Efficacy of Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis: A Randomized Clinical Trial | Arthritis, Rheumatoid | Drug: Methotrexate;Biological: Seasonal Influenza vaccine | Seoul National University Hospital | NULL | Completed | 18 Years | N/A | Both | 277 | Phase 4 | Korea, Republic of |
| 3 | NCT02311855 (ClinicalTrials.gov) | August 2014 | 4/12/2014 | Duration of Immune Response to Influenza Vaccination in Patients With RA | Duration of Immune Response to Influenza Vaccination in Patients With Rheumatoid Arthritis Receiving Treatment With Biologic Agents | Rheumatoid Arthritis | Biological: Influenza vaccine | Bassett Healthcare | New York State Department of Health | Completed | 40 Years | 75 Years | All | 87 | Phase 4 | United States |
| 4 | NCT01980836 (ClinicalTrials.gov) | November 2013 | 4/11/2013 | Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine | The Effect of Tocilizumab on the Cellular Immune Response to Seasonal Influnza Vaccine in Patients With Rheumatoid Arthritis | Rheumatoid Arthritis;Cellular Immune Response | Biological: Seasonal influenza vaccine | Tel-Aviv Sourasky Medical Center | NULL | Not yet recruiting | 18 Years | N/A | Both | 40 | Phase 4 | Israel |
| 5 | NCT01436370 (ClinicalTrials.gov) | October 2011 | 15/9/2011 | TIV and High Dose TIV in Subjects With Rheumatoid Arthritis | A Phase II Study in Adults With Rheumatoid Arthritis Receiving TNF-alpha-inhibitor Therapy to Assess the Immunogenicity and Safety of Trivalent Inactivated Vaccine (TIV) and High Dose Trivalent Inactivated Vaccine (High-Dose TIV) Administered at Two Dosage Levels | Influenza | Biological: Trivalent inactivated influenza vaccine | National Institute of Allergy and Infectious Diseases (NIAID) | NULL | Completed | 18 Years | 64 Years | All | 102 | Phase 2 | United States |
| 6 | NCT01151644 (ClinicalTrials.gov) | April 2010 | 25/6/2010 | Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases | Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases | Rheumatoid Arthritis;Spondyloarthritis;Systemic Lupus Erythematosus (SLE);Dermatomyositis (DM);DMixed Connective Tissue Disease;Systemic Vasculitis;Systemic Sclerosis (SSc);Sjögren's Syndrome;Antiphospholipid Syndrome;Juvenile Idiopathic Arthritis;Juvenile SLE;Juvenile DM | Biological: Anti-pandemic H1N1 influenza vaccine | University of Sao Paulo | Fundação de Amparo à Pesquisa do Estado de São Paulo | Active, not recruiting | N/A | N/A | Both | 5000 | Phase 4 | Brazil |
| 7 | NCT00993668 (ClinicalTrials.gov) | September 2009 | 9/10/2009 | Assessing the Use of Certolizumab Pegol in Adult Subjects With Rheumatoid Arthritis on the Antibody Response When Receiving Influenza Virus and Pneumococcal Vaccines | A Phase 4, Randomized, Single-blind, Placebo-controlled, Multicenter Study to Evaluate the Immunogenicity of Pneumococcal and Influenza Vaccines in Adult Subjects With Rheumatoid Arthritis Receiving Certolizumab Pegol or Placebo | Rheumatoid Arthritis | Other: Placebo;Biological: Certolizumab pegol | UCB Pharma | NULL | Completed | 18 Years | N/A | All | 224 | Phase 4 | United States |
| 8 | NCT00466037 (ClinicalTrials.gov) | September 2005 | 24/4/2007 | The Effect of Rituximab on the Humoral Response to Influenza Vaccine | Vaccination Against Influenza in Rheumatoid Arthritis Patients: The Effect of Rituximab on the Humoral Response | Rheumatoid Arthritis | Biological: Influenza vaccine | Tel-Aviv Sourasky Medical Center | NULL | Terminated | 18 Years | 85 Years | Both | 64 | N/A | NULL |