51. Scleroderma Clinical trials / Disease details

Clinical trials : 525 / Drugs : 565 - (DrugBank : 148) / Drug target genes : 114 - Drug target pathways : 217

5 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04797286 (ClinicalTrials.gov)	September 20, 2021	11/3/2021	Sildenafil for Early Pulmonary Vascular Disease in Scleroderma	Sildenafil for Early Pulmonary Vascular Disease in Scleroderma	Scleroderma;Mildly Elevated Pulmonary Pressures	Drug: Sildenafil;Other: Placebo	Johns Hopkins University	Louisiana State University Health Sciences Center in New Orleans	Recruiting	18 Years	N/A	All	30	Phase 2	United States
2	NCT03053739 (ClinicalTrials.gov)	December 2016	29/12/2016	To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis	Randomized Controlled Trial to Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis	Associated Pulmonary Arterial Hypertension	Drug: Sildenafil 20mg and Bosentan 62.5mg;Drug: Sildenafil 20mg and Placebo	Postgraduate Institute of Medical Education and Research	NULL	Recruiting	18 Years	N/A	All	50	Phase 4	India
3	NCT01347008 (ClinicalTrials.gov)	April 2011	2/5/2011	Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis	Effect of Sildenafil on the Microcirculatory Blood Flow and on the Endothelial Progenitor Cells in Patients With Systemic Sclerosis: a Randomized, Double-blind, Placebo-controlled Clinical Trial	Scleroderma, Systemic;Scleroderma, Diffuse;Scleroderma, Limited;Raynaud Phenomenon	Drug: Sildenafil citrate;Drug: Placebo (Sugar pill)	Federal University of São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	Completed	18 Years	N/A	Female	41	Phase 3	Brazil
4	NCT01295736 (ClinicalTrials.gov)	November 2010	11/2/2011	Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDY	Evaluation of the Efficacy of Sildenafil on Time to Healing in Patients With Scleroderma and Ischaemic Digital Ulcers: a Prospective, Longitudinal, Randomized, Comparative, Double-blind, 2-parallel-arm, Placebo-controlled Study	Systemic Scleroderma	Drug: Sildenafil;Drug: placebo	University Hospital, Lille	NULL	Completed	18 Years	N/A	Both	84	Phase 3	France
5	NCT00624273 (ClinicalTrials.gov)	February 2004	14/2/2008	Sildenafil for Treatment of Digital Ulcers in Patients With Systemic Sclerosis	Effect of Sildenafil on Digital Ulcers in Systemic Sclerosis	Active Digital Ulcers	Drug: Sildenafil therapy	Charite University, Berlin, Germany	NULL	Completed	18 Years	80 Years	Both	17	Phase 2	Germany