Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Abatacept [2] Abatacept; ORENCIA[1] D03203 [2] CD80,
CD86 💬		[13] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
2 Abituzumab [1] Abituzumab---[1] 51
3 Acetaminophen [4] Acetaminophen; Paracetamol; Tylenol; Ultracet[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
4 Acetate [1] Acetate---[41] 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
5 Acetylcysteine [3] Acetylcysteine; Mucomyst; N-acetylcysteine[1] D00221 --[21] 6, 13, 19, 20, 21, 49, 51, 53, 58, 63, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
6 Acetylsalicylic acid [2] ACETYLSALICYLIC ACID; Aspirin[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
7 Acotiamide [1] Acotiamide---[1] 51
8 Ajulemic acid [1] Ajulemic acid[1] D11312 [1] CNR2 💬[1] Neuroactive ligand-receptor interaction 💬[3] 50, 51, 299
9 Albendazole [2] Albendazole; Eskazole[1] D00134 --[12] 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127
10 Alemtuzumab [4] Alemtuzumab; Campath; Lemtrada; MABCAMPATH[1] D02802 [1] CD52 💬-[22] 13, 15, 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326
11 Alginic acid [3] Algin; Alginate; Alginic acid[1] D02324 --[4] 51, 53, 97, 299
12 Alprostadil [1] Alprostadil[1] D00180 [1] PTGER1 💬[4] Calcium signaling pathway, Human cytomegalovirus infection, Neuroactive ligand-receptor interaction, Pathways in cancer 💬[2] 51, 70
13 Ambrisentan [3] Ambrisentan; Letairis; Volibris[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211
14 Amlodipine [1] Amlodipine[1] D07450 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298
15 Antithymocyte immunoglobulin (rabbit) [10] Anti-thymocyte globulin; Antithymocyte immunoglobulin; Antithymocyte immunoglobulin (rabbit); Lapine T-Lymphocyte Immune Globulin; Rabbit anti-human thymocyte immunoglobulin; Rabbit antithymocyte globulin; Rabbit ATG; RATG; Thymoglobulin; THYMOGLOBULINE---[12] 13, 36, 49, 51, 60, 62, 65, 96, 283, 285, 286, 326
16 AstraZeneca COVID-19 Vaccine [3] ChAdOx1 nCoV-19; COVID-19 Vaccine AstraZeneca; Vaxzevria---[4] 46, 51, 53, 299
17 Atorvastatin [3] ATORVASTATIN; Atorvastatin Calcium; Lipitor[1] D07474 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
18 Aviptadil [1] Aviptadil[1] D12127 --[5] 49, 51, 84, 85, 86
19 Baricitinib [2] Baricitinib; OLUMIANT[1] D10308 [2] JAK1,
JAK2 💬		[35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[13] 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
20 Belimumab [2] Belimumab; BENLYSTA[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300
21 Belumosudil [1] Belumosudil[1] D11815 [1] ROCK2 💬[21] Axon guidance, Chemokine signaling pathway, Focal adhesion, Human cytomegalovirus infection, Leukocyte transendothelial migration, Lipid and atherosclerosis, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Proteoglycans in cancer, Regulation of actin cytoskeleton, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Tight junction, Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 85
22 Bentiromide [0] [1] D01346 --[3] 51, 117, 298
23 Benzoic acid [1] Benzoic acid[1] D00038 --[1] 51
24 Bermekimab [1] BERMEKIMAB[1] D11253 [1] IL1A 💬[21] AGE-RAGE signaling pathway in diabetic complications, Alzheimer disease, Cellular senescence, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Inflammatory bowel disease, Influenza A, Leishmaniasis, MAPK signaling pathway, Measles, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Rheumatoid arthritis, Tuberculosis, Type I diabetes mellitus 💬[1] 51
25 BMS-986020 [1] BMS-986020---[2] 51, 85
26 Bortezomib [3] BORTEZOMIB; Bortezomib Accord; VELCADE[1] D03150 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331
27 Bosentan [2] Bosentan; Tracleer[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
28 Botulinum toxin type A [8] Botox; Botulinum toxin A; BOTULINUM TOXIN TYPE A; BTX-A; Dysport; IncobotulinumtoxinA; OnabotulinumtoxinA; Xeomin[1] D00783 [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226
29 Botulinum toxin type B [3] Botulinum toxin type B; MYOBLOC; NEUROBLOC[1] D02735 [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[4] 2, 6, 13, 51
30 Bovine type I collagen [1] Bovine type I collagen---[1] 51
31 Brentuximab vedotin [2] Brentuximab; Brentuximab Vedotin[1] D09587 [10] TNFRSF8,
TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		[11] Alzheimer disease, Amyotrophic lateral sclerosis, Cytokine-cytokine receptor interaction, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬[2] 49, 51
32 Brodalumab [1] Brodalumab[1] D10061 [1] IL17RA 💬[3] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway 💬[2] 37, 51
33 Bupivacaine [2] Bupivacaine; BUPIVACAINE HYDROCHLORIDE[1] D07552 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[8] 46, 51, 53, 70, 96, 168, 226, 298
34 Buspirone [2] Buspirone; Buspirone Hydrochloride[1] D07593 [2] DRD2,
HTR1A 💬		[10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 51
35 Busulfan [3] Busilvex; Busulfan; BUSULFANO[1] D00248 --[13] 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326
36 Butyric Acid [4] Butanoic acid; Butyrate; Butyric Acid; Sodium Butyrate---[7] 34, 46, 51, 97, 156, 222, 291
37 Calcipotriol [2] Calcipotriene; CALCIPOTRIOL[1] D01125 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[2] 36, 51
38 Calcium [2] Calcio; Calcium---[27] 6, 13, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 156, 214, 215, 222, 224, 235, 265, 274, 298, 299
39 Cannabidiol [4] Cannabidiol; Epidiolex; Epidyolex; Sativex[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
40 Cetuximab [2] Cetuximab; Erbitux[1] D03455 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[2] 51, 86
41 Chloride ion [1] Chloride---[28] 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 288, 296, 297, 299, 338
42 Cholecalciferol [5] Cholecalciferol; COLECALCIFEROL; Multivitamin; Vitamin D; Vitamin D3[1] D00188 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[24] 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
43 Cilostazol [2] Cilostazol; PLETAL[1] D01896 [3] PDE3A,
PDE3B,
TBXA2R 💬		[14] Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 46, 51, 70
44 Clobetasol [1] Clobetasol[1] D07715 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[4] 39, 46, 51, 162
45 Clopidogrel [1] Clopidogrel[3] D07729 ,
D10823 ,
D10824 		[1] P2RY12 💬[1] Platelet activation 💬[3] 49, 51, 86
46 Coenzyme M [2] MESNA; UROMITEXAN---[10] 11, 13, 44, 45, 51, 60, 65, 85, 96, 164
47 Cyclophosphamide [6] Ciclofosfamida; Ciclofosfamide; Cyclophosphamid; CYCLOPHOSPHAMIDE; Cyclophosphamidum; Cytoxan[2] D00287 ,
D07760 		--[44] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 274, 283, 284, 285, 288, 326, 331
48 Dabigatran [1] Dabigatran[1] D09707 [1] F2 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton 💬[5] 51, 75, 85, 91, 124
49 Dabigatran etexilate [1] Dabigatran Etexilate[1] D07144 [1] F2 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton 💬[2] 51, 75
50 Dasatinib [1] Dasatinib[2] D03658 ,
D06414 		[8] ABL1,
EPHA2,
FYN,
KIT,
LCK,
PDGFRB,
SRC,
YES1 💬		[77] Acute myeloid leukemia, Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, Glioma, GnRH signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Mitophagy - animal, NF-kappa B signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Primary immunodeficiency, Prion disease, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Sphingolipid signaling pathway, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[2] 51, 85
51 Deferoxamine [3] Deferoxamine; Desferal; Desferrioxamine[1] D03670 --[5] 46, 51, 53, 284, 286
52 Diltiazem [2] Diltiazem; Diltiazem Hydrochloride[1] D07845 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86
53 Dimethyl fumarate [3] DIMETHYL FUMARATE; Dimethylfumarat; TECFIDERA[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[5] 13, 49, 51, 86, 296
54 Diphenhydramine [2] Diphenhydramine; Diphenhydramine hydrochloride[1] D00300 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[8] 11, 13, 49, 51, 70, 86, 222, 256
55 Dipyridamole [1] Dipyridamole[1] D00302 [2] PDE4A,
PDE5A 💬		[6] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 46, 49, 51, 66, 96, 224
56 Domperidone [1] Domperidone[2] D01745 ,
D07868 		[1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 6, 13, 17, 51, 230
57 Dupilumab [2] DUPILUMAB; Dupixent[1] D10354 [1] IL4R 💬[8] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Inflammatory bowel disease, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation 💬[5] 51, 97, 98, 160, 162
58 Factor XIII (human) [1] Factor XIII---[3] 51, 97, 288
59 Fasudil [1] Fasudil[1] D07941 [2] ROCK1,
ROCK2 💬		[23] Axon guidance, Chemokine signaling pathway, Focal adhesion, Human cytomegalovirus infection, Leukocyte transendothelial migration, Lipid and atherosclerosis, MicroRNAs in cancer, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Proteoglycans in cancer, Regulation of actin cytoskeleton, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, TGF-beta signaling pathway, Tight junction, Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 2, 5, 7, 51
60 Filgrastim [7] Filgrastim; Filgrastim Hexal; G-CSF; GRANULOCYTE COLONY STIMULATING FACTOR; Neupogen; TEVAGRASTIM; ZARZIO[1] D03235 [1] CSF3R 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[35] 2, 6, 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
61 Fludarabine [4] FLUDARA; Fludarabina; Fludarabine; FLUDARABINE PHOSPHATE[1] D07966 [1] RRM1 💬[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
62 Fresolimumab [2] Fresolimumab; GC1008[1] D09620 [3] TGFB1,
TGFB2,
TGFB3 💬		[35] AGE-RAGE signaling pathway in diabetic complications, Amoebiasis, Cell cycle, Cellular senescence, Chagas disease, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Diabetic cardiomyopathy, Dilated cardiomyopathy, FoxO signaling pathway, Gastric cancer, Hepatitis B, Hepatocellular carcinoma, Hippo signaling pathway, Human T-cell leukemia virus 1 infection, Hypertrophic cardiomyopathy, Inflammatory bowel disease, Intestinal immune network for IgA production, Leishmaniasis, MAPK signaling pathway, Malaria, MicroRNAs in cancer, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬[3] 51, 85, 222
63 Glycyrrhizic acid [1] Glycyrrhizin[1] D00157 --[2] 46, 51
64 Guselkumab [2] GUSELKUMAB; TREMFYA[1] D10438 [1] IL23A 💬[9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis 💬[5] 37, 41, 51, 96, 97
65 Human immunoglobulin G [19] Bivigam; CUTAQUIG; CUVITRU; GAMMAGARD LIQUID; Gammaplex; GAMUNEX-C; Hizentra; Human immunoglobulin G; Human normal immunoglobulin; HYQVIA; Immune globulin; Immunoglobulin; IMMUNOGLOBULIN G; IVIg; KIOVIG; Octagam; PANZYGA; PRIVIGEN; Vivaglobin---[10] 11, 13, 14, 17, 43, 45, 50, 51, 63, 65
66 Human interleukin-2 [3] Human interleukin-2; IL-2; INTERLEUKIN-2---[18] 2, 13, 35, 46, 49, 50, 51, 53, 55, 56, 60, 63, 65, 95, 96, 97, 162, 271
67 Human Umbilical Cord Mesenchymal Stem Cells [4] Human Umbilical Cord Mesenchymal Stem Cells; Mesenchymal Stromal Cells; UC-MSCs; WJ-MSCs---[13] 2, 13, 36, 46, 49, 51, 60, 96, 97, 107, 113, 274, 284
68 Hyaluronidase [2] Hyaluronidase; Hyaluronoglucosaminidase[3] D04455 ,
D04456 ,
D06604 		--[5] 14, 28, 51, 65, 331
69 Iguratimod [1] Iguratimod[1] D01146 [1] NFKB1 💬[76] AGE-RAGE signaling pathway in diabetic complications, Acute myeloid leukemia, Adipocytokine signaling pathway, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, Apoptosis, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, Cocaine addiction, Coronavirus disease - COVID-19, Cytosolic DNA-sensing pathway, Diabetic cardiomyopathy, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Longevity regulating pathway, MAPK signaling pathway, Measles, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prolactin signaling pathway, Prostate cancer, RIG-I-like receptor signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Salmonella infection, Shigellosis, Small cell lung cancer, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Viral carcinogenesis, Yersinia infection, cAMP signaling pathway 💬[5] 46, 51, 53, 271, 300
70 Iloprost [2] Iloprost; Ventavis[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86
71 Imatinib [4] Gleevec; GLIVEC; Imatinib; Imatinib Mesylate[1] D08066 [3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
72 Imiquimod [1] Imiquimod[1] D02500 [1] TLR7 💬[5] Coronavirus disease - COVID-19, Influenza A, Measles, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway 💬[2] 34, 51
73 Indocyanine green [1] INDOCYANINE GREEN[1] D01342 --[8] 22, 46, 51, 96, 235, 278, 291, 296
74 Indole [1] Indole---[1] 51
75 Inebilizumab [2] Inebilizumab; Uplizna[1] D11757 [1] CD19 💬[5] B cell receptor signaling pathway, Epstein-Barr virus infection, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Primary immunodeficiency 💬[4] 11, 13, 51, 300
76 Interleukin-1 alpha, human recombinant [1] None---[18] 6, 46, 51, 65, 66, 84, 85, 96, 97, 140, 161, 171, 222, 231, 246, 271, 299, 337
77 Itacitinib [1] Itacitinib[1] D10944 [1] JAK1 💬[27] Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[4] 46, 51, 97, 228
78 Ixazomib [2] Ixazomib; Ninlaro[1] D10130 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[5] 13, 16, 28, 51, 61
79 Lactobacillus delbrueckii bulgaricus [1] Lactobacillus---[5] 6, 46, 51, 97, 299
80 Lanifibranor [1] LANIFIBRANOR---[1] 51
81 Leuprolide [3] Leuprolide; Leuprolide acetate depot; Leuprorelin---[6] 1, 2, 3, 51, 67, 76
82 Lidocaine [4] Aloe; Lidocaine; Lignocaine; Xylocaine[2] D00358 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
83 Macitentan [2] MACITENTAN; Opsumit[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210
84 Magnesium [1] Magnesium---[19] 6, 11, 13, 46, 51, 63, 64, 70, 93, 97, 111, 166, 225, 235, 284, 291, 296, 297, 298
85 Medroxyprogesterone acetate [1] Medroxyprogesterone[1] D00951 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[8] 13, 35, 46, 49, 50, 51, 60, 107
86 Methotrexate [6] Methotrexat; Methotrexate; METHOTREXATE SODIUM; METOJECT; METOTREXATO; Méthotrexate[1] D00142 [2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
87 Methoxsalen [2] Methoxsalen; UVADEX[1] D00139 --[4] 36, 46, 51, 96
88 Methylprednisolone [4] Medrol; Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE[1] D00407 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[46] 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296
89 Methylprednisolone hemisuccinate [4] Methylprednisolone hemisuccinate; METHYLPREDNISOLONE SODIUM SUCCINATE; Methylprednisolone succinate; Solu-Medrol[1] D05000 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[7] 13, 49, 50, 51, 53, 97, 211
90 Metoclopramide [1] METOCLOPRAMIDE[1] D00726 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 46, 51
91 Metronidazole [3] Flagyl; Metronidazol; METRONIDAZOLE[1] D00409 --[7] 46, 51, 63, 94, 96, 97, 291
92 Mizoribine [2] BREDININ; Mizoribine[1] D01392 [2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[8] 46, 49, 51, 53, 66, 94, 222, 224
93 Moderna COVID-19 Vaccine [4] COVID-19 Vaccine Moderna; Elasomeran; Moderna COVID-19 Vaccine; Spikevax[1] D12114 --[5] 13, 46, 51, 65, 299
94 Monomethyl fumarate [2] Bafiertam; Monomethyl fumarate[1] D11492 --[16] 13, 35, 40, 46, 49, 50, 51, 60, 65, 66, 107, 162, 222, 224, 226, 299
95 Mycophenolate mofetil [3] CELLCEPT; Mycophenolate mofetil; Mycophenolate mofetil TEVA[1] D00752 [2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
96 Mycophenolic acid [5] Acido Micofenolico; MICOFENOLICO ACIDO; Mycophenolate; Mycophenolic Acid; Myfortic[1] D05096 [2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
97 N-acetylsulfanilyl chloride [0] ---[4] 36, 51, 96, 97
98 Nemolizumab [1] Nemolizumab[1] D11080 [1] IL31RA 💬[2] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway 💬[1] 51
99 Nilotinib [2] Nilotinib; TASIGNA[1] D08953 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86
100 Nintedanib [2] Nintedanib; Ofev[1] D10481 [8] FGFR1,
FGFR2,
FGFR3,
FLT1,
FLT4,
KDR,
PDGFRA,
PDGFRB 💬		[34] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, Gap junction, Gastric cancer, Glioma, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Transcriptional misregulation in cancer, VEGF signaling pathway 💬[5] 51, 85, 89, 227, 228
101 Nitroglycerin [2] Nitroglycerin; Nitroglycerine[1] D00515 --[2] 46, 51
102 Nitroprusside [2] Nitroprusside; SODIUM NITROPRUSSIDE---[1] 51
103 Nivolumab [1] Nivolumab[1] D10316 [1] PDCD1 💬[3] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer, T cell receptor signaling pathway 💬[12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159
104 Omeprazole [4] Losec; Omeprazol; Omeprazole; OMEPRAZOLE MAGNESIUM[1] D00455 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[14] 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
105 ORM-12741 [1] ORM-12741---[1] 51
106 Ozone [1] Ozone---[3] 49, 51, 226
107 Paquinimod [1] Paquinimod---[2] 49, 51
108 Penicillamine [2] D-penicillamine; PENICILLAMINE[1] D00496 --[2] 51, 171
109 Phosphate ion [1] Phosphate---[32] 2, 3, 6, 11, 12, 13, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
110 Pirfenidone [2] ESBRIET; Pirfenidone[1] D01583 [6] CCL2,
IL10,
IL1A,
IL1B,
IL6,
TNF 💬		[84] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
111 Pomalidomide [3] Imnovid; Pomalidomida; Pomalidomide[1] D08976 [2] IL6,
TNF 💬		[80] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[5] 28, 51, 85, 227, 331
112 Prednisolone [3] Prednisolona; Prednisolone; Prednisolonum[1] D00472 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[42] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300
113 Prednisone [3] Prednisona; Prednisone; RAYOS[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331
114 Propylene glycol [1] Propylene glycol[1] D00078 --[1] 51
115 Prucalopride [2] PRUCALOPRIDE; Resolor[1] D09205 [1] HTR4 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, cAMP signaling pathway 💬[3] 13, 51, 96
116 Pyrimethamine [2] Daraprim; Pyrimethamine[1] D00488 --[12] 2, 4, 6, 13, 19, 46, 51, 63, 65, 96, 97, 265
117 Rabbit [1] Rabbit---[8] 11, 13, 49, 51, 60, 65, 96, 285
118 Rabeprazole [1] Rabeprazole[1] D08463 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 2, 51
119 Rilonacept [1] Rilonacept[1] D06635 [2] IL1A,
IL1B 💬		[45] AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Herpes simplex virus 1 infection, Human cytomegalovirus infection, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Rheumatoid arthritis, Salmonella infection, Shigellosis, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Tuberculosis, Type I diabetes mellitus, Yersinia infection 💬[4] 51, 106, 107, 266
120 Riociguat [2] Adempas; Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[6] 51, 84, 86, 88, 225, 299
121 Rituximab [6] MABTHERA; Rituxan; RITUXIMAB; Rixathon; Ruxience; Truxima[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
122 Rosuvastatin [3] Crestor; Rosuvastatin; ROSUVASTATIN CALCIUM[1] D08492 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
123 Saccharomyces cerevisiae [1] Saccharomyces---[1] 51
124 Sapropterin [5] 6R-BH4; KUVAN; SAPROPTERIN; SAPROPTERIN DIHYDROCHLORIDE; Tetrahydrobiopterin[1] D08505 --[5] 51, 86, 124, 240, 299
125 Selexipag [2] SELEXIPAG; Uptravi[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[5] 51, 70, 84, 86, 88
126 Sildenafil [6] Mysildecard; Revatio; SILDENAFIL; SILDENAFIL CITRATE; SILDENAFILO; Viagra[1] D08514 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
127 Simvastatin [3] SIMVASTATIN; Simvastatina; Simvastatine[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
128 Sirolimus [3] Rapamune; Rapamycin; Sirolimus[1] D00753 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331
129 Sodium chloride [6] Lactated Ringers; Natriumchlorid; REBIF; SALINE; SODIUM CHLORIDE; SPORANOX[1] D02056 --[20] 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 168, 193, 227, 228, 288, 299
130 Sodium fluoride [1] Sodium fluoride[1] D00943 --[1] 51
131 Sodium tetradecyl sulfate [0] [1] D06882 --[2] 50, 51
132 Sulodexide [0] [1] D08547 [2] SERPINC1,
SERPIND1 💬		[1] Complement and coagulation cascades 💬[2] 51, 271
133 Tacrolimus [2] Prograf; Tacrolimus[2] D00107 ,
D08556 		[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
134 Tadalafil [4] Adcirca; CIALIS; TADALAFIL; TADALAFILO[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[7] 6, 51, 75, 84, 86, 113, 210
135 Teprotumumab [1] TEPEZZA[1] D09680 [1] IGF1R 💬[29] AMPK signaling pathway, Adherens junction, Autophagy - animal, Breast cancer, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Focal adhesion, FoxO signaling pathway, Glioma, HIF-1 signaling pathway, Hepatocellular carcinoma, Long-term depression, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Melanoma, Oocyte meiosis, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, mTOR signaling pathway 💬[1] 51
136 Terguride [1] Terguride[1] D01348 [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 51, 86
137 Thalidomide [1] Thalidomide[1] D00754 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
138 Thiotepa [1] Thiotepa[1] D00583 --[12] 13, 19, 20, 28, 51, 60, 65, 85, 96, 164, 284, 285
139 Tocilizumab [3] Actemra; RoActemra; TOCILIZUMAB[1] D02596 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
140 Tofacitinib [4] Tasocitinib; Tofacitinib; XELJANZ; Xeljanz XR[1] D09970 [4] JAK1,
JAK2,
JAK3,
TYK2 💬		[37] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
141 Tozinameran [2] Comirnaty; Tozinameran[1] D11971 --[5] 13, 46, 51, 53, 299
142 Treprostinil [4] Remodulin; Treprostinil; Treprostinilo; Tyvaso[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 51, 84, 85, 86, 88, 210
143 Trimebutine [1] Trimebutine[1] D08639 [2] OPRK1,
OPRM1 💬		[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 51
144 Tromethamine [4] Tham; Tris; Trometamol; Tromethamine[1] D00396 --[5] 51, 96, 97, 226, 299
145 Veledimex [1] Veledimex[1] D10678 --[1] 51
146 Yellow fever vaccine [1] Yellow fever vaccine[1] D06347 --[8] 40, 44, 46, 50, 51, 52, 53, 107
147 Zibotentan [1] Zibotentan[1] D07741 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51
148 Ziritaxestat [1] Ziritaxestat[1] D11844 [1] ENPP2 💬[2] Ether lipid metabolism, Metabolic pathways 💬[2] 51, 85