6. Parkinson disease Clinical trials / Disease details
Clinical trials : 2,307 / Drugs : 2,007 - (DrugBank : 349) / Drug target genes : 188 - Drug target pathways : 199
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ChiCTR2000039697 | 2020-11-15 | 2020-11-06 | Application of etomidate in deep brain stimulation under general anesthesia for Parkinson's disease | Application of etomidate in deep brain stimulation under general anesthesia for Parkinson's disease | Parkinson Disease | Experimental group:Etomidate-based anesthesia;Control group: Propofol-based anesthesia; | Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-Sen University | NULL | Recruiting | 18 | 80 | Both | Experimental group:30;Control group:30; | Phase 4 | China |
| 2 | NCT04502550 (ClinicalTrials.gov) | October 15, 2020 | 30/7/2020 | Brain Networks and Consciousness | Subcortical-cortical Network Dynamics of Anesthesia and Consciousness | Loss of Consciousness;Parkinson Disease;Essential Tremor;Anesthesia | Drug: Propofol | University of Texas Southwestern Medical Center | University of California, Los Angeles | Recruiting | 18 Years | N/A | All | 144 | United States | |
| 3 | ChiCTR1900021760 | 2019-03-09 | 2019-03-08 | Effect-site concentration of remifentanil for I-gel insertion in male patients with Parkinson’s disease undergoing deep brain stimulator implantation during target-controlled infusion of propofol | Effect-site concentration of remifentanil for I-gel insertion in male patients with Parkinson’s disease undergoing deep brain stimulator implantation during target-controlled infusion of propofol | Parkinson’s disease | Parkinson’s disease:propofol and remifentanil;Non-Parkinson’s disease:propofol and remifentanil; | The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China | NULL | Recruiting | 40 | 64 | Male | Parkinson’s disease:25;Non-Parkinson’s disease:25; | N/A | China |
| 4 | ChiCTR1800014542 | 2018-01-22 | 2018-01-20 | Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease | Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease | Parkinson's Disease | PD group:propofol;NPD group:propofol; | Xuanwu Hospital of CCMU | NULL | Recruiting | 18 | 65 | Both | PD group:40;NPD group:40; | China | |
| 5 | ChiCTR-IOR-16010168 | 2016-12-20 | 2016-12-15 | Propofol-remifetanyl vs dexmedetomidine continous infusion for deep brain stimulation implantation | Propofol-remifetanyl vs dexmedetomidine continous infusion for deep brain stimulation implantation | Parkinson's Disease | propofol-remifentanyl group:propofol-remifentany infusion for monitored anesthesia care during awake deep brain stimulation surgery;dexmedetomidine group:dexmedetomidine infusion for monitored anesthesia care during awake deep brain stimulation surgery; | West China Hospital, Sichuan University | NULL | Recruiting | 18 | Both | propofol-remifentanyl group:25;dexmedetomidine group:25; | China | ||
| 6 | NCT02256319 (ClinicalTrials.gov) | September 2014 | 30/9/2014 | Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators | Effects of Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity (Local Field Potentials) Measured Through Implanted Stimulators | Parkinson's Disease | Drug: Dexmedetomidine;Drug: Propofol | Clinica Universidad de Navarra, Universidad de Navarra | NULL | Completed | 18 Years | N/A | Both | 12 | Phase 4 | Spain |
| 7 | EUCTR2014-000868-17-ES (EUCTR) | 26/06/2014 | 17/03/2014 | Effect of dexmedetomidine vs propofol on basal ganglia activity (local field potentials) recorded through implanted stimulators | Effect of dexmedetomidine vs propofol on basal ganglia activity (local field potentials) recorded through implanted stimulators | Parkinson's disease MedDRA version: 16.1;Level: LLT;Classification code 10013113;Term: Disease Parkinson's;System Organ Class: 100000004852;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Dexdor Product Name: Dexdor INN or Proposed INN: DEXMEDETOMIDINE Other descriptive name: DEXMEDETOMIDINA Trade Name: Propofol-Lipuro Product Name: Propofol-Lipuro INN or Proposed INN: PROPOFOL Other descriptive name: PROPOFOL | Clínica Universidad de Navarra/Universidad de Navarra | NULL | Not Recruiting | Female: yes Male: yes | Spain | ||||
| 8 | NCT00615472 (ClinicalTrials.gov) | October 2003 | 9/1/2008 | Intravenous Versus Inhalational Anesthesia in Parkinson's Disease | Intravenous General Anesthesia Versus Inhalational General Anesthesia in Parkinson's Disease | Parkinson's Disease | Drug: Isoflurane;Drug: Remifentanil;Drug: Propofol | Columbia University | NULL | Terminated | 18 Years | N/A | All | 58 | N/A | United States |