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e.g. Sirolimus, Adalimumab

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12 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Avacincaptad pegol [1] Avacincaptad pegol;  -  -  -  [1] 301 💬
 2  Decitabine [1] Decitabine;  [1] D03665 💬 [3] DNMT1, DNMT3A, DNMT3B 💬 [3] Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer  [4] 13, 63, 90, 301 💬
 3  Doconexent - -  -  -  [10]  6 , 46, 48, 49, 90, 94, 113, 240, 299, 301 💬
 4  Emixustat [3] Emixustat; Emixustat hydrochloride; Emixustat hydrochloride (acu-4429);  [1] D10348 💬  -  -  [1] 301 💬
 5  Fomepizole - [1] D00707 💬 [3] ADH1A, ADH1B, ADH1C 💬 [9] Chemical carcinogenesis, Drug metabolism - cytochrome P450, Fatty acid degradation, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pyruvate metabolism, Retinol metabolism, Tyrosine metabolism  [1] 301 💬
 6  Icosapent [4] Eicosapentaenoic acid; Ethyl icosapent; Ethyl-icosapent; Icosapent;  [1] D08061 💬  -  -  [10]  8 , 46, 48, 49, 96, 97, 113, 296, 297, 301 💬
 7  Interferon Gamma [5] Fully human anti-interferon gamma monoclonal antibody; Interferon gamma; Interferon gamma 1b; Interferon gamma-1b; Interferon gamma-1b (actimmune);  -  -  -  [8] 18, 65, 85, 107, 228, 299, 301, 326 💬
 8  Interferon gamma-1b [2] Interferon gamma-1b; Interferon gamma-1b (actimmune);  [1] D00747 💬 [2] IFNGR1, IFNGR2 💬 [18] Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis  [7] 18, 65, 85, 228, 299, 301, 326 💬
 9  Metformin [21] 750 mg metformin and 7.5 g l-citrulline daily p.o.; Glucophage (metformin); L-citrulline and metformin & l-citrulline; Metformin; Metformin (generic); Metformin 500mg; Metformin and metformin & l-citrulline; Metformin hcl; Metformin hydrochloride; Metformin treatment; Metformin/cp-690,550; Metformina; Metformina - 500 30 compresse 500 mg; Metformine; Metformine arrow 500mg; Metformine hcl 500 pch; Metformine sandoz 850 mg filmomhulde tabletten; Other: metformin; Pioglitazone or metformin; Sitagliptin and metformin; [metformina];  [2] D00944
D04966 💬		 [2] PRKAA1, PRKAA2 💬 [19] AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway  [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
 10  Ranibizumab [3] Intravitreal injection ranibizumab; Ranibizumab; Ranibizumab injection (0.5 mg);  [1] D05697 💬 [1] VEGFA 💬 [22] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Calcium signaling pathway, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway  [4] 34, 166, 227, 301 💬
 11  Sildenafil [32] 20 mg sildenafil citrate by mouth; 5% sildenafil cream; Access program - sildenafil citrate, viagra, revatio; Bosentan and sildenafil; Duo-therapy with sildenafil + bosentan; Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); G04be03- sildenafil - sildenafil (citrato); Mono-therapy with sildenafil; Oral sildenafil; Other: standard of care sildenafil; Sildenafil; Sildenafil (50 mg); Sildenafil (acute-1 hour); Sildenafil (as citrate); Sildenafil (revatio); Sildenafil (revatio) 20 mg tid; Sildenafil (subchronic-4 weeks); Sildenafil 20 mg tablets; Sildenafil 20mg; Sildenafil 20mg and bosentan 62.5mg; Sildenafil 40mg oral capsule; Sildenafil and losartan; Sildenafil by injection; Sildenafil citrate; Sildenafil citrate (uk-92,480); Sildenafil filmtabletten; Sildenafil singly or in association with bosentan; Sildenafil therapy; Sildenafilo; Sitaxsentan and sildenafil; Sodium tanshinone iia sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth; Tadalafil and sildenafil;  [2] D02229
D08514 💬		 [1] PDE5A 💬 [3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway  [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
 12  Vanillic acid - -  -  -  [3] 90, 301, 302 💬