23. Prion disease
4 clinical trials,   5 drugs   (DrugBank: 2 drugs),   0 gene,   0 pathway

Searched query = "Prion disease", "Creutzfeldt-Jakob disease", "CJD", "Gerstmann-Straussler-Scheinker syndrome", "Fatal familial insomnia", "Kuru disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1EUCTR2010-022233-28-IT
(EUCTR)
20/06/201105/03/2012Fatal familial insomnia: preventive treatment with doxycycline of at risk individuals - Doxycycline in FFI individuals Subjects born between 1958 and 1969 belonging to the Treviso FFI family, tested previously for Prion D178N/129M mutation
MedDRA version: 14.1;Level: SOC;Classification code 10029205;Term: Nervous system disorders;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Trade Name: BASSADO
INN or Proposed INN: DOXYCYCLINE HYCLATE
IST. DI RICERCHE FARMACOLOG. M. NEGRINULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Italy
2EUCTR2006-001858-27-IT
(EUCTR)
21/06/200612/04/2007A randomized, double-blind pilot study vs placebo for the evaluation of efficacy and tolerability of doxycline administered by oral route in patients affected by Creutzfeldt-Jakob disease. - NDA randomized, double-blind pilot study vs placebo for the evaluation of efficacy and tolerability of doxycline administered by oral route in patients affected by Creutzfeldt-Jakob disease. - ND Creutzfeldt-Jakob Disease.
MedDRA version: 9.1;Level: LLT;Classification code 10011384;Term: Creutzfeldt-Jakob disease
Trade Name: BASSADO 10CPS 100MG
INN or Proposed INN: Doxycycline
ISTITUTO NEUROLOGICO CARLO BESTANULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Italy
3NCT00183092
(ClinicalTrials.gov)
April 200514/9/2005CJD (Creutzfeldt-Jakob Disease) Quinacrine StudyNovel Therapeutics For Prion Diseases: A Randomized, Double-blinded, Placebo-controlled Study of the Efficacy of Quinacrine in the Treatment of Sporadic Creutzfeldt-Jakob DiseaseCreutzfeldt-Jakob DiseaseDrug: Quinacrine;Drug: PlaceboUniversity of California, San FranciscoNational Institute on Aging (NIA)Completed18 YearsN/AAll69Phase 2United States
4NCT00104663
(ClinicalTrials.gov)
June 20043/3/2005PRION-1: Quinacrine for Human Prion DiseasePRION-1: Quinacrine for Human Prion Disease. A Partially Randomized Patient Preference Trial to Evaluate the Activity and Safety of Quinacrine in Human Prion DiseasePrion DiseaseDrug: QuinacrineMedical Research CouncilNULLCompleted12 YearsN/ABoth160N/AUnited Kingdom