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Creatine monohydrate    (DrugBank: Creatine)

12 diseases
告示番号疾患名（ページ内リンク）臨床試験数
1球脊髄性筋萎縮症1
2筋萎縮性側索硬化症2
5進行性核上性麻痺0
6パーキンソン病0
8ハンチントン病5
13多発性硬化症／視神経脊髄炎0
46悪性関節リウマチ0
49全身性エリテマトーデス0
50皮膚筋炎／多発性筋炎0
113筋ジストロフィー2
156レット症候群1
201アンジェルマン症候群0

1. 球脊髄性筋萎縮症　［臨床試験数：17，薬物数：16（DrugBank：8），標的遺伝子数：10，標的パスウェイ数：15］
Searched query = "Spinal and bulbar muscular atrophy", "Spinobulbar muscular atrophy", "SBMA", "Kennedy disease", "Kennedy-Alter-Sung syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 17 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1JPRN-UMIN000012503
2014/06/0125/12/2013Effect of creatine in SBMA patients: A double-blind, placebo-controlled clinical study Spinal and Bulbar Muscular AtrophyCreatine monohydrate 10 g, daily for 8 weeks
Creatine monohydrate 15 g, daily for 8 weeks
placebo for 8 weeks		Department of Neurology, Nagoya University Graduate School of MedicineNULLComplete: follow-up continuing20years-old80years-oldMale45Not applicableJapan

2. 筋萎縮性側索硬化症　［臨床試験数：508，薬物数：530（DrugBank：146），標的遺伝子数：170，標的パスウェイ数：221］
Searched query = "Amyotrophic lateral sclerosis", "ALS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 508 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT00069186
(ClinicalTrials.gov)		June 200317/9/2003Study of Creatine Monohydrate in Patients With Amyotrophic Lateral SclerosisA Phase III, Multi-Center, Double-Blind, Placebo Controlled, Randomized Study of Creatine Monohydrate in Patients With Amyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis (ALS)Drug: Creatine MonohydrateThe Avicena GroupNULLActive, not recruiting21 Years80 YearsBoth107Phase 3United States
2NCT00070993
(ClinicalTrials.gov)		December 20029/10/2003Creatine for the Treatment of Amyotrophic Lateral SclerosisClinical Trial of Creatine in Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisDrug: creatine monohydrateNational Center for Complementary and Integrative Health (NCCIH)Office of Dietary Supplements (ODS)Completed21 Years80 YearsBoth110Phase 2United States

5. 進行性核上性麻痺　［臨床試験数：82，薬物数：107（DrugBank：36），標的遺伝子数：60，標的パスウェイ数：90］
Searched query = "Progressive supranuclear palsy", "PSP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 82 trial found

6. パーキンソン病　［臨床試験数：2,123，薬物数：2,046（DrugBank：324），標的遺伝子数：183，標的パスウェイ数：198］
Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 2,123 trial found

8. ハンチントン病　［臨床試験数：197，薬物数：171（DrugBank：54），標的遺伝子数：82，標的パスウェイ数：144］
Searched query = "Huntington disease", "Huntington chorea"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
5 / 197 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01411163
(ClinicalTrials.gov)		April 20104/8/2011Premanifest Huntington's Disease Extension Study II: Creatine Safety & TolerabilityPremanifest Huntington's Disease Extension Study II: Creatine Safety & TolerabilityHuntington's DiseaseDrug: Creatine monohydrateMassachusetts General HospitalNational Institutes of Health (NIH)Completed26 YearsN/ABoth24Phase 2United States
2NCT00712426
(ClinicalTrials.gov)		September 20098/7/2008Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)Huntington's DiseaseDrug: Creatine Monohydrate;Drug: PlaceboMassachusetts General HospitalUniversity of Rochester;National Center for Complementary and Integrative Health (NCCIH)Terminated18 YearsN/ABoth553Phase 3United States;Australia;Canada;New Zealand
3NCT01411150
(ClinicalTrials.gov)		May 20094/8/2011Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension StudyPremanifest Huntington's Disease: Creatine Safety & Tolerability Extension StudyHuntington's DiseaseDrug: Creatine MonohydrateMassachusetts General HospitalNational Institutes of Health (NIH)Completed26 YearsN/ABoth38Phase 2United States
4NCT00592995
(ClinicalTrials.gov)		December 200728/12/2007Creatine Safety and Tolerability in Premanifest HD: PRECRESTCreatine Safety and Tolerability in Premanifest HD: PRECRESTHuntington DiseaseDrug: Creatine monohydrate;Drug: PlaceboMassachusetts General HospitalNULLCompleted26 YearsN/ABoth64Phase 2United States
5NCT01412151
(ClinicalTrials.gov)		April 20055/8/2011Creatine Safety & Tolerability in Huntington's DiseaseCreatine Safety & Tolerability in Huntington's Disease (CREST-X): A Single-Center, Open-Label, Long-Term Safety & Tolerability Extension Study of Creatine in Subjects With HDHuntington's Disease (HD)Drug: Creatine monohydrateMassachusetts General HospitalNULLCompleted18 YearsN/AAll10Phase 2United States

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13. 多発性硬化症／視神経脊髄炎　［臨床試験数：3,050，薬物数：2,147（DrugBank：348），標的遺伝子数：244，標的パスウェイ数：228］
Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 3,050 trial found

46. 悪性関節リウマチ　［臨床試験数：4,183，薬物数：2,538（DrugBank：401），標的遺伝子数：183，標的パスウェイ数：219］
Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 4,183 trial found

49. 全身性エリテマトーデス　［臨床試験数：827，薬物数：638（DrugBank：168），標的遺伝子数：108，標的パスウェイ数：191］
Searched query = "Systemic lupus erythematosus", "SLE"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 827 trial found

50. 皮膚筋炎／多発性筋炎　［臨床試験数：157，薬物数：207（DrugBank：76），標的遺伝子数：47，標的パスウェイ数：142］
Searched query = "Dermatomyositis", "Polymyositis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 157 trial found

113. 筋ジストロフィー　［臨床試験数：567，薬物数：442（DrugBank：93），標的遺伝子数：55，標的パスウェイ数：151］
Searched query = "Muscular dystrophy", "Dystrophinopathies", "Myotilinopathy", "Laminopathy", "Caveolinopathy", "LGMD1C", "Desminopathy", "Sarcoglycanopathy", "α-dystroglycanopathy", "FCMD", "Walker-Warburg syndrome", "Muscle-eye-brain disease", "Myotonic dystrophy", "Integrin α7 deficient CMD", "Rigid spine syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 567 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT00018109
(ClinicalTrials.gov)		June 20013/7/2001A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD)A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD)Muscular Dystrophy, DuchenneDrug: glutamine;Drug: creatine monohydrateNational Center for Research Resources (NCRR)Children's Research InstituteCompleted5 Years10 YearsMalePhase 3United States
2NCT00016653
(ClinicalTrials.gov)		June 200021/5/2001Creatine and Glutamine in Steroid-Naive Duchenne Muscular DystrophyA Multicenter Randomized Placebo-controlled Double-blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular DystrophyMuscular Dystrophy, DuchenneDrug: Creatine Monohydrate;Drug: GlutamineCooperative International Neuromuscular Research GroupNULLCompleted5 Years9 YearsMale48Phase 2;Phase 3United States;Belgium;Israel;Puerto Rico

156. レット症候群　［臨床試験数：36，薬物数：49（DrugBank：19），標的遺伝子数：77，標的パスウェイ数：112］
Searched query = "Rett syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 36 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01147575
(ClinicalTrials.gov)		January 200517/6/2010Effects of Creatine Supplementation in Rett SyndromeEffects of Creatine Supplementation in Rett Syndrome: A Randomized, Placebo-controlled TrialRett SyndromeDietary Supplement: Creatine monohydrate;Dietary Supplement: PlaceboMedical University of ViennaNULLCompleted3 Years24 YearsFemale21N/AAustria

201. アンジェルマン症候群　［臨床試験数：19，薬物数：30（DrugBank：7），標的遺伝子数：22，標的パスウェイ数：20］
Searched query = "Angelman syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 19 trial found

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