DDrare: Database of Drug Development for Rare Diseases

Leflunomide 20 mg+prednisone 0.5mg/kg/d (DrugBank: Prednisone, Leflunomide)

10 diseases

ID	Disease name (Link within this page)	Number of trials
11	Myasthenia	0
40	Takayasu arteritis	0
46	Malignant rheumatoid arthritis	0
49	Systemic lupus erythematosus	0
53	Sjogren syndrome	0
66	IgA nephropathy	1
162	Pemphigoid	0
224	Purpura nephritis	0
271	Ankylosing spondylitis	0
300	IgG4-related disease	0

11. Myasthenia [ 226 clinical trials, 172 drugs, (DrugBank: 45 drugs), 43 drug target genes, 118 drug target pathways]

Searched query = "Myasthenia", "MG"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 226 trial found

40. Takayasu arteritis [ 22 clinical trials, 46 drugs, (DrugBank: 20 drugs), 22 drug target genes, 111 drug target pathways]

Searched query = "Takayasu arteritis", "Aortitis syndrome", "Pulseless disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 22 trial found

46. Malignant rheumatoid arthritis [ 4,183 clinical trials, 2,538 drugs, (DrugBank: 401 drugs), 183 drug target genes, 219 drug target pathways]

Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 4,183 trial found

49. Systemic lupus erythematosus [ 827 clinical trials, 638 drugs, (DrugBank: 168 drugs), 108 drug target genes, 191 drug target pathways]

Searched query = "Systemic lupus erythematosus", "SLE"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 827 trial found

53. Sjogren syndrome [ 234 clinical trials, 270 drugs, (DrugBank: 85 drugs), 49 drug target genes, 174 drug target pathways]

Searched query = "Sjogren syndrome", "Sjögren syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 234 trial found

66. IgA nephropathy [ 199 clinical trials, 214 drugs, (DrugBank: 57 drugs), 32 drug target genes, 128 drug target pathways]

Searched query = "IgA nephropathy", "IgA nephritis", "Berger disease", "IgA-IgG nephropathy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 199 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04020328 (ClinicalTrials.gov)	September 12, 2019	10/7/2019	Leflunomide Plus Low Dose Corticosteroid in Immunoglobulin A (IgA) Nephropathy With Renal Insufficiency	A Randomized, Controlled Trial to Evaluate Leflunomide Plus Low Dose Corticosteroid Therapy in Progressive IgA Nephropathy With Renal Insufficiency	Glomerulonephritis, IGA;Renal Insufficiency, Chronic	Drug: Leflunomide 20 mg+prednisone 0.5mg/kg/d	Shenzhen Second People's Hospital	NULL	Recruiting	14 Years	65 Years	All	70	Phase 4	China

162. Pemphigoid [ 70 clinical trials, 117 drugs, (DrugBank: 46 drugs), 30 drug target genes, 128 drug target pathways]

Searched query = "Pemphigoid", "Epidermolysis bullosa acquisita"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 70 trial found

224. Purpura nephritis [ 10 clinical trials, 41 drugs, (DrugBank: 19 drugs), 15 drug target genes, 56 drug target pathways]

Searched query = "Purpura nephritis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 10 trial found

271. Ankylosing spondylitis [ 531 clinical trials, 343 drugs, (DrugBank: 66 drugs), 41 drug target genes, 141 drug target pathways]

Searched query = "Ankylosing spondylitis", "Spondylarthritis ankylopoietica"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 531 trial found

300. IgG4-related disease [ 31 clinical trials, 33 drugs, (DrugBank: 16 drugs), 11 drug target genes, 81 drug target pathways]

Searched query = "IgG4-related disease", "Autoimmune pancreatitis", "IgG4-related sclerosing cholangitis", "IgG4-related lacrimal gland, orbital, and salivary gland lesions", "IgG4-related kidney disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 31 trial found