DDrare: Database of Drug Development for Rare Diseases

Sinemet (carbidopa/levodopa) (DrugBank: Carbidopa, Levodopa)

8 diseases

ID	Disease name (Link within this page)	Number of trials
2	Amyotrophic lateral sclerosis	0
4	Primary lateral sclerosis	0
6	Parkinson disease	1
17	Multiple system atrophy	0
90	Retinitis pigmentosa	0
140	Dorabe syndrome	0
164	Oculocutaneous albinism	0
201	Angelman syndrome	0

2. Amyotrophic lateral sclerosis [ 508 clinical trials, 530 drugs, (DrugBank: 146 drugs), 170 drug target genes, 221 drug target pathways]

Searched query = "Amyotrophic lateral sclerosis", "ALS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 508 trial found

4. Primary lateral sclerosis [ 6 clinical trials, 16 drugs, (DrugBank: 8 drugs), 19 drug target genes, 32 drug target pathways]

Searched query = "Primary lateral sclerosis", "PLS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 6 trial found

6. Parkinson disease [ 2,123 clinical trials, 2,046 drugs, (DrugBank: 324 drugs), 183 drug target genes, 198 drug target pathways]

Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 2,123 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01617135 (ClinicalTrials.gov)	May 2012	7/5/2012	Safety, Pharmacokinetics and Efficacy Study of CVT-301 Inpatients With Parkinson's Disease and Off Episodes	A Randomized, Placebo-Controlled, Phase 2 Study of the Safety, Pharmacokinetics and Pharmacodynamics of CVT-310 (Levodopa Inhalation Powder) in Patients With Parkinson's Disease and Motor Response Fluctuations (Off Episodes)	Idiopathic Parkinson's Disease	Drug: CVT-301;Drug: Placebo;Drug: Sinemet (carbidopa/levodopa)	Acorda Therapeutics	Michael J. Fox Foundation for Parkinson's Research	Completed	30 Years	N/A	All	25	Phase 2	Israel;Serbia;United Kingdom

17. Multiple system atrophy [ 107 clinical trials, 153 drugs, (DrugBank: 48 drugs), 59 drug target genes, 104 drug target pathways]

Searched query = "Multiple system atrophy", "MSA-C", "MSA-P", "Olivopontocerebellar atrophy", "OPCA", "Striatonigral degeneration", "Shy-Drager syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 107 trial found

90. Retinitis pigmentosa [ 103 clinical trials, 158 drugs, (DrugBank: 42 drugs), 52 drug target genes, 107 drug target pathways]

Searched query = "Retinitis pigmentosa", "Rod dystrophy", "Rod-Cone Dystrophy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 103 trial found

140. Dorabe syndrome [ 83 clinical trials, 54 drugs, (DrugBank: 13 drugs), 48 drug target genes, 62 drug target pathways]

Searched query = "Dorabe syndrome", "Dravet syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 83 trial found

164. Oculocutaneous albinism [ 15 clinical trials, 57 drugs, (DrugBank: 34 drugs), 34 drug target genes, 136 drug target pathways]

Searched query = "Oculocutaneous albinism", "Hermansky-Pudlak syndrome", "Chediak-Higashi syndrome", "Griscelli syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 15 trial found

201. Angelman syndrome [ 19 clinical trials, 30 drugs, (DrugBank: 7 drugs), 22 drug target genes, 20 drug target pathways]

Searched query = "Angelman syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 19 trial found