DDrare: Database of Drug Development for Rare Diseases

Isotretinoin (DrugBank: Isotretinoin)

4 diseases

ID	Disease name (Link within this page)	Number of trials
36	Epidermolysis bullosa	1
39	Toxic epidermal necrolysis	1
159	Xeroderma pigmentosum	1
160	Congenital ichthyosis	1

36. Epidermolysis bullosa [ 147 clinical trials, 170 drugs, (DrugBank: 40 drugs), 32 drug target genes, 113 drug target pathways]

Searched query = "Epidermolysis bullosa", "EBS", "JEB", "DDEB", "RDEB", "Kindler syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 147 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00014729 (ClinicalTrials.gov)	October 2000	10/4/2001	Phase I Study of Isotretinoin in Patients With Recessive Dystrophic Epidermolysis Bullosa		Epidermolysis Bullosa	Drug: isotretinoin	University of North Carolina	NULL	Completed	15 Years	N/A	Both	20	Phase 1	NULL

39. Toxic epidermal necrolysis [ 11 clinical trials, 18 drugs, (DrugBank: 8 drugs), 11 drug target genes, 101 drug target pathways]

Searched query = "Toxic epidermal necrolysis", "Toxic epidermal necrosis", "TEN"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 11 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02795143 (ClinicalTrials.gov)	November 2016	6/6/2016	Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study	Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study	Toxic Epidermal Necrolysis	Drug: Isotretinoin;Other: Placebo	Massachusetts General Hospital	NULL	Recruiting	18 Years	69 Years	Both	40	N/A	United States

159. Xeroderma pigmentosum [ 5 clinical trials, 13 drugs, (DrugBank: 4 drugs), 4 drug target genes, 13 drug target pathways]

Searched query = "Xeroderma pigmentosum", "XP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 5 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00025012 (ClinicalTrials.gov)	June 1991	11/10/2001	Isotretinoin in Preventing Skin Cancer	Use Of Isotretinion For Prevention Of Skin Cancer In Patients With Xeroderma Pigmentosum Or Nevoid Basal Cell Carcinoma Syndrome	Melanoma (Skin);Non-melanomatous Skin Cancer	Drug: isotretinoin	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	NULL	Completed	2 Years	N/A	Both		N/A	United States

160. Congenital ichthyosis [ 32 clinical trials, 62 drugs, (DrugBank: 18 drugs), 15 drug target genes, 107 drug target pathways]

Searched query = "Congenital ichthyosis", "Keratinopathic ichthyosis", "Epidermolytic ichthyosis", "Harlequin ichthyosis", "Congenital Ichthyosiform Erythroderma", "Foliate ichthyosis", "Ichthyosis syndrome", "Netherton syndrome", "Sjogren-Larsson syndrome", "Sjögren-Larsson syndrome", "Keratitis-ichtyosis-deafness syndrome", "Dorfman-Chanarin syndrome", "Neutral lipid storage disease", "NLSD", "Multiple sulfatase deficiency", "Austin disease", "Recessive X-linked ichthyosis", "RXLI", "X-linked recessive ichthyosis", "Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature", "IBID", "Trichothiodystrophy", "Follicular ichthyosis", "Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome", "CHILD syndrome", "Conradi-Hunermann-Happle syndrome", "Conradi-Hünermann-Happle syndrome", "CHHS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 32 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04154293 (ClinicalTrials.gov)	December 3, 2019	1/11/2019	A Vehicle Controlled Study to Evaluate Safety and Efficacy of Topical TMB-001 for Treatment of Congenital Ichthyosis	A Randomized, Parallel, Double-Blind, Vehicle Controlled Study to Evaluate the Safety and Efficacy of Two Concentrations of Topical TMB-001 for the Treatment of Congenital Ichthyosis	Congenital Ichthyosis	Drug: Isotretinoin;Other: Vehicle	Timber Pharmceuticals LLC	NULL	Recruiting	9 Years	N/A	All	45	Phase 2	United States;Australia