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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
10 mg Prednisone1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 44
25 mg Prednisone1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 44
3Abatacept1件: Abatacept1件: D03203 2件: CD80,
CD86 💬		12件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
4Abatacept (CTLA4-Ig)1件: Abatacept1件: D03203 2件: CD80,
CD86 💬		12件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬1件: 44
5ALEMTUZUMAB1件: Alemtuzumab1件: D02802 1件: CD52 💬-17件: 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284
6Avacopan1件: Avacopan1件: D11093 1件: C5AR1 💬6件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬3件: 43, 44, 222
7Azathioprin-ratiopharm® 25 mg Filmtabletten----1件: 44
8Azathioprine1件: Azathioprine2件: D00238 ,
D03033 		--21件: 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
9Azathioprine 25 mg1件: Azathioprine2件: D00238 ,
D03033 		--1件: 44
10AZD7986----2件: 44, 299
11BELIMUMAB1件: Belimumab1件: D03068 1件: TNFSF13B 💬4件: Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
12Benralizumab1件: Benralizumab1件: D09874 1件: IL5RA 💬4件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬5件: 44, 45, 98, 162, 299
13Biological: Benralizumab, Biological: Placebo to Mepolizumab2件: Benralizumab,
Mepolizumab		2件: D04923 ,
D09874 		2件: IL5,
IL5RA 💬		13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬1件: 44
14Biological: Mepolizumab, Biological: Placebo to Benralizumab2件: Benralizumab,
Mepolizumab		2件: D04923 ,
D09874 		2件: IL5,
IL5RA 💬		13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬1件: 44
15Blisibimod1件: Blisibimod1件: D10311 --5件: 43, 44, 49, 63, 66
16CCX168----5件: 43, 44, 66, 109, 222
17Chimeric monoclonal antibody, IgG4 subtype----2件: 43, 44
18Corticosteroid----10件: 13, 42, 43, 44, 45, 66, 84, 96, 97, 222
19Corticosteroid and azathioprine1件: Azathioprine2件: D00238 ,
D03033 		--4件: 42, 43, 44, 45
20Cyclophosphamide1件: Cyclophosphamide2件: D00287 ,
D07760 		--45件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331
21Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids3件: Azathioprine,
Cyclophosphamide,
Methotrexate		6件: D00142 ,
D00238 ,
D00287 ,
D02115 ,
D03033 ,
D07760 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
22Cyclophosphamide/azathioprine2件: Azathioprine,
Cyclophosphamide		4件: D00238 ,
D00287 ,
D03033 ,
D07760 		--1件: 44
23Cyclophosphamidum1件: Cyclophosphamide2件: D00287 ,
D07760 		--1件: 44
24Cyclophosphamidum 500 mg1件: Cyclophosphamide2件: D00287 ,
D07760 		--1件: 44
25Depemokimab----1件: 44
26ENDOXAN----7件: 13, 28, 43, 44, 85, 96, 222
27Endoxan® 500 mg----1件: 44
28Fasenra1件: Benralizumab1件: D09874 1件: IL5RA 💬4件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬5件: 44, 45, 98, 162, 299
29GALEN® tablet----2件: 43, 44
30Glucocorticoid (GC)----2件: 43, 44
31Glucocorticoids----8件: 40, 41, 43, 44, 60, 62, 75, 300
32Glucocorticoids (GC)----2件: 43, 44
33Glucocorticoids - Reduced Dose----2件: 43, 44
34Glucocorticoids - Standard Dose----2件: 43, 44
35Glucocorticoids [Reduced Dose]----2件: 43, 44
36Glucocorticoids [Standard Dose]----2件: 43, 44
37Gusperimus1件: Gusperimus1件: D08032 --1件: 44
38Gusperimus + glucocorticoids1件: Gusperimus1件: D08032 --1件: 44
39Hydroxychloroquine1件: Hydroxychloroquine1件: D08050 --27件: 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299
40IFX-11件: Vilobelimab1件: D11838 1件: C5 💬10件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬3件: 43, 44, 269
41INS1007----2件: 44, 299
42L04AC06----2件: 44, 45
43MabThera1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬22件: 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271
44Mabthera®1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬6件: 13, 35, 43, 44, 46, 93
45MEDI-563----5件: 44, 45, 98, 162, 299
46MEPOLIZUMAB1件: Mepolizumab1件: D04923 1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬4件: 44, 45, 98, 162
47Mesna1件: Coenzyme M---11件: 11, 13, 44, 45, 49, 51, 60, 65, 85, 96, 164
48Metex 2,5 mg Tabletten----1件: 44
49Methotrexate1件: Methotrexate2件: D00142 ,
D02115 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
50Methotrexate 2.5 mg1件: Methotrexate2件: D00142 ,
D02115 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
51Methotrexate 25 mg1件: Methotrexate2件: D00142 ,
D02115 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
52METOJECT 10 mg/ml, solution injectable en seringue pré-remplie1件: Methotrexate2件: D00142 ,
D02115 		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44
53Mycophenolate1件: Mycophenolic acid1件: D05096 2件: IMPDH1,
IMPDH2 💬		3件: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
54Mycophenolate mofetil2件: Mycophenolate mofetil,
Mycophenolic acid		4件: D00752 ,
D05094 ,
D05095 ,
D05096 		2件: IMPDH1,
IMPDH2 💬		3件: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
55Mycophénolate mofétil----1件: 44
56Naltrexone1件: Naltrexone2件: D02095 ,
D05113 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬12件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226
57NALTREXONE HYDROCHLORIDE1件: Naltrexone2件: D02095 ,
D05113 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬8件: 10, 40, 41, 42, 43, 44, 45, 96
58NUCALA1件: Mepolizumab1件: D04923 1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 45
59Nucala 100 mg powder for solution for injection1件: Mepolizumab1件: D04923 1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 45
60ORENCIA1件: Abatacept1件: D03203 2件: CD80,
CD86 💬		12件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬14件: 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 160, 222, 271
61Other: No Plasma Exchange----2件: 43, 44
62Pednisone----2件: 43, 44
63Plaquenil - Hydroxychloroquine 200mg Film coated tablets1件: Hydroxychloroquine1件: D08050 --3件: 43, 44, 45
64Plasma exchange----5件: 13, 43, 44, 64, 222
65PREDNISOLONE1件: Prednisolone8件: D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
66Prednison acis® 20 mg----2件: 43, 44
67Prednison acis® 5 mg----2件: 43, 44
68Prednison acis¿ 20 mg----2件: 43, 44
69Prednison acis¿ 5 mg----2件: 43, 44
70Prednisone1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
71PredniSONE Tablets, USP1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬3件: 41, 43, 44
72Recombinant humanized monoclonal antibody specific for human IL-5----1件: 44
73Remission induction therapy----2件: 43, 44
74Reslizumab1件: Reslizumab1件: D08985 1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 98
75Rituximab1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬49件: 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
76Rituximab (Arm A)1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬2件: 43, 44
77Rituximab (Arm B)1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬2件: 43, 44
78RO0452294/V01----2件: 43, 44
79RO0452294/V02----3件: 35, 43, 44
80RoActemra1件: Tocilizumab1件: D02596 1件: IL6R 💬12件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬11件: 40, 41, 44, 46, 50, 51, 86, 107, 266, 271, 331
81SB-240563----3件: 44, 45, 98
82SB-240563 (mepolizumab)1件: Mepolizumab1件: D04923 1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 45
83Sulfamethoxazole1件: Sulfamethoxazole1件: D00447 --5件: 44, 49, 61, 85, 299
84Tocilizumab1件: Tocilizumab1件: D02596 1件: IL6R 💬12件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
85Tofacitinib1件: Tofacitinib1件: D09970 4件: JAK1,
JAK2,
JAK3,
TYK2 💬		37件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
86Trimethoprim1件: Trimethoprim2件: D00145 ,
D06236 		--7件: 36, 44, 49, 60, 61, 85, 299
87Trimethoprim Sulfamethoxazole2件: Sulfamethoxazole,
Trimethoprim		3件: D00145 ,
D00447 ,
D06236 		--1件: 44
88Vilobelimab1件: Vilobelimab1件: D11838 1件: C5 💬10件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬2件: 43, 44
89Vitamin D1件: Vitamin D---24件: 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
90Yellow fever vaccine1件: Yellow fever vaccine1件: D06347 --8件: 40, 44, 46, 50, 51, 52, 53, 107
91Yellow Fever vaccine (17D)1件: Yellow fever vaccine1件: D06347 --8件: 40, 44, 46, 50, 51, 52, 53, 107