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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
118F-AV-1451----3件: 5, 7, 127
218F-FDG1件: Fludeoxyglucose (18F)---13件: 5, 6, 7, 8, 13, 41, 46, 53, 84, 85, 96, 127, 300
318F-RO6958948----3件: 5, 7, 127
44-benzyl-2-naphtalen-1-yl-1,2,4-thiadiazolidine-3,5-dione----1件: 5
59-CIS, 12-CIS-11,11-D2-LINOLEIC ACID ETHYL ESTER1件: Linoleic acid---2件: 2, 5
6[18F] APN-1607----1件: 5
7[18F]-PI2620----1件: 5
8[18F]Florbetapir----1件: 5
9[18F]MNI-815 (MNI-815)----1件: 5
10[18F]MNI-952----1件: 5
11[18F]MNI-958----1件: 5
12[18F]T807 ([18F]MNI-777)----2件: 5, 6
13[F18]-FDDNP----1件: 5
14AB1010----6件: 2, 5, 6, 13, 46, 96
15ABBV-8E12----2件: 5, 7
16AL----10件: 5, 7, 13, 28, 51, 67, 86, 97, 114, 127
17AL-108----1件: 5
18Alpha-lipoic acid and L-acetyl carnitine2件: Levocarnitine,
Lipoic acid		5件: D00048 ,
D00086 ,
D02030 ,
D02176 ,
D04713 		--1件: 5
19Anti-Parkinson medication----5件: 5, 6, 7, 8, 17
20Antisense oligonucleotide----1件: 5
21Apomorphine1件: Apomorphine2件: D02004 ,
D07460 		2件: DRD1,
DRD2 💬		11件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 5, 6, 7
22ASK Nr. 21972----1件: 5
23Azilect1件: Rasagiline3件: D02562 ,
D08469 ,
D10829 		1件: MAOB 💬14件: Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬4件: 2, 5, 6, 17
24AZP2006 oral solution----1件: 5
25Bepranemab----1件: 5
26BIIB092----3件: 5, 7, 127
27BMS-9861681件: Gosuranemab1件: D11293 1件: MAPT 💬4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬1件: 5
28BMS986168----1件: 5
29BOTULINUM TOXIN TYPE A1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬10件: 2, 5, 6, 7, 13, 15, 17, 70, 113, 149
30Brain PET scan----3件: 5, 7, 127
31Carnitine1件: Levocarnitine3件: D02030 ,
D02176 ,
D04713 		--9件: 5, 13, 58, 86, 96, 97, 265, 298, 316
32Coenzym Q10 Nanodispersion----1件: 5
33Coenzym Q10, Ubiquinon, Ubichinon----1件: 5
34Coenzyme Q101件: Ubidecarenone1件: D01065 --12件: 2, 5, 6, 8, 10, 18, 46, 57, 113, 193, 214, 215
35CoQ10----3件: 5, 6, 8
36Creatine1件: Creatine---16件: 1, 2, 3, 5, 6, 8, 13, 15, 21, 46, 49, 50, 113, 156, 201, 256
37DaTSCAN1件: Ioflupane I-123---4件: 2, 5, 6, 17
38DaTSCAN™ Ioflupane (123I) Injection1件: Ioflupane I-123---3件: 5, 6, 17
39Davunetide1件: Davunetide1件: D09401 --3件: 5, 7, 127
40Davunetide (AL-108, NAP)1件: Davunetide1件: D09401 --3件: 5, 7, 127
41Deep Brain Stimulation----5件: 5, 6, 7, 8, 17
42Diagnostic Test: [18F]-RO6958948----5件: 5, 6, 7, 17, 127
43Diagnostic Test: Elecsys (Roche) Abeta42, Ttau and Ptau----5件: 5, 6, 7, 17, 127
44Diagnostic Test: Flutemetamol F18 Injection2件: Flutemetamol,
Flutemetamol (18F)		---5件: 5, 6, 7, 17, 127
45Diagnostic Test: Lumipulse (Fujirebio) Abeta42, Ttau and Ptau----5件: 5, 6, 7, 17, 127
46Donepezil1件: Donepezil2件: D00670 ,
D07869 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬9件: 5, 6, 13, 46, 78, 124, 127, 156, 206
47Droxidopa1件: Droxidopa1件: D01277 9件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		14件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 5, 6, 17, 169, 170
48Emeramide1件: Emeramide---2件: 5, 17
49Example1件: Hydroxide ion---1件: 5
50Exelon 1,5 mg Hartkapseln1件: Rivastigmine2件: D02558 ,
D03822 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬1件: 5
51Exelon 3,0 mg Hartkapseln1件: Rivastigmine2件: D02558 ,
D03822 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬1件: 5
52Exelon 6,0 mg Hartkapseln1件: Rivastigmine2件: D02558 ,
D03822 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬1件: 5
53F-18----2件: 5, 127
54F-18 AV 1451----1件: 5
55Fasudil1件: Fasudil1件: D07941 2件: ROCK1,
ROCK2 💬		23件: Axon guidance, Chemokine signaling pathway, Focal adhesion, Human cytomegalovirus infection, Leukocyte transendothelial migration, Lipid and atherosclerosis, MicroRNAs in cancer, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Proteoglycans in cancer, Regulation of actin cytoskeleton, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, TGF-beta signaling pathway, Tight junction, Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 2, 5, 7, 51
56Flortaucipir1件: Flortaucipir1件: D11210 1件: MAPT 💬4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬3件: 5, 7, 127
57Flortaucipir F181件: Flortaucipir1件: D11210 1件: MAPT 💬4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬3件: 5, 7, 127
58Flutemetamol1件: Flutemetamol (18F)---5件: 5, 6, 7, 17, 127
59Flutemetamol F182件: Flutemetamol,
Flutemetamol (18F)		---5件: 5, 6, 7, 17, 127
60Fresh Frozen Plasma----1件: 5
61GDNF & Synchro Med Infusion System----1件: 5
62Gold1件: Gold---43件: 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 171, 193, 218, 222, 224, 227, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318
63Hydrogen1件: Hydrogen---7件: 5, 6, 13, 17, 83, 97, 226
64Leucine1件: Leucine1件: D00030 --11件: 5, 6, 7, 19, 65, 96, 97, 127, 283, 284, 299
65Linoleic acid1件: Linoleic acid---4件: 2, 5, 13, 299
66Lipoic acid1件: Lipoic acid2件: D00048 ,
D00086 		--5件: 2, 5, 13, 14, 20
67Lithium1件: Lithium citrate1件: D04749 --5件: 2, 5, 6, 7, 8
68MASITINIB1件: Masitinib1件: D10229 1件: KIT 💬11件: Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬6件: 2, 5, 6, 13, 46, 96
69Masitinib 100mg1件: Masitinib1件: D10229 1件: KIT 💬11件: Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬2件: 2, 5
70Masitinib 200mg1件: Masitinib1件: D10229 1件: KIT 💬11件: Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬2件: 2, 5
71MASITINIB MESYLATE1件: Masitinib1件: D10229 1件: KIT 💬11件: Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬6件: 2, 5, 6, 13, 46, 96
72N1,N3-BIS(2-MERCAPTOETHYL) ISOPHTHALAMIDE----2件: 5, 17
73NBMI----2件: 5, 17
74Niacinamide1件: Nicotinamide1件: D00036 --4件: 5, 6, 13, 67
75Nitrogen1件: Nitrogen1件: D00083 --6件: 5, 6, 17, 171, 211, 299
76NP031112----1件: 5
77NP031112 600mg----1件: 5
78NP031112 800mg----1件: 5
79NT 101----4件: 5, 6, 7, 17
80Other: 13C6 Leucine1件: Leucine1件: D00030 --3件: 5, 7, 127
81Placebo----27件: 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
82Pyruvate, creatine, niacinamide2件: Creatine,
Nicotinamide		1件: D00036 --1件: 5
83Raclopride1件: Raclopride---4件: 5, 6, 7, 17
84Radiopharmaceuticals----1件: 5
85Rasagilin----2件: 5, 6
86Rasagiline1件: Rasagiline3件: D02562 ,
D08469 ,
D10829 		1件: MAOB 💬14件: Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬4件: 2, 5, 6, 17
87RASAGILINE MESILATE1件: Rasagiline3件: D02562 ,
D08469 ,
D10829 		1件: MAOB 💬14件: Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬3件: 2, 5, 6
88RILUZOLE1件: Riluzole1件: D00775 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
89RIVASTIGMINE1件: Rivastigmine2件: D02558 ,
D03822 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬3件: 5, 6, 13
90RT001----3件: 2, 5, 120
91Salsalate1件: Salsalate1件: D00428 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 5
92Single dose C2N-8E12----1件: 5
93Stem cell therapy----1件: 5
94Sugar pill----8件: 5, 6, 49, 67, 70, 86, 206, 210
95Suvorexant1件: Suvorexant1件: D10082 2件: HCRTR1,
HCRTR2 💬		1件: Neuroactive ligand-receptor interaction 💬3件: 5, 6, 13
96Tideglusib1件: Tideglusib---2件: 5, 113
97Tolfenamic Acid1件: Tolfenamic acid1件: D01183 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 5
98TPI 287 2 mg/m2----2件: 5, 7
99TPI-287 20 mg/m2----2件: 5, 7
100TPI-287 6.3 mg/m2----2件: 5, 7
101TPN-101, 100 mg/day----1件: 5
102TPN-101, 200 mg/day----1件: 5
103TPN-101, 400 mg/day----3件: 2, 5, 127
104Trihexyphenidyl1件: Trihexyphenidyl2件: D00787 ,
D08638 		5件: CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		13件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬2件: 5, 6
105Ubidecarenon----1件: 5
106UCB0107 (bepranemab)----1件: 5
107Valproic Acid1件: Valproic acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬10件: 3, 5, 26, 34, 65, 89, 90, 222, 256, 331
108Vizamyl1件: Flutemetamol (18F)---3件: 5, 7, 127
109Vizamyl (flutemetamol(F-18))2件: Flutemetamol,
Flutemetamol (18F)		---3件: 5, 7, 127
110Water1件: Water1件: D00001 --23件: 2, 5, 6, 13, 17, 19, 22, 35, 46, 51, 53, 56, 57, 63, 65, 67, 78, 84, 96, 97, 226, 278, 299
111Xeomin1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬7件: 5, 6, 7, 13, 15, 17, 113
112Zoledronic acid1件: Zoledronic acid4件: D01968 ,
D06378 ,
D06379 ,
D08689 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬12件: 5, 6, 13, 17, 46, 93, 95, 96, 270, 274, 299, 333
113Zoledronic Acid 5Mg/Bag 100Ml Inj1件: Zoledronic acid4件: D01968 ,
D06378 ,
D06379 ,
D08689 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬3件: 5, 6, 17
114Zolpidem1件: Zolpidem2件: D00706 ,
D08690 		16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬3件: 5, 6, 46