Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acetaminophen
(Synonym: Acetaminophen Extended Release)		5件: Acetaminophen; Oxycodone/Acetaminophen; PARACETAMOL; Tylenol; Ultracet1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬18件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
2 Acetazolamide
(Synonym: Acetazolamide Extended-release)		1件: Acetazolamide2件: D00218 ,
D01196 		13件: CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		7件: Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬8件: 13, 86, 90, 115, 154, 155, 225, 230
3 Acetylsalicylic acid
(Synonym: Aspirin Coated for Delayed Release Extra Strength)		2件: Acetylsalicylic acid; Aspirin1件: D00109 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬15件: 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
4 Alfuzosin
(Synonym: Alfuzosin Hydrochloride extended release)		1件: Alfuzosin2件: D01692 ,
D07124 		1件: ADRA1A 💬7件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 13
5 alpha-Tocopherol acetate
(Synonym: Icaps Time Release)		3件: Tocopherol acetate; TOCOPHERYL ACETATE; Vitamin E---2件: 49, 206
6 Alprazolam
(Synonym: Alprazolam Extended-release)		1件: Alprazolam1件: D00225 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 8, 75
7 Amoxicillin
(Synonym: Amoxicillin and Clavulanate Potassium Extended Release)		4件: Amoxicilina; Amoxicillin; Amoxycillin; Augmentin3件: D00229 ,
D02925 ,
D07452 		--9件: 6, 19, 46, 63, 84, 96, 97, 222, 299
8 Ascorbic acid
(Synonym: Vitamin C Timed Release Tab 500mg)		4件: Acidum ascorbicum; Ascorbic Acid; Iron; Vitamin C1件: D00018 --8件: 10, 97, 192, 206, 210, 211, 212, 298
9 Beta carotene
(Synonym: Icaps Time Release)		3件: Beta carotene; Beta-Carotene; BETACAROTENE1件: D03101 --2件: 13, 96
10 Biotin
(Synonym: Timed Release B-complex 50)		4件: BIOTIN; Biotina; D-BIOTIN; Vitamin B71件: D00029 --5件: 2, 8, 10, 13, 20
11 Bisacodyl
(Synonym: Delayed Release Laxative Bisacodyl)		1件: Bisacodyl1件: D00245 --1件: 13
12 Bupropion
(Synonym: Naltrexone Hydrochloride and Bupropion Hydrochloride Extended-Release)		2件: Bupropion; Bupropion Hydrochloride3件: D00817 (Name: BUPROPION HYDROCHLORIDE EXTENDED RELEASE),
D07591 ,
D07938 		2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬5件: 8, 18, 21, 96, 171
13 Calcium
(Synonym: Timed Release and Esterified Vitamin C-500)		2件: Calcio; Calcium---30件: 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
14 Calcium carbonate
(Synonym: Swiss One Timed Release Tab)		3件: Calcio carbonato; Calcium; Calcium Carbonate2件: D00932 ,
D10802 		--9件: 13, 19, 46, 53, 75, 96, 235, 274, 299
15 Chlorpheniramine
(Synonym: Tussicaps Extended-release)		1件: Clorfenamina4件: D00665 ,
D00668 ,
D07398 ,
D07803 		1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬1件: 14
16 Choline
(Synonym: Timed Release B-complex 100)		1件: Choline1件: D07690 --4件: 93, 171, 193, 299
17 Chromium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Chromium---1件: 46
18 Clarithromycin
(Synonym: Clarithromycin Extended-Release)		1件: Clarithromycin1件: D00276 --8件: 6, 63, 84, 96, 97, 222, 228, 299
19 Clavulanic acid
(Synonym: Amoxicillin and Clavulanate Potassium Extended Release)		4件: AMOXICILLIN; Augmentin; Clavulanate; CLAVULANIC ACID1件: D07711 --1件: 299
20 Clonidine
(Synonym: Clonidine hydrochloride extended-release)		4件: Clonidin; Clonidina; Clonidine; Clonidine hydrochloride2件: D00281 ,
D00604 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬4件: 6, 65, 70, 78
21 Copper
(Synonym: Timed Release Vita-vim Srt)		2件: Copper; Nicotinamide---4件: 2, 169, 170, 171
22 Cyanocobalamin
(Synonym: Timed Release B Complex 100 Srt)		2件: Cianocobalamina; Vitamin B124件: D00166 ,
D03615 ,
D03616 ,
D03617 		--5件: 6, 13, 201, 229, 299
23 Cysteamine
(Synonym: PROCYSBI Delayed-release)		8件: 2-aminoethanethiol; Beta-Mercaptoethylamine; CYSTADROPS; Cystagon; Cysteamine; Mercaptamina; Mercaptamine; PROCYSBI2件: D03634 ,
D03635 		--4件: 8, 19, 21, 299
24 Darifenacin
(Synonym: Darifenacin Hydrobromide Extended-Release)		2件: Darifenacin; Emselex2件: D01699 ,
D03654 		1件: CHRM3 💬11件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬2件: 6, 13
25 Dextromethorphan
(Synonym: Tylenol Cold Nightime Rapid Release)		4件: Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta3件: D00848 ,
D03742 ,
D03744 		6件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
26 Diclofenac
(Synonym: Diclofenac Sodium Delayed-release)		3件: Diclofenac; Diclofenac Sodium; Diclofenac SR3件: D00903 ,
D00904 (Name: DICLOFENAC SODIUM DELAYED RELEASE),
D07816 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬5件: 13, 34, 46, 78, 271
27 Diltiazem
(Synonym: Diltiazem Hydrochloride Extended Release Extended Release)		2件: Diltiazem; Diltiazem Hydrochloride3件: D00616 (Name: DILTIAZEM HYDROCHLORIDE EXTENDED RELEASE),
D03830 ,
D07845 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 58, 86
28 Dimethyl fumarate
(Synonym: Sandoz Dimethyl Fumarate Delayed-release Capsules)		3件: Dimethyl fumarate; Dimethylfumarat; TECFIDERA1件: D03846 1件: KEAP1 💬6件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬5件: 13, 49, 51, 86, 296
29 Diphenhydramine
(Synonym: Rx Act Pain Relief PM Extra Strengh Rapid Release)		2件: Diphenhydramine; Diphenhydramine hydrochloride6件: D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
30 Dipyridamole
(Synonym: Aspirin and Extended-release Dipyridamole)		1件: Dipyridamole1件: D00302 2件: PDE4A,
PDE5A 💬		6件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 46, 49, 51, 66, 96, 224
31 Donepezil
(Synonym: Memantine and Donepezil Hydrochlorides Extended-release)		3件: ARICEPT; Donepezil; Donepezil hydrochloride2件: D00670 ,
D07869 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬9件: 5, 6, 13, 46, 78, 124, 127, 156, 206
32 Doxycycline
(Synonym: Doxycycline Hyclate Delayed Release)		4件: Doxycyclin; DOXYCYCLINE; Doxycycline Hyclate; Doxycycline Tablets5件: D00307 ,
D02129 ,
D03903 ,
D03904 ,
D07876 		--16件: 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 161, 162, 167, 227, 280, 299
33 Duloxetine
(Synonym: Duloxetine Hydrochloride Delayed Release)		3件: CYMBALTA; Duloxetine; Duloxetine hydrochloride2件: D01179 ,
D07880 		2件: SLC6A2,
SLC6A4 💬		2件: Serotonergic synapse, Synaptic vesicle cycle 💬2件: 6, 13
34 Ergocalciferol
(Synonym: Timed Release Vita-vim Srt)		3件: Ergocalciferol; Vitamin D; Vitamin D21件: D00187 1件: VDR 💬5件: Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬6件: 46, 49, 84, 96, 97, 299
35 Erythromycin
(Synonym: Eryc Delayed-release Capsules)		1件: Erythromycin9件: D00140 ,
D00851 ,
D01361 ,
D02009 ,
D02184 ,
D02523 ,
D02524 ,
D02525 ,
D04054 		--5件: 6, 36, 164, 228, 291
36 Ferrous sulfate anhydrous
(Synonym: Iron Cap 50mg Time Release)		0件: ---1件: 46
37 Folic acid
(Synonym: Time Release B 100 Compound - Tablet)		5件: Acide folique; Folate; Folic Acid; Multivitamin; NICOTINAMIDE1件: D00070 --6件: 6, 13, 41, 46, 49, 84
38 Guanfacine
(Synonym: Guanfacine Extended-Release)		1件: Guanfacine2件: D00606 (Name: GUANFACINE EXTENDED-RELEASE),
D08031 		1件: ADRA2A 💬2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 193
39 Hydromorphone
(Synonym: Hydromorph Contin-controlled Release Cap - 18mg)		1件: Hydromorphone2件: D00839 ,
D08047 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
40 Ibuprofen
(Synonym: Nuprin Immediate Release)		2件: Ibuprofen; IBUPROFEN 200MG4件: D00126 ,
D01122 ,
D04490 ,
D06606 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬7件: 13, 46, 65, 107, 113, 271, 299
41 Indomethacin
(Synonym: Indomethacin extended-release)		2件: INDOMETACIN; Indomethacin3件: D00141 (Name: INDOMETHACIN EXTENDED-RELEASE),
D01565 ,
D02110 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬3件: 225, 271, 298
42 Inositol
(Synonym: Timed Release B Complex 100 Srt)		1件: Inositol1件: D08079 --2件: 96, 97
43 Iodine
(Synonym: Timed Release Vita-vim Srt)		2件: Iodine; Iodo1件: D00108 --3件: 28, 46, 88
44 Iron
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Iron---6件: 18, 96, 97, 238, 254, 284
45 Ketoprofen
(Synonym: Oruvail Extended-Release)		1件: Ketoprofen1件: D00132 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 46
46 Lamotrigine
(Synonym: Lamotrigine Extended Release)		2件: Lamictal; LAMOTRIGINE1件: D00354 (Name: LAMOTRIGINE EXTENDED RELEASE)5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬5件: 13, 34, 38, 114, 144
47 Lansoprazole
(Synonym: Equate Lansoprazole Delayed Release)		1件: Lansoprazole1件: D00355 2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬7件: 63, 71, 85, 98, 166, 222, 299
48 Levetiracetam
(Synonym: LEVETIRACETAM Extended-release)		2件: KEPPRA; Levetiracetam1件: D00709 (Name: LEVETIRACETAM EXTENDED RELEASE)1件: SV2A 💬1件: ECM-receptor interaction 💬5件: 2, 4, 6, 13, 307
49 Lidocaine
(Synonym: Lidovix Delayed Release)		4件: Aloe; Lidocaine; Lignocaine; Xylocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬13件: 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
50 Loratadine
(Synonym: KIRKLAND SIGNATURE ALLERCLEAR D 24 HR Extended Release)		2件: Loratadina; LORATADINE1件: D00364 1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬4件: 13, 46, 89, 98
51 Magnesium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Magnesium---21件: 3, 6, 11, 13, 15, 46, 51, 64, 70, 93, 97, 111, 166, 225, 235, 256, 284, 291, 296, 297, 298
52 Magnesium gluconate
(Synonym: Swiss One Timed Release Tab)		2件: Magnesium; Magnesium gluconate1件: D04835 --2件: 296, 297
53 Manganese citrate
(Synonym: Release)		1件: Release---12件: 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
54 Melatonin
(Synonym: Melatonin Rapid Release Gelcaps 5 mg)		2件: Circadin; Melatonin1件: D08170 2件: MTNR1A,
MTNR1B 💬		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬12件: 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
55 Memantine
(Synonym: Memantine and Donepezil Hydrochlorides Extended-release)		3件: EBIXA; Memantine; MEMANTINE HYDROCHLORIDE2件: D04905 ,
D08174 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬7件: 2, 6, 8, 13, 49, 127, 205
56 Mesalazine
(Synonym: Pentasa Extended-release Tablets 250mg)		10件: 5-Aminosalicylic acid; 5-ASA; ASACOL; Mesalamine; MESALAZINA; MESALAZINE; Mesalazinum; MEZAVANT; Pentasa; Salofalk1件: D00377 --4件: 46, 96, 97, 164
57 Metformin
(Synonym: Metformin Hydrochloride Extended-Release)		5件: Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine2件: D00944 (Name: METFORMIN HYDROCHLORIDE EXTENDED RELEASE),
D04966 		2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
58 Methylphenidate
(Synonym: Methylphenidate Hydrochloride Extended-Release)		3件: Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin2件: D01296 (Name: METHYLPHENIDATE HYDROCHLORIDE EXTENDED RELEASE),
D04999 		2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬7件: 6, 13, 34, 84, 113, 179, 206
59 Metoprolol
(Synonym: Metoprolol Succinate Extended-release)		2件: Metoprolol; Metoprolol succinate3件: D00601 ,
D02358 ,
D05011 		1件: ADRB1 💬11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 17, 57, 58, 113, 193, 226
60 Minocycline
(Synonym: Minolira Extended Release)		3件: Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin2件: D00850 (Name: MINOLIRA EXTENDED RELEASE),
D05045 		--14件: 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
61 Misoprostol
(Synonym: Diclofenac Sodium and Misoprostol Delayed-Release)		1件: Misoprostol1件: D00419 3件: PTGER2,
PTGER3,
PTGER4 💬		9件: Calcium signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways in cancer, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway 💬3件: 46, 70, 271
62 Morphine
(Synonym: Oramorph SR Sustained Release)		2件: Morphine; Morphine Sulfate3件: D00842 ,
D02271 ,
D08233 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬6件: 36, 46, 70, 85, 86, 298
63 Naltrexone
(Synonym: Naltrexone Hydrochloride and Bupropion Hydrochloride Extended-Release)		2件: Naltrexone; Naltrexone Hydrochloride2件: D02095 ,
D05113 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬13件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
64 Naproxen
(Synonym: Naproxen Delayed-release)		5件: Naprosyn; Naproxen; Naproxen oral suspension; NAPROXEN SODIUM; Propanoic acid1件: D00118 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬4件: 13, 46, 107, 271
65 Nevirapine
(Synonym: Nevirapine Extended Release)		1件: Nevirapine1件: D00435 --1件: 265
66 Niacin
(Synonym: Niodan 500 Mg Time Release Tablets)		2件: Niacin; Nicotinic acid1件: D00049 --4件: 6, 78, 79, 265
67 Nicotinamide
(Synonym: B Plus C 300mg Timed Release)		4件: Ginseng; Multivitamin; Niacinamide; Nicotinamide1件: D00036 --11件: 2, 5, 6, 13, 18, 49, 65, 67, 107, 162, 191
68 Nifedipine
(Synonym: Nifedipine Extended-Release)		1件: Nifedipine1件: D00437 4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 50, 81
69 Omeprazole
(Synonym: Aspirin and Omeprazole Delayed-release Tab)		5件: Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM4件: D00455 ,
D01207 ,
D05259 ,
D05261 		2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
70 Oxybutynin
(Synonym: Oxybutynin Chloride Extended Release)		1件: Oxybutynin2件: D00465 ,
D00722 		5件: CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		13件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬3件: 6, 13, 53
71 Oxycodone
(Synonym: Oxycodone Hydrochloride Controlled-release)		3件: OXYCODONE; OXYCODONE HYDROCHLORIDE; Oxycodone/Acetaminophen3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬7件: 6, 13, 46, 70, 226, 231, 298
72 Oxymorphone
(Synonym: Oxymorphone Hydrochloride Extended-Release)		1件: Opana1件: D08323 1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
73 Pantoprazole
(Synonym: Pantoprazole Sodium Delayed-Release)		1件: PANTOPRAZOLE2件: D02593 ,
D05353 		2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬2件: 13, 65
74 Paroxetine
(Synonym: PAROXETINE HYDROCHLORIDE Controlled-Release)		1件: Paroxetine4件: D02260 ,
D02362 ,
D05374 ,
D05375 		1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬4件: 6, 13, 46, 85
75 Phenylephrine
(Synonym: Rapid Release Multi-Symptom Allergy Relief)		1件: Phenylephrine2件: D00511 ,
D08365 		3件: ADRA1A,
ADRA1B,
ADRA1D 💬		7件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 22
76 Potassium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Potassium1件: D08403 --12件: 36, 46, 66, 67, 88, 94, 98, 115, 167, 179, 215, 235
77 Pramipexole
(Synonym: Pramipexole Dihydrochloride Extended-Release)		7件: Mirapex; Mirapex ER; Mirapexin; Pramipexol; PRAMIPEXOLE; PRAMIPEXOLE DIHYDROCHLORIDE; SIFROL2件: D00559 ,
D05575 		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 2, 6, 20
78 Pregabalin
(Synonym: Pregabalin Extended Release)		2件: Lyrica; Pregabalin1件: D02716 (Name: PREGABALIN EXTENDED RELEASE)4件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		7件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬5件: 13, 36, 46, 70, 298
79 Pseudoephedrine
(Synonym: KIRKLAND SIGNATURE ALLERCLEAR D 24 HR Extended Release)		1件: Pseudoephedrine4件: D00485 ,
D05648 ,
D05649 ,
D08449 		9件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		14件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 17
80 Pyridoxine
(Synonym: Timed Release B Complex 100 Srt)		2件: Pyridoxine; Vitamin B62件: D02179 ,
D08454 		--5件: 6, 93, 145, 206, 320
81 Quetiapine
(Synonym: Quetiapine Extended-Release)		2件: Quetiapine; Seroquel2件: D00458 ,
D08456 		2件: DRD2,
HTR2A 💬		11件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬2件: 6, 13
82 Rabeprazole
(Synonym: Rabeprazole Sodium Delayed-release)		1件: Rabeprazole2件: D00724 (Name: RABEPRAZOLE SODIUM DELAYED-RELEASE),
D08463 		2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬2件: 2, 51
83 Ranitidine
(Synonym: Ranitidine Immediate release)		1件: Ranitidine2件: D00422 ,
D00673 		1件: HRH2 💬3件: Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬2件: 13, 65
84 Riboflavin
(Synonym: B Plus C 300mg Timed Release)		2件: Riboflavin; Vitamin B23件: D00050 ,
D01622 ,
D01913 		--8件: 13, 38, 46, 96, 97, 162, 168, 265
85 Salicylic acid
(Synonym: Smart Release Mandelic 11 PERCENT)		2件: 2-Hydroxybenzoic acid; Salicylic acid1件: D00097 --1件: 97
86 Selenium
(Synonym: Icaps Time Release)		1件: Selenium---4件: 13, 96, 278, 298
87 Sodium fluoride
(Synonym: Flor-Opal Sustained-Release Fluoride)		2件: Beam; Sodium fluoride1件: D00943 --1件: 51
88 Somatostatin
(Synonym: Synthetic growth hormone release-inhibiting hormone)		1件: Somatostatin1件: D07431 5件: SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬		4件: Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬2件: 67, 78
89 Sulfasalazine
(Synonym: Sulfasalazine Delayed-Release)		3件: Salazosulfapyridine; Salicylazosulfapyridine; SULFASALAZINE1件: D00448 --6件: 46, 86, 94, 107, 270, 271
90 Theophylline
(Synonym: Theophylline Extended Release)		1件: Theophylline5件: D00371 ,
D01712 ,
D02017 ,
D06103 ,
D06104 		19件: ADORA1,
ADORA2A,
ADORA2B,
PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		24件: Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 236, 299
91 Thiamine
(Synonym: Time Release B 100 Compound - Tablet)		2件: Thiamine; Vitamin B11件: D08580 --5件: 8, 13, 93, 145, 265
92 Tolterodine
(Synonym: Tolterodine Tartrate Extended Release)		1件: Tolterodine2件: D00646 ,
D01148 (Name: TOLTERODINE TARTRATE EXTENDED RELEASE)		1件: CHRM3 💬11件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬2件: 17, 53
93 Tramadol
(Synonym: Tramadol Hydrochloride Extended-Release)		2件: Tramadol; Ultracet2件: D01355 ,
D08623 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬5件: 46, 70, 78, 226, 271
94 Valproic acid
(Synonym: Divalproex Sodium Delayed Release)		3件: Valproate; VALPROATE SODIUM; Valproic acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
95 Venlafaxine
(Synonym: Effexor XR Extended-Release)		2件: Venlafaxine; VENLAFAXINE HYDROCHLORIDE2件: D00821 ,
D08670 		2件: SLC6A2,
SLC6A4 💬		2件: Serotonergic synapse, Synaptic vesicle cycle 💬3件: 6, 13, 46
96 Vitamin A
(Synonym: Swiss One Timed Release Tab)		1件: Vitamin A2件: D00069 ,
D06543 		2件: RARA,
RARB 💬		8件: Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬3件: 13, 53, 90
97 Vitamin D
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		3件: Calciferol; Cod liver oil; Vitamin D---24件: 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
98 Vitamin E
(Synonym: Swiss One Timed Release Tab)		2件: Alpha-tocopherol; Vitamin E1件: D02331 --12件: 2, 6, 13, 20, 46, 49, 90, 96, 97, 206, 299, 317
99 Zinc
(Synonym: Timed Release Vita-vim Srt)		3件: Nicotinamide; Wilzin; Zinc---4件: 2, 113, 171, 299
100 Zinc gluconate
(Synonym: Swiss One Timed Release Tab)		1件: ZINC GLUCONATE1件: D02390 --1件: 171
101 Zolpidem
(Synonym: Zolpidem Tartrate Extended-Release)		2件: Zolpidem; Zolpidem Tartrate2件: D00706 ,
D08690 		16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬3件: 5, 6, 46