Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 JAK-STAT signaling pathway 💬
 1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
2 JAK-STAT signaling pathway 💬
 1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
3 JAK-STAT signaling pathway 💬
 1件: CSF2RA 💬 D09930 💬 Mavrilimumab 2件: 41, 46 💬
4 JAK-STAT signaling pathway 💬
 1件: CSF2RA 💬 D05066 💬 Molgramostim 3件: 97, 229, 299 💬
5 JAK-STAT signaling pathway 💬
 1件: CSF2RA 💬 D05712 💬 Regramostim 1件: 229 💬
6 JAK-STAT signaling pathway 💬
 1件: CSF2RA 💬 D05803 💬 Sargramostim 7件:  6 , 28, 60, 62, 96, 229, 285 💬
7 JAK-STAT signaling pathway 💬
 1件: CSF3R 💬 D03235 💬 Filgrastim 34件:  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
8 JAK-STAT signaling pathway 💬
 1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
9 JAK-STAT signaling pathway 💬
 1件: CSF3R 💬 D06889 💬 Pegfilgrastim 1件: 60 💬
10 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
11 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
12 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
13 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
14 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
15 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
16 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
17 JAK-STAT signaling pathway 💬
 1件: EGFR 💬 D11772 💬 Tesevatinib 1件: 67 💬
18 JAK-STAT signaling pathway 💬
 1件: EPOR 💬 D03231 💬 Erythropoietin 10件:  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
19 JAK-STAT signaling pathway 💬
 1件: EPOR 💬 D09946 💬 Peginesatide 1件: 283 💬
20 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D11486 💬 Lonapegsomatropin 1件: 78 💬
21 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
22 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
23 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D05394 💬 Pegvisomant 1件: 78 💬
24 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D11194 💬 Somapacitan 1件: 78 💬
25 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D02691 💬 Somatotropin 23件:  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
26 JAK-STAT signaling pathway 💬
 1件: GHR 💬 D11193 💬 Somavaratan 1件: 78 💬
27 JAK-STAT signaling pathway 💬
 13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab 1件: 49 💬
28 JAK-STAT signaling pathway 💬
 13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab 1件: 49 💬
29 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab 2件: 46, 49 💬
30 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa 6件: 13, 25, 26, 28, 56, 96 💬
31 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a 1件: 56 💬
32 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b 2件: 25, 34 💬
33 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a 4件: 13, 26, 96, 97 💬
34 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b 1件: 13 💬
35 JAK-STAT signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a 1件: 13 💬
36 JAK-STAT signaling pathway 💬
 1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
37 JAK-STAT signaling pathway 💬
 1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
38 JAK-STAT signaling pathway 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
39 JAK-STAT signaling pathway 💬
 2件: IL10, IL6 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
40 JAK-STAT signaling pathway 💬
 1件: IL11RA 💬 D05266 💬 Oprelvekin 2件: 96, 288 💬
41 JAK-STAT signaling pathway 💬
 3件: IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
42 JAK-STAT signaling pathway 💬
 1件: IL13 💬 D08857 💬 Anrukinzumab 1件: 97 💬
43 JAK-STAT signaling pathway 💬
 1件: IL13 💬 D09633 💬 Lebrikizumab 1件: 85 💬
44 JAK-STAT signaling pathway 💬
 1件: IL13 💬 D09979 💬 Tralokinumab 2件: 85, 97 💬
45 JAK-STAT signaling pathway 💬
 1件: IL20 💬 D11756 💬 Fletikumab 1件: 46 💬
46 JAK-STAT signaling pathway 💬
 1件: IL22 💬 D11953 💬 Efmarodocokin alfa 2件: 96, 97 💬
47 JAK-STAT signaling pathway 💬
 1件: IL23A 💬 D10912 💬 Brazikumab 2件: 96, 97 💬
48 JAK-STAT signaling pathway 💬
 1件: IL23A 💬 D10438 💬 Guselkumab 5件: 37, 41, 51, 96, 97 💬
49 JAK-STAT signaling pathway 💬
 1件: IL23A 💬 D11123 💬 Mirikizumab 3件: 37, 96, 97 💬
50 JAK-STAT signaling pathway 💬
 1件: IL23A 💬 D11052 💬 Risankizumab 4件: 37, 96, 97, 271 💬
51 JAK-STAT signaling pathway 💬
 1件: IL23A 💬 D10400 💬 Tildrakizumab 2件: 162, 271 💬
52 JAK-STAT signaling pathway 💬
 1件: IL2RA 💬 D03058 💬 Basiliximab 6件:  2 , 50, 66, 97, 222, 228 💬
53 JAK-STAT signaling pathway 💬
 1件: IL2RA 💬 D03639 💬 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284 💬
54 JAK-STAT signaling pathway 💬
 3件: IL2RA, IL2RB, IL2RG 💬 D00748 💬 Aldesleukin 6件:  2 , 35, 49, 65, 96, 97 💬
55 JAK-STAT signaling pathway 💬
 1件: IL4 💬 D03117 💬 Binetrakin 1件: 46 💬
56 JAK-STAT signaling pathway 💬
 1件: IL4R 💬 D10354 💬 Dupilumab 4件: 51, 98, 160, 162 💬
57 JAK-STAT signaling pathway 💬
 1件: IL5 💬 D04923 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
58 JAK-STAT signaling pathway 💬
 1件: IL5 💬 D08985 💬 Reslizumab 2件: 44, 98 💬
59 JAK-STAT signaling pathway 💬
 1件: IL5RA 💬 D09874 💬 Benralizumab 5件: 44, 45, 98, 162, 299 💬
60 JAK-STAT signaling pathway 💬
 1件: IL6 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
61 JAK-STAT signaling pathway 💬
 1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
62 JAK-STAT signaling pathway 💬
 1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
63 JAK-STAT signaling pathway 💬
 1件: IL6R 💬 D10161 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
64 JAK-STAT signaling pathway 💬
 1件: IL6R 💬 D11079 💬 Satralizumab 2件: 11, 13 💬
65 JAK-STAT signaling pathway 💬
 1件: IL6R 💬 D02596 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
66 JAK-STAT signaling pathway 💬
 1件: JAK1 💬 D10871 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬
67 JAK-STAT signaling pathway 💬
 1件: JAK1 💬 D10944 💬 Itacitinib 5件: 46, 51, 60, 97, 228 💬
68 JAK-STAT signaling pathway 💬
 1件: JAK1 💬 D10994 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬
69 JAK-STAT signaling pathway 💬
 2件: JAK1, JAK2 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
70 JAK-STAT signaling pathway 💬
 2件: JAK1, JAK2 💬 D09959 💬 Ruxolitinib 1件: 228 💬
71 JAK-STAT signaling pathway 💬
 3件: JAK1, JAK2, JAK3 💬 D10653 💬 Peficitinib 1件: 46 💬
72 JAK-STAT signaling pathway 💬
 4件: JAK1, JAK2, JAK3, TYK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
73 JAK-STAT signaling pathway 💬
 1件: LEPR 💬 D05014 💬 Metreleptin 1件: 265 💬
74 JAK-STAT signaling pathway 💬
 1件: MPL 💬 D10306 💬 Avatrombopag 2件: 60, 63 💬
75 JAK-STAT signaling pathway 💬
 1件: MPL 💬 D08990 💬 Romiplostim 4件: 60, 63, 64, 65 💬
76 JAK-STAT signaling pathway 💬
 1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
77 JAK-STAT signaling pathway 💬
 1件: MTOR 💬 D00753 💬 Sirolimus 41件:  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
78 JAK-STAT signaling pathway 💬
 1件: MTOR 💬 D06068 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
79 JAK-STAT signaling pathway 💬
 1件: PDGFRA 💬 D01441 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
80 JAK-STAT signaling pathway 💬
 1件: PDGFRA 💬 D08066 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
81 JAK-STAT signaling pathway 💬
 2件: PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
82 JAK-STAT signaling pathway 💬
 2件: PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
83 JAK-STAT signaling pathway 💬
 2件: PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
84 JAK-STAT signaling pathway 💬
 2件: PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
85 JAK-STAT signaling pathway 💬
 1件: PDGFRB 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
86 JAK-STAT signaling pathway 💬
 1件: PDGFRB 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
87 JAK-STAT signaling pathway 💬
 2件: PDGFRB, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
88 JAK-STAT signaling pathway 💬
 2件: PDGFRB, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
89 JAK-STAT signaling pathway 💬
 3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
90 JAK-STAT signaling pathway 💬
 1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
91 JAK-STAT signaling pathway 💬
 1件: PRL 💬 D00780 💬 Bromocriptine 2件:  6 , 74 💬
92 JAK-STAT signaling pathway 💬
 1件: PRL 💬 D03165 💬 Bromocriptine 2件:  6 , 74 💬
93 JAK-STAT signaling pathway 💬
 1件: PRL 💬 D00987 💬 Cabergoline 3件:  6 , 74, 75 💬
94 JAK-STAT signaling pathway 💬
 1件: PRL 💬 D01348 💬 Terguride 2件: 51, 86 💬
95 JAK-STAT signaling pathway 💬
 1件: TYK2 💬 D11817 💬 Deucravacitinib 2件: 96, 97 💬