Target Gene/Pathway Pathway / Gene
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No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
---|---|---|---|---|---|
1 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
CCL2 4件: CCL2, IL1B, IL6, TNF 💬 |
D01583 D01583 💬 |
Pirfenidone | 013 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 |
2 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
CSF2 1件: CSF2 💬 |
D11343 D11343 💬 |
Otilimab | 046 2件: 46, 256 💬 |
3 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IFNG 1件: IFNG 💬 |
D11120 D11120 💬 |
Emapalumab | 049 2件: 49, 107 💬 |
4 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IFNG 1件: IFNG 💬 |
D04242 D04242 💬 |
Fontolizumab | 046 1件: 46 💬 |
5 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL13 1件: IL13 💬 |
D08857 D08857 💬 |
Anrukinzumab | 097 1件: 97 💬 |
6 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL13 1件: IL13 💬 |
D09633 D09633 💬 |
Lebrikizumab | 085 1件: 85 💬 |
7 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL13 1件: IL13 💬 |
D09979 D09979 💬 |
Tralokinumab | 085 2件: 85, 97 💬 |
8 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL17A 1件: IL17A 💬 |
D10071 D10071 💬 |
Ixekizumab | 036 6件: 36, 37, 107, 162, 269, 271 💬 |
9 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL17A 1件: IL17A 💬 |
D09967 D09967 💬 |
Secukinumab | 013 8件: 13, 37, 41, 46, 107, 160, 269, 271 💬 |
10 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL17A 1件: IL17A 💬 |
D11127 D11127 💬 |
Tibulizumab | 053 1件: 53 💬 |
11 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL17A 2件: IL17A, IL17F 💬 |
D11550 D11550 💬 |
Bimekizumab | 046 3件: 46, 97, 271 💬 |
12 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL17RA 1件: IL17RA 💬 |
D10061 D10061 💬 |
Brodalumab | 037 2件: 37, 51 💬 |
13 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL1B 1件: IL1B 💬 |
D09315 D09315 💬 |
Canakinumab | 046 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 |
14 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL1B 1件: IL1B 💬 |
D09911 D09911 💬 |
Gevokizumab | 041 4件: 41, 50, 56, 269 💬 |
15 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL1B 1件: IL1B 💬 |
D06635 D06635 💬 |
Rilonacept | 051 4件: 51, 106, 107, 266 💬 |
16 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL4 1件: IL4 💬 |
D03117 D03117 💬 |
Binetrakin | 046 1件: 46 💬 |
17 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL5 1件: IL5 💬 |
D04923 D04923 💬 |
Mepolizumab | 044 4件: 44, 45, 98, 162 💬 |
18 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL5 1件: IL5 💬 |
D08985 D08985 💬 |
Reslizumab | 044 2件: 44, 98 💬 |
19 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL6 1件: IL6 💬 |
D09669 D09669 💬 |
Siltuximab | 028 2件: 28, 331 💬 |
20 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL6 1件: IL6 💬 |
D10080 D10080 💬 |
Sirukumab | 041 2件: 41, 46 💬 |
21 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
IL6 2件: IL6, TNF 💬 |
D08976 D08976 💬 |
Pomalidomide | 028 6件: 28, 34, 51, 85, 227, 331 💬 |
22 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
MAPK11 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 |
D09639 D09639 💬 |
Losmapimod | 113 2件: 113, 222 💬 |
23 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
MAPK11 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 |
D10959 D10959 💬 |
Neflamapimod | 008 1件: 8 💬 |
24 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
MMP13 1件: MMP13 💬 |
D08859 D08859 💬 |
Apratastat | 046 1件: 46 💬 |
25 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
NFKB1 1件: NFKB1 💬 |
D01146 D01146 💬 |
Iguratimod | 046 4件: 46, 51, 53, 271 💬 |
26 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D01545 D01545 💬 |
Aceclofenac | 046 1件: 46 💬 |
27 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00217 D00217 💬 |
Acetaminophen | 003 18件: 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337 💬 |
28 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00109 D00109 💬 |
Acetylsalicylic acid | 013 15件: 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬 |
29 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00567 D00567 💬 |
Celecoxib | 002 10件: 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 |
30 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00903 D00903 💬 |
Diclofenac | 013 5件: 13, 34, 46, 78, 271 💬 |
31 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00904 D00904 💬 |
Diclofenac | 013 5件: 13, 34, 46, 78, 271 💬 |
32 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D07816 D07816 💬 |
Diclofenac | 013 5件: 13, 34, 46, 78, 271 💬 |
33 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00130 D00130 💬 |
Diflunisal | 028 1件: 28 💬 |
34 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00315 D00315 💬 |
Etodolac | 046 1件: 46 💬 |
35 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D03710 D03710 💬 |
Etoricoxib | 046 2件: 46, 271 💬 |
36 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00330 D00330 💬 |
Flurbiprofen | 013 3件: 13, 21, 46 💬 |
37 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D01475 D01475 💬 |
Flurbiprofen | 013 3件: 13, 21, 46 💬 |
38 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D02290 D02290 💬 |
Flurbiprofen | 013 3件: 13, 21, 46 💬 |
39 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00126 D00126 💬 |
Ibuprofen | 013 7件: 13, 46, 65, 107, 113, 271, 299 💬 |
40 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D01122 D01122 💬 |
Ibuprofen | 013 7件: 13, 46, 65, 107, 113, 271, 299 💬 |
41 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D04490 D04490 💬 |
Ibuprofen | 013 7件: 13, 46, 65, 107, 113, 271, 299 💬 |
42 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D06606 D06606 💬 |
Ibuprofen | 013 7件: 13, 46, 65, 107, 113, 271, 299 💬 |
43 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00141 D00141 💬 |
Indomethacin | 225 3件: 225, 271, 298 💬 |
44 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D01565 D01565 💬 |
Indomethacin | 225 3件: 225, 271, 298 💬 |
45 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D02110 D02110 💬 |
Indomethacin | 225 3件: 225, 271, 298 💬 |
46 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00132 D00132 💬 |
Ketoprofen | 046 1件: 46 💬 |
47 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00813 D00813 💬 |
Ketorolac | 070 2件: 70, 226 💬 |
48 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D08104 D08104 💬 |
Ketorolac | 070 2件: 70, 226 💬 |
49 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D08149 D08149 💬 |
Loxoprofen | 046 2件: 46, 271 💬 |
50 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D03714 D03714 💬 |
Lumiracoxib | 046 1件: 46 💬 |
51 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00969 D00969 💬 |
Meloxicam | 046 4件: 46, 49, 271, 296 💬 |
52 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00118 D00118 💬 |
Naproxen | 013 4件: 13, 46, 107, 271 💬 |
53 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D01049 D01049 💬 |
Nimesulide | 046 1件: 46 💬 |
54 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D03716 D03716 💬 |
Parecoxib | 046 2件: 46, 271 💬 |
55 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00568 D00568 💬 |
Rofecoxib | 046 1件: 46 💬 |
56 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00428 D00428 💬 |
Salsalate | 005 1件: 5 💬 |
57 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D00120 D00120 💬 |
Sulindac | 206 1件: 206 💬 |
58 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D01183 D01183 💬 |
Tolfenamic acid | 005 1件: 5 💬 |
59 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
PTGS2 1件: PTGS2 💬 |
D02709 D02709 💬 |
Valdecoxib | 046 1件: 46 💬 |
60 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
RELA 1件: RELA 💬 |
D12181 D12181 💬 |
Edasalonexent | 113 1件: 113 💬 |
61 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬 |
62 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D03441 D03441 💬 |
Certolizumab pegol | 037 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬 |
63 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D00742 D00742 💬 |
Etanercept | 015 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬 |
64 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D04358 D04358 💬 |
Golimumab | 046 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬 |
65 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D02598 D02598 💬 |
Infliximab | 035 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 |
66 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D04687 D04687 💬 |
Lenalidomide | 016 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬 |
67 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D09944 D09944 💬 |
Ozoralizumab | 046 1件: 46 💬 |
68 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D05393 D05393 💬 |
Pegsunercept | 046 1件: 46 💬 |
69 | IL-17 signaling pathway 💬 Related to 20 target genes, 59 drugs (DrugBank) and 83 diseases in DDrare |
TNF 1件: TNF 💬 |
D00754 D00754 💬 |
Thalidomide | 002 20件: 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 |