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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
15009111000001105----[1] 43
2ALEMTUZUMAB[1] Alemtuzumab[1] D02802 [1] CD52 💬-[17] 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284
3Avacopan[1] Avacopan[1] D11093 [1] C5AR1 💬[6] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬[3] 43, 44, 222
4Azathioprine[1] Azathioprine[2] D00238 ,
D03033 		--[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
5BELIMUMAB[1] Belimumab[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[12] 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
6Belimumab 10 mg/kg[1] Belimumab[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[3] 43, 46, 49
7Benlysta[1] Belimumab[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[5] 43, 49, 53, 66, 222
8Benlysta 400 mg powder for concentrate for solution for infusion[1] Belimumab[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[2] 43, 49
9Benlysta 400mg polvere per concentrato per soluzione per infusione[1] Belimumab[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[1] 43
10Blisibimod[1] Blisibimod[1] D10311 --[5] 43, 44, 49, 63, 66
11CCX168----[5] 43, 44, 66, 109, 222
12CELLCEPT----[5] 11, 13, 42, 43, 49
13CellCept (Mycophenolate Mofetil)[2] Mycophenolate mofetil,
Mycophenolic acid		[4] D00752 ,
D05094 ,
D05095 ,
D05096 		[2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[2] 42, 43
14Chimeric monoclonal antibody, IgG4 subtype----[2] 43, 44
15Corticosteroid----[10] 13, 42, 43, 44, 45, 66, 84, 96, 97, 222
16Corticosteroid and azathioprine[1] Azathioprine[2] D00238 ,
D03033 		--[4] 42, 43, 44, 45
17Cyclophosphamide[1] Cyclophosphamide[2] D00287 ,
D07760 		--[45] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331
18Cyclophosphamide, Azathioprine,prednisone,methylprednisolone[4] Azathioprine,
Cyclophosphamide,
Methylprednisolone,
Prednisone		[11] D00238 ,
D00287 ,
D00407 ,
D00473 ,
D00751 ,
D00979 ,
D03033 ,
D05000 ,
D05001 ,
D05002 ,
D07760 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 42, 43, 45
19DELTACORTENE----[2] 43, 97
20ENDOXAN----[7] 13, 28, 43, 44, 85, 96, 222
21ENDOXAN BAXTER----[3] 13, 43, 96
22Freeze-Dried Sulfonated Human Normal Immunoglobulin (GGS)[1] Human immunoglobulin G---[3] 14, 43, 45
23GALEN® tablet----[2] 43, 44
24Glucocorticoid (GC)----[2] 43, 44
25Glucocorticoids----[8] 40, 41, 43, 44, 60, 62, 75, 300
26Glucocorticoids (GC)----[2] 43, 44
27Glucocorticoids - Reduced Dose----[2] 43, 44
28Glucocorticoids - Standard Dose----[2] 43, 44
29Glucocorticoids [Reduced Dose]----[2] 43, 44
30Glucocorticoids [Standard Dose]----[2] 43, 44
31Human normal immunoglobulin[1] Human immunoglobulin G---[9] 11, 13, 14, 43, 45, 50, 51, 63, 65
32Hydroxychloroquine[1] Hydroxychloroquine[1] D08050 --[27] 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299
33IFX-1[1] Vilobelimab[1] D11838 [1] C5 💬[10] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[3] 43, 44, 269
34Infliximab[1] Infliximab[1] D02598 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[26] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
35Intravenous immunoglobulins (human immunoglobulins G)----[1] 43
36Intravenous methyl prednisolone[1] Prednisolone[8] D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43
37MabThera[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[22] 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271
38Mabthera®[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[6] 13, 35, 43, 44, 46, 93
39MabThera® 100MG[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 43
40MabThera® 500MG[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 43
41Methotrexate[1] Methotrexate[2] D00142 ,
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
42Methyl prednisolone[1] Prednisolone[8] D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 43, 49, 96
43Methylprednisolone[1] Methylprednisolone[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
44Methylprednisolone (or other glucocorticoid)[1] Methylprednisolone[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43
45Mycophenolate[1] Mycophenolic acid[1] D05096 [2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
46Mycophenolate mofetil[2] Mycophenolate mofetil,
Mycophenolic acid		[4] D00752 ,
D05094 ,
D05095 ,
D05096 		[2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
47Mycophenolate mofetil,methotrexate[3] Methotrexate,
Mycophenolate mofetil,
Mycophenolic acid		[6] D00142 ,
D00752 ,
D02115 ,
D05094 ,
D05095 ,
D05096 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		[7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45
48Mycophenolic acid[1] Mycophenolic acid[1] D05096 [2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[8] 11, 43, 49, 51, 60, 66, 96, 222
49Naltrexone[1] Naltrexone[2] D02095 ,
D05113 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[12] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226
50NALTREXONE HYDROCHLORIDE[1] Naltrexone[2] D02095 ,
D05113 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[8] 10, 40, 41, 42, 43, 44, 45, 96
51Other: No Plasma Exchange----[2] 43, 44
52Pednisone----[2] 43, 44
53Placebo (physiological saline)----[2] 43, 45
54Plaquenil - Hydroxychloroquine 200mg Film coated tablets[1] Hydroxychloroquine[1] D08050 --[3] 43, 44, 45
55Plasma exchange----[5] 13, 43, 44, 64, 222
56PREDNISOLONE[1] Prednisolone[8] D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[43] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
57Prednison acis® 20 mg----[2] 43, 44
58Prednison acis® 5 mg----[2] 43, 44
59Prednison acis¿ 20 mg----[2] 43, 44
60Prednison acis¿ 5 mg----[2] 43, 44
61Prednisone[1] Prednisone[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
62Prednisone (and methylprednisolone)[2] Methylprednisolone,
Prednisone		[7] D00407 ,
D00473 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43
63PredniSONE Tablets, USP[1] Prednisone[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 41, 43, 44
64Prednisone, methylprednisolone,cyclophosphamides[2] Methylprednisolone,
Prednisone		[7] D00407 ,
D00473 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 42, 43, 45
65Remission induction therapy----[2] 43, 44
66Rituximab[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[49] 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
67Rituximab (Arm A)[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[2] 43, 44
68Rituximab (Arm B)[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[2] 43, 44
69Rixathon[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[3] 43, 46, 85
70RIXATHON 500mg[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 43
71RO0452294/V01----[2] 43, 44
72RO0452294/V02----[3] 35, 43, 44
73Ro106-1443----[1] 43
74Sendoxan----[2] 13, 43
75Tocilizumab[1] Tocilizumab[1] D02596 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
76Vilobelimab[1] Vilobelimab[1] D11838 [1] C5 💬[10] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[2] 43, 44
77Vitamin D[1] Vitamin D---[24] 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299