Drug Description in Trials / DrugBank / KEGG DRUG /

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1(-)-Epicatechin[1] Epicatechin---[2] 86, 113
2(Pyr1)apelin-13----[1] 86
3(S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid----[1] 86
4(S)-3-((3-(1-((6-(3,4-DIMETHOXYPHENYL)PRYAZIN-2- YL)AMINO)ETHYL)PHENYL)CARBAMOYL)-5-METHYLPRIDIN-1-IUM----[1] 86
5(S)-3-((3-(1-((6-(3,4-DIMETHOXYPHENYL)PRYAZIN-2-YL)AMINO)ETHYL)PHENYL)CARBAMOYL)-5-METHYLPRIDIN-1-IUM----[1] 86
6**Comment**- IMP inhalation solution identical to ventavis inhalation solution, but IMP is in a different volume presentation. Please see covering letter.[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
710-nitro-9(E)-octadec-9-enoic acid----[1] 86
811C-ACETATE[2] Acetate,
Acetic acid C-11		---[3] 13, 86, 88
9120 mg sodium nitrite inhalation solution[1] Nitrite---[1] 86
10129Xe Hyperpolarized----[1] 86
1115 mg sodium nitrite inhalation solution[1] Nitrite---[1] 86
12150mg CXA-10[1] CXA-10---[1] 86
13171----[1] 86
142-(4-[5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy)-N-(methylsulfonyl)actamide----[1] 86
152-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl) acetamide[1] Acetamide---[1] 86
1620 mg sildenafil citrate by mouth[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
1720 mg/ml Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
1825% MTD sodium nitrite inhalation solution[1] Nitrite---[1] 86
19400 mg BIA 5-1058[1] BIA---[1] 86
2045 mg sodium nitrite inhalation solution[1] Nitrite---[1] 86
214AU76----[1] 86
2266215-101----[1] 86
236R-BH4[1] Sapropterin[1] D08505 --[3] 86, 124, 240
2475mg CXA-10[1] CXA-10---[1] 86
2590 mg sodium nitrite inhalation solution[1] Nitrite---[1] 86
26: 2-{4-[(5,6-difenilpirazin-2-yl)(isopropil)amino]butoxi}-N-----[1] 86
27[11C]-GSK2256098 500 MBq[1] GSK2256098---[1] 86
28[18F] FES----[1] 86
29[18F]Fluoro-2-deoxy-2-D-glucose[1] D-glucose[1] D00009 --[2] 86, 88
30ABI-009, nab-rapamycin, albumin-bound rapamycin[1] Sirolimus[1] D00753 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[1] 86
31Access program - sildenafil citrate, Viagra, Revatio[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
32ACE-011----[1] 86
33Acetamide[1] Acetamide---[2] 86, 154
34Acetaminophen[1] Acetaminophen[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[16] 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
35Acetate[1] Acetate---[43] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
36ACT - 064992----[1] 86
37ACT-050089----[1] 86
38ACT-050089 (Ro 61-0612)----[1] 86
39ACT-064992----[5] 51, 85, 86, 88, 210
40ACT-064992 / JNJ-67896062----[1] 86
41ACT-064992/ JNJ-67896062----[1] 86
42ACT-064992D----[1] 86
43ACT-178418----[1] 86
44ACT-293987----[3] 51, 86, 88
45ACT-293987 (NS-304)----[1] 86
46ACT-385781A----[1] 86
47ACT-385781A (Actelion Epoprostenol)[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
48ActRIIA-IgG1Fc----[1] 86
49Adcirca[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
50ADCIRCA 20 mg film-coated tablets[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
51Adcirca®[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
52Adempas[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[5] 51, 86, 88, 225, 299
53Adempas (active agent riociguat)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 88
54Adempas (Riociguat, BAY63-2521)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 88
55ADEMPAS - 0,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
56ADEMPAS - 1 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 51, 86
57ADEMPAS - 1,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 51, 86
58ADEMPAS - 2 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 51, 86
59ADEMPAS - 2,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 51, 86
60Adempas 0.5 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 299
61Adempas 0.5 mg Film Coated Tablet[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
62Adempas 1 mg Film Coated Tablet[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
63Adempas 1.0 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 299
64Adempas 1.5 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
65Adempas 1.5 mg Film Coated Tablet[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
66Adempas 2 mg Film Coated Tablet[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
67Adempas 2.0 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 299
68Adempas 2.5 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
69Adempas 2.5 mg Film Coated Tablet[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
70Adempas®[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 88
71Adempas® 0.5 mg film-coated tablets[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
72Adempas® 1.0 mg film-coated tablets[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
73Adempas® 1.5 mg film-coated tablets[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
74Adempas® 2.0 mg film-coated tablets[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
75Adempas® 2.5 mg film-coated tablets[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
76Adempas¿ 0.5 mg compressa rivestita con film[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
77Adempas¿ 1.0[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
78Adempas¿ 1.5 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
79Adempas¿ 2.0 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
80Adempas¿ 2.5 mg[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
81Adipose derived mesenchymal stem cells----[1] 86
82AER-901 Solution for Nebulization----[1] 86
83Aerosolized iloprost[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
84AIR001----[1] 86
85AIR001 (sodium nitrite inhalation solution)[1] Nitrite---[1] 86
86AIR001 Inhalation Solution----[1] 86
87AIR001 Inhalation Solution (Expansion arm)----[1] 86
88AL----[10] 5, 7, 13, 28, 51, 67, 86, 97, 114, 127
89Albuterol[1] Salbutamol[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 12, 13, 86, 89, 113, 231, 256, 299
90Albuterol.[1] Salbutamol[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
91Allogeneic Human Cardiosphere-Derived Stem Cells----[1] 86
92Ambrisentan[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211
93Ambrisentan - high dose[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
94Ambrisentan - low dose[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
95Ambrisentan 5 mg film-coated tablets[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
96Ambrisentan 5mg film-coated tablets [marketed product][1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
97Ambrisentan plus Spironolactone[2] Ambrisentan,
Spironolactone		[2] D00443 ,
D07077 		[2] EDNRA,
NR3C2 💬		[8] Aldosterone-regulated sodium reabsorption, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
98Ambrisentan Tablet[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
99Ammonia[1] Ammonia[1] D02916 --[3] 86, 88, 296
100AMN107----[2] 34, 86
101Anakinra[1] Anakinra[1] D02934 [2] IL1R1,
IL1R2 💬		[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[17] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 84, 86, 97, 106, 107, 299
102ANASTROZOLE[1] Anastrozole[1] D00960 [1] CYP19A1 💬[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[3] 78, 86, 193
103Angiotensin[1] Angiotensin II[2] D00150 ,
D02014 		[2] AGTR1,
AGTR2 💬		[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[7] 17, 19, 46, 66, 86, 222, 224
104Apabetalone[1] Apabetalone[1] D11131 [4] BRD2,
BRD3,
BRD4,
BRDT 💬		-[1] 86
105APD811----[1] 86
106Apelin----[1] 86
107AR392830----[1] 86
108Aspirin[1] Acetylsalicylic acid[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[12] 13, 22, 34, 46, 49, 51, 58, 86, 113, 158, 210, 231
109Assigned pulmonary hypertension medication----[1] 86
110Autologous EPCs transfected----[1] 86
111Autologous EPCs transfected with human eNOS----[1] 86
112AV-101[1] AV-101---[2] 6, 86
113Aviptadil[1] Aviptadil[1] D12127 --[5] 49, 51, 84, 85, 86
114Axially Oscillating Sphere dry powder inhaler (AOS DPI)----[1] 86
115AZD4831----[1] 86
116B-lines SE----[3] 58, 86, 215
117Bardoxolone[1] Bardoxolone[1] D09584 --[7] 66, 67, 84, 85, 86, 218, 222
118Bardoxolone methyl[2] Bardoxolone,
Bardoxolone methyl		[2] D09584 ,
D09585 		--[7] 66, 67, 84, 85, 86, 218, 222
119Bardoxolone methyl capsules[2] Bardoxolone,
Bardoxolone methyl		[2] D09584 ,
D09585 		--[4] 66, 67, 86, 222
120BARDOXOLONE METHYL, CDDO-Me, CDDO-Methyl Ester, NSC 713200, Chemical Name: Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester[2] Bardoxolone,
Bardoxolone methyl		[2] D09584 ,
D09585 		--[1] 86
121BAY 63-2521----[2] 86, 88
122BAY 63-2521 0.06 %----[1] 86
123BAY 63-2521 0.3 %----[1] 86
124BAY 63-2521 coated tablets 0.5 mg----[2] 86, 88
125BAY 63-2521 coated tablets 1 mg----[2] 86, 88
126BAY 63-2521 coated tablets 1.5 mg----[2] 86, 88
127BAY 63-2521 coated tablets 2 mg----[2] 86, 88
128BAY 63-2521 coated tablets 2.5 mg----[2] 86, 88
129BAY 63-2521 IR tablets 0.5 mg----[1] 86
130BAY 63-2521 IR tablets 1 mg----[1] 86
131BAY 63-2521 IR tablets 1.0 mg----[1] 86
132BAY 63-2521 IR tablets 1.5 mg----[1] 86
133BAY 63-2521 IR tablets 2.0 mg----[1] 86
134BAY 63-2521 IR tablets 2.5 mg----[1] 86
135BAY 63-2521 Tablet----[1] 86
136BAY 63-2521 tablets 0.5 mg----[2] 86, 88
137BAY 63-2521 tablets 1 mg----[2] 86, 88
138BAY 63-2521 tablets 1.5 mg----[2] 86, 88
139BAY 63-2521 tablets 2 mg----[2] 86, 88
140BAY 63-2521 tablets 2.5 mg----[2] 86, 88
141Bay Q 6256----[1] 86
142BAY1237592----[2] 86, 88
143BAY63-2521----[3] 51, 86, 299
144Beetroot juice----[1] 86
145Benzbromaron----[1] 86
146Benzbromaron AL----[1] 86
147BENZBROMARONE[1] Benzbromarone[1] D01056 [1] SLC22A12 💬-[1] 86
148Beraprost[1] Beraprost[1] D02720 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
149Beraprost Sodium[1] Beraprost[1] D02720 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
150Beraprost Sodium 314d Modified Release Tablets[1] Beraprost[1] D02720 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
151Beraprost Sodium Modified Release[1] Beraprost[1] D02720 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
152Bevacizumab[1] Bevacizumab[1] D06409 [1] VEGFA 💬[24] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Calcium signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway 💬[9] 13, 34, 85, 86, 87, 89, 227, 280, 331
153BH4----[5] 51, 86, 124, 240, 299
154BIA[1] BIA---[2] 6, 86
155BIA 5-1058[1] BIA---[1] 86
156BIA-5-1058[1] BIA---[1] 86
157Biological DMARDs----[2] 86, 107
158BISOPROLOL[1] Bisoprolol[2] D00634 ,
D02342 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 67, 86, 113
159Blood test----[6] 36, 51, 86, 113, 162, 299
160Bosentan[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
161Bosentan administration[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
162Bosentan and Sildenafil[2] Bosentan,
Sildenafil		[4] D01227 ,
D02229 ,
D07538 ,
D08514 		[3] EDNRA,
EDNRB,
PDE5A 💬		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
163BOSENTAN MONOHIDRATO[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
164Bosentan monohydrat[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
165BOSENTAN MONOHYDRATE[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 51, 84, 86, 88
166Bosentan, Ambrisentan[2] Ambrisentan,
Bosentan		[3] D01227 ,
D07077 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
167BPS-314d-MR----[1] 86
168BPS-MR----[1] 86
169Breelib nebulizer----[1] 86
170Bromure d'Ipratropium[1] Ipratropium[1] D02212 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 86
171BSF 208075----[1] 86
172BSF 208075 or LU 208075----[1] 86
173C07AB07----[1] 86
174C225----[2] 51, 86
175Capsaicin[1] Capsaicin[1] D00250 [1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[5] 2, 6, 19, 86, 226
176Captopril[1] Captopril[1] D00251 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[2] 17, 86
177Carbon[1] Activated charcoal---[9] 6, 46, 50, 51, 85, 86, 96, 97, 298
178Carbon monoxide[2] Activated charcoal,
Carbon monoxide		[1] D09706 --[3] 85, 86, 298
179Carnitine[1] Levocarnitine[3] D02030 ,
D02176 ,
D04713 		--[9] 5, 13, 58, 86, 96, 97, 265, 298, 316
180Carvedilol[1] Carvedilol[2] D00255 ,
D03415 		[5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 57, 86, 113, 210
181Cetuximab[1] Cetuximab[1] D03455 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[5] 34, 51, 86, 89, 331
182Chlorhexidine[1] Chlorhexidine[4] D00858 ,
D01345 ,
D03463 ,
D07668 		--[2] 86, 299
183Cialis[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 51, 86
184Cialis 10 mg film-coated tablets[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 113
185Cialis 2.5 mg film-coated tablets[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 113
186CIALIS 20 mg comprimidos recubiertos con película[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
187Cialis 20 mg film-coated tablets[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 113
188Cialis 5 mg film-coated tablets[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 113
189Cicletanine[1] Cicletanine[1] D03487 --[1] 86
190Cicletanine hydrochloride[1] Cicletanine[1] D03487 --[1] 86
191Citrulline[1] Citrulline[1] D07706 --[2] 86, 113
192CJNJ-68150420-ZZZ-G001 (ACT- 064992D)----[1] 86
193CJNJ-68150420-ZZZ-G001 (ACT-064992D)----[1] 86
194CJNJ-68150420-ZZZ-G001(ACT-064992D)----[1] 86
195Clopidogrel[1] Clopidogrel[4] D00769 ,
D07729 ,
D10823 ,
D10824 		[1] P2RY12 💬[1] Platelet activation 💬[2] 49, 86
196Coenzyme Q-10[1] Ubidecarenone[1] D01065 --[1] 86
197Coenzyme Q-10 in Normal Control subjects[1] Ubidecarenone[1] D01065 --[1] 86
198Coenzyme Q-10 in Pulmonary Hypertension subjects[1] Ubidecarenone[1] D01065 --[1] 86
199Combination Product:----[1] 86
200Combination Product: Implantable System for Remodulin (treprostinil)[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
201Combination Product: Treprostinil via implanted pump[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
202Commercial Ventavis® (iloprost)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
203Conivaptan[1] Conivaptan[2] D01236 ,
D07748 		[2] AVPR1A,
AVPR2 💬		[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[1] 86
204Conventional drug therapy(expectorant,bronchodilator)----[1] 86
205Coronary flow reserve SE----[3] 58, 86, 215
206CosmoFer----[3] 86, 96, 97
207Crono Five ambulatory pump----[1] 86
208CS1 Administration----[1] 86
209Current marketed FLOLAN (epoprostenol sodium)[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
210CXA-10[1] CXA-10---[2] 86, 222
211D-glucose[2] D-glucose,
Dextrose, unspecified form		[1] D00009 --[3] 49, 86, 88
212D.3.6.2 - dose massima specificare: giornaliera----[1] 86
213DHEA[1] Prasterone[1] D08409 [3] AR,
ESR1,
ESR2 💬		[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[3] 49, 86, 96
214DHEA tablet[1] Prasterone[1] D08409 [3] AR,
ESR1,
ESR2 💬		[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[1] 86
215Diagnostic Test: Cardiac MRI (Gadolinium enhanced)[1] Gadolinium---[1] 86
216Diagnostic Test: CMRI----[2] 51, 86
217Diagnostic Test: Endogenous thrombin potential[1] Thrombin[1] D00090 --[2] 86, 88
218Diagnostic Test: Light transmission aggregometry----[2] 86, 88
219Diagnostic Test: PET-CT Imaging with [89Zr]-bevacizumab[1] Bevacizumab[1] D06409 [1] VEGFA 💬[24] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Calcium signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway 💬[1] 86
220Diagnostic Test: Platelet function analyzer-100----[2] 86, 88
221Diagnostic Test: Rotational thromboelastometry----[2] 86, 88
222Diastolic function SE----[3] 58, 86, 215
223Dichloroacetate[1] Dichloroacetic acid---[1] 86
224Dichloroacetate Sodium[1] Dichloroacetic acid---[1] 86
225Dietanolamina de treprostinilo[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
226Diltiazem[1] Diltiazem[3] D00616 ,
D03830 ,
D07845 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86
227Diltiazem Hydrochloride[1] Diltiazem[3] D00616 ,
D03830 ,
D07845 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
228DIMETHYL FUMARATE[1] Dimethyl fumarate[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[4] 13, 51, 86, 296
229Dimethyl Fumarate (DMF)[1] Dimethyl fumarate[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[3] 13, 51, 86
230Diphenhydramine[1] Diphenhydramine[6] D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
231Duo-Therapy with Sildenafil + Bosentan[2] Bosentan,
Sildenafil		[4] D01227 ,
D02229 ,
D07538 ,
D08514 		[3] EDNRA,
EDNRB,
PDE5A 💬		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
232EFI/ACT-385781A----[1] 86
233Elafin[1] Elafin---[1] 86
234EndoPAT measurement----[1] 86
235Endothelin receptor antagonist therapy----[1] 86
236Endothelin Receptor Antagonists----[1] 86
237Endothelin-3----[1] 86
238ENOS transfected EPCs will be delivered via a PA line----[1] 86
239Epicatechin[1] Epicatechin---[2] 86, 113
240EPOPROSTENOL[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
241Epoprostenol for injection[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
242EPOPROSTENOL SODICO[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
243EPOPROSTENOL SODIUM[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
244Epoprostenol-Actelion[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
245Epoprostenolo per iniezione----[1] 86
246Equal----[5] 6, 13, 67, 86, 230
247ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)[4] Bosentan,
Macitentan,
Sildenafil,
Tadalafil		[6] D01227 ,
D02008 ,
D02229 ,
D07538 ,
D08514 ,
D10135 		[3] EDNRA,
EDNRB,
PDE5A 💬		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
248ERA as specific PAH treatment----[1] 86
249Erbitux[1] Cetuximab[1] D03455 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[2] 51, 86
250Esomeprazole[1] Esomeprazole[4] D01984 ,
D04056 ,
D07917 ,
D09339 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[8] 13, 46, 86, 98, 107, 113, 298, 299
251ESR-specific PET scan----[1] 86
252Esuberaprost----[1] 86
253Eutonic Treprostinil Solution[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
254Famotidine[1] Famotidine[1] D00318 [1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[6] 6, 46, 86, 98, 107, 300
255Famotidine 20 MG[1] Famotidine[1] D00318 [1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[1] 86
256FDC macitentan/tadalafil[2] Macitentan,
Tadalafil		[2] D02008 ,
D10135 		[3] EDNRA,
EDNRB,
PDE5A 💬		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
257Ferinject----[2] 86, 299
258Ferinject or CosmoFer----[1] 86
259FERRIC CARBOXYMALTOSE[1] Ferric carboxymaltose[1] D08920 --[4] 86, 96, 97, 299
260Ferricarboxymaltose----[1] 86
261FK506 level 2-3 ng/ml----[1] 86
262FK506 level 3-5 ng/ml----[1] 86
263FK506 level < 2 ng/ml----[1] 86
264Flolan[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
265FLOLAN injection with currently marketed diluent[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
266FLOLAN injection with reformulated diluent[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
267FLOLAN TM and Glycine Diluent[2] Epoprostenol,
Glycine		[3] D00011 ,
D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
268Flolan®[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
269FLOLAN™ and Glycine Diluent[2] Epoprostenol,
Glycine		[3] D00011 ,
D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
270FLUOXETINE[1] Fluoxetine[2] D00326 ,
D00823 		[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 13, 17, 78, 86
271Fulvestrant[1] Fulvestrant[1] D01161 [2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[1] 86
272G04BE03----[1] 86
273G04BE03- Sildenafil - sildenafil (citrato)[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
274G04BE08----[1] 86
275Gadolinium[1] Gadolinium---[6] 13, 34, 46, 58, 65, 86
276GB002----[1] 86
277GB002 (seralutinib)----[1] 86
278GB002 Capsules----[1] 86
279Generic Dry Powder Inhaler----[1] 86
280GLIVEC[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[2] 51, 86
281GLIVEC 100 mg comprimidos recubiertos con película[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[2] 34, 86
282Glivec 100 mg Filmtabletten[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[2] 51, 86
283Glivec 100 mg Hartkapsel[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[1] 86
284Glivec®[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[1] 86
285Glivec® 100 mg Filmtabletten[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[1] 86
286Glucose[1] Dextrose, unspecified form---[15] 2, 6, 13, 49, 50, 65, 75, 86, 88, 96, 160, 195, 254, 257, 299
287GLYCINE[1] Glycine[1] D00011 --[5] 35, 60, 86, 226, 299
288GMA301 Injection----[1] 86
289Gold[1] Gold---[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 171, 193, 218, 222, 224, 227, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318
290Gradient----[4] 58, 86, 149, 215
291GS-4997 18 mg----[1] 86
292GS-4997 2 mg----[1] 86
293GS-4997 6 mg----[1] 86
294GSK1325760----[2] 86, 88
295GSK1325760A----[1] 86
296GSK2256098[1] GSK2256098---[1] 86
297GSK2586881----[1] 86
298HGP1206----[1] 86
299Hydroxyurea[1] Hydroxyurea[1] D00341 [1] RRM2 💬[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬[8] 3, 13, 19, 20, 65, 85, 86, 284
300Hyperpolarized 129Xe----[1] 86
301HypotonicTreprostinil Solution----[1] 86
302I-Neb AAD system----[1] 86
303I.v. selexipag[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
304Ifetroban[1] Ifetroban[1] D04500 [1] TBXA2R 💬[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation 💬[3] 51, 86, 113
305Ilomedin 20----[1] 86
306Ilomedin 20 [20 µg / ml]----[1] 86
307Iloprost[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86
308Iloprost (5 µg)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
309Iloprost (Ventavis BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
310Iloprost (Ventavis inhaled, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
311Iloprost (Ventavis, BAYQ 6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
312Iloprost (Ventavis, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
313Iloprost (Ventavis®)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
314Iloprost Inhalation Solution (Ventavis)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[2] 85, 86
315Iloprost PD-15[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
316Iloprost PD-6[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
317Iloprost,(Ventavis, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
318Imatinib[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
319IMATINIB MESILATE[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[3] 13, 86, 88
320Imatinib Mesylate[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 13, 28, 34, 51, 86
321Inhaled dry powder treprostinil (LIQ861)[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
322Inhaled Iloprost (5 µg)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
323Inhaled iloprost (Ventavis, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
324Inhaled Nitric Oxide[1] Nitric Oxide[1] D00074 --[2] 85, 86
325Inhaled nitric oxide & INOpulse delivery[1] Nitric Oxide[1] D00074 --[1] 86
326Inhaled nitric oxide 75 mcg/kg IBW/hr[1] Nitric Oxide[1] D00074 --[2] 85, 86
327Inhaled NO with pulsed delivery----[1] 86
328Inhaled prostacyclin[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
329Inhaled Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[3] 84, 85, 86
330INO----[2] 85, 86
331Intestinal microbiota transplant (IMT)----[1] 86
332Intravenous administration of ferric carboxymaltose[1] Ferric carboxymaltose[1] D08920 --[1] 86
333Intravenous Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
334Intravenous/Subcutaneous Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
335Ipratropium[1] Ipratropium[1] D02212 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 6, 86
336Iron supplement----[1] 86
337JNJ-67896049----[1] 86
338JNJ-67896049 (ACT-293987)----[1] 86
339JNJ-67896062 / ACT-064992----[2] 86, 88
340JNJ-67896062/ ACT-064992----[2] 86, 88
341JTT-251----[1] 86
342KAR5585 Capsules----[1] 86
343L-Carnitine[1] Levocarnitine[3] D02030 ,
D02176 ,
D04713 		--[7] 13, 86, 96, 97, 265, 298, 316
344L-Citrulline Malate[1] Citrulline[1] D07706 --[1] 86
345L606 (Liposomal Treprostinil) Inhalation Solution 51ug[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
346L606 Inhalation System----[1] 86
347Left ventricular contractile reserve SE----[3] 58, 86, 215
348Left ventricular outflow tract gradient SE----[3] 58, 86, 215
349Levitra[1] Vardenafil[3] D02731 ,
D03260 ,
D08668 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 13, 86
350Lidocaine[1] Lidocaine[3] D00358 ,
D02086 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[12] 6, 13, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256
351LIQ861 100 µg----[1] 86
352LIQ861 106 µg----[1] 86
353LIQ861 25 µg----[1] 86
354LIQ861 26.5 µg----[1] 86
355LIQ861 50 µg----[1] 86
356LIQ861 53 µg----[1] 86
357LIQ861 75 µg----[1] 86
358LIQ861 79.5 µg----[1] 86
359LIQ861 Inhaled Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
360LISURIDE[1] Lisuride[2] D01462 ,
D08132 		[3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 86
361Lloprost(Ventavis,BAYQ6252, 10 µg/mL)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
362Lloprost(Ventavis,BAYQ6252, 20 µg/mL)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
363LTP001----[1] 86
364LY450190----[1] 86
365Macitentan[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210
366Macitentan (ACT-064992)[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
367Macitentan 10 mg[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 86, 88
368Macitentan 10 mg tablet, once daily.[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
369Macitentan 37.5 mg[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
370Macitentan 75 mg[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
371MACITENTAN COMPRESSE[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 86, 88
372Macitentan Group[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
373MACITENTAN TABLETS[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 86, 88
374MD-711----[1] 86
375Medical air[2] Medical air,
Oxygen		[1] D00003 --[3] 85, 86, 193
376Metformin[1] Metformin[2] D00944 ,
D04966 		[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
377Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo----[1] 86
378Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine-3-yl]-5-pyrimidinyl(methyl)carb----[2] 86, 88
379Methyl [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]meth----[2] 86, 88
380Methylprednisolone[1] Methylprednisolone[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
381MHealth Intervention----[1] 86
382Mitral regurgitation SE----[3] 58, 86, 215
383MK-4836----[1] 86
384MK-5475----[1] 86
385MK-8892----[1] 86
386MONITOR[1] Methamidophos---[20] 2, 11, 13, 19, 28, 46, 49, 58, 65, 70, 81, 85, 86, 98, 113, 118, 129, 298, 299, 300
387Mono-Therapy with Sildenafil[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
388Morphine[1] Morphine[3] D00842 ,
D02271 ,
D08233 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[6] 36, 46, 70, 85, 86, 298
389MORPHINE SULFATE[2] Morphine,
Sulfate ion		[3] D00842 ,
D02271 ,
D08233 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[3] 46, 85, 86
390Moxifloxacin[1] Moxifloxacin[2] D00874 ,
D08237 		--[9] 2, 6, 46, 49, 85, 86, 113, 240, 299
391Moxifloxacin 400 mg[1] Moxifloxacin[2] D00874 ,
D08237 		--[1] 86
392MultiHance[1] Gadobenic acid[2] D04283 ,
D08018 		--[2] 86, 88
393Nebulized combination ipratropium bromide with salbutamol[2] Ipratropium,
Salbutamol		[2] D02147 ,
D02212 		[6] ADRB2,
CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[18] Adrenergic signaling in cardiomyocytes, Alzheimer disease, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Taste transduction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
394Nebulized ipratropium bromide[1] Ipratropium[1] D02212 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 86
395New thermo stable formulation of epoprostenol sodium[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
396Nicardipine[1] Nicardipine[2] D00617 ,
D08270 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 70, 86
397Nilotinib[1] Nilotinib[1] D08953 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86
398Nilotinib 50 mg[1] Nilotinib[1] D08953 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[1] 86
399Nitric Oxide[1] Nitric Oxide[1] D00074 --[8] 46, 85, 86, 98, 210, 251, 294, 299
400Nitric Oxide for inhalation[1] Nitric Oxide[1] D00074 --[2] 86, 299
401Nitric Oxide generated by the GeNO nitrosyl delivery system[1] Nitric Oxide[1] D00074 --[1] 86
402Nitric Oxide plus Oxygen[2] Nitric Oxide,
Oxygen		[2] D00003 ,
D00074 		--[1] 86
403Nitrite[1] Nitrite---[3] 58, 86, 299
404Nitrosyl[1] Nitric Oxide[1] D00074 --[1] 86
405NO----[12] 6, 13, 46, 58, 62, 86, 96, 97, 222, 226, 299, 321
406Non-Biologic DMARDs----[3] 46, 86, 107
407NS-304----[3] 70, 86, 88
408Null----[16] 6, 13, 15, 28, 37, 46, 49, 51, 63, 86, 90, 96, 97, 107, 145, 271
409NX1011----[1] 86
410Observational study with patients treated with Tracleer, Ventavis, Veletri, Opsumit and/or Uptravi[4] Epoprostenol,
Iloprost,
Macitentan,
Selexipag		[5] D00106 ,
D01337 ,
D02721 ,
D09994 ,
D10135 		[3] EDNRA,
EDNRB,
PTGIR 💬		[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Platelet activation, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
411Olaparib[1] Olaparib[1] D09730 [2] PARP1,
PARP2 💬		[5] Apoptosis, Base excision repair, Diabetic cardiomyopathy, NF-kappa B signaling pathway, Necroptosis 💬[2] 86, 285
412Opsumit[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210
413Opsumit (macitentan)[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
414Opsumit®[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210
415Oral anticoagulant treatment----[1] 86
416Oral ERA----[1] 86
417Oral Ifetroban[1] Ifetroban[1] D04500 [1] TBXA2R 💬[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation 💬[2] 51, 86
418Oral PDE5 inhibitors----[1] 86
419Oral selexipag (Uptravi)[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
420Oral sildenafil[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
421Oral treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[2] 51, 86
422Oral treprostinil (UT-15C) Sustained Release Tablets[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
423Ossido Nitrico----[1] 86
424Other: Iloprost (Ventavis inhaled, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
425Other: Noninvasive actigraphy monitor[1] Methamidophos---[1] 86
426Other: Oxygen Supplementation[1] Oxygen[1] D00003 --[1] 86
427Other: Standard-of-care----[1] 86
428Other: Standardized meals----[1] 86
429Other: Subacute hypoxic exposures----[1] 86
430Oxygen[1] Oxygen[1] D00003 --[20] 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
431Oxygen supplementation[1] Oxygen[1] D00003 --[1] 86
432Oxygen, liquid[1] Oxygen[1] D00003 --[2] 86, 88
433PADN----[1] 86
434PAH----[3] 49, 53, 86
435PAH medication----[1] 86
436PAH Therapies----[1] 86
437Parenteral Remodulin (treprostinil) injection[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
438PB1046----[1] 86
439PB1046 Subcutaneous Injection----[1] 86
440PB1046, VIP-ELP1-120, Vasomera----[1] 86
441PDE5 inhibitor----[1] 86
442Pemziviptadil (PB1046)----[1] 86
443Pemziviptadil (PB1046) Injection----[1] 86
444PF-00489791[1] PF-00489791---[1] 86
445Pioglitazone[1] Pioglitazone[2] D00945 ,
D08378 		[1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
446Placebo----[27] 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
447PLX-PAD[1] Placental Mesenchymal Stem Cells---[1] 86
448Prednisone[1] Prednisone[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
449Prostacyclin[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
450Pulmonary hemodynamics SE----[3] 58, 86, 215
451Puri-Nethol----[3] 86, 96, 97
452Q4W GMA301 IV injections (1000 mg)----[1] 86
453Q4W GMA301 IV injections (300 mg)----[1] 86
454Q4W GMA301 IV injections (600 mg)----[1] 86
455QCC374----[1] 86
456QCC374 0.015 mg----[1] 86
457QCC374 0.06 mg----[1] 86
458QTI571----[1] 86
459Qutenza----[1] 86
460Qutenza (8% capsaicin)[1] Capsaicin[1] D00250 [1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 86
461Radiation: PET/CT Scan: Two PET scans using 1. C-11 HED and 2. N-13 Ammonia or rubidium-82[2] Ammonia,
Rubidium		[1] D02916 --[1] 86
462RALINEPAG[1] Ralinepag[1] D10725 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
463Ranolazine[1] Ranolazine[2] D05700 ,
D05701 		--[6] 2, 58, 86, 96, 113, 114
464Rapamycin[1] Sirolimus[1] D00753 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[19] 2, 15, 34, 35, 46, 49, 51, 60, 61, 67, 86, 89, 96, 157, 158, 193, 256, 278, 279
465Rapid Dose Titration Group of Subcutaneous Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
466Recombinant Human Angiotensin-Converting Enzyme 2[2] Alunacedase alfa,
Angiotensin II		[2] D00150 ,
D02014 		[2] AGTR1,
AGTR2 💬		[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
467Recombinant Human Angiotensin-converting enzyme 2 (ACE2), APN01[2] Alunacedase alfa,
Angiotensin II		[2] D00150 ,
D02014 		[2] AGTR1,
AGTR2 💬		[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
468Remodulin[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[2] 86, 88
469Remodulin (treprostinil sodium)[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
470Remodulin® (treprostinil) 1 mg/ml solution for infusion[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
471Remodulin® (treprostinil) 10 mg/ml solution for infusion[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
472Remodulin® (treprostinil) 2.5 mg/ml solution for infusion[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
473Remodulin® (treprostinil) 5 mg/ml solution for infusion[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
474Revatio[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[3] 85, 86, 113
475Revatio 10 mg/ml powder for oral suspension[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
476Revatio 20 mg film coated tablets[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
477Revatio 20 mg film-coated tablets----[1] 86
478Revatio 20 mg Filmtabletten[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
479REVATIO 20 mg, comprimidos recubiertos con película[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
480Revatio inyectable[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
481Revatio oral[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
482Revatio POS[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
483Revatio Tablets[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
484Revatio ® 20 mg film-coated tablets[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
485Revatio®[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
486Riciguat Group----[1] 86
487Rifampin[1] Rifampicin[1] D00211 --[5] 6, 13, 84, 86, 299
488RIOCIGUAT[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[6] 51, 84, 86, 88, 225, 299
489Riociguat (Adempas, BAY63-2521)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 51, 86, 88, 299
490Riociguat (BAY63-2521)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
491Riociguat granules 0.3% for oral application[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
492Riociguat Oral Product[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
493Riociguat Pill[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86
494Ritonavir[1] Ritonavir[1] D00427 --[3] 2, 86, 265
495Rituximab[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[49] 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
496Ro 47-0203----[4] 51, 85, 86, 88
497Ro 47-0203 / ACT-050088----[1] 86
498Ro-47-0203----[1] 86
499Ro-47-0203/029----[1] 86
500Ro47-0203----[1] 86
501Ro47-0203 / ACT-050088----[2] 51, 86
502RoActemra[1] Tocilizumab[1] D02596 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[11] 40, 41, 44, 46, 50, 51, 86, 107, 266, 271, 331
503Rodatristat ethyl----[1] 86
504Rodatristat Ethyl 300 mg tablet----[1] 86
505RT234 - vardenafil inhalation powder[1] Vardenafil[3] D02731 ,
D03260 ,
D08668 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
506RTA 402----[3] 67, 86, 218
507Rubidium[1] Rubidium---[2] 84, 86
508RVG 33865----[1] 86
509RVT-1201----[1] 86
510Salbutamol[1] Salbutamol[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[9] 3, 11, 49, 85, 86, 111, 228, 256, 299
511Saline----[10] 6, 13, 17, 53, 67, 78, 86, 97, 168, 299
512Sapropterin[1] Sapropterin[1] D08505 --[3] 86, 124, 240
513Sapropterin dihydrochloride (6R-BH4)[1] Sapropterin[1] D08505 --[1] 86
514Saquinavir[1] Saquinavir[2] D00429 ,
D01160 		--[2] 86, 265
515Saquinavir and ritonavir[2] Ritonavir,
Saquinavir		[3] D00427 ,
D00429 ,
D01160 		--[1] 86
516Sauerstoff----[2] 86, 88
517Selexipag[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 47, 51, 70, 84, 86, 88
518Selexipag (Uptravi)[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
519Selexipag, ACT-293987 (NS-304)[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
520Selonsertib[1] Selonsertib[1] D10988 [1] MAP3K5 💬[20] Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Platinum drug resistance, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬[1] 86
521Seralutinib----[1] 86
522Serine[1] Serine[1] D00016 --[4] 2, 6, 86, 96
523Sham O2 (medical air)[2] Medical air,
Oxygen		[1] D00003 --[1] 86
524Sham PADN----[1] 86
525SILDENAF----[1] 86
526Sildenafil[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
527Sildenafil (as citrate)[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
528Sildenafil (REVATIO)[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
529Sildenafil (Revatio) 20 mg TID[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
530Sildenafil 20mg[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 51, 86
531Sildenafil 20mg and Bosentan 62.5mg[2] Bosentan,
Sildenafil		[4] D01227 ,
D02229 ,
D07538 ,
D08514 		[3] EDNRA,
EDNRB,
PDE5A 💬		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 86
532Sildenafil citrate[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[4] 51, 85, 86, 225
533Sildenafil citrate (UK-92,480)[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
534Sildenafil Filmtabletten[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
535Sildenafil singly or in association with Bosentan[2] Bosentan,
Sildenafil		[4] D01227 ,
D02229 ,
D07538 ,
D08514 		[3] EDNRA,
EDNRB,
PDE5A 💬		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
536SILDENAFILO[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
537Simvastatin[1] Simvastatin[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
538Simvastatin 40 mg[1] Simvastatin[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[1] 86
539Simvastatin 40 mg tablets[1] Simvastatin[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[1] 86
540Sitaxentan[1] Sitaxentan[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
541Sitaxentan sodium[1] Sitaxentan[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
542Sitaxsentan[1] Sitaxentan[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
543Sitaxsentan alone[1] Sitaxentan[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
544Sitaxsentan and Sildenafil[2] Sildenafil,
Sitaxentan		[3] D02229 ,
D07171 ,
D08514 		[2] EDNRA,
PDE5A 💬		[9] Calcium signaling pathway, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
545SITAXSENTAN SODIUM[1] Sitaxentan[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
546Slow Dose Titration Group of Subcutaneous Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
547SODIUM NITRITE[1] Nitrite---[2] 86, 299
548Sodium Nitrite Inhalation Solution[1] Nitrite---[1] 86
549Sodium tanshinone IIA sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth[2] Dextrose, unspecified form,
Sildenafil		[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
550Sorafenib[1] Sorafenib[2] D06272 ,
D08524 		[8] BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬		[89] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 34, 86
551SOTATERCEPT[1] Sotatercept[1] D09670 [1] ACVR2A 💬[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[2] 86, 284
552Sotatercept - 45 mg/vial[1] Sotatercept[1] D09670 [1] ACVR2A 💬[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[1] 86
553Sotatercept - 60 mg/vial[1] Sotatercept[1] D09670 [1] ACVR2A 💬[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[1] 86
554Spironolactone[1] Spironolactone[1] D00443 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[7] 58, 67, 86, 113, 210, 218, 225
555Spironolactone and conivaptan[2] Conivaptan,
Spironolactone		[3] D00443 ,
D01236 ,
D07748 		[3] AVPR1A,
AVPR2,
NR3C2 💬		[6] Aldosterone-regulated sodium reabsorption, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[1] 86
556Spironolactone captopril carvedilol[3] Captopril,
Carvedilol,
Spironolactone		[4] D00251 ,
D00255 ,
D00443 ,
D03415 		[7] ACE,
ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2,
NR3C2 💬		[19] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone-regulated sodium reabsorption, Calcium signaling pathway, Chagas disease, Chemical carcinogenesis - receptor activation, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dilated cardiomyopathy, Gap junction, Hypertrophic cardiomyopathy, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Renin-angiotensin system, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
557STI571----[2] 51, 86
558Subcutaneous and intravenous prostacyclin[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
559Subcutaneous Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
560Sugar pill----[8] 5, 6, 49, 67, 70, 86, 206, 210
561SULFASALAZINE[1] Sulfasalazine[1] D00448 --[6] 46, 86, 94, 107, 270, 271
562Sulfate[1] Sulfate ion---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
563Tadalafil[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[7] 6, 51, 75, 84, 86, 113, 210
564Tadalafil 20 mg film-coated tablets[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
565Tadalafil 40 mg[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
566Tadalafil and ambrisentan upfront combination therapy[2] Ambrisentan,
Tadalafil		[2] D02008 ,
D07077 		[2] EDNRA,
PDE5A 💬		[9] Calcium signaling pathway, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 86
567Tadalafil oral suspension[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
568Tadalafil- Tablet or Oral suspension[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
569TADALAFILO[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 86
570Tamoxifen[1] Tamoxifen[2] D00966 ,
D08559 		[2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[4] 2, 86, 113, 227
571Tasigna[1] Nilotinib[1] D08953 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[2] 34, 86
572Tasigna®[1] Nilotinib[1] D08953 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[1] 86
573Tasigna® 150 mg[1] Nilotinib[1] D08953 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[1] 86
574TBD----[4] 19, 86, 276, 299
575Tegaderm----[1] 86
576Terguride[1] Terguride[1] D01348 [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 51, 86
577Terguride 0,5mg tablet[1] Terguride[1] D01348 [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 86
578Terguride 0.5 mg tablet[1] Terguride[1] D01348 [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 86
579Tezosentan[1] Tezosentan---[1] 86
580The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:----[1] 86
581The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:----[1] 86
582Thelin[1] Sitaxentan[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
583Threonine[1] Threonine[1] D00041 --[3] 86, 96, 97
584Thrombin[1] Thrombin[1] D00090 --[2] 86, 88
585Tocilizumab[1] Tocilizumab[1] D02596 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
586TPN171H----[1] 86
587TPN171H single dose----[1] 86
588Traclear----[1] 86
589Tracleer[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 13, 51, 84, 85, 86, 88, 210, 211
590TRACLEER 62,5 mg comprimidos recubiertos con película[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
591TRACLEER 62,5MG 56CPR RIV.[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
592TRACLEER*125MG 56CPR RIV.[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 86
593TRACLEER*56CPR RIV 125MG[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 86, 88
594Tracleer®----[1] 86
595Transdihydrolisuride----[2] 51, 86
596TRE----[1] 86
597Treprosinil Diethanolamine----[1] 86
598Treprostin----[1] 86
599Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 51, 84, 85, 86, 88, 210
600Treprostinil dietanolamina[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
601Treprostinil diethanolamine[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[2] 51, 86
602Treprostinil Diolamine[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
603Treprostinil Inhalation Powder[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
604Treprostinil inhalations[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
605Treprostinil Injectable Product[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
606Treprostinil Palmitil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
607TREPROSTINIL SODIUM[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[3] 51, 86, 88
608Treprostinil Sodium Solution for Inhalation[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
609TREPROSTINIL SODIUM, UT-15[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
610Treprostinil, UT-15, LRX-15, 15AU81, BW A15AU, U-62, 840[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
611Treprostinilo[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
612Trimetazidine[1] Trimetazidine[1] D08642 --[3] 2, 58, 86
613Trisuva(r)----[1] 86
614TRK-100STP----[1] 86
615Tyrosine[1] Tyrosine[1] D00022 --[3] 6, 86, 111
616Tyvaso[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
617Tyvaso Inhalation Solution[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
618Ubenimex[1] Ubenimex[1] D00087 [1] ANPEP 💬[4] Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system 💬[1] 86
619Udenafil[1] Udenafil[1] D10027 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 210
620UK 092480----[1] 86
621UK-92,480----[1] 86
622UK-92,480-10----[1] 86
623ULARITIDE[1] Ularitide---[1] 86
624Uptravi[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[3] 84, 86, 88
625Urodilatin----[1] 86
626Usual Care----[1] 86
627UT-15C----[1] 86
628UT-15C (treprostinil diethanolamine)[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
629UT-15C 0.25 mg----[1] 86
630UT-15C 1 mg----[1] 86
631UT-15C 5 mg----[1] 86
632UT-15C LP----[1] 86
633UT-15C SR----[2] 51, 86
634UT-15C SR (treprostinil diethanolamine)[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
635UT-15C-SR----[2] 51, 86
636Vardenafil[1] Vardenafil[3] D02731 ,
D03260 ,
D08668 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[3] 13, 86, 299
637Vasomera (PB1046) Injection----[1] 86
638Veletri[1] Epoprostenol[2] D00106 ,
D01337 		[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
639Ventavis[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
640Ventavis (Iloprost, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
641Ventavis 10[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
642Ventavis(Iloprost)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
643VIAGRA[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[3] 86, 96, 225
644VIP----[3] 49, 51, 86
645Volibris[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 51, 85, 86, 88
646VOLIBRIS 10 mg comprimidos recubiertos con película[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
647VOLIBRIS 5 mg comprimidos recubiertos con película[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
648VOLIBRIS® (ambrisentan)[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
649VOLIBRIS™ tablets[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
650Warfarin[1] Warfarin[3] D00564 ,
D01280 ,
D08682 		[2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
651ZAMICASTAT[1] Zamicastat---[1] 86