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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
11-20190----[1] 93
211C-CSar----[2] 93, 94
313-15mg/kg/d Ursodeoxycholic----[1] 93
418-22mg/kg/d Ursodeoxycholic----[1] 93
53 mg [14C]-A4250 capsule----[3] 93, 297, 338
63-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-----[1] 93
73a,7a-dihydroxy-6a-ethyl-5betacholan-24-oic acid----[1] 93
83a,7a-dihydroxy-6a-ethyl-5ßcholan-24-oic acid----[1] 93
96 alpha-ethylchenodeoxycholic acid (6-EDCA), OCA, INT-747----[1] 93
106-ECDCA[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
116-ethylchenodeoxycholic acid[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
126?-ethylchenodeoxycholic acid (6-ECDCA), OCA, INT-747[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
136a-ethylchenodeoxycholic acid (6-ECDCA), OCA, INT-747[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
146a-ethylchenodeoxycholic acid , 6-ethylchenodeoxycholic acid[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
156a-ethylchenodeoxycholic acid , 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5betacholan-24-o[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
166a-ethylchenodeoxycholic acid , 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5betacholan-24-o, obeticholic acid (OCA)[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
176a-ethylchenodeoxycholic acid , 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5ßcholan-24-o[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
186a-ethylchenodeoxycholic acid , 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5ßcholan-24-o, obeticholic acid (OCA)[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
196a-ethylchenodeoxycholic acid, 6-ethylchenodeoxycholic acid[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
206a-ethylchenodeoxycholic acid, 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5betacholan-24-o[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
216a-ethylchenodeoxycholic acid, 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5betacholan-24-o , obeticholic acid (OCA)[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
226a-ethylchenodeoxycholic acid, 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5ßcholan-24-o[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
236a-ethylchenodeoxycholic acid, 6-ethylchenodeoxycholic acid, 3a,7a-dihydroxy-6a-ethyl-5ßcholan-24-o , obeticholic acid (OCA)[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
24A11HA02----[1] 93
25A4250----[4] 93, 296, 297, 338
26Abatacept[1] Abatacept[1] D03203 [2] CD80,
CD86 💬		[12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
27Acido Obeticolico----[2] 93, 94
28Acido ursodessicolico----[1] 93
29Alkaline Phosphatase[1] Alkaline Phosphatase---[4] 46, 93, 97, 172
30APD334----[5] 93, 96, 97, 98, 269
31ASC42 10 mg----[1] 93
32ASC42 15 mg----[1] 93
33ASC42 5 mg----[1] 93
34Atorvastatin[1] Atorvastatin[3] D00258 ,
D00887 ,
D07474 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
35Azathioprine[1] Azathioprine[2] D00238 ,
D03033 		--[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
36Baricitinib[1] Baricitinib[1] D10308 [2] JAK1,
JAK2 💬		[35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
37BCD-085----[2] 93, 271
38Bezafibrat----[1] 93
39Bezafibrat Genericon retard 400 mg----[1] 93
40Bezafibrate[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[7] 20, 93, 94, 160, 296, 316, 324
41Bezafibrate 100 MG[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
42Bezafibrate 200 MG[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
43Bezafibrate 200 MG Oral Tablet[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
44Bezafibrate 400 MG[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
45Bezafibrate IR[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
46Bezafibrate SR[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
47Bezafibrate, Beza, BZF, Bezalip[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
48Bezafibrate, Beza, BZF, Bezalip mono[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
49Bezalip----[3] 93, 94, 160
50Bezalip mono----[1] 93
51Biological: mesenchymal stem cell----[1] 93
52Budenofalk 3mg----[2] 93, 97
53BUDESONIDE[1] Budesonide[1] D00246 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[9] 66, 93, 94, 95, 96, 97, 98, 228, 299
54Calcium[1] Calcium---[30] 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
55Choline[1] Choline[1] D07690 --[4] 93, 171, 193, 299
56Cilofexor[1] Cilofexor---[2] 93, 94
57CNP-104----[1] 93
58CNTO1275----[6] 46, 49, 84, 93, 96, 97
59Colchicine[1] Colchicine[1] D00570 [9] TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		[10] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬[7] 2, 42, 46, 56, 93, 210, 266
60Combination antiviral therapy----[1] 93
61CR845 1.0 mg----[1] 93
62CRC (A3384)----[3] 93, 297, 338
63Cyclophosphamide[1] Cyclophosphamide[2] D00287 ,
D07760 		--[45] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331
64Cyclosporin[1] Cyclosporine[1] D00184 [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[17] 38, 46, 49, 50, 53, 56, 60, 62, 63, 93, 95, 97, 113, 164, 222, 274, 326
65Cyclosporin A[1] Cyclosporine[1] D00184 [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[11] 46, 49, 53, 56, 60, 62, 63, 93, 95, 113, 164
66Denosumab[1] Denosumab[1] D03684 [1] TNFSF11 💬[8] Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬[7] 46, 50, 93, 95, 96, 274, 299
67E6011----[3] 46, 93, 96
68EDP-305----[1] 93
69EDP-305 Dose 1----[1] 93
70EDP-305 Dose 2----[1] 93
71ELAFIBRANOR[1] Elafibranor[1] D11208 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
72Elafibranor 120 mg[1] Elafibranor[1] D11208 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
73Elafibranor 80 mg[1] Elafibranor[1] D11208 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
74Elafibranor 80mg[1] Elafibranor[1] D11208 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
75Emtricitabine[1] Emtricitabine[1] D01199 --[4] 25, 93, 265, 325
76Emtricitabine (FTC)/Tenofovir Disoproxil (TDF)[2] Emtricitabine,
Tenofovir disoproxil		[2] D01199 ,
D01982 		--[1] 93
77Experimental: Seladelpar / MBX-8025 200 mg[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
78Experimental: Seladelpar / MBX-8025 50 mg[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
79Ezetimibe[1] Ezetimibe[1] D01966 [1] NPC1L1 💬[1] Fat digestion and absorption 💬[4] 49, 79, 93, 260
80Ezetrol----[2] 93, 260
81EZT----[1] 93
82Fenofibrate[1] Fenofibrate[1] D00565 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[5] 8, 79, 93, 94, 265
83Fenofibrate IDD-P (Insoluble Drug Delivery-Micro Particle)[1] Fenofibrate[1] D00565 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
84FFP104----[2] 93, 96
85Fibroscan----[2] 93, 171
86Fully human monoclonal antibody directed against CXCL10----[1] 93
87Fuzhenghuayu----[1] 93
88GFT505----[1] 93
89GKT137831----[2] 85, 93
90Gold[1] Gold---[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 171, 193, 218, 222, 224, 227, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318
91GS-9674----[2] 93, 94
92GS-9674 100 mg----[1] 93
93GS-9674 30 mg----[1] 93
94GSK2330672----[1] 93
95GYPP-06 (GKT137831 free base), C10071301-D----[1] 93
96High protein high fiber diet----[2] 93, 95
97HTD1801 (BUDCA)----[1] 93
98ICG----[3] 93, 94, 235
99INT-747----[1] 93
100INT-747, OCA----[2] 93, 94
101Kaletra[1] Lopinavir[1] D01425 --[1] 93
102Linerixibat----[1] 93
103Linerixibat (GSK2330672) 40 mg----[1] 93
104Linerixibat (GSK2330672) 45 mg----[1] 93
105Linerixibat (GSK2330672) 45mg----[1] 93
106Liver biopsy----[4] 93, 171, 231, 240
107LJN452----[1] 93
108LJN452, 0,01 mg----[1] 93
109LJN452, 0,03 mg----[1] 93
110LJN452, 0,1 mg----[1] 93
111LUM001----[4] 93, 94, 297, 338
112LY3009104----[6] 46, 49, 50, 93, 107, 325
113MabThera[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[22] 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271
114Mabthera®[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[6] 13, 35, 43, 44, 46, 93
115Magnesium[1] Magnesium---[19] 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
116MBX 8025----[1] 93
117MBX-8025----[3] 79, 93, 94
118MBX-8025 10 mg Capsule----[1] 93
119MBX-8025 2 mg Capsule----[1] 93
120MBX-8025 5 mg Capsule----[1] 93
121MBX-8025, DSIC----[1] 93
122MBX-8025, Formulation 2----[1] 93
123Methionine[1] Methionine[2] D00019 ,
D04983 		--[7] 34, 75, 84, 93, 229, 298, 300
124Methotrexate[1] Methotrexate[2] D00142 ,
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
125Methylprednisolone[1] Methylprednisolone[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
126Methylprednisolone and azathioprine[2] Azathioprine,
Methylprednisolone		[8] D00238 ,
D00407 ,
D00751 ,
D00979 ,
D03033 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[2] 93, 95
127Methylprednisolone and Mycophenolate mofetil[3] Methylprednisolone,
Mycophenolate mofetil,
Mycophenolic acid		[10] D00407 ,
D00751 ,
D00752 ,
D00979 ,
D05000 ,
D05001 ,
D05002 ,
D05094 ,
D05095 ,
D05096 		[3] IMPDH1,
IMPDH2,
NR3C1 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Neuroactive ligand-receptor interaction, Purine metabolism 💬[2] 93, 95
128Minodronic acid[1] Minodronic acid---[4] 6, 46, 93, 95
129MODAFINIL[1] Modafinil[1] D01832 --[4] 6, 13, 49, 93
130Moexipril[1] Moexipril[2] D00623 ,
D08225 		[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 93
131MXB-8025----[1] 93
132Mycophenolate[1] Mycophenolic acid[1] D05096 [2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
133Mycophenolate mofetil[2] Mycophenolate mofetil,
Mycophenolic acid		[4] D00752 ,
D05094 ,
D05095 ,
D05096 		[2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
134NCA 500mg----[1] 93
135NGM282----[2] 93, 94
136NI-0801----[1] 93
137Non-myeloablative Hematopoietic Stem Cell Transplantation----[1] 93
138Norucholic acid[1] norUrsodeoxycholic acid---[2] 93, 94
139Norucholic acid (NCA) 500 mg[1] norUrsodeoxycholic acid---[1] 93
140Obeticholic Acid[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[3] 93, 265, 296
141Obeticholic Acid (OCA)[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
142Obeticholic Acid 5 MG[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
143Obeticholic Acid Tablets[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
144OCA (INT-747)----[1] 93
145OCA, INT-747----[1] 93
146Ocaliva[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[2] 93, 296
147Ocaliva 10mg[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
148Ocaliva 5mg[1] Obeticholic acid[1] D09360 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
149Olumiant[1] Baricitinib[1] D10308 [2] JAK1,
JAK2 💬		[35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[4] 46, 49, 93, 107
150OP-724----[1] 93
151Other: Blood samples----[1] 93
152Other: Questionnaires----[5] 6, 13, 41, 93, 96
153Part 1: LJN452----[1] 93
154Part 2: LJN452 Dose level 1----[1] 93
155Part 2: LJN452 Dose level 2----[1] 93
156Pemafibrate[1] Pemafibrate[1] D10711 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 93
157Pentoxifylline[1] Pentoxifylline[1] D00501 --[10] 26, 56, 84, 93, 96, 113, 220, 222, 296, 298
158PHENYLBUTYRATE[1] Phenylbutyric acid---[12] 2, 3, 6, 8, 15, 93, 94, 244, 251, 297, 299, 338
159Probiotic----[7] 2, 6, 93, 96, 97, 193, 266
160PYRIDOXINE[1] Pyridoxine[2] D02179 ,
D08454 		--[3] 93, 145, 320
161Pyridoxine 10mg[1] Pyridoxine[2] D02179 ,
D08454 		--[1] 93
162Pyridoxine 10mg BP[1] Pyridoxine[2] D02179 ,
D08454 		--[1] 93
163Questran[1] Cholestyramine---[4] 93, 254, 297, 338
164Raltegravir[1] Raltegravir[1] D06676 --[4] 13, 26, 93, 265
165RhuDex 100 mg (127 mg RhuDex choline salt) granules[1] Choline[1] D07690 --[1] 93
166RhuDex 25 mg (31.75 mg RhuDex choline salt) granules[1] Choline[1] D07690 --[1] 93
167RhuDex 50 mg (63.5 mg RhuDex choline salt) granules[1] Choline[1] D07690 --[1] 93
168RhuDex choline salt[1] Choline[1] D07690 --[1] 93
169Rifampicin[1] Rifampicin[1] D00211 --[6] 6, 17, 46, 93, 299, 338
170Rifaximin[1] Rifaximin[1] D02554 --[7] 6, 65, 93, 96, 97, 99, 296
171Risedronic acid[1] Risedronic acid[3] D00942 ,
D03234 ,
D08484 		[1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[3] 93, 95, 274
172Rituximab[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[49] 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
173S-adenosyl-L-methionine[1] Methionine[2] D00019 ,
D04983 		--[1] 93
174S-adenosyl-methionine (SAMe) capsules[2] Ademetionine,
Methionine		[3] D00019 ,
D04983 ,
D07128 		--[1] 93
175SAMe[1] Ademetionine[1] D07128 --[1] 93
176Saroglitazar[1] Saroglitazar---[1] 93
177Saroglitazar Magnesium 1 mg[2] Magnesium,
Saroglitazar		---[1] 93
178Saroglitazar Magnesium 2 mg[2] Magnesium,
Saroglitazar		---[1] 93
179Saroglitazar magnesium 4 mg[2] Magnesium,
Saroglitazar		---[1] 93
180SELADELPAR[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[2] 93, 94
181Seladelpar 10 mg[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
182Seladelpar 10 mg Capsule[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
183Seladelpar 10 mg or less[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
184Seladelpar 5 mg[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
185Seladelpar 5 mg Capsule[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
186Seladelpar 5-10 mg[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[1] 93
187SETANAXIB----[1] 93
188Sortis----[1] 93
189Sortis 10 mg----[1] 93
190Sublimated mare milk----[1] 93
191TAUROURSODEOXYCHOLIC ACID[1] Tauroursodeoxycholic acid[1] D11836 --[4] 2, 13, 93, 299
192Tauroursodeoxycholic Acid Capsules[1] Tauroursodeoxycholic acid[1] D11836 --[1] 93
193Tenofovir[1] Tenofovir disoproxil[1] D01982 --[6] 2, 13, 25, 93, 265, 325
194Tenofovir disoproxil[1] Tenofovir disoproxil[1] D01982 --[2] 93, 265
195Tetrathiomolybdate[1] Tetrathiomolybdate---[3] 85, 93, 171
196Thiamine[1] Thiamine[1] D08580 --[4] 8, 13, 93, 265
197Tiamin DAK----[1] 93
198Tiamin SAD----[1] 93
199Tigecycline[1] Tigecycline[1] D01079 --[1] 93
200TQA3526----[1] 93
201Tropifexor[1] Tropifexor[1] D11548 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
202Truvada and Kaletra[1] Lopinavir[1] D01425 --[1] 93
203UDCA[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[6] 46, 67, 93, 94, 97, 296
204UDCA (Ursodeoxycholic acid)[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
205Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation----[2] 93, 296
206Ursodeoxycholic acid[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[9] 6, 46, 67, 84, 93, 94, 95, 96, 97
207Ursodeoxycholic Acid (URSO)[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
208Ursodeoxycholic Acid 300mg capsule[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
209Ursodeoxycholic Acid 300mg tablet[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
210Ursodeoxycholic Acid Capsules[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
211Ursodeoxycholic acid combination of immunosuppressive agents[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[2] 93, 95
212Ursodeoxycholic acid combined with total glucosides of paeony[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
213Ursodeoxycholic acid only[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
214Ursodeoxycholic acid+Low Dose Glucocorticoid(Methylprednisolone)[2] Methylprednisolone,
Ursodeoxycholic acid		[7] D00407 ,
D00734 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[2] NR1H4,
NR3C1 💬		[2] Bile secretion, Neuroactive ligand-receptor interaction 💬[1] 93
215Ursodeoxycholsäure----[1] 93
216Ursodiol[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[6] 8, 20, 93, 97, 234, 299
217Ursofalk[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[4] 93, 94, 96, 97
218Ursofalk® 500 mg film-coated tablets[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
219Ursofalk® 500 mg Filmtabletten[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
220Ursofalk® capsules[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 93
221Ustekinumab[1] Ustekinumab[1] D09214 [3] IL12A,
IL12B,
IL23A 💬		[28] African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Malaria, Measles, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus 💬[17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
222Ustekinumab 180 mg[1] Ustekinumab[1] D09214 [3] IL12A,
IL12B,
IL23A 💬		[28] African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Malaria, Measles, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus 💬[1] 93
223Ustekinumab 45 mg[1] Ustekinumab[1] D09214 [3] IL12A,
IL12B,
IL23A 💬		[28] African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Malaria, Measles, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus 💬[1] 93
224Ustekinumab 90 mg[1] Ustekinumab[1] D09214 [3] IL12A,
IL12B,
IL23A 💬		[28] African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Malaria, Measles, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus 💬[4] 49, 50, 93, 96
225Vitamin D[1] Vitamin D---[24] 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
226Volixibat[1] Volixibat[1] D11007 --[2] 93, 94
227Zoledronic acid[1] Zoledronic acid[4] D01968 ,
D06378 ,
D06379 ,
D08689 		[1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[12] 5, 6, 13, 17, 46, 93, 95, 96, 270, 274, 299, 333