Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Acetaminophen
(Synonym: Nitetime Cold Medicine Liq)		[5] Acetaminophen; Oxycodone/Acetaminophen; Paracetamol; Tylenol; Ultracet[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
2 Acetylsalicylic acid
(Synonym: Alka-Seltzer Plus Day Non Drowsy Cold Medicine Citrus)		[2] ACETYLSALICYLIC ACID; Aspirin[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
3 Allantoin
(Synonym: Orajel Multi-action Cold Sore Medicine)		[1] ALLANTOIN[1] D00121 --[1] 36
4 Bisacodyl
(Synonym: The Medicine Shoppe Gentle Laxative)		[1] Bisacodyl[1] D00245 --[1] 13
5 Butylene glycol
(Synonym: QIZHOUGUAI Chinese medicine patch)		[0] [1] D10695 --[2] 28, 46
6 Caffeine
(Synonym: Only For FIRST AID MEDICINE)		[1] Caffeine[2] D00528 ,
D01453 		[11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
7 Calcium carbonate
(Synonym: Welly Childrens Travel Medicine)		[3] Calcio carbonato; Calcium; Calcium carbonate[2] D00932 ,
D10802 		--[9] 13, 19, 46, 53, 75, 96, 235, 274, 299
8 Chlorpheniramine
(Synonym: XL-3 Cold Medicine)		[1] Clorfenamina[4] D00665 ,
D00668 ,
D07398 ,
D07803 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 14
9 Citric acid
(Synonym: Premier Value Antacid and Pain Relief Medicine)		[1] Citric acid[2] D00037 ,
D01222 		--[2] 53, 291
10 Dextromethorphan
(Synonym: Baczol Cold Medicine)		[4] Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta[3] D00848 ,
D03742 ,
D03744 		[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
11 Diphenhydramine
(Synonym: Complete Allergy Medicine)		[2] Diphenhydramine; Diphenhydramine hydrochloride[6] D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
12 Ibuprofen
(Synonym: Ibuprofen Fast relief medicine for pain)		[2] Ibuprofen; IBUPROFEN 200MG[4] D00126 ,
D01122 ,
D04490 ,
D06606 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
13 Loperamide
(Synonym: Welly Travel Medicine Kit)		[2] Loperamide; Loperamide hydrochloride[3] D00729 ,
D07113 ,
D08144 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[2] 13, 97
14 Loratadine
(Synonym: Medicine Shoppe Allergy Relief D24)		[2] Loratadina; Loratadine[1] D00364 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 13, 46, 89, 98
15 Petrolatum
(Synonym: Orajel Multi-action Cold Sore Medicine)		[1] Petrolatum[1] D05331 --[3] 35, 158, 162
16 Phenylephrine
(Synonym: Father Johns Cough Medicine Plus)		[1] Phenylephrine[2] D00511 ,
D08365 		[3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 22
17 Pseudoephedrine
(Synonym: Nighttime Cold and Flu Extra Strength Medicine)		[1] Pseudoephedrine[4] D00485 ,
D05648 ,
D05649 ,
D08449 		[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 17
18 Sodium bicarbonate
(Synonym: Premier Value Antacid and Pain Relief Medicine)		[1] Sodium Bicarbonate[1] D01203 --[1] 299