2. 筋萎縮性側索硬化症 Amyotrophic lateral sclerosis Clinical trials / Disease details


臨床試験数 : 624 薬物数 : 611 - (DrugBank : 160) / 標的遺伝子数 : 172 - 標的パスウェイ数 : 225

  
7 trials found
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1NCT04952155
(ClinicalTrials.gov)
January 1, 202027/6/2021Low Dose IL-2 in the Treatment of Immune-associated ALS SyndromeA Single-center, Open-label Clinical Study to Evaluate the Efficacy and Safety of Low-dose IL-2 in the Treatment of Immune-associated ALS SyndromeAmyotrophic Lateral SclerosisDrug: IL-2Peking University Third HospitalNULLRecruiting18 Years70 YearsAll13Phase 2China
2ChiCTR2000035966
2019-10-102020-08-20Clinical efficacy of expanded autologous regulatory T cells infusion in amyotrophic lateral sclerosisClinical efficacy and safety of expanded autologous peripheral blood mononuclear cells in amyotrophic lateral sclerosis Amyotrophic lateral sclerosisCase series:T cell therapy + Herb Qu + Interleukin-2;Nanjing Hospital Affiliated to Nanjing University of traditional Chinese MedicineNULLRecruitingBothCase series:30;China
3NCT04055623
(ClinicalTrials.gov)
August 7, 201912/8/2019T-regulatory Cells in ALSPhase 2a Study of the Expansion and Infusion of Autologous T-Regulatory Cells in Amyotrophic Lateral SclerosisALS (Amyotrophic Lateral Sclerosis)Biological: Monthly autologous Treg cells infusions + 3 times per week Interleukin-2 injections;Other: Monthly placebo infusions + 3 times per week placebo injectionsThe Methodist Hospital Research InstituteMassachusetts General Hospital;The Center for Clinical and Translational Sciences (CCTS) Clinical Research Unit at The University of Texas Health Science Center at Houston;North East Amyotrophic Lateral Sclerosis ConsortiumActive, not recruiting18 YearsN/AAll12Phase 2United States
4NCT03039673
(ClinicalTrials.gov)
June 19, 201731/1/2017MIROCALS: Modifying Immune Response and OutComes in ALSEfficacy and Safety of Low-dose IL-2 (Ld-IL-2) as a Treg Enhancer for Controlling Neuro-inflammation in Newly Diagnosed Amyotrophic Lateral Sclerosis (ALS) Patients: A Randomized, Double-blind, Placebo- Controlled, Phase-II Proof of Concept/ Proof of Mechanism Clinical TrialAmyotrophic Lateral SclerosisDrug: Riluzole;Drug: IL-2;Drug: 5% glucose water solutionCentre Hospitalier Universitaire de NimesNULLCompleted18 Years75 YearsAll304Phase 2France;United Kingdom
5EUCTR2015-005347-14-GB
(EUCTR)
25/08/201609/05/2016Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for controlling neuro-inflammation in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patientsEfficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for controlling neuro-inflammation in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients:A randomized, double-blind, placebo- controlled, phase-II Proof of Concept/ Proof of Mechanism Clinical Trial - MIROCALS Amyotrophic Lateral Sclerosis (ALS)
MedDRA version: 20.0;Level: PT;Classification code 10002026;Term: Amyotrophic lateral sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Trade Name: Proleukin 18 MUI
Product Name: proleukin
CHU DE NIMESNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
216Phase 2United Kingdom
6NCT03241784
(ClinicalTrials.gov)
May 16, 201627/7/2017T-Regulatory Cells in Amyotrophic Lateral SclerosisExpansion and Infusion of T-Regulatory Cells in Amyotrophic Lateral SclerosisALS (Amyotrophic Lateral Sclerosis)Biological: Autologous T-regulatory lymphocytes;Biological: Interleukin-2Stanley H. Appel, MDNULLUnknown status18 YearsN/AAll4Phase 1United States
7NCT02059759
(ClinicalTrials.gov)
September 20157/2/2014Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2Amyotrophic Lateral SclerosisDrug: Placebo;Drug: 1.0 MIU IL-2 per day;Drug: 2.0 MIU IL-2 per dayCentre Hospitalier Universitaire de NimesNULLCompleted18 Years75 YearsBoth36Phase 2France