Disease details

Clinical trials : 3,342 / Drugs : 2,355 - (DrugBank : 406) / Drug target genes : 269 - Drug target pathways : 241

4 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2008-001940-38-IT (EUCTR)	22/04/2008	14/04/2008	Functional RMN study to evaluate the prompt and middle term effect of the treatment with Donepezil in patients affected by multiple sclerosis and mild impairment of cognitive function. - ND	Functional RMN study to evaluate the prompt and middle term effect of the treatment with Donepezil in patients affected by multiple sclerosis and mild impairment of cognitive function. - ND	patients affected by multiple sclerosis MedDRA version: 9.1;Level: LLT;Classification code 10063399;Term: Relapsing-remitting multiple sclerosis	Trade Name: ARICEPT INN or Proposed INN: Donepezil Trade Name: ARICEPT INN or Proposed INN: Donepezil	OSPEDALE S. RAFFAELE	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Italy
2	EUCTR2005-003410-15-SE (EUCTR)	21/11/2005	29/09/2005	A twelve-month double-blind placebo-controlled cross-over study of the effect ofAricept treatment on cognitive dysfunction in multiple sclerosis. - Aricept in MS	A twelve-month double-blind placebo-controlled cross-over study of the effect ofAricept treatment on cognitive dysfunction in multiple sclerosis. - Aricept in MS	Multiple sclerosis is a devastating inflammation in the central nervous system and it can often give cognitive dysfunction, affecting memory, mental concentration. Lately it has been shown that the cognitive dysfunction has a big impact on life quality. Immunomodulatory medication can only partially limit the bouts but there is no effective cure at the moment. There is little options to treat the effects on higher functions for the moment.	Trade Name: Aricept 5 mg filmdragerade tabletter Product Name: Aricept 5 mg INN or Proposed INN: Donepezil Trade Name: Aricept 10 mg filmdragerade tabletter Product Name: Aricept 10 mg INN or Proposed INN: Donepezil	Neurology Unit	NULL	Not Recruiting			Female: yes Male: yes	20		Sweden
3	NCT00315367 (ClinicalTrials.gov)	September 2004	14/4/2006	A fMRI(Functional Magnetic Resonance Imaging) Research Study to Learn More About Multiple Sclerosis and Individuals Potentially Experiencing Memory Difficulties	A Double-Blind, Crossover Trial of Aricept® in Memory-Impaired Patients With Multiple Sclerosis: A Phase IV Demonstration of Functional MRI (fMRI) as a Surrogate Marker of Brain Activity Associated With Improvement in Memory Function	Relapsing-Remitting Multiple Sclerosis	Drug: Donepezil HCI (drug)	Neurognostics	NULL	Completed	18 Years	65 Years	Both	26	Phase 4	United States
4	NCT00062972 (ClinicalTrials.gov)	September 1999	18/6/2003	Improving Memory in Patients With Multiple Sclerosis	Interventions to Improve Memory in Patients With Multiple Sclerosis	Multiple Sclerosis	Drug: donepezil;Drug: glucose	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	U.S. Department of Education	Withdrawn	18 Years	56 Years	All	0	Phase 3	United States