Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 (S)-Warfarin [2] S-Warfarin; Warfarin---[1] 13
2 Abatacept [2] Abatacept; Orencia[1] D03203 [2] CD80,
CD86 💬		[12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
3 ABX-1431 [1] ABX-1431---[1] 13
4 Acetaminophen [5] Acetaminophen; Oxycodone/Acetaminophen; PARACETAMOL; Tylenol; Ultracet[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
5 Acetate [1] Acetate---[43] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
6 Acetazolamide [1] Acetazolamide[2] D00218 ,
D01196 		[13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[8] 13, 86, 90, 115, 154, 155, 225, 230
7 Acetic acid C-11 [1] 11C-ACETATE---[3] 13, 86, 88
8 Acetylcysteine [3] Acetylcysteine; Mucomyst; N-Acetylcysteine[1] D00221 --[20] 6, 13, 19, 20, 34, 49, 51, 53, 58, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
9 Acetylsalicylic acid [2] Acetylsalicylic Acid; Aspirin[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
10 Acyclovir [3] ACICLOVIR; Acycloguanosine; Acyclovir[1] D00222 --[5] 13, 28, 46, 53, 60
11 Adenosine [2] Adenosine; Ginseng[1] D00045 [4] ADORA1,
ADORA2A,
ADORA2B,
ADORA3 💬		[12] Alcoholism, Calcium signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 13, 58, 65
12 Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins [1] HB-adMSCs---[7] 2, 4, 6, 13, 46, 49, 113
13 Alanine [2] Alanine; L-alanine[1] D00012 --[5] 6, 13, 251, 298, 299
14 Albendazole [2] Albendazole; Eskazole[1] D00134 --[12] 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127
15 Alemtuzumab [4] Alemtuzumab; Campath; Lemtrada; MABCAMPATH[1] D02802 [1] CD52 💬-[22] 13, 15, 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326
16 Alfuzosin [1] Alfuzosin[2] D01692 ,
D07124 		[1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 13
17 Amantadine [3] Amantadine; AMANTADINE HYDROCHLORIDE; GOCOVRI[2] D00777 ,
D07441 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[4] 6, 8, 13, 127
18 Amiloride [3] AMILORIDE; Amiloride Hydrochloride; Midamor[2] D00649 ,
D07447 		[3] SCNN1A,
SCNN1B,
SCNN1G 💬		[2] Aldosterone-regulated sodium reabsorption, Taste transduction 💬[4] 13, 67, 225, 299
19 Aminosalicylic acid [2] 4-Aminosalicylic acid; AMINOSALICYLIC ACID[1] D00162 --[3] 13, 96, 97
20 Amlodipine [1] Amlodipine[3] D00615 ,
D02914 ,
D07450 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298
21 Ampicillin [1] ABPC[3] D00204 ,
D01251 ,
D02119 		--[5] 2, 6, 13, 84, 299
22 Anakinra [2] Anakinra; Kineret[1] D02934 [2] IL1R1,
IL1R2 💬		[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[19] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
23 Antithymocyte immunoglobulin (rabbit) [10] Anti-thymocyte globulin; Antithymocyte immunoglobulin; Antithymocyte immunoglobulin (rabbit); Lapine T-Lymphocyte Immune Globulin; Rabbit anti-human thymocyte immunoglobulin; Rabbit antithymocyte globulin; Rabbit ATG; RATG; Thymoglobulin; Thymoglobuline---[12] 13, 36, 49, 51, 60, 62, 65, 96, 283, 285, 286, 326
24 Arbaclofen [2] Arbaclofen; BACLOFEN[1] D09791 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[2] 13, 206
25 Arbaclofen Placarbil [1] Arbaclofen Placarbil[1] D08861 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[1] 13
26 Armodafinil [2] Armodafinil; MODAFINIL[1] D03215 [1] SLC6A3 💬[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[3] 6, 13, 84
27 Aspartame [0] [1] D02381 [2] TAS1R2,
TAS1R3 💬		[2] Carbohydrate digestion and absorption, Taste transduction 💬[5] 6, 13, 67, 86, 230
28 Atacicept [2] ATACICEPT; TACI-Fc5[1] D09704 [2] TNFSF13,
TNFSF13B 💬		[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[4] 13, 46, 49, 66
29 ATL1102 [1] ATL1102---[1] 13
30 Atomoxetine [2] Atomoxetine; Strattera[2] D02574 ,
D07473 		[1] SLC6A2 💬[1] Synaptic vesicle cycle 💬[4] 6, 8, 13, 17
31 Atorvastatin [3] Atorvastatin; Atorvastatin Calcium; Lipitor[3] D00258 ,
D00887 ,
D07474 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
32 Azathioprine [3] AZATHIOPRINE; Azatioprina; Imuran[2] D00238 ,
D03033 		--[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
33 Azithromycin [5] AZITHROMYCIN; AZITHROMYCIN DIHYDRATE; Azithromycin monohydrate; AZITHROMYCINE; ZITHROMAX[3] D02134 ,
D06390 ,
D07486 		--[6] 13, 84, 85, 96, 228, 299
34 Baclofen [2] BACLOFEN; Kemstro[1] D00241 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[7] 2, 10, 13, 18, 65, 149, 206
35 Baminercept [2] Baminercept; Baminercept alfa[1] D08866 [1] LTB 💬[3] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[4] 13, 46, 53, 97
36 Bazedoxifene [1] Bazedoxifene---[1] 13
37 Belimumab [2] Belimumab; Benlysta[1] D03068 [1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[12] 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
38 Beta carotene [3] Beta carotene; Beta-Carotene; BETACAROTENE[1] D03101 --[2] 13, 96
39 beta-Alanine [1] Beta-Alanine[1] D07561 --[1] 13
40 Bevacizumab [2] AVASTIN; Bevacizumab[1] D06409 [1] VEGFA 💬[24] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Calcium signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway 💬[9] 13, 34, 85, 86, 87, 89, 227, 280, 331
41 Bexarotene [2] Bexarotene; Targretin[1] D03106 [3] RXRA,
RXRB,
RXRG 💬		[17] Adipocytokine signaling pathway, Bile secretion, Chemical carcinogenesis - receptor activation, Gastric cancer, Hepatitis C, Lipid and atherosclerosis, Non-alcoholic fatty liver disease, Non-small cell lung cancer, PI3K-Akt signaling pathway, PPAR signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer 💬[2] 13, 75
42 Biotin [4] Biotin; Biotina; D-BIOTIN; Vitamin B7[1] D00029 --[5] 2, 8, 10, 13, 20
43 Bisacodyl [1] Bisacodyl[1] D00245 --[1] 13
44 Borage oil [1] BORAGE OIL---[1] 13
45 Bortezomib [3] Bortezomib; Bortezomib Accord; VELCADE[1] D03150 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331
46 Bosentan [2] BOSENTAN; TRACLEER[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
47 Botulinum toxin type A [8] Botox; Botulinum toxin A; BOTULINUM TOXIN TYPE A; BTX-A; Dysport; IncobotulinumtoxinA; OnabotulinumtoxinA; Xeomin[1] D00783 [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226
48 Botulinum toxin type B [3] Botulinum toxin type B; NEUROBLOC; RimabotulinumtoxinB[1] D02735 [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[4] 2, 6, 13, 51
49 Brimonidine [2] Brimonidine; Brimonidine Tartrate[2] D02076 ,
D07540 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[2] 13, 90
50 Caffeine [1] Caffeine[2] D00528 ,
D01453 		[11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
51 Calcium [2] Calcio; Calcium---[30] 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
52 Calcium carbonate [3] Calcio carbonato; Calcium; Calcium carbonate[2] D00932 ,
D10802 		--[9] 13, 19, 46, 53, 75, 96, 235, 274, 299
53 Cannabidiol [3] CANNABIDIOL; Epidyolex; Sativex[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[19] 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
54 Carbamazepine [1] Carbamazepine[1] D00252 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[2] 13, 231
55 Carbidopa [7] Carbidopa; DUODOPA; Lodosyn; PARCOPA; SINEMET; SINEMET CR; Stalevo[1] D00558 [1] DDC 💬[9] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[9] 2, 4, 6, 13, 17, 90, 140, 164, 201
56 Carbon monoxide [1] Carbon Monoxide[1] D09706 --[8] 6, 13, 53, 70, 85, 86, 149, 298
57 Carbonate ion [1] Carbonate---[12] 2, 13, 17, 18, 19, 46, 53, 75, 96, 127, 235, 299
58 Carmustine [1] Carmustine[1] D00254 --[5] 11, 13, 14, 28, 60
59 Carnosine [1] Carnosine---[2] 6, 13
60 CDP323 [1] CDP323---[1] 13
61 Ceralifimod [1] Ceralifimod---[1] 13
62 Cetirizine [3] CETIRIZINA; Cetirizine; CETIRIZINE HYDROCHLORIDE[2] D00664 ,
D07662 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 13, 28, 35, 300
63 Chloride ion [1] Chloride---[29] 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 271, 288, 296, 297, 299, 338
64 Chlormezanone [0] [1] D00268 --[1] 13
65 Cholecalciferol [5] Cholecalciferol; COLECALCIFEROL; Multivitamin; Vitamin D; Vitamin D3[1] D00188 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[25] 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 75, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
66 Cholestyramine [3] Cholestyramine; COLESTYRAMINE; Questran---[3] 13, 79, 254
67 Cisapride [1] CISAPRIDE[2] D00274 ,
D02092 		[3] HTR2A,
HTR3A,
HTR4 💬		[7] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[1] 13
68 Citalopram [1] Citalopram[2] D00822 ,
D07704 		[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[7] 6, 8, 13, 18, 46, 98, 127
69 Cladribine [4] 2-CdA; CLADRIBINA; Cladribine; MAVENCLAD[1] D01370 [1] RRM1 💬[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬[3] 11, 13, 94
70 Clemastine [2] Clemastine; CLEMASTINE FUMARATE[2] D00666 ,
D03535 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 13
71 Clenbuterol [1] Clenbuterol[1] D07713 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 1, 2, 6, 13, 256
72 Clidinium [0] ---[4] 13, 20, 50, 272
73 Clostridium botulinum [1] Clostridium botulinum---[1] 13
74 Clostridium tetani toxoid antigen (formaldehyde inactivated) [4] Boostrix; Nimenrix; Tetanus toxoid; Tetanus toxoid adsorbed---[4] 13, 14, 46, 50
75 Coconut [1] Coconut---[3] 13, 53, 226
76 Coconut oil [1] Coconut oil[1] D05326 --[2] 13, 226
77 Coenzyme M [2] MESNA; UROMITEXAN---[11] 11, 13, 44, 45, 49, 51, 60, 65, 85, 96, 164
78 Corticotropin [5] ACTH; Acthar; Adrenocorticotropic hormone; Corticotrophin; Corticotropin[1] D00146 [1] MC2R 💬[5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[15] 2, 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222
79 Corynebacterium diphtheriae CRM197 protein [1] CRM197---[3] 11, 13, 46
80 Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) [2] Boostrix; DIPHTHERIA TOXOID---[2] 13, 46
81 Cranberry [1] Cranberry---[1] 13
82 Creatine [1] Creatine---[16] 1, 2, 3, 5, 6, 8, 13, 15, 21, 46, 49, 50, 113, 156, 201, 256
83 Creatinolfosfate [0] [1] D07162 --[1] 13
84 Curcumin [1] Curcumin---[11] 2, 13, 46, 49, 67, 74, 94, 96, 97, 139, 299
85 CVnCoV [1] SARS-COV-2 mRNA Vaccine---[1] 13
86 Cyanocobalamin [2] Cianocobalamina; Vitamin B12[4] D00166 ,
D03615 ,
D03616 ,
D03617 		--[5] 6, 13, 201, 229, 299
87 Cyclophosphamide [6] Ciclofosfamida; Ciclofosfamide; Cyclophosphamid; Cyclophosphamide; Cyclophosphamidum; Cytoxan[2] D00287 ,
D07760 		--[45] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331
88 Cysteine [2] Cysteine; Cysteine hydrochloride[2] D00026 ,
D02326 		--[11] 6, 13, 19, 34, 84, 85, 88, 90, 254, 296, 310
89 Cytarabine [1] Cytarabine[3] D00168 ,
D03046 ,
D03637 		--[7] 11, 13, 14, 25, 49, 60, 65
90 Daclizumab [3] Daclizumab; Zenapax; Zinbryta[1] D03639 [1] IL2RA 💬[11] Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, JAK-STAT signaling pathway, Measles, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[8] 13, 56, 60, 65, 97, 107, 283, 284
91 Dalfampridine [7] 4-Aminopyridine; 4-AP; AMPYRA; Dalfampridine; FAMPRIDINA; FAMPRIDINE; FAMPYRA[1] D04127 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[5] 3, 4, 6, 13, 14
92 Dantrolene [2] Dantrolene; Dantrolene sodium[2] D02274 ,
D02347 		--[2] 13, 233
93 Dapirolizumab pegol [1] Dapirolizumab pegol---[2] 13, 49
94 Darifenacin [2] Darifenacin; Emselex[2] D01699 ,
D03654 		[1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13
95 Decitabine [1] Decitabine[1] D03665 [3] DNMT1,
DNMT3A,
DNMT3B 💬		[3] Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer 💬[3] 13, 60, 63
96 Desloratadine [1] Desloratadine[1] D03693 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 13
97 Dexamethasone [5] Decadron; Dexametasona; Dexamethasone; Dexamethasone sodium phosphate; Maxidex[9] D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
98 Dexchlorpheniramine [1] Dexchlorpheniramine[1] D07803 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[2] 13, 49
99 Dexrazoxane [1] Dexrazoxane[1] D03730 [2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[1] 13
100 Dextromethorphan [4] Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta[3] D00848 ,
D03742 ,
D03744 		[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
101 Dextrose, unspecified form [2] Dextrose; Glucose---[19] 2, 6, 13, 49, 50, 56, 60, 65, 70, 75, 86, 88, 96, 160, 195, 226, 254, 257, 299
102 Diazoxide [1] Diazoxide[1] D00294 [2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[2] 13, 193
103 Diclofenac [3] Diclofenac; Diclofenac sodium; Diclofenac SR[3] D00903 ,
D00904 ,
D07816 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[5] 13, 34, 46, 78, 271
104 Dimethyl fumarate [3] Dimethyl fumarate; Dimethylfumarat; TECFIDERA[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[5] 13, 49, 51, 86, 296
105 Dimethyltryptamine [0] ---[1] 13
106 Diphenhydramine [2] Diphenhydramine; Diphenhydramine hydrochloride[6] D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
107 Diroximel fumarate [1] Diroximel fumarate[1] D11154 --[1] 13
108 Dirucotide [1] Dirucotide[1] D09396 --[1] 13
109 Domperidone [1] Domperidone[2] D01745 ,
D07868 		[1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 6, 13, 17, 51, 230
110 Donepezil [3] Aricept; Donepezil; Donepezil hydrochloride[2] D00670 ,
D07869 		[1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
111 Doxycycline [4] Doxycyclin; Doxycycline; Doxycycline Hyclate; Doxycycline Tablets[5] D00307 ,
D02129 ,
D03903 ,
D03904 ,
D07876 		--[16] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 161, 162, 167, 227, 280, 299
112 Dronabinol [4] Delta-9-tetrahydrocannabinol; DRONABINOL; SATIVEX; Tetrahydrocannabinol[1] D00306 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[8] 2, 8, 13, 36, 46, 96, 271, 298
113 Dulaglutide [2] Dulaglutide; Trulicity[1] D09889 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[2] 13, 299
114 Duloxetine [3] CYMBALTA; Duloxetine; Duloxetine hydrochloride[2] D01179 ,
D07880 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 13
115 Dydrogesterone [1] DYDROGESTERONE[1] D01217 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[1] 13
116 Eculizumab [2] ECULIZUMAB; SOLIRIS[1] D03940 [1] C5 💬[10] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[7] 11, 13, 14, 61, 62, 109, 222
117 Efalizumab [2] EFALIZUMAB; Raptiva[1] D03959 [1] ITGAL 💬[12] Cell adhesion molecules, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Leukocyte transendothelial migration, Malaria, Natural killer cell mediated cytotoxicity, Neutrophil extracellular trap formation, Rap1 signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, Staphylococcus aureus infection, Viral myocarditis 💬[9] 11, 13, 37, 46, 49, 53, 61, 95, 96
118 Elezanumab [1] Elezanumab[1] D11355 [1] RGMA 💬[2] Axon guidance, TGF-beta signaling pathway 💬[1] 13
119 Epigallocatechin [1] Epigallocatechin---[5] 8, 13, 28, 85, 113
120 Epigallocatechin gallate [2] EGCG; Epigallocatechin gallate---[9] 6, 8, 13, 17, 28, 85, 113, 206, 299
121 Erythropoietin [4] EPOETIN ALFA; Epoetin beta; Erythropoietin; Neorecormon[1] D03231 [1] EPOR 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[10] 2, 6, 13, 18, 22, 46, 47, 70, 95, 96
122 Escitalopram [3] Citalopram; Escitalopram; Escitalopram oxalate[3] D02567 ,
D07704 ,
D07913 		[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 2, 6, 13
123 Esomeprazole [3] Esomeprazole; Nexium; Omeprazole[4] D01984 ,
D04056 ,
D07917 ,
D09339 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[8] 13, 46, 86, 98, 107, 113, 298, 299
124 Estradiol [1] Estradiol[8] D00105 ,
D01413 ,
D01617 ,
D01953 ,
D04061 ,
D04063 ,
D04064 ,
D04065 		[2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[7] 13, 46, 49, 65, 76, 226, 299
125 Estriol [1] Estriol[2] D00185 ,
D01986 		[2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[2] 13, 227
126 Eszopiclone [2] Eszopiclone; Zopiclone[1] D02624 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 6, 13, 46
127 Ethanol [3] Alcohol; Ethanol; PREDNISONE[4] D00068 ,
D02798 ,
D04855 ,
D06542 		--[7] 13, 51, 58, 97, 279, 280, 298
128 Ethinylestradiol [3] Ethinyl estradiol; ETHINYLESTRADIOL; Ortho-Novum 777[1] D00554 [1] ESR1 💬[9] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[4] 13, 46, 49, 299
129 Etifoxine [1] Etifoxine[1] D07320 --[1] 13
130 Etoposide [1] Etoposide[2] D00125 ,
D04107 		[2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331
131 Evobrutinib [1] EVOBRUTINIB---[3] 13, 46, 49
132 Famciclovir [1] Famciclovir[1] D00317 --[1] 13
133 Febuxostat [1] Febuxostat[1] D01206 [1] XDH 💬[5] Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Peroxisome, Purine metabolism 💬[3] 2, 6, 13
134 Fenamole [0] [1] D04139 --[3] 6, 13, 160
135 Fenebrutinib [1] FENEBRUTINIB[1] D11457 [1] BTK 💬[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[1] 13
136 Ferric oxide [1] Iron oxide[1] D04168 --[1] 13
137 Ferric pyrophosphate citrate [0] [1] D10933 --[1] 13
138 Ferumoxytol [2] Feraheme; Ferumoxytol[1] D04177 --[1] 13
139 Fexofenadine [1] Fexofenadine[2] D00671 ,
D07958 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[2] 13, 46
140 Filgrastim [7] Filgrastim; Filgrastim Hexal; G-CSF; GRANULOCYTE COLONY STIMULATING FACTOR; NEUPOGEN; TEVAGRASTIM; Zarzio[1] D03235 [1] CSF3R 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[34] 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
141 Fingolimod [2] FINGOLIMOD; GILENYA[1] D10001 [1] S1PR1 💬[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[3] 13, 14, 156
142 Firategrast [1] Firategrast[1] D06590 [1] ITGA4 💬[14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬[1] 13
143 Fish oil [4] Fish oil; Omegaven; Smofkabiven; SMOFLipid---[7] 13, 46, 49, 66, 96, 260, 299
144 Florbetapir (18F) [2] Amyvid; Florbetapir (18F)---[2] 13, 127
145 Fludarabine [4] FLUDARA; FLUDARABINA; FLUDARABINE; Fludarabine Phosphate[2] D01907 ,
D07966 		[1] RRM1 💬[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬[19] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
146 Fludeoxyglucose (18F) [3] 18F-FDG; Fludeoxyglucose; Fludeoxyglucose F 18---[14] 5, 6, 7, 8, 13, 34, 41, 46, 53, 84, 85, 96, 127, 300
147 Flumazenil [1] Flumazenil[1] D00697 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[5] 6, 13, 17, 18, 206
148 Fluoxetine [5] Fluoxetin; Fluoxetine; FLUOXETINE HYDROCHLORIDE; Fluoxétine; PROZAC[2] D00326 ,
D00823 		[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[6] 13, 17, 78, 86, 179, 206
149 Flupirtine [1] Flupirtine[1] D07978 --[1] 13
150 Flurbiprofen [1] Flurbiprofen[3] D00330 ,
D01475 ,
D02290 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 13, 21, 46
151 Folic acid [5] Acide folique; Folate; Folic Acid; Multivitamin; NICOTINAMIDE[1] D00070 --[6] 6, 13, 41, 46, 49, 84
152 Foralumab [1] Foralumab---[2] 13, 96
153 Fumaric acid [1] Fumaric acid[1] D02308 --[2] 13, 49
154 Gabapentin [4] Gabapentin; GABAPENTINA; Gabapentine; NEURONTIN[1] D00332 [5] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		[9] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬[5] 6, 13, 19, 70, 298
155 Gadobenic acid [2] Gadobenate; MultiHance[2] D04283 ,
D08018 		--[3] 13, 86, 88
156 Gadobutrol [1] Gadobutrol[1] D07420 --[3] 13, 22, 46
157 Gadolinium [1] Gadolinium---[6] 13, 34, 46, 58, 65, 86
158 Gadopentetic acid [1] Gadopentetate[2] D01707 ,
D08006 		--[2] 13, 34
159 Gadoteric acid [3] Dotarem; Gadoterate; Gadoteric acid[1] D08007 --[2] 13, 53
160 Gadoteridol [1] Gadoteridol[1] D01137 --[1] 13
161 gamma-Tocopherol [1] Gamma-Tocopherol---[1] 13
162 Gamolenic acid [2] Gamma-Linolenic acid; Linolenic acid[1] D07213 --[3] 13, 19, 46
163 Ginkgo biloba [3] Ginkgo; Ginkgo biloba; Tanakan---[5] 6, 13, 18, 47, 90
164 Ginseng [1] Ginseng[1] D06772 --[3] 13, 46, 53
165 Glatiramer [5] COP-1; COPAXONE; Copolymer-1; Glatiramer; Glatiramer acetate[1] D04318 [20] HLA-A,
HLA-B,
HLA-C,
HLA-DMA,
HLA-DMB,
HLA-DOA,
HLA-DOB,
HLA-DPA1,
HLA-DPB1,
HLA-DQA1,
HLA-DQA2,
HLA-DQB1,
HLA-DRA,
HLA-DRB1,
HLA-DRB3,
HLA-DRB4,
HLA-DRB5,
HLA-E,
HLA-F,
HLA-G 💬		[32] Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cellular senescence, Endocytosis, Epstein-Barr virus infection, Graft-versus-host disease, Hematopoietic cell lineage, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Inflammatory bowel disease, Influenza A, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Phagosome, Rheumatoid arthritis, Staphylococcus aureus infection, Systemic lupus erythematosus, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Viral carcinogenesis, Viral myocarditis 💬[4] 2, 13, 96, 156
166 Glycerin [3] Bee venom; Glycerine; Glycerol[1] D00028 --[6] 6, 13, 79, 265, 316, 317
167 Gold [1] Gold---[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 171, 193, 218, 222, 224, 227, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318
168 GSK-2018682 [0] ---[1] 13
169 GSK-239512 [0] ---[1] 13
170 Guanabenz [1] GUANABENZ[1] D04375 [3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[2] 2, 13
171 Haemophilus influenzae type B strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen [1] Hiberix---[4] 13, 61, 62, 66
172 Histamine [1] Histamine[1] D08040 [4] HRH1,
HRH2,
HRH3,
HRH4 💬		[4] Calcium signaling pathway, Gastric acid secretion, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 13
173 Histidine [2] Histidine; L-Histidine[1] D00032 --[3] 13, 169, 170
174 Human C1-esterase inhibitor [3] C1 inhibitor; C1-INH; Cinryze---[3] 13, 61, 65
175 Human immunoglobulin G [18] Bivigam; CUTAQUIG; CUVITRU; GAMMAGARD LIQUID; Gammaplex; GAMUNEX-C; Hizentra; HUMAN IMMUNOGLOBULIN G; HUMAN NORMAL IMMUNOGLOBULIN; HyQvia; Immune globulin; Immunoglobulin; IMMUNOGLOBULIN G; IVIg; KIOVIG; PANZYGA; Privigen; Vivaglobin---[11] 11, 13, 14, 17, 35, 43, 45, 50, 51, 63, 65
176 Human interferon beta [3] Human interferon beta; Interferon beta; Interferon-Beta---[6] 13, 20, 26, 50, 96, 97
177 Human interleukin-2 [3] Human interleukin-2; IL-2; INTERLEUKIN-2---[18] 2, 13, 35, 46, 49, 51, 53, 55, 56, 60, 63, 65, 95, 96, 97, 107, 162, 271
178 Human Umbilical Cord Mesenchymal Stem Cells [4] Human Umbilical Cord Mesenchymal Stem Cells; Mesenchymal Stromal Cells; UC-MSCs; WJ-MSCs---[13] 2, 13, 36, 46, 49, 51, 60, 96, 97, 107, 113, 274, 284
179 Hydrochlorothiazide [2] Esidrix; Hydrochlorothiazide[1] D00340 [1] SLC12A3 💬-[4] 13, 67, 225, 235
180 Hydrogen [2] Dihydrogen; Hydrogen---[8] 5, 6, 13, 17, 65, 83, 97, 226
181 Hydrogen peroxide [1] Hydrogen peroxide[1] D00008 --[1] 13
182 Hydroxychloroquine [3] Hydroxychloroquine; HYDROXYCHLOROQUINE SULFATE; Plaquenil[1] D08050 --[27] 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299
183 Hydroxytyrosol [1] Hydroxytyrosol---[1] 13
184 Hydroxyurea [1] Hydroxyurea[1] D00341 [1] RRM2 💬[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬[8] 3, 13, 19, 20, 65, 85, 86, 284
185 Ibudilast [1] IBUDILAST[1] D01385 [8] CYSLTR1,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PTGIR 💬		[16] Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 13
186 Ibuprofen [2] IBUPROFEN; IBUPROFEN 200MG[4] D00126 ,
D01122 ,
D04490 ,
D06606 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
187 Idebenone [2] Idebenone; Raxone[1] D01750 --[6] 6, 8, 13, 18, 113, 302
188 Imatinib [4] Gleevec; GLIVEC; Imatinib; Imatinib Mesylate[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
189 Indapamide [1] Indapamide[2] D00345 ,
D06401 		[1] SLC12A3 💬-[1] 13
190 Indian frankincense [2] Boswellia Serrata; Boswellia Serrata Extract---[1] 13
191 Inebilizumab [2] Inebilizumab; Uplizna[1] D11757 [1] CD19 💬[5] B cell receptor signaling pathway, Epstein-Barr virus infection, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Primary immunodeficiency 💬[4] 11, 13, 51, 300
192 Inosine [1] Inosine[1] D00054 --[6] 2, 6, 13, 17, 85, 122
193 Interferon alfa [1] Interferon alfa[1] D03305 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[6] 13, 25, 26, 28, 56, 96
194 Interferon beta-1a [6] AVONEX; Interferon Beta 1-A; Interferon Beta 1a; Interferon beta-1a; Interferon-beta-1a; REBIF[1] D04554 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[4] 13, 26, 96, 97
195 Interferon beta-1b [7] BETAFERON; Betaseron; EXTAVIA; Interferon beta 1B; INTERFERON BETA-1B; Interferon-beta-1b; RECOMBINANT INTERFERON BETA-1B[1] D00746 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 13
196 IR208 [0] ---[1] 13
197 Iron polymaltose [1] Fusion---[9] 11, 13, 46, 49, 69, 70, 86, 271, 299
198 Isoxaflutole [1] Balance---[8] 6, 11, 13, 81, 113, 122, 149, 299
199 Isoxsuprine [2] Isoxsuprine; Isoxsuprine Hydrochloride[1] D08092 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13
200 Ixazomib [2] Ixazomib; Ninlaro[1] D10130 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[5] 13, 16, 28, 51, 61
201 Josamycin [0] [1] D01235 --[2] 6, 13
202 Ketamine [2] Ketamine; NMDA[2] D00711 ,
D08098 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 4, 6, 13, 70, 113, 156, 215
203 Ketoconazole [2] Ketoconazole; NIZORAL[1] D00351 [1] CYP17A1 💬[6] Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Steroid hormone biosynthesis 💬[3] 8, 13, 75
204 Keyhole limpet hemocyanin [1] Keyhole limpet hemocyanin---[2] 13, 46
205 Lactobacillus casei [2] Fusion; Lactobacillus casei[1] D04351 --[10] 6, 11, 13, 46, 49, 69, 70, 97, 271, 296
206 Lactose [1] Lactose[2] D00046 ,
D03226 		--[6] 2, 6, 13, 97, 228, 310
207 Lactulose [1] Lactulose[1] D00352 --[3] 13, 96, 291
208 Lamotrigine [2] Lamictal; Lamotrigine[1] D00354 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[5] 13, 34, 38, 114, 144
209 Laquinimod [1] Laquinimod---[4] 8, 13, 49, 96
210 Lenograstim [2] G-CSF; LENOGRASTIM[1] D03247 [1] CSF3R 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[7] 2, 13, 16, 18, 19, 57, 65
211 Levetiracetam [2] KEPPRA; Levetiracetam[1] D00709 [1] SV2A 💬[1] ECM-receptor interaction 💬[5] 2, 4, 6, 13, 307
212 Levocarnitine [4] Carnitine; L-Carnitine; Levocarnitine; Xyzal[3] D02030 ,
D02176 ,
D04713 		--[11] 3, 5, 13, 53, 58, 86, 96, 97, 265, 298, 316
213 Levoleucovorin [1] Levofolene---[1] 13
214 Levonorgestrel [1] LEVONORGESTREL[1] D00950 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[1] 13
215 Lidocaine [4] Aloe; Lidocaine; Lignocaine; Xylocaine[3] D00358 ,
D02086 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
216 Linoleic acid [1] Linoleic acid---[8] 2, 5, 6, 13, 75, 76, 222, 299
217 Liothyronine [4] Liothyronine; Liothyronine sodium; Thyroid; Triiodothyronine[2] D01011 ,
D08128 		[2] THRA,
THRB 💬		[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[4] 13, 78, 210, 212
218 Lipoic acid [3] Alpha Lipoic Acid; ALPHA-LIPOIC ACID; Lipoic acid[2] D00048 ,
D00086 		--[5] 2, 5, 13, 14, 20
219 Lisdexamfetamine [1] Lisdexamfetamine[1] D08130 [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[1] 13
220 Lithium carbonate [2] Lithium; Lithium Carbonate[1] D00801 --[6] 2, 13, 17, 18, 19, 127
221 Loperamide [2] LOPERAMIDE; Loperamide hydrochloride[3] D00729 ,
D07113 ,
D08144 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[2] 13, 97
222 Loratadine [2] Loratadina; LORATADINE[1] D00364 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 13, 46, 89, 98
223 Lubiprostone [1] Lubiprostone[1] D04790 [1] CLCN2 💬[1] Mineral absorption 💬[4] 6, 13, 290, 299
224 Lutein [1] Lutein---[3] 13, 90, 164
225 Lysine [1] Lysine[1] D02304 --[5] 13, 19, 97, 228, 299
226 Magnesium [1] Magnesium---[21] 3, 6, 11, 13, 15, 46, 51, 64, 70, 93, 97, 111, 166, 225, 235, 256, 284, 291, 296, 297, 298
227 Maltodextrin [1] Maltodextrin[1] D02329 --[4] 6, 13, 96, 97
228 Mangafodipir [1] Mangafodipir[1] D08262 --[2] 13, 58
229 Manganese citrate [1] Release---[12] 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
230 Mannitol [4] Aridol; Bronchitol; Mannite; Mannitol[1] D00062 --[7] 6, 13, 28, 60, 96, 113, 299
231 Mannose [1] Mannose---[2] 13, 256
232 Masitinib [1] Masitinib[1] D10229 [1] KIT 💬[11] Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬[6] 2, 5, 6, 13, 46, 96
233 Medical air [1] Medical air---[9] 3, 13, 51, 58, 85, 86, 97, 193, 299
234 Medical Cannabis [3] Cannabis; Marijuana; Medical Cannabis---[9] 2, 6, 13, 19, 46, 90, 96, 97, 271
235 Medroxyprogesterone acetate [1] Medroxyprogesterone[2] D00951 ,
D08166 		[1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[6] 13, 35, 46, 49, 51, 60
236 Melatonin [2] Circadin; Melatonin[1] D08170 [2] MTNR1A,
MTNR1B 💬		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[12] 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
237 Melphalan [3] ALKERAN; Melphalan; Melphalan Hydrochloride[1] D00369 --[15] 11, 13, 14, 19, 20, 28, 60, 62, 65, 96, 164, 234, 284, 285, 299
238 Memantine [3] Ebixa; Memantine; MEMANTINE HYDROCHLORIDE[2] D04905 ,
D08174 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[7] 2, 6, 8, 13, 49, 127, 205
239 Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine [1] Menveo---[6] 11, 13, 61, 62, 66, 222
240 Meningococcal polysaccharide vaccine group A [2] Menveo; Nimenrix[1] D04910 --[7] 11, 13, 50, 61, 62, 66, 222
241 Meningococcal polysaccharide vaccine group C [2] Menveo; Nimenrix[1] D06415 --[7] 11, 13, 50, 61, 62, 66, 222
242 Meningococcal polysaccharide vaccine group W-135 [2] Menveo; Nimenrix---[7] 11, 13, 50, 61, 62, 66, 222
243 Meningococcal polysaccharide vaccine group Y [2] Menveo; Nimenrix---[7] 11, 13, 50, 61, 62, 66, 222
244 Metformin [5] Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine[2] D00944 ,
D04966 		[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
245 Methamidophos [1] MONITOR---[20] 2, 11, 13, 19, 28, 46, 49, 58, 65, 70, 81, 85, 86, 98, 113, 118, 129, 298, 299, 300
246 Methotrexate [6] Methotrexat; METHOTREXATE; METHOTREXATE SODIUM; METOJECT; Metotrexato; Méthotrexate[2] D00142 ,
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
247 Methylphenidate [3] Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin[2] D01296 ,
D04999 		[2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[7] 6, 13, 34, 84, 113, 179, 206
248 Methylprednisolone [4] Medrol; Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
249 Methylprednisolone hemisuccinate [4] Methylprednisolone hemisuccinate; METHYLPREDNISOLONE SODIUM SUCCINATE; Methylprednisolone succinate; Solu-Medrol[1] D05000 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[7] 13, 49, 50, 51, 53, 97, 211
250 Midazolam [2] Midazolam; Midazolam injection[3] D00550 ,
D00696 ,
D05028 		[16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
251 Minocycline [3] Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin[2] D00850 ,
D05045 		--[14] 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
252 Mirabegron [1] Mirabegron[1] D09535 [1] ADRB3 💬[8] Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cGMP-PKG signaling pathway 💬[4] 6, 13, 53, 226
253 Mitoquinone [1] Mitoquinone---[3] 6, 13, 97
254 Mitoxantrone [2] Mitoxantrone; Novantrone[2] D02166 ,
D08224 		[2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[1] 13
255 MK-0812 [0] ---[2] 13, 46
256 Modafinil [2] Modafinil; Provigil[1] D01832 --[5] 6, 13, 49, 93, 113
257 Moderna COVID-19 Vaccine [4] COVID-19 Vaccine Moderna; Elasomeran; Moderna COVID-19 Vaccine; Spikevax[1] D12114 --[5] 13, 46, 51, 65, 299
258 Monomethyl fumarate [2] Bafiertam; Monomethyl fumarate[1] D11492 --[15] 13, 35, 40, 46, 49, 50, 51, 60, 65, 66, 162, 222, 224, 226, 299
259 Montelukast [3] Montelukast; MONTELUKAST SODIUM; Singulair[2] D00529 ,
D08229 		[1] CYSLTR1 💬[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction 💬[8] 6, 13, 46, 61, 63, 85, 98, 228
260 Mycophenolate mofetil [3] CELLCEPT; Mycophenolate Mofetil; Mycophenolate mofetil TEVA[3] D00752 ,
D05094 ,
D05095 		[2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
261 Mycophenolic acid [5] Acido Micofenolico; MICOFENOLICO ACIDO; Mycophenolate; MYCOPHENOLIC ACID; Myfortic[1] D05096 [2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
262 Nabilone [1] NABILONE[1] D05099 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[2] 6, 13
263 Nabiximols [1] Nabiximols[1] D09317 --[1] 13
264 Naltrexone [2] Naltrexone; Naltrexone Hydrochloride[2] D02095 ,
D05113 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
265 Naproxen [5] Naprosyn; Naproxen; Naproxen oral suspension; NAPROXEN SODIUM; Propanoic acid[1] D00118 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[4] 13, 46, 107, 271
266 Natalizumab [2] Natalizumab; TYSABRI[1] D06886 [1] ITGA4 💬[14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬[6] 13, 15, 25, 46, 63, 96
267 Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen [1] Menveo---[6] 11, 13, 61, 62, 66, 222
268 Neisseria meningitidis group c capsular oligosaccharide diphtheria crm197 protein conjugate antigen [1] Menveo---[6] 11, 13, 61, 62, 66, 222
269 Neisseria meningitidis group w-135 capsular oligosaccharide diphtheria crm197 protein conjugate antigen [1] Menveo---[6] 11, 13, 61, 62, 66, 222
270 Neisseria meningitidis group y capsular oligosaccharide diphtheria crm197 protein conjugate antigen [1] Menveo---[6] 11, 13, 61, 62, 66, 222
271 Neisseria meningitidis serogroup b fhbp fusion protein antigen [1] Bexsero---[6] 11, 13, 61, 62, 66, 222
272 Neisseria meningitidis serogroup b nada protein antigen [1] Bexsero---[6] 11, 13, 61, 62, 66, 222
273 Neisseria meningitidis serogroup b nhba fusion protein antigen [1] Bexsero---[6] 11, 13, 61, 62, 66, 222
274 Neisseria meningitidis serogroup B strain NZ98/254 outer membrane vesicle [1] Bexsero---[6] 11, 13, 61, 62, 66, 222
275 Neramexane [1] Neramexane---[1] 13
276 Nerispirdine [1] Nerispirdine---[1] 13
277 Nicotinamide [4] Ginseng; Multivitamin; Niacinamide; Nicotinamide[1] D00036 --[11] 2, 5, 6, 13, 18, 49, 65, 67, 107, 162, 191
278 Nicotine [2] NICOTINE; Nicotine gum[3] D03365 ,
D05156 ,
D05157 		[16] CHRNA1,
CHRNA10,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNA6,
CHRNA7,
CHRNA9,
CHRNB1,
CHRNB2,
CHRNB3,
CHRNB4,
CHRND,
CHRNE,
CHRNG 💬		[7] Alzheimer disease, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases 💬[3] 6, 13, 84
279 Nitric Oxide [3] INOmax; NITRIC OXIDE; Nitrosyl[1] D00074 --[16] 6, 13, 46, 58, 85, 86, 96, 97, 98, 210, 222, 226, 251, 294, 299, 321
280 Nitrofurantoin [1] Nitrofurantoin[1] D00439 --[1] 13
281 Nivolumab [1] Nivolumab[1] D10316 [1] PDCD1 💬[3] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer, T cell receptor signaling pathway 💬[12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159
282 Nomegestrol [1] Nomegestrol[1] D07222 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[1] 13
283 Nomegestrol acetate [1] Nomegestrol acetate[1] D08281 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[1] 13
284 Norethisterone [3] Norethindrone; Ortho-novum; Ortho-Novum 777[2] D00182 ,
D00953 		[1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[4] 13, 46, 49, 299
285 Ocrelizumab [2] OCRELIZUMAB; OCREVUS[1] D05218 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[3] 13, 46, 49
286 Ofatumumab [4] Arzerra; HuMax-CD20; Kesimpta; Ofatumumab[1] D09314 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[3] 13, 35, 46
287 Olea europaea leaf [1] Olive---[3] 13, 49, 53
288 Oleic Acid [1] Oleic Acid[1] D02315 --[2] 13, 299
289 Olive oil [1] Olive Oil[1] D03311 --[3] 13, 49, 53
290 Omega-3 fatty acids [6] Omega 3 fatty acids; Omega-3; Omega-3 fatty acid; Omega-3 fatty acids; OMEGA-3-ACID TRIGLYCERIDES; Phospholipids---[8] 13, 46, 49, 53, 66, 79, 96, 299
291 Omeprazole [5] Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM[4] D00455 ,
D01207 ,
D05259 ,
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
292 Opicinumab [1] Opicinumab[1] D11767 [1] LINGO1 💬-[1] 13
293 Orelabrutinib [1] Orelabrutinib[1] D12160 [1] BTK 💬[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[3] 13, 61, 63
294 Oxcarbazepine [2] Oxcarbazepine; Trileptal[1] D00533 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 13
295 Oxybutynin [1] Oxybutynin[2] D00465 ,
D00722 		[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 53
296 Oxycodone [3] OXYCODONE; OXYCODONE HYDROCHLORIDE; Oxycodone/Acetaminophen[3] D03783 ,
D05312 ,
D05462 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 13, 46, 70, 226, 231, 298
297 Oxygen [3] Medical air; Nitrogen; Oxygen[1] D00003 --[20] 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
298 Oxyquinoline [1] Oxine[1] D05321 --[1] 13
299 Ozanimod [2] OZANIMOD; Zeposia[1] D10968 [5] S1PR1,
S1PR2,
S1PR3,
S1PR4,
S1PR5 💬		[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[3] 13, 96, 97
300 Palifermin [2] Kepivance; Palifermin[1] D05338 [1] FGFR2 💬[13] Calcium signaling pathway, Central carbon metabolism in cancer, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Gastric cancer, MAPK signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells 💬[5] 13, 36, 38, 39, 65
301 Panax quinquefolius whole [2] American Ginseng; Panax Quinquefolius---[2] 13, 46
302 Pantoprazole [1] PANTOPRAZOLE[2] D02593 ,
D05353 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 13, 65
303 Paroxetine [1] Paroxetine[4] D02260 ,
D02362 ,
D05374 ,
D05375 		[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
304 Peanut [1] Peanut---[1] 13
305 Peginterferon beta-1a [2] PEGINTERFERON BETA-1A; Plegridy[1] D10483 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 13
306 Penciclovir [0] [2] D02124 ,
D05407 		--[1] 13
307 Pertussis vaccine [1] Pertussis vaccine[1] D06514 --[2] 13, 46
308 Pfizer-BioNTech COVID-19 Vaccine [2] Comirnaty; Tozinameran[1] D11971 --[5] 13, 46, 51, 53, 299
309 Phenoxymethylpenicillin [0] [3] D00497 ,
D02506 ,
D05411 		--[3] 13, 97, 215
310 Phenytoin [1] Phenytoin[2] D00512 ,
D02103 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 13
311 Phosphate ion [1] Phosphate---[33] 2, 3, 6, 11, 12, 13, 15, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
312 Phylloquinone [4] Phylloquinone; Phytomenadione; Vitamin K; Vitamin K1[1] D00148 --[6] 13, 46, 96, 97, 288, 299
313 Pioglitazone [1] Pioglitazone[2] D00945 ,
D08378 		[1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
314 Pirfenidone [2] Esbriet; PIRFENIDONE[1] D01583 [6] CCL2,
IL10,
IL1A,
IL1B,
IL6,
TNF 💬		[84] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
315 Pixantrone [1] Pixantrone[1] D05522 [2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[2] 11, 13
316 Polyethylene glycol [4] Macrogol; Macrogol 4000; Polyethylene glycol; Polyethylene Glycol 3350[1] D03370 --[14] 6, 13, 41, 46, 65, 78, 96, 97, 140, 144, 235, 240, 276, 299
317 Ponesimod [1] PONESIMOD[1] D11215 [1] S1PR1 💬[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[1] 13
318 Pravastatin [2] Pravastatin; Pravastatin sodium[2] D00893 ,
D08410 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[9] 13, 46, 49, 67, 79, 96, 164, 265, 333
319 Prednisolone [3] Prednisolona; PREDNISOLONE; Prednisolonum[8] D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[43] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
320 Prednisone [3] PREDNISONA; Prednisone; RAYOS[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
321 Pregabalin [2] Lyrica; Pregabalin[1] D02716 [4] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		[7] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬[5] 13, 36, 46, 70, 298
322 Prucalopride [2] Prucalopride; Resolor[1] D09205 [1] HTR4 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, cAMP signaling pathway 💬[3] 13, 51, 96
323 Pyridoxal phosphate [0] [1] D00006 --[1] 13
324 Pyrimethamine [2] Daraprim; Pyrimethamine[1] D00488 --[11] 2, 4, 6, 13, 19, 46, 51, 65, 96, 97, 265
325 Quetiapine [2] Quetiapine; Seroquel[2] D00458 ,
D08456 		[2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[2] 6, 13
326 Quinidine [4] Nuedexta; Quinidina; Quinidine; Quinidine Sulfate[4] D00642 ,
D00643 ,
D02272 ,
D08458 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[3] 2, 8, 13
327 Rabbit [1] Rabbit---[8] 11, 13, 49, 51, 60, 65, 96, 285
328 Raltegravir [2] ISENTRESS; Raltegravir[1] D06676 --[4] 13, 26, 93, 265
329 Ramatroban [1] Ramatroban[1] D01128 [2] PTGDR,
TBXA2R 💬		[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation 💬[1] 13
330 Ranitidine [1] Ranitidine[2] D00422 ,
D00673 		[1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[2] 13, 65
331 Rasagiline [4] Azilect; Rasagilina; Rasagiline; RASAGILINE MESYLATE[3] D02562 ,
D08469 ,
D10829 		[1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[7] 2, 5, 6, 13, 17, 58, 66
332 Ravulizumab [2] RAVULIZUMAB; Ultomiris[1] D11054 [1] C5 💬[10] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[7] 2, 11, 13, 50, 62, 66, 109
333 Riboflavin [2] Riboflavin; Vitamin B2[3] D00050 ,
D01622 ,
D01913 		--[8] 13, 38, 46, 96, 97, 162, 168, 265
334 Rifampicin [2] Rifampicin; Rifampin[1] D00211 --[9] 6, 13, 17, 46, 84, 86, 93, 299, 338
335 Riluzole [2] RILUTEK; Riluzole[1] D00775 [14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[9] 2, 3, 5, 8, 13, 17, 18, 203, 206
336 Rituximab [6] MabThera; Rituxan; Rituximab; Rixathon; Ruxience; TRUXIMA[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[49] 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
337 Rivastigmine [3] EXELON; RIVASTIGMINE; Rivastigmine Transdermal System[2] D02558 ,
D03822 		[1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[3] 5, 6, 13
338 Rolipram [1] Rolipram[1] D01783 [4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[2] 8, 13
339 Salbutamol [3] Albuterol; Salbutamol; Ventolin[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[14] 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299
340 SARS-CoV-2 mRNA vaccine [1] SARS-COV-2 mRNA Vaccine---[1] 13
341 Satralizumab [2] Enspryng; SATRALIZUMAB[1] D11079 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[2] 11, 13
342 Secukinumab [2] Cosentyx; SECUKINUMAB[1] D09967 [1] IL17A 💬[6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[8] 13, 37, 41, 46, 107, 160, 269, 271
343 Selenium [1] Selenium---[4] 13, 96, 278, 298
344 Silodosin [2] Silodosin; Silodyx[1] D01965 [1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 6, 13
345 Simethicone [1] Simethicone[1] D05841 --[2] 13, 96
346 Simvastatin [3] Simvastatin; Simvastatina; Simvastatine[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
347 Siponimod [2] Mayzent; SIPONIMOD[1] D11460 [2] S1PR1,
S1PR5 💬		[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[2] 13, 50
348 Sirolimus [3] RAPAMUNE; Rapamycin; Sirolimus[1] D00753 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[41] 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
349 Sivelestat [1] Sivelestat[1] D03788 [1] ELANE 💬[3] Neutrophil extracellular trap formation, Systemic lupus erythematosus, Transcriptional misregulation in cancer 💬[3] 13, 85, 96
350 Sodium chloride [6] Lactated Ringers; Natriumchlorid; REBIF; Saline; SODIUM CHLORIDE; Sporanox[1] D02056 --[21] 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 168, 193, 227, 228, 271, 288, 299
351 Solifenacin [2] Solifenacin; Solifenacin Succinate[2] D01269 ,
D08522 		[1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[3] 6, 13, 53
352 Somatorelin [2] GHRH; Somatorelin[1] D08523 [1] GHRHR 💬[2] Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬[2] 13, 78
353 Somatotropin [17] Genotropin; Growth hormone; Human growth hormone; Humatrope; Norditropin; Norditropin SimpleXx; NUTROPIN; Nutropin AQ; NutropinAq; OMNITROPE; Recombinant human growth hormone; RhGH; SAIZEN; Somatotropin; Somatropin; SOMATROPINA; Zomacton[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[23] 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
354 Spectinomycin [0] [2] D00869 ,
D08526 		--[1] 13
355 Streptococcus pneumoniae type 1 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
356 Streptococcus pneumoniae type 14 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
357 Streptococcus pneumoniae type 18c capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
358 Streptococcus pneumoniae type 19a capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
359 Streptococcus pneumoniae type 19f capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
360 Streptococcus pneumoniae type 23f capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
361 Streptococcus pneumoniae type 3 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
362 Streptococcus pneumoniae type 4 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
363 Streptococcus pneumoniae type 5 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
364 Streptococcus pneumoniae type 6b capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
365 Streptococcus pneumoniae type 7f capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
366 Streptococcus pneumoniae type 9v capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
367 Sulfate ion [1] Sulfate---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
368 Sulodexide [0] [1] D08547 [2] SERPINC1,
SERPIND1 💬		[1] Complement and coagulation cascades 💬[4] 13, 51, 271, 288
369 Suvorexant [1] Suvorexant[1] D10082 [2] HCRTR1,
HCRTR2 💬		[1] Neuroactive ligand-receptor interaction 💬[3] 5, 6, 13
370 Tacrolimus [2] Prograf; Tacrolimus[2] D00107 ,
D08556 		[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
371 Tarenflurbil [2] FLURBIPROFEN; Tarenflurbil[1] D09010 [4] APH1A,
NCSTN,
PSEN1,
PSENEN 💬		[6] Alzheimer disease, Human papillomavirus infection, Neurotrophin signaling pathway, Notch signaling pathway, Pathways of neurodegeneration - multiple diseases, Wnt signaling pathway 💬[1] 13
372 Taurine [1] Taurine[1] D00047 --[2] 13, 337
373 Tauroursodeoxycholic acid [2] Tauroursodeoxycholic acid; TUDCA[1] D11836 --[4] 2, 13, 93, 299
374 Temelimab [1] TEMELIMAB---[1] 13
375 Temsirolimus [1] Temsirolimus[1] D06068 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[4] 13, 34, 89, 331
376 Tenofovir [1] Tenofovir[1] D06074 --[6] 2, 13, 25, 93, 265, 325
377 Tenofovir alafenamide [1] Tenofovir alafenamide[1] D10428 --[2] 2, 13
378 Teriflunomide [2] AUBAGIO; TERIFLUNOMIDE[1] D10172 [1] DHODH 💬[3] Biosynthesis of cofactors, Metabolic pathways, Pyrimidine metabolism 💬[3] 13, 25, 26
379 Testosterone [1] Testosterone[6] D00075 ,
D00957 ,
D00958 ,
D00959 ,
D06085 ,
D06087 		[1] AR 💬[4] Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬[9] 1, 2, 3, 13, 60, 76, 78, 113, 265
380 Testosterone enanthate [2] Testosterone Enanthate; Xyosted[1] D00958 [1] AR 💬[4] Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬[2] 13, 113
381 Testosterone undecanoate [1] Testosterone undecanoate[1] D06087 [1] AR 💬[4] Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬[2] 13, 60
382 Tetracycline [2] Tetracyclin; Tetracycline[1] D00201 --[5] 13, 36, 46, 53, 97
383 Thiamine [2] Thiamine; Vitamin B1[1] D08580 --[5] 8, 13, 93, 145, 265
384 Thiotepa [1] Thiotepa[1] D00583 --[12] 13, 19, 20, 28, 51, 60, 65, 85, 96, 164, 284, 285
385 Thymol [1] Thymol[1] D01039 --[1] 13
386 Tioguanine [0] [2] D06109 ,
D08603 		[1] HPRT1 💬[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[2] 13, 37
387 Tizanidine [1] Tizanidine[2] D00776 ,
D08611 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 13
388 Tocilizumab [3] ACTEMRA; RoActemra; Tocilizumab[1] D02596 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
389 Tocopherol [2] Tocoferol; Tocopherol[1] D02332 --[6] 13, 49, 90, 206, 257, 298
390 Tolperisone [1] Tolperisone[1] D08617 --[1] 13
391 Topramezone [0] ---[8] 6, 13, 46, 50, 53, 96, 97, 299
392 Treosulfan [2] OVASTAT; Treosulfan[1] D07253 --[6] 13, 19, 62, 65, 283, 286
393 Tricaprylin [2] Caprylic Triglyceride; Tricaprilin---[2] 13, 145
394 TRO19622 [1] TRO19622---[3] 2, 3, 13
395 Tropicamide [1] Tropicamide[1] D00397 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 19
396 Ublituximab [1] UBLITUXIMAB[1] D11243 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 13
397 Valproic acid [3] Valproate; VALPROATE SODIUM; Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
398 Vardenafil [3] Levitra; Vardenafil; Vardenafilo[3] D02731 ,
D03260 ,
D08668 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[3] 13, 86, 299
399 Vatelizumab [1] Vatelizumab---[2] 13, 97
400 Venlafaxine [2] Venlafaxine; VENLAFAXINE HYDROCHLORIDE[2] D00821 ,
D08670 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 6, 13, 46
401 Vidofludimus [1] Vidofludimus---[5] 13, 46, 94, 96, 97
402 Vitamin A [1] Vitamin A[2] D00069 ,
D06543 		[2] RARA,
RARB 💬		[8] Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[3] 13, 53, 90
403 Vitamin D [3] Calciferol; Cod liver oil; Vitamin D---[24] 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
404 Vitamin E [2] Alpha-tocopherol; Vitamin E[1] D02331 --[12] 2, 6, 13, 20, 46, 49, 90, 96, 97, 206, 299, 317
405 Warfarin [2] Warfarin; Warfarin Sodium[3] D00564 ,
D01280 ,
D08682 		[2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
406 Water [9] AVONEX; ENBREL; Glucagon; Hiberix; Indocyanine green; OMNITROPE; Sterile Water for Injection; Water; WATER FOR INJECTION[1] D00001 --[23] 2, 5, 6, 13, 17, 19, 22, 35, 46, 51, 53, 56, 57, 63, 65, 67, 78, 84, 96, 97, 226, 278, 299
407 Zoledronic acid [4] Aclasta; Zoledronate; Zoledronic acid; Zometa[4] D01968 ,
D06378 ,
D06379 ,
D08689 		[1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333