43. Microscopic polyangiitis Clinical trials / Disease details
Clinical trials : 87 / Drugs : 84 - (DrugBank : 20) / Drug target genes : 15 - Drug target pathways : 88
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT00987389 (ClinicalTrials.gov) | May 2010 | 23/9/2009 | Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis | Plasma Exchange and Glucocorticoid Dosing in the Treatment of Anti-neutrophil Cytoplasm Antibody Associated Vasculitis: an International Randomized Controlled Trial | Granulomatosis With Polyangiitis (Wegener's) (GPA);Microscopic Polyangiitis (MPA) | Procedure: Plasma Exchange;Other: No Plasma Exchange;Drug: Glucocorticoids [Standard Dose];Drug: Glucocorticoids [Reduced Dose] | University of Pennsylvania | Cambridge University Hospitals NHS Foundation Trust;University of Birmingham;National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Completed | 15 Years | N/A | All | 704 | Phase 3 | United States;Australia;Belgium;Canada;Czechia;Denmark;France;Greece;Italy;Japan;Mexico;New Zealand;Norway;Sweden;United Kingdom;Czech Republic |
| 2 | NCT03919825 (ClinicalTrials.gov) | May 2010 | 15/4/2019 | Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis (PEXIVAS) - Glucocorticoids | Plasma Exchange and Glucocorticoid Dosing in the Treatment of Anti-neutrophil Cytoplasm Antibody Associated Vasculitis: an International Randomized Controlled Trial [Glucocorticoids] | Granulomatosis With Polyangiitis (Wegener's) (GPA);Microscopic Polyangiitis (MPA) | Drug: Glucocorticoids - Standard Dose;Drug: Glucocorticoids - Reduced Dose | University of Pennsylvania | NULL | Completed | 15 Years | N/A | All | 704 | Phase 3 | NULL |
| 3 | EUCTR2009-013220-24-IT (EUCTR) | 22/01/2010 | 10/12/2009 | Plasma exchange and glucocorticoid dosing in the treatment of ANCA-associated vasculitis: a multicentre randomized controlled tria - PEXIVAS | Plasma exchange and glucocorticoid dosing in the treatment of ANCA-associated vasculitis: a multicentre randomized controlled tria - PEXIVAS | Acute renal severe to moderate failure with Wegener`s Granulomatosis or microscopic polyangiitis MedDRA version: 9.1;Level: HLGT;Classification code 10003816 MedDRA version: 9.1;Level: LLT;Classification code 10018378 | Trade Name: DELTACORTENE INN or Proposed INN: Prednisone Trade Name: DELTACORTENE INN or Proposed INN: Prednisone | AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA | NULL | Not Recruiting | Female: yes Male: yes | 500 | Phase 4 | Czech Republic;Poland;Spain;Denmark;United Kingdom;Italy;Sweden | ||
| 4 | NCT00753103 (ClinicalTrials.gov) | January 2003 | 15/9/2008 | Anti-Cytokine Therapy for Vasculitis | Phase II Pilot Cohort Study to Investigate the Safety and Efficacy of Infliximab as Additional Therapy in the Treatment if Anti-Neutrophil Cytoplasm Antibody Associated Vasculitis | Wegener's Granulomatosis;Renal Limited Vasculitis;Microscopic Polyangiitis | Biological: Infliximab;Drug: Cyclophosphamide;Drug: Prednisolone;Drug: Azathioprine;Procedure: Plasma exchange;Drug: Mycophenolate mofetil;Drug: Methylprednisolone | University Hospital Birmingham NHS Foundation Trust | NULL | Completed | 18 Years | N/A | Both | 37 | Phase 2 | United Kingdom |
| 5 | NCT01408836 (ClinicalTrials.gov) | March 1995 | 2/8/2011 | Plasma Exchange for Renal Vasculitis | Randomised Trial of Plasma Exchange or High Dose Methyl Prednisolone as Adjunctive Therapy for Severe Renal Vasculitis | Wegener's Granulomatosis;Microscopic Polyangiitis | Procedure: Plasma exchange;Drug: Intravenous methyl prednisolone;Drug: Methyl prednisolone | Cambridge University Hospitals NHS Foundation Trust | University Hospital Birmingham;Imperial College London;London North West Healthcare NHS Trust;University Hospitals, Leicester;Lund University Hospital;University Medical Centre Groningen;Fundacio Clinic;Helsinki University | Terminated | 18 Years | 80 Years | Both | 150 | Phase 2/Phase 3 | United Kingdom |