Metformin hydrochloride ( DrugBank: Metformin )

5 diseases

81. 先天性副腎皮質酵素欠損症

臨床試験数 : 88 / 薬物数 : 90 - (DrugBank : 23) / 標的遺伝子数 : 12 - 標的パスウェイ数 : 68

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2013-002395-40-BE (EUCTR)	24/03/2014	19/11/2013	Prospective intervention trial with adjuvant metformin in girls and boys with classic congenital adrenal hyperplasia.	Prospective intervention trial with adjuvant metformin in girls and boys with classic CAH (METFOR CAH). - METFOR CAH	congenital adrenal hyperplasia (CAH) MedDRA version: 16.1;Level: LLT;Classification code 10010323;Term: Congenital adrenal hyperplasia;System Organ Class: 100000004850;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]	Trade Name: Metformine Sandoz 850 mg filmomhulde tabletten Product Name: Metformine INN or Proposed INN: METFORMIN HYDROCHLORIDE Other descriptive name: METFORMIN HYDROCHLORIDE	Ghent University Hospital	NULL	Not Recruiting			Female: yes Male: yes	90	Phase 3	Belgium

臨床試験数 : 108 / 薬物数 : 67 - (DrugBank : 17) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 118

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2011-001319-30-GB (EUCTR)	04/04/2012	05/09/2011	Metformin as a treatment for people with the genetic disease Tuberous Sclerosis Complex.	A randomized, double-blind, parallel group, placebo-controlled trial of metformin in tuberous sclerosis complex. - Metformin in Tuberous Sclerosis Complex (MiTS) V1.0	Tuberous Sclerosis Complex MedDRA version: 14.1;Level: PT;Classification code 10045138;Term: Tuberous sclerosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]	Trade Name: metformin (generic) Product Name: Metformin Product Code: n/a INN or Proposed INN: metformin hydrochloride Other descriptive name: -	University Hospitals Bristol NHS Foundation Trust	NULL	Not Recruiting			Female: yes Male: yes	100	Phase 4	United Kingdom

臨床試験数 : 116 / 薬物数 : 170 - (DrugBank : 61) / 標的遺伝子数 : 26 - 標的パスウェイ数 : 97

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00015691 (ClinicalTrials.gov)	April 2001	1/5/2001	Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities	A Randomized, Double-Blind, Placebo-Controlled Study of Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Subjects With Hyperinsulinemia and Elevated Waist/Hip Ratio	HIV Infections;Lipodystrophy;Hyperinsulinemia	Drug: Metformin hydrochloride;Drug: Rosiglitazone maleate	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Completed	18 Years	65 Years	Both	105	N/A	United States

臨床試験数 : 1,696 / 薬物数 : 1,644 - (DrugBank : 272) / 標的遺伝子数 : 96 - 標的パスウェイ数 : 170

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04530383 (ClinicalTrials.gov)	February 14, 2022	24/8/2020	Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related Diabetes	A Randomized, Double-blind, Crossover Clinical Trial of Metformin in Those With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function	Cystic Fibrosis-related Diabetes;Cystic Fibrosis	Drug: Metformin Hydrochloride	University of Kansas Medical Center	NULL	Recruiting	18 Years	N/A	All	36	Phase 2	United States

臨床試験数 : 45 / 薬物数 : 46 - (DrugBank : 12) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 67

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04545736 (ClinicalTrials.gov)	November 23, 2020	10/9/2020	Oral Metformin for Treatment of ABCA4 Retinopathy	Oral Metformin for Treatment of ABCA4 Retinopathy	ABCA4 Retinopathy;Stargardt Disease;Retinal Dystrophy;Retinal Degeneration	Drug: Metformin hydrochloride	National Eye Institute (NEI)	NULL	Recruiting	12 Years	N/A	All	38	Phase 1/Phase 2	United States